Strahlentherapie und Onkologie OnlineFirst articles

15.05.2024 | Case Study

Intraoperative radiation therapy for brain metastasis in a pregnant patient: a case report

We present the rare case of a 42-year-old woman with oligometastatic lung adenocarcinoma in her first trimester of pregnancy who was treated for brain metastases with metastasectomy and intraoperative radiation therapy (IORT) using the INTRABEAM® …

verfasst von:: Dr. med. K. P. Aninditha, S. Baumbach, T. Ellethy, G. Klumpp, A. Golle, S. Kuhn, N. Wegner, O. Ganslandt, M. W. Münter

Open Access 15.05.2024 | Original Article

Reirradiation for diffuse intrinsic pontine glioma: prognostic radiomic factors at progression

verfasst von:: Dominik Wawrzuta, Marzanna Chojnacka, Monika Drogosiewicz, Katarzyna Pędziwiatr, Bożenna Dembowska-Bagińska

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Open Access 14.05.2024 | Strahlentherapie | Literatur kommentiert

Validierung des genomischen Profils zur personalisierten Behandlung des Mammakarzinoms: POLAR-Studie

Die Studie nutzt vorhandene Daten aus prospektiven Studien mit langer Nachbeobachtungszeit zur Wirkung der adjuvanten Strahlentherapie auf die Rezidivrate. Die Methode zur Entwicklung des prognostischen Genexpressionsprofils verbessert …

verfasst von:: Adrianna Monika Cieslak, Mathias Alexander Sonnhoff

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Open Access 14.05.2024 | Lymphadenektomie | Literatur kommentiert

Weniger ist nicht mehr, aber genauso gut. Der Verzicht auf eine axilläre Lymphknotendissektion ist bei adäquater adjuvanter Therapie möglich

In den letzten zehn Jahren hat die Verwendung der Axilladissektion bei Mammakarzinom erheblich abgenommen, beeinflusst durch die Ergebnisse der AMAROS-Studie [ 1 ] und der ACOSOG-Z0011-Studien [ 2 ], welche gezeigt haben, dass eine zusätzliche …

verfasst von:: Mathias Alexander Sonnhoff, Adrianna Monika Cieslak, David Krug

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Open Access 10.05.2024 | Original Article

Correlation of microscopic tumor extension with tumor microenvironment in esophageal cancer patients

With ever-increasing precision of radiation modalities, i.e., particle therapy, and improved imaging enabling adaptive radiotherapy, profound understanding of the gross tumor volume (GTV) and the clinical target volume (CTV), which includes the …

verfasst von:: Benjamin Terfa Igbo, Christina Jentsch, Annett Linge, Ioana Plesca, Yalçin Kuzay, Steffen Löck, Mani Sankari Kumaravadivel, Susanne Doms, Liane Stolz-Kieslich, Daniela Pollack, Sascha Brückmann, Hannes Tittlbach, Jürgen Weitz, Daniela Aust, Rudi Apolle, Marc Schmitz, Esther G. C. Troost

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Open Access 30.04.2024 | Original Article

Managing hepatocellular carcinoma across the stages: efficacy and outcomes of stereotactic body radiotherapy

A retrospective study

Liver cancer, ranking as the 6th most prevalent malignancy globally and standing as the third leading cause of cancer-related death, is a challenging malignancy and is surpassed only by lung and colorectal cancer [ 1 ]. Hepatocellular carcinoma …

verfasst von:: Ahmed Allam Mohamed, Marie-Luise Berres, Philipp Bruners, Sven Arke Lang, Christian Trautwein, Georg Wiltberger, Alexandra Barabasch, Michael Eble

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Open Access 29.04.2024 | Original Article

Knowledge and competences in hematological malignancies amongst radiation oncology residents in Germany—results from a national survey

Continued medical education during residency is a key factor to enable formation of a professional identity [ 1 ]. With approximately 1500 practicing board-certified physicians in Germany, radiation oncology (RO) represents a small but important …

verfasst von:: Stephan Rehn, Michael Oertel, Philipp Linde, Matthias Mäurer, Khaled Elsayad, Niklas B. Pepper, Daniel Rolf, Jenna M. Kahn, John P. Plastaras, Jillian R. Gunther, Hans T. Eich

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26.04.2024 | Review Article

Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis

Head and neck (H&N) cancer comprises neoplasms located primarily in the lip, mucosal epithelium of the oral cavity, pharynx, and larynx [ 1 ]. Incidence data show that H&N cancer was the sixth most common cancer worldwide in 2020, with 931,931 new …

verfasst von:: Beatriz Regina Lima Aguiar, Elaine Barros Ferreira, Ana Gabriela Costa Normando, Sabrina dos Santos Dias, Eliete Neves Silva Guerra, Paula Elaine Diniz Reis, PhD

Open Access 23.04.2024 | Short Communication

Patient vulnerability in stereotactic arrhythmia radioablation (STAR): a preliminary ethical appraisal from the STOPSTORM.eu consortium

This preliminary ethical appraisal from the STOPSTORM.eu consortium is meant to raise critical points that clinicians administering stereotactic arrhythmia radioablation should consider to meet the highest standards in medical ethics and thus …

verfasst von:: Carlo Botrugno, Chiara Crico, Mauro Iori, Oliver Blanck, Slawomir Blamek, Pieter G. Postema, Aurelio Quesada, Etienne Pruvot, Joost J. C. Verhoeff, Ludovica De Panfilis

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22.04.2024 | Original Article

Dosimetric comparison of advanced radiation techniques for scalp-sparing in low-grade gliomas

Gliomas are the most common type of malignant tumor that develops in the central nervous system (CNS), with an average annual incidence rate of 5.95 per 100,000 population in the United States [ 1 , 2 ]. Low-grade gliomas (LGG), classified as World …

verfasst von:: Hang Yu, MS, Shuangshuang He, MS, Yisong He, MS, Guyu Dai, MS, Yuchuan Fu, PhD, Xianhu Zeng, PhD, Mengyuan Liu, MS, Ping Ai, MD

Open Access 22.04.2024 | Rektumkarzinom | Literatur kommentiert

5-Jahres-Follow-up der RAPIDO-Studie: Zurück in die Zukunft der Langzeitradiochemotherapie bei totaler neoadjuvanter Therapie (TNT) des lokal fortgeschrittenen Rektumkarzinoms?

Die Ergebnisse der RAPIDO-Studie zeigten im 3‑ und 5‑Jahres-Follow-up für Patienten mit LARC einen Vorteil bezüglich DrTF und DM [ 1 , 2 ]. In 2021 wurde die TNT – mit SCRT oder LZ-RCT – als neue präferierte Therapieoption bewertet [ 1 ]. Die nun …

verfasst von:: Dr. Marcus Edelmann, MD, Prof. Dr. Stefan Rieken, MD, PD Dr. Leif Hendrik Dröge, MD

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Open Access 18.04.2024 | Strahlentherapie | Literatur kommentiert

Radiotherapie plus Durvalumab beim lokal fortgeschrittenen NSCLC: die DOLPHIN-Studie

Die PACIFIC-Studie prüfte als erste Studie die Kombination aus Radiochemo- und Immuntherapie bei Patienten mit NSCLC im UICC-Stadium III mit großem Erfolg. Die Gabe von Durvalumab nach vorheriger RCT verbesserte nicht nur das PFS, sondern auch das …

verfasst von:: Dr. Maike Trommer

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10.04.2024 | Review Article

Advances and residual knowledge gaps in the neck management of head and neck squamous cell carcinoma patients with advanced nodal disease undergoing definitive (chemo)radiotherapy for their primary

Lymph node (LN) metastases are common in head and neck squamous cell carcinoma (HNSCC) and are a major driver of prognosis [ 1 ]. The practice and indications of neck dissection (ND) have evolved significantly since the first ND by Crile in the …

verfasst von:: Dr. Florent Carsuzaa, MD, Dr. Emilien Chabrillac, MD, Dr. Pierre Yves Marcy, MD, Prof. Hisham Mehanna, MD PhD, Prof. Juliette Thariat, MD PhD

Open Access 05.04.2024 | Letter to the Editor

Letter to the Editor: reply to “Comparison of patient setup accuracy for optical surface-guided and X-ray-guided imaging with respect to the impact on intracranial stereotactic radiotherapy”

verfasst von:: Adi Robinson

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05.04.2024 | Letter to the Editor

Reply to Letter to the Editor: Reply to comparison of patient setup accuracy for optical surface-guided and X-ray-guided imaging with respect to the impact on intracranial stereotactic radiotherapy

verfasst von:: M. Schöpe, J. Sahlmann, S. Jaschik, A. Findeisen, G. Klautke

Open Access 28.03.2024 | Original Article

Sarcopenia is associated with chemoradiotherapy discontinuation and reduced progression-free survival in glioblastoma patients

Glioblastoma patients face a limited prognosis despite trimodal therapy regimens (surgical resection followed by chemoradiotherapy) [ 1 , 2 ]. Early progression is common and median overall survival is 14 months [ 1 ]. However, within the cohort …

verfasst von:: Fabian M. Troschel, MD, Benjamin O. Troschel, Maren Kloss, Johanna Jost, Niklas B. Pepper, Amelie S. Völk-Troschel, Rainer G. Wiewrodt, Walter Stummer, Dorothee Wiewrodt, Hans Theodor Eich

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Open Access 26.03.2024 | Original Article

Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden

During decades of successful adjuvant radiotherapy for breast cancer, reduction of acute and late side effects such as skin reactions and pneumonitis has been an important topic of research, aiming at a continuous improvement of the therapeutic …

verfasst von:: Prof. Dr. Carsten Nieder, Silje K. Johnsen, Annette M. Winther, Bård Mannsåker

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18.03.2024 | Original Article

Enhancing the prediction of symptomatic radiation pneumonitis for locally advanced non-small-cell lung cancer by combining 3D deep learning-derived imaging features with dose–volume metrics: a two-center study

Lung cancer is currently prevalent worldwide and is associated with a high mortality rate [ 1 ]. Chemoradiotherapy is the primary treatment for unresectable locally advanced non-small-cell lung cancer (LA-NSCLC) [ 2 ]. However, radiation …

verfasst von:: Yan Kong, Mingming Su, Yan Zhu, Xuan Li, Jinmeng Zhang, Wenchao Gu, Fei Yang, Jialiang Zhou, Jianjiao Ni, Xi Yang, Zhengfei Zhu, Jianfeng Huang

15.03.2024 | Case Study

Spinal and cervical nodal metastases in a patient with glioblastoma

This article presents the rare case of a 54-year-old gentleman with primary glioblastoma developing multiple extracranial metastases 7 months after diagnosis. Initially, the patient complained of progressive headaches, confusion, and weakness of …

verfasst von:: Silvio Heinig, Thomas Aigner, Heinz-Georg Bloß, Gerhard G. Grabenbauer

Open Access 15.03.2024 | Original Article

Radiotherapy in localized prostate cancer: a multicenter analysis evaluating tumor control and late toxicity after brachytherapy and external beam radiotherapy in 1293 patients

Prostate cancer is an age-related disease [ 1 ]. Being the most common cancer in men [ 1 ] in an aging society, more cases are to be expected and more resources for treatment are required. For localized prostate cancer, 3 different options for …

verfasst von:: Matthias Moll, Elisabeth Nechvile, Christian Kirisits, Oxana Komina, Thomas Pajer, Bettina Kohl, Marcin Miszczyk, Joachim Widder, Tomas-Hendrik Knocke-Abulesz, Gregor Goldner

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin