Ausgabe 3/2021
Inhalt (58 Artikel)
Natural History Studies and Clinical Trial Readiness for Genetic Developmental and Epileptic Encephalopathies
Elizabeth E. Palmer, Katherine Howell, Ingrid E. Scheffer
Clinical Trial Design for Disease-Modifying Therapies for Genetic Epilepsies
Dylan C. Brock, Scott Demarest, Tim A. Benke
Diagnostic Considerations in the Epilepsies—Testing Strategies, Test Type Advantages, and Limitations
Wei-Liang Chen, Heather C. Mefford
Screening Platforms for Genetic Epilepsies—Zebrafish, iPSC-Derived Neurons, and Organoids
Aleksandr Shcheglovitov, Randall T. Peterson
Haploinsufficiency, Dominant Negative, and Gain-of-Function Mechanisms in Epilepsy: Matching Therapeutic Approach to the Pathophysiology
Gemma L. Carvill, Tyler Matheny, Jay Hesselberth, Scott Demarest
Gene Editing and Modulation: the Holy Grail for the Genetic Epilepsies?
Jenna C. Carpenter, Gabriele Lignani
Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy
Lori L. Isom, Kelly G. Knupp
Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome
Nycole A. Copping, Stephanie M. McTighe, Kyle D. Fink, Jill L. Silverman
Precision Therapy for Epilepsy Related to Brain Malformations
Alissa M. D’Gama, Annapurna Poduri
Novel Therapeutics for Neonatal Seizures
Julie M. Ziobro, Krista Eschbach, Renée A. Shellhaas
Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury
Chris G. Dulla, Asla Pitkänen
A Milestone in Multiple Sclerosis Therapy: Monoclonal Antibodies Against CD20—Yet Progress Continues
Esther S. Frisch, Roxanne Pretzsch, Martin S. Weber
Targeting Neuromyelitis Optica Pathogenesis: Results from Randomized Controlled Trials of Biologics
Laura Cacciaguerra, Paola Tortorella, Maria A. Rocca, Massimo Filippi
Nutritional Ketosis in Parkinson’s Disease — a Review of Remaining Questions and Insights
Alexander Choi, Mark Hallett, Debra Ehrlich
Medications for Multiple Sclerosis and Risk of Malignancy: What Next?
Daniel B. Horton, Anthony T. Reder
Multiple Sclerosis: Switching from Natalizumab to Other High-Efficacy Treatments to Mitigate Progressive Multifocal Leukoencephalopathy Risk
Hans-Peter Hartung, Jan Mares, Sven G. Meuth, Thomas Berger
Association Between Disease-Modifying Therapies Prescribed to Persons with Multiple Sclerosis and Cancer: a WHO Pharmacovigilance Database Analysis
Charles Dolladille, Basile Chrétien, Laure Peyro-Saint-Paul, Joachim Alexandre, Olivier Dejardin, Sophie Fedrizzi, Gilles Defer
Network Substrates of Centromedian Nucleus Deep Brain Stimulation in Generalized Pharmacoresistant Epilepsy
Cristina V. Torres Diaz, Gabriel González-Escamilla, Dumitru Ciolac, Marta Navas García, Paloma Pulido Rivas, Rafael G. Sola, Antonio Barbosa, Jesús Pastor, Lorena Vega-Zelaya, Sergiu Groppa
Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis
Giulia Fiscon, Federica Conte, Susanna Amadio, Cinzia Volonté, Paola Paci
FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation
Alexander Svanbergsson, Fredrik Ek, Isak Martinsson, Jordi Rodo, Di Liu, Edoardo Brandi, Caroline Haikal, Laura Torres-Garcia, Wen Li, Gunnar Gouras, Roger Olsson, Tomas Björklund, Jia-Yi Li
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
Nan Zhang, Brittani Bewick, Jason Schultz, Anjana Tiwari, Robert Krencik, Aijun Zhang, Kaho Adachi, Guangbin Xia, Kyuson Yun, Partha Sarkar, Tetsuo Ashizawa
KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson’s Disease
Min-Ho Nam, Jong-Hyun Park, Hyo Jung Song, Ji Won Choi, Siwon Kim, Bo Ko Jang, Hyung Ho Yoon, Jun Young Heo, Hyowon Lee, Heeyoung An, Hyeon Jeong Kim, Sun Jun Park, Doo-Wan Cho, Young-Su Yang, Su-Cheol Han, Sangwook Kim, Soo-Jin Oh, Sang Ryong Jeon, Ki Duk Park, C. Justin Lee
Oleoylethanolamide Delays the Dysfunction and Death of Purkinje Cells and Ameliorates Behavioral Defects in a Mouse Model of Cerebellar Neurodegeneration
Ester Pérez-Martín, Rodrigo Muñoz-Castañeda, Marie-Jo Moutin, Carmelo A. Ávila-Zarza, José M. Muñoz-Castañeda, Carlos Del Pilar, José R. Alonso, Annie Andrieux, David Díaz, Eduardo Weruaga
The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N-Degron Pathway
Jun Hyoung Jeon, Tae Rim Oh, Seoyoung Park, Sunghoo Huh, Ji Hyeon Kim, Binh Khanh Mai, Jung Hoon Lee, Se Hyun Kim, Min Jae Lee
Fingolimod Therapy in Multiple Sclerosis Leads to the Enrichment of a Subpopulation of Aged NK Cells
Svenja C. Schwichtenberg, Anne Wisgalla, Maria Schroeder-Castagno, Cesar Alvarez-González, Stephan Schlickeiser, Nadja Siebert, Judith Bellmann-Strobl, Klaus-Dieter Wernecke, Friedemann Paul, Jan Dörr, Carmen Infante-Duarte
Specific Blockade of Bone Morphogenetic Protein-2/4 Induces Oligodendrogenesis and Remyelination in Demyelinating Disorders
Karin Mausner-Fainberg, Moshe Benhamou, Maya Golan, Nadav Bleich Kimelman, Uri Danon, Ehud Marom, Arnon Karni
N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice
Pauline Bottemanne, Owein Guillemot-Legris, Adrien Paquot, Julien Masquelier, Michael Malamas, Alexandros Makriyannis, Mireille Alhouayek, Giulio G. Muccioli
Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis
Marjan Gharagozloo, Matthew D. Smith, Elias S. Sotirchos, Jing Jin, Keya Meyers, Michelle Taylor, Thomas Garton, Riley Bannon, Hannah-Noelle Lord, Ted M. Dawson, Valina L. Dawson, Seulki Lee, Peter A. Calabresi
Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2
María E. Prados, Alejandro Correa-Sáez, Juan D. Unciti-Broceta, Martín Garrido-Rodríguez, Carla Jimenez-Jimenez, Massimiliano Mazzone, Alberto Minassi, Giovanni Appendino, Marco A. Calzado, Eduardo Muñoz
Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice
Katja Schmitz, Sandra Trautmann, Lisa Hahnefeld, Caroline Fischer, Yannick Schreiber, Annett Wilken-Schmitz, Robert Gurke, Robert Brunkhorst, Ernst R. Werner, Katrin Watschinger, Sabine Wicker, Dominique Thomas, Gerd Geisslinger, Irmgard Tegeder
Clarithromycin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage via Suppressing Periostin-Related Pathways in Mice
Hideki Kanamaru, Fumihiro Kawakita, Hirofumi Nishikawa, Fumi Nakano, Reona Asada, Hidenori Suzuki
α7-Acetylcholine Receptor Signaling Reduces Neuroinflammation After Subarachnoid Hemorrhage in Mice
Ari Dienel, Remya A Veettil, Kanako Matsumura, Jude P J Savarraj, H Alex Choi, Peeyush Kumar T, Jaroslaw Aronowski, Pramod Dash, Spiros L Blackburn, Devin W McBride
Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis via ERK/GSK-3β/TIP60 Pathway After Subarachnoid Hemorrhage in Rats
Hui Shi, Yuanjian Fang, Lei Huang, Ling Gao, Cameron Lenahan, Takeshi Okada, Zachary D. Travis, Shucai Xie, Hong Tang, Qin Lu, Rui Liu, Jiping Tang, Yuan Cheng, John H. Zhang
Neurokinin Receptor 1 (NK1R) Antagonist Aprepitant Enhances Hematoma Clearance by Regulating Microglial Polarization via PKC/p38MAPK/NFκB Pathway After Experimental Intracerebral Hemorrhage in Mice
Peng Jin, Shuixiang Deng, Prativa Sherchan, Yuhui Cui, Lei Huang, Gaigai Li, Lifei Lian, Shucai Xie, Cameron Lenahan, Zachary D. Travis, John H. Zhang, Ye Gong, Jiping Tang
Mesenchymal Stem Cell (MSC)–Derived Extracellular Vesicles Protect from Neonatal Stroke by Interacting with Microglial Cells
Praneeti Pathipati, Matthieu Lecuyer, Joel Faustino, Jacqueline Strivelli, Donald G. Phinney, Zinaida S. Vexler
Transcutaneous Spinal Neuromodulation Reorganizes Neural Networks in Patients with Cerebral Palsy
Parag Gad, Susan Hastings, Hui Zhong, Gaurav Seth, Sachin Kandhari, V. Reggie Edgerton
Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling
Sebastian Peters, Sabrina Kuespert, Eva Wirkert, Rosmarie Heydn, Benjamin Jurek, Siw Johannesen, Ohnmar Hsam, Sven Korte, Florian Timo Ludwig, Lars Mecklenburg, Heike Mrowetz, Barbara Altendorfer, Rodolphe Poupardin, Susanne Petri, Dietmar R. Thal, Andreas Hermann, Jochen H. Weishaupt, Joachim Weis, Inci Sevval Aksoylu, Sebastian A. Lewandowski, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn
CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway
Elisabet Ampudia-Mesias, Francisco Puerta-Martinez, Miurel Bridges, David Zellmer, Andrew Janeiro, Matt Strokes, Yuk Y. Sham, Ayman Taher, Maria G. Castro, Christopher L. Moertel, G. Elizabeth Pluhar, Michael R. Olin
Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities
Bi-Xin Zheng, Xinying Guo, Sfian Albik, Jean Eloy, Yuan-Xiang Tao
Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy
Laura Micheli, Raghavan Rajagopalan, Elena Lucarini, Alessandra Toti, Carmen Parisio, Donatello Carrino, Alessandra Pacini, Carla Ghelardini, Parthasarathi Rajagopalan, Lorenzo Di Cesare Mannelli
Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice
Cheng-Yi Yang, Yu-Chieh Hung, Kuan-Hsiang Cheng, Pin Ling, Kuei-Sen Hsu
Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux
Natalia Mast, Alexey M. Petrov, Erin Prendergast, Ilya Bederman, Irina A. Pikuleva
Development of EQ-6, a Novel Analogue of Ethoxyquin to Prevent Chemotherapy-Induced Peripheral Neuropathy
Aysel Cetinkaya-Fisgin, Jing Zhu, Xinghua Luan, Jun-Soon Kim, Byoungchol Oh, Cory Brayton, Jesse Alt, Rana Rais, Barbara Slusher, Ahmet Höke
Histone Mark Profiling in Pediatric Astrocytomas Reveals Prognostic Significance of H3K9 Trimethylation and Histone Methyltransferase SUV39H1
Alexia Klonou, Penelope Korkolopoulou, Antonios N. Gargalionis, Dimitrios S. Kanakoglou, Hector Katifelis, Maria Gazouli, Sarantis Chlamydas, Andreas Mitsios, Theodosis Kalamatianos, George Stranjalis, Marios S. Themistocleous, Kostas A. Papavassiliou, Spyros Sgouros, Athanasios G. Papavassiliou, Christina Piperi
In Vivo Wireless Brain Stimulation via Non-invasive and Targeted Delivery of Magnetoelectric Nanoparticles
Tyler Nguyen, Jianhua Gao, Ping Wang, Abhignyan Nagesetti, Peter Andrews, Sehban Masood, Zoe Vriesman, Ping Liang, Sakhrat Khizroev, Xiaoming Jin
Donepezil Protects Against Doxorubicin-Induced Chemobrain in Rats via Attenuation of Inflammation and Oxidative Stress Without Interfering With Doxorubicin Efficacy
Benjamin Ongnok, Thawatchai Khuanjing, Titikorn Chunchai, Patcharapong Pantiya, Sasiwan Kerdphoo, Busarin Arunsak, Wichwara Nawara, Thidarat Jaiwongkam, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Correction to: Multiple Sclerosis: Switching from Natalizumab to Other High-Efficacy Treatments to Mitigate Progressive Multifocal Leukoencephalopathy Risk
Hans-Peter Hartung, Jan Mares, Sven G. Meuth, Thomas Berger
Correction to: The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis
Poulomee Bose, Elsa Tremblay, Claudia Maios, Vijay Narasimhan, Gary A. B. Armstrong, Meijiang Liao, J. Alex Parker, Richard Robitaille, Xiao Yan Wen, Christopher Barden, Pierre Drapeau
Correction to: Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain
Xu-Hui Li, Qi-Yu Chen, Min Zhuo
Correction to: Reldesemtiv in Patients with Spinal Muscular Atrophy: a Phase 2 Hypothesis-Generating Study
Stacy A. Rudnicki, Jinsy A. Andrews, Tina Duong, Bettina M. Cockroft, Fady I. Malik, Lisa Meng, Jenny Wei, Andrew A. Wolff, Angela Genge, Nicholas E. Johnson, Carolina Tesi-Rocha, Anne M. Connolly, Basil T. Darras, Kevin Felice, Richard S. Finkel, Perry B. Shieh, Jean K. Mah, Jeffrey Statland, Craig Campbell, Ali A. Habib, Nancy L. Kuntz, Maryam Oskoui, John W. Day
Correction to: CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway
Elisabet Ampudia-Mesias, Francisco Puerta-Martinez, Miurel Bridges, David Zellmer, Andrew Janeiro, Matt Strokes, Yuk Y. Sham, Ayman Taher, Maria G. Castro, Christopher L. Moertel, G. Elizabeth Pluhar, Michael R. Olin
Correction to: Nutritional Ketosis in Parkinson’s Disease — a Review of Remaining Questions and Insights
Alexander Choi, Mark Hallett, Debra Ehrlich