Introduction
Methods
Study population
Exposures
Outcomes
Statistical methods
Results
Baseline characteristics
N with complete information | CCI 0 (N = 105,108) | CCI 1 (N = 43,080) | CCI 2–3 (N = 51,814) | CCI > 3 (N = 30,057) | All (N = 230,059) | |
---|---|---|---|---|---|---|
Age | 230,059 | |||||
0–15 years | 0% (0) | 0% (0) | 0% (0) | 0% (0) | 0% (0) | |
16–24 years | 15% (16,187) | 4% (1545) | 2% (802) | 0% (145) | 8% (18,679) | |
25–44 years | 25% (25,946) | 10% (4331) | 5% (2679) | 5% (1433) | 15% (34,389) | |
45–64 years | 30% (31,232) | 31% (13,258) | 27% (13,846) | 29% (8791) | 29% (67,127) | |
65–84 years | 27% (28,057) | 49% (20,898) | 58% (30,308) | 59% (17,605) | 42% (96,868) | |
> 84 years | 4% (3686) | 7% (3048) | 8% (4179) | 7% (2083) | 6% (12,996) | |
Sex | 230,056 | |||||
Male | 56% (59,110) | 59% (25,273) | 59% (30,812) | 62% (18,659) | 58% (133,854) | |
ICU admission diagnosis | 230,059 | |||||
Trauma | 32% (33,978) | 13% (5678) | 10% (5046) | 8% (2384) | 20% (47,086) | |
Circulatory | 13% (13,456) | 19% (8266) | 17% (9022) | 17% (5185) | 16% (35,929) | |
Respiratory | 9% (9520) | 15% (6462) | 18% (9435) | 17% (5013) | 13% (30,430) | |
Digestive tract | 6% (6141) | 8% (3548) | 10% (4976) | 14% (4094) | 8% (18,759) | |
Infection | 4% (4063) | 4% (1792) | 7% (3468) | 8% (2306) | 5% (11,629) | |
Endocrine | 3% (3671) | 5% (2301) | 4% (2222) | 5% (1576) | 4% (9770) | |
Mental disorder | 6% (5837) | 2% (931) | 1% (416) | 0% (148) | 3% (7332) | |
Nervous system | 3% (2818) | 2% (943) | 2% (924) | 1% (430) | 2% (5115) | |
Malignancy/Hematology | 1% (654) | 0% (169) | 4% (2101) | 4% (1342) | 2% (4266) | |
Urogenital | 1% (1132) | 1% (519) | 2% (1188) | 4% (1067) | 2% (3906) | |
Pregnancy | 2% (1899) | 0% (71) | 0% (12) | 0% (3) | 1% (1985) | |
Other | 15% (15,530) | 18% (7781) | 17% (8958) | 16% (4927) | 16% (37,196) | |
Missing | 6% (6409) | 11% (4619) | 8% (4046) | 5% (1582) | 7% (16,656) | |
SAPS3 score | 123,119 | |||||
< 40 | 36% (20,846) | 18% (3897) | 10% (2598) | 4% (751) | 23% (28,092) | |
40–49 | 25% (14,506) | 25% (5325) | 19% (5122) | 14% (2486) | 22% (27,439) | |
50–59 | 18% (10,397) | 25% (5373) | 26% (7048) | 25% (4306) | 22% (27,124) | |
≥ 60 | 20% (11,400) | 32% (6905) | 46% (12,512) | 56% (9647) | 33% (40,464) | |
No of ICU admissions previous year | 230,059 | |||||
0 | 92% (96,263) | 84% (36,373) | 82% (42,649) | 78% (23,558) | 86% (198,843) | |
1 | 6% (6343) | 12% (5011) | 13% (6705) | 16% (4680) | 10% (22,739) | |
2 | 1% (1453) | 2% (1022) | 3% (1531) | 4% (1197) | 2% (5203) | |
3 | 0% (499) | 1% (303) | 1% (447) | 1% (401) | 1% (1650) | |
4–5 | 0% (369) | 1% (220) | 0% (237) | 1% (176) | 0% (1002) | |
> 5 | 0% (181) | 0% (151) | 0% (245) | 0% (45) | 0% (622) | |
Time since previous ICU stay | 230,059 | |||||
0–7 days | 2% (2270) | 5% (2003) | 5% (2805) | 6% (1725) | 4% (8803) | |
8–30 days | 2% (1739) | 4% (1583) | 4% (2136) | 5% (1428) | 3% (6886) | |
31–90 days | 2% (1603) | 3% (1095) | 3% (1614) | 4% (1223) | 2% (5535) | |
91–365 days | 3% (3244) | 5% (2030) | 5% (2623) | 7% (2130) | 4% (10,027) | |
> 365 days | 92% (96,252) | 84% (36,369) | 82% (42,636) | 78% (23,551) | 86% (198,808) | |
Total ICU length of stay previous year | 230,059 | |||||
< 24 h | 96% (100,410) | 90% (38,833) | 88% (45,364) | 84% (25,365) | 91% (209,972) | |
1–7d | 3% (3640) | 7% (3120) | 9% (4479) | 11% (3404) | 6% (14,643) | |
8–30d | 1% (857) | 2% (975) | 3% (1624) | 4% (1079) | 2% (4535) | |
31–365d | 0% (201) | 0% (152) | 1% (347) | 1% (209) | 0% (909) | |
Number of comorbidity categories | 230,059 | |||||
0 | 46% (48,478) | 1% (330) | 0% (2) | 0% (0) | 21% (48,810) | |
1 | 19% (20,161) | 14% (5967) | 6% (2954) | 0% (135) | 13% (29,217) | |
2 | 14% (14,823) | 22% (9415) | 10% (5401) | 3% (1038) | 13% (30,677) | |
3 | 9% (9612) | 22% (9305) | 16% (8471) | 6% (1950) | 13% (29,338) | |
4 | 6% (5962) | 17% (7419) | 19% (9623) | 11% (3198) | 11% (26,202) | |
5 | 3% (3153) | 11% (4656) | 17% (8674) | 13% (3927) | 9% (20,410) | |
6 | 2% (1609) | 7% (2864) | 13% (6581) | 15% (4366) | 7% (15,420) | |
7 | 1% (743) | 4% (1587) | 9% (4410) | 14% (4279) | 5% (11,019) | |
8 | 0% (336) | 2% (854) | 5% (2663) | 12% (3684) | 3% (7537) | |
9 | 0% (125) | 1% (366) | 3% (1521) | 9% (2785) | 2% (4797) | |
> 9 | 0% (106) | 1% (317) | 3% (1514) | 16% (4695) | 3% (6632) | |
Comorbidity categories | 230,059 | |||||
Infectious disease | 13% (13,247) | 31% (13,316) | 44% (22,762) | 57% (17,231) | 29% (66,556) | |
Hypertension | 9% (9737) | 36% (15,654) | 45% (23,107) | 54% (16,090) | 28% (64,588) | |
Ischemic heart disease | 5% (5244) | 24% (10,451) | 34% (17,529) | 42% (12,741) | 20% (45,965) | |
Injury | 14% (15,130) | 20% (8634) | 20% (10,489) | 23% (6935) | 18% (41,188) | |
Cardiac arrhythmias | 6% (6740) | 22% (9395) | 28% (14,606) | 32% (9684) | 18% (40,425) | |
Neurological disease | 9% (9603) | 19% (8181) | 23% (11,941) | 28% (8445) | 17% (38,170) | |
Diabetes | 0% (37) | 16% (6997) | 26% (13,633) | 46% (13,767) | 15% (34,434) | |
Chronic pulmonary disease | 1% (1536) | 19% (8126) | 25% (13,203) | 29% (8789) | 14% (31,654) | |
Bone/muscle disease | 7% (7723) | 15% (6651) | 18% (9508) | 23% (7033) | 13% (30,915) | |
Tumor non-metastatic | 0% (109) | 0% (104) | 27% (13,876) | 40% (11,919) | 11% (26,008) | |
Peripheral vascular disease | 1% (1482) | 13% (5734) | 16% (8441) | 31% (9326) | 11% (24,983) | |
Cerebrovascular disease | 0% (16) | 15% (6476) | 17% (8626) | 24% (7071) | 10% (22,189) | |
Alcohol abuse | 9% (9704) | 10% (4487) | 7% (3568) | 12% (3650) | 9% (21,409) | |
Renal disease | 2% (1948) | 5% (2026) | 13% (6537) | 32% (9756) | 9% (20,267) | |
Other anemias | 2% (2602) | 7% (2866) | 13% (6480) | 24% (7139) | 8% (19,087) | |
Valvular disease | 5% (4900) | 11% (4639) | 10% (5195) | 9% (2825) | 8% (17,559) | |
Depression | 8% (8577) | 7% (2870) | 6% (2930) | 6% (1823) | 7% (16,200) | |
Poisoning | 9% (9097) | 7% (2893) | 4% (2128) | 5% (1431) | 7% (15,549) | |
Drug abuse | 6% (6715) | 9% (3757) | 6% (2962) | 6% (1913) | 7% (15,347) | |
Fluid balance disorder | 2% (2406) | 6% (2436) | 8% (4028) | 14% (4068) | 6% (12,938) | |
Other endocrine disease | 2% (2371) | 7% (2807) | 8% (4282) | 11% (3208) | 6% (12,668) | |
Hepatic disease | 0% (372) | 7% (3218) | 6% (3092) | 18% (5321) | 5% (12,003) | |
Rheumatic/autoimmune disease | 0% (513) | 4% (1767) | 7% (3490) | 8% (2504) | 4% (8274) | |
Pulmonary circulation disorders | 1% (1056) | 3% (1246) | 5% (2449) | 6% (1711) | 3% (6462) | |
Tumor metastatic | 0% (3) | 0% (0) | 0% (19) | 20% (6156) | 3% (6178) | |
Obesity | 1% (1500) | 3% (1196) | 3% (1684) | 5% (1397) | 3% (5777) | |
Hematological disease | 1% (695) | 2% (707) | 4% (2029) | 7% (1974) | 2% (5405) | |
Blood loss anemia | 1% (695) | 2% (753) | 3% (1548) | 7% (1971) | 2% (4967) | |
Psychoses | 2% (2441) | 2% (1059) | 2% (923) | 2% (492) | 2% (4915) | |
Hematological malignancy | 0% (11) | 0% (9) | 5% (2736) | 5% (1438) | 2% (4194) | |
Transplantation-related disorder | 0% (65) | 0% (181) | 2% (897) | 4% (1252) | 1% (2395) | |
Coagulopathy | 0% (367) | 1% (381) | 1% (678) | 2% (650) | 1% (2076) | |
Malnutrition | 0% (361) | 1% (344) | 1% (649) | 2% (501) | 1% (1855) | |
Immunodeficiency | 0% (107) | 0% (139) | 0% (242) | 1% (394) | 0% (882) |