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28.01.2022 | Original articles

Association between MTHFR C677T polymorphism and risk of coronary artery disease in the Chinese population: meta-analysis

verfasst von: Li Li, Hao Yu, Huan Zhang, Jiangjun Wang, Wei Hu

Erschienen in: Herz | Ausgabe 6/2022

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Abstract

Background

Previous studies have investigated the close association between the MTHFR C677T polymorphism and the risk of coronary heart disease (CAD) in the Chinese population. However, the results remain inconclusive. Therefore, this meta-analysis was performed to derive a more precise estimate of these associations.

Methods

Odds ratios (OR) with 95% confidence intervals (CI) were used to assess the relationship between the MTHFR C677T polymorphism and the risk of CAD. Studies were identified by searching the literature for articles published before 2017.

Results

A total of 39 studies comprising 12,101 individuals (6117 cases and 5984 controls) were included. For the allelic model T vs. C, the pooled OR was 1.43 (95% CI: 1.30–1.57, p < 0.0001); for the recessive model TT vs. CC + TC, the pooled OR was 1.48 (95% CI: 1.29–1.70, p < 0.0001); for the dominant model TT + TC vs. CC, the pooled OR was 1.65 (95% CI: 1.43–1.89, p < 0.0001).

Conclusion

In the subgroup analysis of high-quality studies, an obvious association was observed between the MTHFR C677T polymorphism and CAD risk in the Chinese population.

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Titel: Association between MTHFR C677T polymorphism and risk of coronary artery disease in the Chinese population: meta-analysis
verfasst von: Li Li
Hao Yu
Huan Zhang
Jiangjun Wang
Wei Hu
Publikationsdatum: 28.01.2022
Verlag: Springer Medizin
Erschienen in: Herz / Ausgabe 6/2022
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-021-05087-2

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Association between MTHFR C677T polymorphism and risk of coronary artery disease in the Chinese population: meta-analysis

Abstract

Background

Methods

Results

Conclusion

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Background

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