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08.12.2021 | Review articles

Associations between genetic variations in microRNA and myocardial infarction susceptibility: a meta-analysis and systematic review

verfasst von: Yang Yang, Xiajun Shi, Zhengxun Du, Gendong Zhou, Xiaohong Zhang

Erschienen in: Herz | Ausgabe 6/2022

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Abstract

Background

Current genetic association studies have reported conflicting results regarding the association between miRNA polymorphisms and myocardial infarction (MI) risk

Methods

Relevant studies were retrieved from the PubMed, EMBASE, ISI Web of Science, and Scopus databases. Eligible studies determining the association between miRNA polymorphisms and MI susceptibility were included and a meta-analysis was performed to quantify the associations between miRNA polymorphisms and MI risk.

Results

A total of eight studies with 2507 MI patients and 3796 healthy controls were included, dealing with nine miRNA genes containing 11 different loci, including miR-149 (rs71428439 and rs2292832), miR-126 (rs4636297 and rs1140713), miR-146a (rs2910164), miR-218 (rs11134527), miR-196a2 (rs11614913), miR-499 (rs3746444), miR-27a (rs895819), miR-26a‑1 (rs7372209), and miR-100 (rs1834306). miR-146a rs2910164 and miR-499 rs3746444 were determined to have a significant association with MI susceptibility, a finding that was supported by the meta-analysis (rs2910164: GG/CC, odds ratio [OR]: 1.40, 95% confidence interval [95% CI]: 1.05–1.74, p < 0.001; rs3746444: AA + AG/GG, OR = 2.04, 95% CI: 1.37–2.70, p < 0.001). Limited or conflicting data were found for the relationship between the other miRNA polymorphisms (rs71428439, rs4636297, rs1140713, rs11134527, rs11614913, rs895819, rs7372209, rs1834306, rs2292832) and MI risk.

Conclusion

There was a significant association between rs2910164 and rs3746444 and MI susceptibility. Further studies are required to investigate the role of miRNA polymorphisms in MI risk.

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Titel: Associations between genetic variations in microRNA and myocardial infarction susceptibility: a meta-analysis and systematic review
verfasst von: Yang Yang
Xiajun Shi
Zhengxun Du
Gendong Zhou
Xiaohong Zhang
Publikationsdatum: 08.12.2021
Verlag: Springer Medizin
Erschienen in: Herz / Ausgabe 6/2022
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-021-05086-3

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Associations between genetic variations in microRNA and myocardial infarction susceptibility: a meta-analysis and systematic review

Abstract

Background

Methods

Results

Conclusion

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Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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