Refractive outcomes of immediately sequential bilateral cataract surgery in eyes with long and short axial lengths

Age-related cataracts are usually bilateral; therefore, performing surgery on both eyes on the same day, termed immediately sequential bilateral cataract surgery (ISBCS), offers several logistical and economic advantages to patients and healthcare systems [1, 2]. Ophthalmologists have had concerns about ISBCS, especially postoperative refractive error in both eyes due to the inability to adjust the intraocular lens (IOL) power for the second surgery based on the refractive results of the first surgery [3, 4]. However, systematic comparisons of ISBCS and delayed sequential bilateral cataract surgeries (DSBCS) reveal minimal to no differences in refractive outcomes or complications [5, 6].

ISBCS has been suggested as a favorable option for patients with abnormally short or long eyes to avoid postoperative anisometropia [7]. However, biometry can be less accurate in eyes with abnormal ALs [8‐10]. Short axial length (AL) eyes are considered to have an AL less than or equal to 22.00 mm [11, 12], while long AL eyes measure 25.00 mm or more [9, 13]. Furthermore, variations of up to 1.00 D are tolerated by manufacturers for IOLs with powers greater than 30 D, which can contribute to the risk of postoperative refractive surprise in short AL eyes [10]. Despite advances in biometry and IOL formulas, achieving target refraction remains a challenge for eyes with AL outside of the normal range. Indeed, up to 20% of eyes with an AL > 26.00 mm can experience postoperative deviation from their target refraction greater than ±0.50 D [14].

Few studies to date have assessed refractive outcomes in high myopic or hyperopic eyes undergoing ISBCS. Furthermore, the unavailability of axial length data [15, 16] and the exclusion of eyes with extremes of axial length [17, 18] are limitations of prior research. Therefore, this study examined the refractive outcomes of eyes with short or long AL undergoing ISBCS.

This study retrospectively reviewed the electronic medical records of patients who underwent ISBCS for bilateral visually significant cataracts between August 1, 2020 and October 31, 2022 at the Centre Hospitalier de l’Université de Montréal, Montréal, Quebec, Canada. In this publicly funded hospital setting, ophthalmic nurses or technicians ascertained visual acuity and autorefraction at each patient visit. Any post-operative prescription of refractive correction and evaluation for laser refractive surgery was done in non-affiliated private healthcare settings.

Patients were eligible for inclusion if preoperative biometry showed bilateral AL ≤22.00 mm (short AL) or ≥ 25.00 mm (long AL). All types of implanted IOLs were considered, whether monofocal, extended depth of focus (EDOF), multifocal, or toric IOLs. Patients with prior corneal laser refractive surgery and ectasia were excluded, as were those missing postoperative follow-up data.

Ethics review board approval was obtained through the Centre hospitalier de l’Université de Montréal professional services department (PSD-21027), and the tenets of declaration of Helsinki were strictly adhered to while conducting the study.

A review of 1559 ISBCSs over 26 months identified 37 patients (74 eyes) with long ALs (≥25.00 mm) and 18 patients (36 eyes) with short ALs (≤22.00 mm) eligible for inclusion. Patients were between 55 and 85 years old (Table 1). In the long AL group, the ALs were between 25.00 mm and 27.00 mm in 53 eyes (71.6%), between 27.01 mm and 30.00 mm in 19 eyes (25.7%) and > 30.00 mm in 2 eyes (2.7%). In the short AL group, the AL was between 21.01 mm and 22.00 mm in 27 eyes (75.0%) and between 20.00 mm and 21.00 mm in 9 eyes (25.0%). No eyes had an AL < 20.00 mm.

Prior ocular diagnoses included dry eye disease (6 eyes in the long AL group), primary angle closure suspect (16 eyes in the short AL group), and open angle glaucoma or glaucoma suspect (14 eyes in the long AL group and 4 eyes in the short AL group). No intraoperative complications were noted, and all incisions were sealed without sutures.

In long AL eyes, the IOLs implanted were monofocal in 66 eyes (89.2%), including 8 monofocal toric IOLs (mean IOL cylinder 2.48 D, range 1.50 to 3.00 D); multifocal in 4 eyes (5.4%); and EDOF in 4 eyes (5.4%), including 2 toric EDOF IOLs. In all the short AL eyes, a monofocal IOL was implanted, 3 of which were toric IOLs (mean IOL cylinder 3.25 D, range 1.50 to 5.25 D).

Although ISBCS has become increasingly popular, few data exist regarding refractive outcomes in patients with bilateral short or long AL. AL is a critical variable in IOL calculations; a 1 mm error in AL measurement translates to an over 2 D error in IOL power in an average eye of approximately 23.7 ± 1.2 mm and may translate to far greater refractive errors in shorter AL eyes [19, 20]. The purpose of this study was to report the refractive outcome data of ISBCSs in patients with AL ≤22.00 mm or ≥ 25.00 mm. We found that patients with bilateral short AL have higher rates of refractive surprise in both eyes compared to patients with bilateral long ALs.

With advances in IOL formulas, 70–90% of eyes are expected to achieve a refraction within ±0.50 D of predicted after cataract surgery with posterior chamber lens implantation [9, 16, 21], a target that is proposed as the threshold for spectacle independence [22]. The Barrett Universal II formula used in our study is a fourth-generation formula that appears to have a low bias as measured by prediction error with variations in AL, making it a reasonable choice for calculating IOL power in both long and short eyes [9, 23]. In our long AL eyes, the postoperative refraction was ±0.50 D of predicted for 74% of the eyes and within ±1.00 D for 95% of the eyes. However, in short AL eyes, the postoperative refraction was within ±0.50 D of the predicted result in only 44% of eyes and within ±1.00 D in 69% of eyes. These findings match other studies examining single eye outcomes [13, 24]. In the context of ISBCS where there is no opportunity for IOL adjustment between eyes, surgeons may consider informing short AL patients of a higher incidence of unpredictable refractive outcome.

For DSBCS, correction methods aimed at improving the outcome in the second eye after a refractive surprise in the first eye include accounting for 50% of the first eye error in the selection of the IOL in the second eye [25] or applying a regression analysis unique to the IOL formula [26]. Yet studies analyzing the refractive outcomes of ISBCS suggest that adjusting the IOL power for the second eye based on the refractive outcome is not justified in most cases [27‐29]. For example, in a retrospective study of 110 patients (220 eyes), Guber et al. reported achieving within ±0.50 D SE of target refraction in 60% of eyes and deemed only 5% of patients potentially benefited from IOL adjustment in the second eye [30]. Notably, abnormal AL has been an exclusion criterion in some prior studies of ISBCS [17, 18] or AL data have been unavailable for analysis [15, 16]. Given the less predictable refractive outcomes following ISBCS in patients with abnormal ALs (especially ≤22.00 mm), these patients should be distinguished from the regular ALs, which experience comparable outcomes to ISBCS. Our finding that 44% of patients with bilateral short ALs had postoperative refractions greater than ±0.50 D from the predicted value in both eyes, suggests that DSBCS with potential IOL power adjustment based on the refractive result in the first eye should be further studied in these eyes.

This study has several limitations. First, the use of autorefraction as a method for determining refractive error contrasts with the gold standard of subjective manifest refraction [31], although some studies support its use in evaluating post-cataract surgery refractive outcomes [32, 33]. Notably, it has been reported that autorefraction after multifocal IOL implantation may result in more negative SE values than subjective refraction [34, 35]. Second, the lens choice was not homogenous in our long AL cohort, as four eyes received EDOF IOLs and four eyes received multifocal IOLs. Given the small number of eyes, these were not analyzed separately. The use of these IOLs is an important consideration in long and short AL eyes undergoing ISBCS, as patients choosing these IOLs may have higher expectations of achieving post-operative spectacle independence. For multifocal IOLs, a range of IOL formulas, including the Barrett Universal II, were shown to achieve within ±0.50 D of the predicted refraction in 80–84% of eyes, especially in a small subset with AL longer than 26.00 mm [36]. However, none of the four eyes receiving a multifocal IOL in our study were within ±0.50 D of the predicted refraction. Third, the patients’ subjective perspectives were not captured, and it is possible that the refractive errors reported in our study do not correspond to meaningful clinical differences or degree of satisfaction. Fourth, the use of only the Barrett Universal II formula in this study means that the findings are not necessarily generalizable to newer IOL formulas. Although a widely studied topic, there remains uncertainty about the optimal formula in long and short AL eyes. Recently, the newer Olsen and Kane formulas have been suggested to deliver better accuracy compared to other formulas in both long and short AL eyes [21, 37].

To the best of our knowledge, this study is the first to report the outcomes of ISBCSs in patients with long and short ALs. Using the Barrett Universal II formula, this study revealed that ISBCSs in eyes with an AL ≥25.00 mm achieve postoperative refractive targets at comparable rates to those in other reports in the literature. However, the eyes of patients with bilateral ALs ≤22.00 mm achieved lower refractive accuracy and experienced a wider range of SE errors. Clinically, patients with bilateral short AL eyes represent a unique population for which the average outcomes of larger studies of ICBCS may not necessarily apply. Although AL should be considered when counseling patients preoperatively, further studies validating these findings are warranted, as are studies examining approaches to IOL adjustment strategies for DSBCS in patients with bilateral short ALs.