Immunologic Research OnlineFirst articles

16.05.2024 | RESEARCH

Prognostic model incorporating immune checkpoint genes to predict the immunotherapy efficacy for lung adenocarcinoma: a cohort study integrating machine learning algorithms

This study aimed to develop and validate a nomogram based on immune checkpoint genes (ICGs) for predicting prognosis and immune checkpoint blockade (ICB) efficacy in lung adenocarcinoma (LUAD) patients. A total of 385 LUAD patients from the TCGA …

verfasst von:: Xi-Lin Yang, Zheng Zeng, Chen Wang, Guang-Yu Wang, Fu-Quan Zhang

15.05.2024 | Research

Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response

Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe complication of sepsis characterized by acute respiratory distress, hypoxemia, and diffuse bilateral pulmonary infiltrates. The regulation of RIPK1 is an important part …

verfasst von:: Xiaoyu Liu, Yan Li, Weijian Zhang, Nan Gao, Jie Chen, Cheng Xiao, Guoqiang Zhang

Open Access 15.05.2024 | RESEARCH

Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial

The gut microbiome can modulate systemic inflammation and is therefore target for immunomodulation. Immunomodulating effects of EDP1815, a bacterial commensal strain of Prevotella histicola, were studied in healthy participants. Effects on …

verfasst von:: Boukje C. Eveleens Maarse, Micha N. Ronner, Manon A. A. Jansen, Tessa Niemeyer-van der Kolk, Aliede E. in ’t Veld, Erica S. Klaassen, Saira Ahmad, Andrea Itano, Duncan McHale, Matthijs Moerland

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09.05.2024 | Research

Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and cartilage and bone destruction. Lysine-specific demethylase 1 (LSD1), an enzyme involved in transcriptional regulation, has an …

verfasst von:: Ziliang Yu, Peipei Li, Dagong Gao, Yalong Hu, Fei Xia, Lei Liu, Jian Liu, Wei Liu, Haiping Zhang

Open Access 07.05.2024 | ORIGINAL ARTICLE

Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis

Various lymphocyte subpopulations, including NK cells as well as γδ T cells, have been considered an important element in the pathogenesis of autoimmune, inflammatory, rheumatic diseases, such as rheumatoid arthritis (RA) and ankylosing …

verfasst von:: Sylwia Biały, Milena Iwaszko, Jerzy Świerkot, Katarzyna Kolossa, Joanna Wielińska, Sławomir Jeka, Katarzyna Bogunia-Kubik

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02.05.2024 | RESEARCH

DAP1-2: a synthetic peptide targeting IL-1R1 receptor effectively suppresses IL-1β in vitro

The pathological manifestation of the inflammatory process primarily stems from the heightened release of pro-inflammatory cytokines, with IL-1β standing out as a pivotal cytokine. The excessive presence of IL-1β disrupts immune signaling, thereby …

verfasst von:: Ellen De-Pieri, Rubya Pereira Zaccaron, Camille Generoso Mezzari, Mariana de Melo Cardoso, Laura De Roch Casagrande, Paulo Cesar Lock Silveira, Ricardo Andrez Machado-de-Ávila

01.05.2024 | RESEARCH

SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients

This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in humans and to delineate its significance in systemic lupus erythematosus (SLE) patients. We employed multiparametric flow cytometry to …

verfasst von:: Ainizati Hasimu, Ayibaota Bahabayi, Ziqi Xiong, Qi Li, Zhonghui Zhang, Xingyue Zeng, Mohan Zheng, Zihang Yuan, Chen Liu

01.05.2024 | REVIEW

The immunosuppressive landscape in tumor microenvironment

Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate …

verfasst von:: Wuyi Liu, Huyue Zhou, Wenjing Lai, Changpeng Hu, Rufu Xu, Peng Gu, Menglin Luo, Rong Zhang, Guobing Li

30.04.2024 | RESEARCH

FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1

Esophageal cancer (EC) is the 9 th most frequently diagnosed cancer globally with more than 500,000 cancer death each year [ 1 ]. The incidence of EC varies greatly by area, and more than 50% of global cases occur in China [ 2 , 3 ]. EC is composed …

verfasst von:: Guo-yi Shen, Yi Zhang, Rong-zhi Huang, Zhi-yong Huang, Le-yi Yang, Ding-zhu Chen, Shao-bin Yang

27.04.2024 | RESEARCH

Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis

Acute lung injury (ALI) is characterized by acute respiratory failure with tachypnea and widespread alveolar infiltrates, badly affecting patients’ health. Desflurane (Des) is effective against lung injury. However, its mechanism in ALI remains …

verfasst von:: Xiaoyun Shi, Yundie Li, Shibiao Chen, Huaping Xu, Xiuhong Wang

Open Access 22.04.2024 | RESEARCH

Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants

Human Inborn Errors of Immunity (IEIs) encompass a clinically and genetically heterogeneous group of disorders, ranging from mild cases to severe, life-threatening types. Among these, Primary Immune Regulatory Disorders (PIRDs) constitute a subset …

verfasst von:: Ayca Aykut, Asude Durmaz, Neslihan Karaca, Nesrin Gulez, Ferah Genel, Fatih Celmeli, M. Tuba Cogurlu, Mediha Akcan, Dilek Cicek, Funda Erol Cipe, Ayca Kiykim, Alisan Yıldıran, Kursad Unluhizarci, Sara Sebnem Kilic, Guzide Aksu, Omur Ardeniz, Necil Kutukculer

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17.04.2024 | RESEARCH

β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway

Massive evidence shows that intestinal tryptophan metabolites affected by intestinal flora can modulate the progression of rheumatoid arthritis (RA). However, the effects and mechanisms of intestinal tryptophan metabolites on RA are not yet …

verfasst von:: Xiaoran Su, Xinliu Wang, Xin Zhang, Yajie Sun, Yugai Jia

Open Access 16.04.2024 | ORIGINAL ARTICLE

Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence

The long-term symptoms of COVID-19 are the subject of public and scientific discussions. Understanding how those long COVID symptoms co-occur in clusters of syndromes may indicate the pathogenic mechanisms of long COVID. Our study objective was to …

verfasst von:: J. Niewolik, M. Mikuteit, S. Klawitter, D. Schröder, A. Stölting, K. Vahldiek, S. Heinemann, F. Müller, GMN. Behrens, F. Klawonn, A. Dopfer-Jablonka, S. Steffens

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10.04.2024 | Research

Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity

Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders and affects autoantibody diversity and disease subgroups. The primary objective of this study was to characterize diversity of complement (C4) and C4-Human …

verfasst von:: Christina Mary Mariaselvam, Gaurav Seth, Chengappa Kavadichanda, Wahid Boukouaci, Ching-Lien Wu, Bruno Costes, Molly Mary Thabah, Rajagopal Krishnamoorthy, Marion Leboyer, Vir Singh Negi, Ryad Tamouza

06.04.2024 | RESEARCH

Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study

Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease with a risk associated with hormonal and reproductive factors. However, the potential causal effects between these factors and SLE remain unclear. A two-sample Mendelian …

verfasst von:: Runyu Chang, Shate Xiang, Yibo Jin, Xiaofen Xu, Suhai Qian, Lingfeng Chen, Chao Hu, Yufeng Shi, Xinghong Ding

27.03.2024 | RESEARCH

Exploring the causal relationship between Takayasu arteritis and inflammatory bowel disease using Mendelian randomization

Takayasu arteritis (TA) and inflammatory bowel disease (IBD) are two distinct diseases; however, previous studies have reported many cases of IBD-TA coexistence. Additionally, the incidence of IBD in patients with TA is estimated to be …

verfasst von:: Xiaoli Pang, Huizhong Yang, Chi Wang, Suyan Tian

19.03.2024 | RESEARCH

Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice

In modern medical practice, where polyethylene glycol is widely used as a component of various drugs, such as vaccines, chemotherapy drugs, and antibiotics, including vaccines, the issue of allergic reactions to this substance is becoming …

verfasst von:: Maria Zofia Lisiecka

11.03.2024 | CORRESPONDENCE

mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment

verfasst von:: Rafael Cardoso Maciel Costa Silva

Open Access 09.03.2024 | REVIEW

Assessing the steroid-sparing effect of biological agents in randomized controlled trials for lupus: a scoping review

Prompt disease control of flares in patients with systemic lupus erythematosus (SLE) is a priority in treatment strategy planning. However, the long-term dosage-related collateral effects of glucocorticoids (GCs) have pushed researchers towards …

verfasst von:: Savino Sciascia, Silvia Grazietta Foddai, Marta Arbrile, Massimo Radin, Irene Cecchi, Alice Barinotti, Roberta Fenoglio, Dario Roccatello

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06.03.2024 | REVIEW

Involvement of gut microbiota in multiple sclerosis—review of a new pathophysiological hypothesis and potential treatment target

Multiple sclerosis (MS) is a chronic inflammatory disease that leads to demyelination and damage to the central nervous system. It is well known, the significance of the involvement and influence of the immune system in the development and course …

verfasst von:: Piotr Olejnik, Kasper Buczma, Agnieszka Cudnoch-Jędrzejewska, Kaja Kasarełło

Die Highlights vom Kongress des American College of Cardiology 2024

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