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Erschienen in: Herz 7/2016

15.03.2016 | Erkrankungen des Myokards | Übersichten

Thrombusaspiration bei Patienten mit akutem Myokardinfarkt

Wissenschaftliche Evidenz und Empfehlungen in den Leitlinien

verfasst von: Dr. T. Stiermaier, S. de Waha, G. Fürnau, I. Eitel, H. Thiele, S. Desch

Erschienen in: Herz | Ausgabe 7/2016

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Zusammenfassung

Durch Entwicklungen im Bereich der perkutanen Koronarintervention und der Thrombozytenaggregationshemmung sowie durch schnellere „Door-to-balloon“-Zeiten konnte die Therapie des akuten Myokardinfarkts in den letzten Jahren deutlich verbessert werden. Die fehlende myokardiale Perfusion trotz Rekanalisation des Infarktgefäßes stellt jedoch weiterhin ein prognostisch relevantes Problem dar. Die Aspiration von thrombotischem Material im Bereich der Zielläsion zeigte in ersten Studien eine Verbesserung des koronaren Flusses sowie der myokardialen Perfusion und wurde daher in den internationalen Leitlinien empfohlen. Zuletzt konnten jedoch große multizentrische Studien mit klinischen Endpunkten keine Vorteile durch eine routinemäßige Thrombusaspiration bei Patienten mit akutem Myokardinfarkt aufzeigen. Zudem wurde die Sicherheit der Thrombusaspiration aufgrund eines vermehrten Auftretens von Schlaganfällen in Frage gestellt. Dies führte zu einer Herabstufung der Empfehlung in den Leitlinien. Der vorliegende Review fasst die wichtigsten Ergebnisse aus klinischen Studien sowie die derzeitigen Empfehlungen zur Thrombusaspiration bei Patienten mit akutem Myokardinfarkt zusammen.
Literatur
1.
Zurück zum Zitat Libby P (2013) Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med 368:2004–2013CrossRefPubMed Libby P (2013) Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med 368:2004–2013CrossRefPubMed
2.
Zurück zum Zitat Serdoz R, Pighi M, Konstantinidis NV et al (2014) Thrombus aspiration in primary angioplasty for ST-segment elevation myocardial infarction. Curr Atheroscler Rep 16:431CrossRefPubMed Serdoz R, Pighi M, Konstantinidis NV et al (2014) Thrombus aspiration in primary angioplasty for ST-segment elevation myocardial infarction. Curr Atheroscler Rep 16:431CrossRefPubMed
3.
Zurück zum Zitat Bahrmann P, Rach J, Desch S et al (2011) Incidence and distribution of occluded culprit arteries and impact of coronary collaterals on outcome in patients with non-ST-segment elevation myocardial infarction and early invasive treatment strategy. Clin Res Cardiol 100:457–467CrossRefPubMed Bahrmann P, Rach J, Desch S et al (2011) Incidence and distribution of occluded culprit arteries and impact of coronary collaterals on outcome in patients with non-ST-segment elevation myocardial infarction and early invasive treatment strategy. Clin Res Cardiol 100:457–467CrossRefPubMed
4.
Zurück zum Zitat Wang TY, Zhang M, Fu Y et al (2009) Incidence, distribution, and prognostic impact of occluded culprit arteries among patients with non-ST-elevation acute coronary syndromes undergoing diagnostic angiography. Am Heart J 157:716–723CrossRefPubMed Wang TY, Zhang M, Fu Y et al (2009) Incidence, distribution, and prognostic impact of occluded culprit arteries among patients with non-ST-elevation acute coronary syndromes undergoing diagnostic angiography. Am Heart J 157:716–723CrossRefPubMed
5.
Zurück zum Zitat Vlaar PJ, Diercks GF, Svilaas T et al (2008) The feasibility and safety of routine thrombus aspiration in patients with non-ST-elevation myocardial infarction. Catheter Cardiovasc Interv 72:937–942CrossRefPubMed Vlaar PJ, Diercks GF, Svilaas T et al (2008) The feasibility and safety of routine thrombus aspiration in patients with non-ST-elevation myocardial infarction. Catheter Cardiovasc Interv 72:937–942CrossRefPubMed
6.
Zurück zum Zitat Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361:13–20CrossRefPubMed Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361:13–20CrossRefPubMed
7.
Zurück zum Zitat Rogers WJ, Frederick, Stoehr E et al (2008) Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006. Am Heart J 156:1026–1034CrossRefPubMed Rogers WJ, Frederick, Stoehr E et al (2008) Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006. Am Heart J 156:1026–1034CrossRefPubMed
8.
Zurück zum Zitat McLaughlin MG, Stone GW, Aymong E et al (2004) Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarction: the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. J Am Coll Cardiol 44:1215–1223PubMed McLaughlin MG, Stone GW, Aymong E et al (2004) Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarction: the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. J Am Coll Cardiol 44:1215–1223PubMed
9.
Zurück zum Zitat Morishima I, Sone T, Okumura K et al (2000) Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction. J Am Coll Cardiol 36:1202–1209CrossRefPubMed Morishima I, Sone T, Okumura K et al (2000) Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction. J Am Coll Cardiol 36:1202–1209CrossRefPubMed
10.
Zurück zum Zitat Poli A, Fetiveau R, Vandoni P et al (2002) Integrated analysis of myocardial blush and ST-segment elevation recovery after successful primary angioplasty: Real-time grading of microvascular reperfusion and prediction of early and late recovery of left ventricular function. Circulation 106:313–318CrossRefPubMed Poli A, Fetiveau R, Vandoni P et al (2002) Integrated analysis of myocardial blush and ST-segment elevation recovery after successful primary angioplasty: Real-time grading of microvascular reperfusion and prediction of early and late recovery of left ventricular function. Circulation 106:313–318CrossRefPubMed
11.
Zurück zum Zitat Stone GW, Peterson MA, Lansky AJ et al (2002) Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. J Am Coll Cardiol 39:591–597CrossRefPubMed Stone GW, Peterson MA, Lansky AJ et al (2002) Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. J Am Coll Cardiol 39:591–597CrossRefPubMed
12.
Zurück zum Zitat Eeckhout E, Kern MJ (2001) The coronary no-reflow phenomenon: a review of mechanisms and therapies. Eur Heart J 22:729–739CrossRefPubMed Eeckhout E, Kern MJ (2001) The coronary no-reflow phenomenon: a review of mechanisms and therapies. Eur Heart J 22:729–739CrossRefPubMed
13.
Zurück zum Zitat Gregorini L, Marco J, Kozakova M et al (1999) Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction. Circulation 99:482–490CrossRefPubMed Gregorini L, Marco J, Kozakova M et al (1999) Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction. Circulation 99:482–490CrossRefPubMed
14.
Zurück zum Zitat Kotani J, Nanto S, Mintz GS et al (2002) Plaque gruel of atheromatous coronary lesion may contribute to the no-reflow phenomenon in patients with acute coronary syndrome. Circulation 106:1672–1677CrossRefPubMed Kotani J, Nanto S, Mintz GS et al (2002) Plaque gruel of atheromatous coronary lesion may contribute to the no-reflow phenomenon in patients with acute coronary syndrome. Circulation 106:1672–1677CrossRefPubMed
15.
Zurück zum Zitat Topol EJ, Yadav JS (2000) Recognition of the importance of embolization in atherosclerotic vascular disease. Circulation 101:570–580CrossRefPubMed Topol EJ, Yadav JS (2000) Recognition of the importance of embolization in atherosclerotic vascular disease. Circulation 101:570–580CrossRefPubMed
16.
Zurück zum Zitat Jolly SS, Cairns JA, Yusuf S et al (2015) Stroke in the TOTAL trial: a randomized trial of routine thrombectomy vs. percutaneous coronary intervention alone in ST elevation myocardial infarction. Eur Heart J 36:2364–2372CrossRefPubMedPubMedCentral Jolly SS, Cairns JA, Yusuf S et al (2015) Stroke in the TOTAL trial: a randomized trial of routine thrombectomy vs. percutaneous coronary intervention alone in ST elevation myocardial infarction. Eur Heart J 36:2364–2372CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Frobert O, Calais F, James SK et al (2015) ST-elevation myocardial infarction, thrombus aspiration, and different invasive strategies. A TASTE trial substudy. J Am Heart Assoc 4:e001755CrossRefPubMedPubMedCentral Frobert O, Calais F, James SK et al (2015) ST-elevation myocardial infarction, thrombus aspiration, and different invasive strategies. A TASTE trial substudy. J Am Heart Assoc 4:e001755CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Antoniucci D, Valenti R, Migliorini A et al (2004) Comparison of rheolytic thrombectomy before direct infarct artery stenting versus direct stenting alone in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol 93:1033–1035CrossRefPubMed Antoniucci D, Valenti R, Migliorini A et al (2004) Comparison of rheolytic thrombectomy before direct infarct artery stenting versus direct stenting alone in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol 93:1033–1035CrossRefPubMed
19.
Zurück zum Zitat Migliorini A, Stabile A, Rodriguez AE et al (2010) Comparison of AngioJet rheolytic thrombectomy before direct infarct artery stenting with direct stenting alone in patients with acute myocardial infarction. The JETSTENT trial. J Am Coll Cardiol 56:1298–1306CrossRefPubMed Migliorini A, Stabile A, Rodriguez AE et al (2010) Comparison of AngioJet rheolytic thrombectomy before direct infarct artery stenting with direct stenting alone in patients with acute myocardial infarction. The JETSTENT trial. J Am Coll Cardiol 56:1298–1306CrossRefPubMed
20.
Zurück zum Zitat Ali A, Cox D, Dib N et al (2006) Rheolytic thrombectomy with percutaneous coronary intervention for infarct size reduction in acute myocardial infarction: 30-day results from a multicenter randomized study. J Am Coll Cardiol 48:244–252CrossRefPubMed Ali A, Cox D, Dib N et al (2006) Rheolytic thrombectomy with percutaneous coronary intervention for infarct size reduction in acute myocardial infarction: 30-day results from a multicenter randomized study. J Am Coll Cardiol 48:244–252CrossRefPubMed
21.
Zurück zum Zitat Carrabba N, Parodi G, Maehara A et al (2015) Rheolityc thrombectomy in acute myocardial infarction: Effect on microvascular obstruction, infarct size, and left ventricular remodeling. Catheter Cardiovasc Interv. doi:10.1002/ccd.25961PubMed Carrabba N, Parodi G, Maehara A et al (2015) Rheolityc thrombectomy in acute myocardial infarction: Effect on microvascular obstruction, infarct size, and left ventricular remodeling. Catheter Cardiovasc Interv. doi:10.1002/ccd.25961PubMed
22.
Zurück zum Zitat Parodi G, Valenti R, Migliorini A et al (2013) Comparison of manual thrombus aspiration with rheolytic thrombectomy in acute myocardial infarction. Circ Cardiovasc Interv 6:224–230CrossRefPubMed Parodi G, Valenti R, Migliorini A et al (2013) Comparison of manual thrombus aspiration with rheolytic thrombectomy in acute myocardial infarction. Circ Cardiovasc Interv 6:224–230CrossRefPubMed
23.
Zurück zum Zitat De Carlo M, Aquaro GD, Palmieri C et al (2012) A prospective randomized trial of thrombectomy versus no thrombectomy in patients with ST-segment elevation myocardial infarction and thrombus-rich lesions: MUSTELA (MUltidevice Thrombectomy in Acute ST-Segment ELevation Acute Myocardial Infarction) trial. JACC Cardiovasc Interv 5:1223–1230CrossRefPubMed De Carlo M, Aquaro GD, Palmieri C et al (2012) A prospective randomized trial of thrombectomy versus no thrombectomy in patients with ST-segment elevation myocardial infarction and thrombus-rich lesions: MUSTELA (MUltidevice Thrombectomy in Acute ST-Segment ELevation Acute Myocardial Infarction) trial. JACC Cardiovasc Interv 5:1223–1230CrossRefPubMed
24.
Zurück zum Zitat Svilaas T, Vlaar PJ, van der Horst IC et al (2008) Thrombus aspiration during primary percutaneous coronary intervention. N Engl J Med 358:557–567CrossRefPubMed Svilaas T, Vlaar PJ, van der Horst IC et al (2008) Thrombus aspiration during primary percutaneous coronary intervention. N Engl J Med 358:557–567CrossRefPubMed
25.
Zurück zum Zitat Vlaar PJ, Svilaas T, van der Horst IC et al (2008) Cardiac death and reinfarction after 1 year in the thrombus aspiration during Percutaneous coronary intervention in acute myocardial infarction study (TaPaS): a 1‑year follow-up study. Lancet 371:1915–1920CrossRefPubMed Vlaar PJ, Svilaas T, van der Horst IC et al (2008) Cardiac death and reinfarction after 1 year in the thrombus aspiration during Percutaneous coronary intervention in acute myocardial infarction study (TaPaS): a 1‑year follow-up study. Lancet 371:1915–1920CrossRefPubMed
26.
Zurück zum Zitat Stone GW, Maehara A, Witzenbichler B et al (2012) Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction: the INFUSE-AMI randomized trial. JAMA 307:1817–1826CrossRefPubMed Stone GW, Maehara A, Witzenbichler B et al (2012) Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction: the INFUSE-AMI randomized trial. JAMA 307:1817–1826CrossRefPubMed
27.
Zurück zum Zitat Stone GW, Witzenbichler B, Godlewski J et al (2013) Intralesional abciximab and thrombus aspiration in patients with large anterior myocardial infarction: one-year results from the INFUSE-AMI trial. Circ Cardiovasc Interv 6:527–534CrossRefPubMed Stone GW, Witzenbichler B, Godlewski J et al (2013) Intralesional abciximab and thrombus aspiration in patients with large anterior myocardial infarction: one-year results from the INFUSE-AMI trial. Circ Cardiovasc Interv 6:527–534CrossRefPubMed
28.
Zurück zum Zitat Frobert O, Lagerqvist B, Olivecrona GK et al (2013) Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med 369:1587–1597CrossRefPubMed Frobert O, Lagerqvist B, Olivecrona GK et al (2013) Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med 369:1587–1597CrossRefPubMed
29.
Zurück zum Zitat Lagerqvist B, Frobert O, Olivecrona GK et al (2014) Outcomes 1 year after thrombus aspiration for myocardial infarction. N Engl J Med 371:1111–1120CrossRefPubMed Lagerqvist B, Frobert O, Olivecrona GK et al (2014) Outcomes 1 year after thrombus aspiration for myocardial infarction. N Engl J Med 371:1111–1120CrossRefPubMed
30.
Zurück zum Zitat Jolly SS, Cairns JA, Yusuf S et al (2015) Randomized trial of primary PCI with or without routine manual thrombectomy. N Engl J Med 372:1389–1398CrossRefPubMedPubMedCentral Jolly SS, Cairns JA, Yusuf S et al (2015) Randomized trial of primary PCI with or without routine manual thrombectomy. N Engl J Med 372:1389–1398CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Elgendy IY, Huo T, Bhatt DL, Bavry AA (2015) Is aspiration Thrombectomy beneficial in patients undergoing primary Percutaneous coronary intervention? meta-analysis of randomized trials. Circ Cardiovasc Interv 8:e002258CrossRefPubMed Elgendy IY, Huo T, Bhatt DL, Bavry AA (2015) Is aspiration Thrombectomy beneficial in patients undergoing primary Percutaneous coronary intervention? meta-analysis of randomized trials. Circ Cardiovasc Interv 8:e002258CrossRefPubMed
32.
Zurück zum Zitat Deng SB, Wang J, Xiao J et al (2014) Adjunctive manual thrombus aspiration during ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials. PLOS ONE 9:e113481CrossRefPubMedPubMedCentral Deng SB, Wang J, Xiao J et al (2014) Adjunctive manual thrombus aspiration during ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials. PLOS ONE 9:e113481CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Thiele H, de Waha S, Zeymer U et al (2014) Effect of aspiration thrombectomy on microvascular obstruction in NSTEMI patients: the TATORT-NSTEMI trial. J Am Coll Cardiol 64:1117–1124CrossRefPubMed Thiele H, de Waha S, Zeymer U et al (2014) Effect of aspiration thrombectomy on microvascular obstruction in NSTEMI patients: the TATORT-NSTEMI trial. J Am Coll Cardiol 64:1117–1124CrossRefPubMed
34.
Zurück zum Zitat Kampinga MA, Vlaar PJ, Fokkema M et al (2009) Thrombus Aspiration during Percutaneous coronary intervention in Acute non-ST-elevation myocardial infarction Study (TAPAS II)-Study design. Neth Heart J 17:409–413CrossRefPubMedPubMedCentral Kampinga MA, Vlaar PJ, Fokkema M et al (2009) Thrombus Aspiration during Percutaneous coronary intervention in Acute non-ST-elevation myocardial infarction Study (TAPAS II)-Study design. Neth Heart J 17:409–413CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Steg PG, James SK, Atar D et al (2012) ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 33:2569–2619CrossRefPubMed Steg PG, James SK, Atar D et al (2012) ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 33:2569–2619CrossRefPubMed
36.
Zurück zum Zitat O’Gara PT, Kushner FG, Ascheim DD et al (2013) 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 61:78–140CrossRef O’Gara PT, Kushner FG, Ascheim DD et al (2013) 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 61:78–140CrossRef
37.
Zurück zum Zitat Windecker S, Kolh P, Alfonso F et al (2014) 2014 ESC/EaCTS guidelines on myocardial revascularization: the task force on myocardial Revascularization of the european society of cardiology (ESC) and the european association for Cardio-thoracic surgery (EaCTS)developed with the special contribution of the european association of Percutaneous cardiovascular interventions (EaPCI). Eur Heart J 35:2541–2619CrossRefPubMed Windecker S, Kolh P, Alfonso F et al (2014) 2014 ESC/EaCTS guidelines on myocardial revascularization: the task force on myocardial Revascularization of the european society of cardiology (ESC) and the european association for Cardio-thoracic surgery (EaCTS)developed with the special contribution of the european association of Percutaneous cardiovascular interventions (EaPCI). Eur Heart J 35:2541–2619CrossRefPubMed
38.
Zurück zum Zitat Levine GN, O’Gara PT, Bates ER et al (2015) 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol. doi:10.1016/j.jacc.2015.10.005PubMedCentral Levine GN, O’Gara PT, Bates ER et al (2015) 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol. doi:10.1016/j.jacc.2015.10.005PubMedCentral
39.
Zurück zum Zitat Amsterdam EA, Wenger NK, Brindis RG et al (2014) 2014 aHa/aCC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 64:e139–228CrossRefPubMed Amsterdam EA, Wenger NK, Brindis RG et al (2014) 2014 aHa/aCC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 64:e139–228CrossRefPubMed
40.
Zurück zum Zitat Roffi M, Patrono C, Collet JP et al (2015) 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 37:267–315CrossRefPubMed Roffi M, Patrono C, Collet JP et al (2015) 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 37:267–315CrossRefPubMed
41.
Zurück zum Zitat Ikari Y, Sakurada M, Kozuma K et al (2008) Upfront thrombus aspiration in primary coronary intervention for patients with ST-segment elevation acute myocardial infarction: report of the VAMPIRE (VAcuuM asPIration thrombus REmoval) trial. JACC Cardiovasc Interv 1:424–431CrossRefPubMed Ikari Y, Sakurada M, Kozuma K et al (2008) Upfront thrombus aspiration in primary coronary intervention for patients with ST-segment elevation acute myocardial infarction: report of the VAMPIRE (VAcuuM asPIration thrombus REmoval) trial. JACC Cardiovasc Interv 1:424–431CrossRefPubMed
42.
Zurück zum Zitat De Vita M, Burzotta F, Porto I et al (2010) Thrombus aspiration in ST elevation myocardial infarction: comparative efficacy in patients treated early and late after onset of symptoms. Heart 96:1287–1290CrossRefPubMed De Vita M, Burzotta F, Porto I et al (2010) Thrombus aspiration in ST elevation myocardial infarction: comparative efficacy in patients treated early and late after onset of symptoms. Heart 96:1287–1290CrossRefPubMed
43.
44.
Zurück zum Zitat Desch S, Stiermaier T, De Waha S et al (2016) Thrombus aspiration in patients with ST-elevation myocardial infarction presenting late after symptom onset. JACC Cardiovasc Interv 9:113–122CrossRef Desch S, Stiermaier T, De Waha S et al (2016) Thrombus aspiration in patients with ST-elevation myocardial infarction presenting late after symptom onset. JACC Cardiovasc Interv 9:113–122CrossRef
45.
Zurück zum Zitat Watanabe H, Shiomi H, Nakatsuma K et al (2015) Clinical efficacy of thrombus aspiration on 5‑year clinical outcomes in patients with ST-segment elevation acute myocardial infarction undergoing percutaneous coronary intervention. J Am Heart Assoc 4:e001962CrossRefPubMedPubMedCentral Watanabe H, Shiomi H, Nakatsuma K et al (2015) Clinical efficacy of thrombus aspiration on 5‑year clinical outcomes in patients with ST-segment elevation acute myocardial infarction undergoing percutaneous coronary intervention. J Am Heart Assoc 4:e001962CrossRefPubMedPubMedCentral
46.
Zurück zum Zitat Mehilli J, Kastrati A, Schulz S et al (2009) Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: a randomized double-blind trial. Circulation 119:1933–1940CrossRefPubMed Mehilli J, Kastrati A, Schulz S et al (2009) Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: a randomized double-blind trial. Circulation 119:1933–1940CrossRefPubMed
47.
Zurück zum Zitat Stone GW, Witzenbichler B, Guagliumi G et al (2008) Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med 358:2218–2230CrossRefPubMed Stone GW, Witzenbichler B, Guagliumi G et al (2008) Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med 358:2218–2230CrossRefPubMed
48.
Zurück zum Zitat Thiele H, Wohrle J, Hambrecht R et al (2012) Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial. Lancet 379:923–931CrossRefPubMed Thiele H, Wohrle J, Hambrecht R et al (2012) Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial. Lancet 379:923–931CrossRefPubMed
49.
Zurück zum Zitat Desch S, Wohrle J, Hambrecht R et al (2013) Intracoronary versus intravenous abciximab bolus in patients with ST-segment elevation myocardial infarction: 1‑year results of the randomized AIDA STEMI trial. J Am Coll Cardiol 62:1214–1215CrossRefPubMed Desch S, Wohrle J, Hambrecht R et al (2013) Intracoronary versus intravenous abciximab bolus in patients with ST-segment elevation myocardial infarction: 1‑year results of the randomized AIDA STEMI trial. J Am Coll Cardiol 62:1214–1215CrossRefPubMed
50.
Zurück zum Zitat Eitel I, Wohrle J, Suenkel H et al (2013) Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: cardiac magnetic resonance substudy of the AIDA STEMI trial. J Am Coll Cardiol 61:1447–1454CrossRefPubMed Eitel I, Wohrle J, Suenkel H et al (2013) Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: cardiac magnetic resonance substudy of the AIDA STEMI trial. J Am Coll Cardiol 61:1447–1454CrossRefPubMed
51.
Zurück zum Zitat Aung NK, Li L, Su Q, Wu T (2013) Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction. Cochrane Database Syst Rev 6:CD009503 Aung NK, Li L, Su Q, Wu T (2013) Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction. Cochrane Database Syst Rev 6:CD009503
52.
Zurück zum Zitat Antoniucci D, Valenti R, Migliorini A et al (2001) Direct infarct artery stenting without predilation and no-reflow in patients with acute myocardial infarction. Am Heart J 142:684–690CrossRefPubMed Antoniucci D, Valenti R, Migliorini A et al (2001) Direct infarct artery stenting without predilation and no-reflow in patients with acute myocardial infarction. Am Heart J 142:684–690CrossRefPubMed
53.
Zurück zum Zitat Loubeyre C, Morice MC, Lefevre T et al (2002) A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction. J Am Coll Cardiol 39:15–21CrossRefPubMed Loubeyre C, Morice MC, Lefevre T et al (2002) A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction. J Am Coll Cardiol 39:15–21CrossRefPubMed
54.
Zurück zum Zitat Carrick D, Oldroyd KG, McEntegart M et al (2014) A randomized trial of deferred stenting versus immediate stenting to prevent no- or slow-reflow in acute ST-segment elevation myocardial infarction (DEFER-STEMI). J Am Coll Cardiol 63:2088–2098CrossRefPubMedPubMedCentral Carrick D, Oldroyd KG, McEntegart M et al (2014) A randomized trial of deferred stenting versus immediate stenting to prevent no- or slow-reflow in acute ST-segment elevation myocardial infarction (DEFER-STEMI). J Am Coll Cardiol 63:2088–2098CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Gick M, Jander N, Bestehorn HP et al (2005) Randomized evaluation of the effects of filter-based distal protection on myocardial perfusion and infarct size after primary percutaneous catheter intervention in myocardial infarction with and without ST-segment elevation. Circulation 112:1462–1469CrossRefPubMed Gick M, Jander N, Bestehorn HP et al (2005) Randomized evaluation of the effects of filter-based distal protection on myocardial perfusion and infarct size after primary percutaneous catheter intervention in myocardial infarction with and without ST-segment elevation. Circulation 112:1462–1469CrossRefPubMed
56.
Zurück zum Zitat Kelbaek H, Terkelsen CJ, Helqvist S et al (2008) Randomized comparison of distal protection versus conventional treatment in primary percutaneous coronary intervention: the drug elution and distal protection in ST-elevation myocardial infarction (DEDICATION) trial. J Am Coll Cardiol 51:899–905CrossRefPubMed Kelbaek H, Terkelsen CJ, Helqvist S et al (2008) Randomized comparison of distal protection versus conventional treatment in primary percutaneous coronary intervention: the drug elution and distal protection in ST-elevation myocardial infarction (DEDICATION) trial. J Am Coll Cardiol 51:899–905CrossRefPubMed
57.
Zurück zum Zitat Stone GW, Webb J, Cox DA et al (2005) Distal microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction: a randomized controlled trial. JAMA 293:1063–1072CrossRefPubMed Stone GW, Webb J, Cox DA et al (2005) Distal microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction: a randomized controlled trial. JAMA 293:1063–1072CrossRefPubMed
58.
Zurück zum Zitat Stone GW, Abizaid A, Silber S et al (2012) Prospective, randomized, Multicenter evaluation of a polyethylene Terephthalate Micronet mesh-covered Stent (Mguard) in ST-segment elevation myocardial infarction: the MaSTER trial. J Am Coll Cardiol 60:1975–1984CrossRefPubMed Stone GW, Abizaid A, Silber S et al (2012) Prospective, randomized, Multicenter evaluation of a polyethylene Terephthalate Micronet mesh-covered Stent (Mguard) in ST-segment elevation myocardial infarction: the MaSTER trial. J Am Coll Cardiol 60:1975–1984CrossRefPubMed
59.
Zurück zum Zitat Dudek D, Dziewierz A, Brener SJ et al (2015) Mesh-covered embolic protection stent implantation in ST-segment-elevation myocardial infarction: final 1‑year clinical and angiographic results from the MGUARD for acute ST elevation reperfusion trial. Circ Cardiovasc Interv 8:e001484CrossRefPubMed Dudek D, Dziewierz A, Brener SJ et al (2015) Mesh-covered embolic protection stent implantation in ST-segment-elevation myocardial infarction: final 1‑year clinical and angiographic results from the MGUARD for acute ST elevation reperfusion trial. Circ Cardiovasc Interv 8:e001484CrossRefPubMed
60.
Zurück zum Zitat Sabate M, Cequier A, Iniguez A et al (2012) Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trial. Lancet 380:1482–1490CrossRefPubMed Sabate M, Cequier A, Iniguez A et al (2012) Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trial. Lancet 380:1482–1490CrossRefPubMed
61.
Zurück zum Zitat Shehata M (2014) Angiographic and clinical impact of successful manual thrombus aspiration in diabetic patients undergoing primary PCI. Int J Vasc Med 2014:263926PubMedPubMedCentral Shehata M (2014) Angiographic and clinical impact of successful manual thrombus aspiration in diabetic patients undergoing primary PCI. Int J Vasc Med 2014:263926PubMedPubMedCentral
62.
Zurück zum Zitat Hamza MA, Galal A, Suweilam S et al (2014) Local Intracoronary Eptifibatide versus mechanical aspiration in patients with acute ST-elevation myocardial infarction. Int J Vasc Med 2014:294065PubMedPubMedCentral Hamza MA, Galal A, Suweilam S et al (2014) Local Intracoronary Eptifibatide versus mechanical aspiration in patients with acute ST-elevation myocardial infarction. Int J Vasc Med 2014:294065PubMedPubMedCentral
63.
Zurück zum Zitat Woo SI, Park SD, Kim DH et al (2014) Thrombus aspiration during primary percutaneous coronary intervention for preserving the index of microcirculatory resistance: a randomised study. EuroIntervention 9:1057–1062CrossRefPubMed Woo SI, Park SD, Kim DH et al (2014) Thrombus aspiration during primary percutaneous coronary intervention for preserving the index of microcirculatory resistance: a randomised study. EuroIntervention 9:1057–1062CrossRefPubMed
64.
Zurück zum Zitat Onuma Y, Thuesen L, van Geuns RJ et al (2013) Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study – TROFI trial. Eur Heart J 34:1050–1060CrossRefPubMed Onuma Y, Thuesen L, van Geuns RJ et al (2013) Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study – TROFI trial. Eur Heart J 34:1050–1060CrossRefPubMed
65.
Zurück zum Zitat Sim DS, Ahn Y, Kim YH et al (2013) Effect of manual thrombus aspiration during primary percutaneous coronary intervention on infarct size: evaluation with cardiac computed tomography. Int J Cardiol 168:4328–4330CrossRefPubMed Sim DS, Ahn Y, Kim YH et al (2013) Effect of manual thrombus aspiration during primary percutaneous coronary intervention on infarct size: evaluation with cardiac computed tomography. Int J Cardiol 168:4328–4330CrossRefPubMed
66.
Zurück zum Zitat Bulum J, Ernst A, Strozzi M (2012) The impact of successful manual thrombus aspiration on in-stent restenosis after primary PCI: angiographic and clinical follow-up. Coron Artery Dis 23:487–491CrossRefPubMed Bulum J, Ernst A, Strozzi M (2012) The impact of successful manual thrombus aspiration on in-stent restenosis after primary PCI: angiographic and clinical follow-up. Coron Artery Dis 23:487–491CrossRefPubMed
67.
Zurück zum Zitat Ciszewski M, Pregowski J, Teresinska A et al (2011) Aspiration coronary thrombectomy for acute myocardial infarction increases myocardial salvage: single center randomized study. Catheter Cardiovasc Interv 78:523–531CrossRefPubMed Ciszewski M, Pregowski J, Teresinska A et al (2011) Aspiration coronary thrombectomy for acute myocardial infarction increases myocardial salvage: single center randomized study. Catheter Cardiovasc Interv 78:523–531CrossRefPubMed
68.
Zurück zum Zitat Dudek D, Mielecki W, Burzotta F et al (2010) Thrombus aspiration followed by direct stenting: a novel strategy of primary percutaneous coronary intervention in ST-segment elevation myocardial infarction. Results of the Polish-Italian-Hungarian RAndomized ThrombEctomy Trial (PIHRATE Trial). Am Heart J 160:966–972CrossRefPubMed Dudek D, Mielecki W, Burzotta F et al (2010) Thrombus aspiration followed by direct stenting: a novel strategy of primary percutaneous coronary intervention in ST-segment elevation myocardial infarction. Results of the Polish-Italian-Hungarian RAndomized ThrombEctomy Trial (PIHRATE Trial). Am Heart J 160:966–972CrossRefPubMed
69.
Zurück zum Zitat Liu CP, Lin MS, Chiu YW et al (2010) Additive benefit of glycoprotein IIb/IIIa inhibition and adjunctive thrombus aspiration during primary coronary intervention: results of the Initial Thrombosuction and Tirofiban Infusion (ITTI) trial. Int J Cardiol 156:174–179CrossRefPubMed Liu CP, Lin MS, Chiu YW et al (2010) Additive benefit of glycoprotein IIb/IIIa inhibition and adjunctive thrombus aspiration during primary coronary intervention: results of the Initial Thrombosuction and Tirofiban Infusion (ITTI) trial. Int J Cardiol 156:174–179CrossRefPubMed
70.
Zurück zum Zitat Lipiecki J, Monzy S, Durel N et al (2009) Effect of thrombus aspiration on infarct size and left ventricular function in high-risk patients with acute myocardial infarction treated by percutaneous coronary intervention. Results of a prospective controlled pilot study. Am Heart J 157(583):1–7 Lipiecki J, Monzy S, Durel N et al (2009) Effect of thrombus aspiration on infarct size and left ventricular function in high-risk patients with acute myocardial infarction treated by percutaneous coronary intervention. Results of a prospective controlled pilot study. Am Heart J 157(583):1–7
71.
Zurück zum Zitat Liistro F, Grotti S, Angioli P et al (2009) Impact of thrombus aspiration on myocardial tissue reperfusion and left ventricular functional recovery and remodeling after primary angioplasty. Circ Cardiovasc Interv 2:376–383CrossRefPubMed Liistro F, Grotti S, Angioli P et al (2009) Impact of thrombus aspiration on myocardial tissue reperfusion and left ventricular functional recovery and remodeling after primary angioplasty. Circ Cardiovasc Interv 2:376–383CrossRefPubMed
72.
Zurück zum Zitat Sardella G, Mancone M, Bucciarelli-Ducci C et al (2009) Thrombus aspiration during primary percutaneous coronary intervention improves myocardial reperfusion and reduces infarct size: the EXPIRA (thrombectomy with export catheter in infarct-related artery during primary percutaneous coronary intervention) prospective, randomized trial. J Am Coll Cardiol 53:309–315CrossRefPubMed Sardella G, Mancone M, Bucciarelli-Ducci C et al (2009) Thrombus aspiration during primary percutaneous coronary intervention improves myocardial reperfusion and reduces infarct size: the EXPIRA (thrombectomy with export catheter in infarct-related artery during primary percutaneous coronary intervention) prospective, randomized trial. J Am Coll Cardiol 53:309–315CrossRefPubMed
73.
Zurück zum Zitat Chevalier B, Gilard M, Lang I et al (2008) Systematic primary aspiration in acute myocardial percutaneous intervention: a multicentre randomised controlled trial of the export aspiration catheter. EuroIntervention 4:222–228CrossRefPubMed Chevalier B, Gilard M, Lang I et al (2008) Systematic primary aspiration in acute myocardial percutaneous intervention: a multicentre randomised controlled trial of the export aspiration catheter. EuroIntervention 4:222–228CrossRefPubMed
74.
Zurück zum Zitat Chao CL, Hung CS, Lin YH et al (2008) Time-dependent benefit of initial thrombosuction on myocardial reperfusion in primary percutaneous coronary intervention. Int J Clin Pract 62:555–561CrossRefPubMed Chao CL, Hung CS, Lin YH et al (2008) Time-dependent benefit of initial thrombosuction on myocardial reperfusion in primary percutaneous coronary intervention. Int J Clin Pract 62:555–561CrossRefPubMed
75.
Zurück zum Zitat De Luca L, Sardella G, Davidson CJ et al (2006) Impact of intracoronary aspiration thrombectomy during primary angioplasty on left ventricular remodelling in patients with anterior ST elevation myocardial infarction. Heart 92:951–957CrossRefPubMed De Luca L, Sardella G, Davidson CJ et al (2006) Impact of intracoronary aspiration thrombectomy during primary angioplasty on left ventricular remodelling in patients with anterior ST elevation myocardial infarction. Heart 92:951–957CrossRefPubMed
76.
Zurück zum Zitat Silva-Orrego P, Colombo P, Bigi R et al (2006) Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction: the DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) study. J Am Coll Cardiol 48:1552–1559CrossRefPubMed Silva-Orrego P, Colombo P, Bigi R et al (2006) Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction: the DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) study. J Am Coll Cardiol 48:1552–1559CrossRefPubMed
77.
Zurück zum Zitat Kaltoft A, Bottcher M, Nielsen SS et al (2006) Routine thrombectomy in percutaneous coronary intervention for acute ST-segment-elevation myocardial infarction: a randomized, controlled trial. Circulation 114:40–47CrossRefPubMed Kaltoft A, Bottcher M, Nielsen SS et al (2006) Routine thrombectomy in percutaneous coronary intervention for acute ST-segment-elevation myocardial infarction: a randomized, controlled trial. Circulation 114:40–47CrossRefPubMed
78.
Zurück zum Zitat Burzotta F, Trani C, Romagnoli E et al (2005) Manual thrombus-aspiration improves myocardial reperfusion: the randomized evaluation of the effect of mechanical reduction of distal embolization by thrombus-aspiration in primary and rescue angioplasty (REMEDIA) trial. J Am Coll Cardiol 46:371–376CrossRefPubMed Burzotta F, Trani C, Romagnoli E et al (2005) Manual thrombus-aspiration improves myocardial reperfusion: the randomized evaluation of the effect of mechanical reduction of distal embolization by thrombus-aspiration in primary and rescue angioplasty (REMEDIA) trial. J Am Coll Cardiol 46:371–376CrossRefPubMed
Metadaten
Titel
Thrombusaspiration bei Patienten mit akutem Myokardinfarkt
Wissenschaftliche Evidenz und Empfehlungen in den Leitlinien
verfasst von
Dr. T. Stiermaier
S. de Waha
G. Fürnau
I. Eitel
H. Thiele
S. Desch
Publikationsdatum
15.03.2016
Verlag
Springer Medizin
Erschienen in
Herz / Ausgabe 7/2016
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI
https://doi.org/10.1007/s00059-016-4412-x

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