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12.01.2024 | Original Article

Pediatric urogenital schistosomiasis diagnosed in France

verfasst von: Lucas Percheron, Claire Leblanc, Tim Ulinski, Marc Fila, Denis Malvy, Justine Bacchetta, Vincent Guigonis, Cecile Debuisson, Elise Launay, Edouard Martinez, Aurelie Morand, Stéphane Decramer, Joost-Peter Schanstra, Antoine Berry

Erschienen in: Pediatric Nephrology | Ausgabe 6/2024

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Abstract

Background

Schistosomiasis affects approximately 230 million people worldwide. There is an increased incidence of schistosomiasis cases in France acquired from outside the country. This increases the risk of schistosomiasis outbreaks as observed in Corsica. Clinicians from non-endemic regions are not accustomed to diagnosing and managing this pathology. The objective of this study is to provide a better description of the clinical and paraclinical characteristics and disease evolution of affected children.

Methods

Through the French Pediatric Nephrology Society and the Pediatric Infectious Pathology Group, we contacted all French pediatric centers that may have treated children with urinary schistosomiasis between 2013 and 2019. Age, sex, comorbidities, and clinical, biological, and radiological data (at discovery and follow-up) were collected retrospectively.

Results

A total of 122 patients from 10 different centers were included. The median age was 14 years and the sex ratio M/F was 4:1. Hematuria was present in 82% of the patients while urinary tract abnormality was found in 36% of them. Fourteen patients (11%) displayed complicated forms of urinary schistosomiasis including 10 patients with chronic kidney disease. A total of 110 patients received treatment with praziquantel, which was well-tolerated and led to clinical resolution of symptoms in 98% of cases.

Conclusion

Patients with schistosomiasis present frequent kidney, urinary, or genital involvement. Systematic screening of patients returning from endemic areas is therefore recommended, especially since treatment with antiparasitic drugs is effective and well-tolerated. Enhancing medical knowledge of this pathology among all practitioners is essential to improve care and outcomes.

Graphical abstract

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Titel: Pediatric urogenital schistosomiasis diagnosed in France
verfasst von: Lucas Percheron
Claire Leblanc
Tim Ulinski
Marc Fila
Denis Malvy
Justine Bacchetta
Vincent Guigonis
Cecile Debuisson
Elise Launay
Edouard Martinez
Aurelie Morand
Stéphane Decramer
Joost-Peter Schanstra
Antoine Berry
Publikationsdatum: 12.01.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 6/2024
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-06260-x

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Pediatric urogenital schistosomiasis diagnosed in France