European Journal of Epidemiology OnlineFirst articles

10.05.2024 | METHODS

Learning about treatment effects in a new target population under transportability assumptions for relative effect measures

Investigators often believe that relative effect measures conditional on covariates, such as risk ratios and mean ratios, are “transportable” across populations. Here, we examine the identification of causal effects in a target population using an …

verfasst von:: Issa J. Dahabreh, Sarah E. Robertson, Jon A. Steingrimsson

Open Access 06.05.2024 | Correction

Correction: Impact of organised colorectal cancer screening on age-specific population incidences: evidence from a quasi-experimental study in Sweden

In Table 2 of this article, the footnote was missing and should have read ‘Over the period 2003–2006, data on colon cancers have been complemented from the Cancer Registry due to lack of registration of colon cancers in the Swedish Colorectal …

verfasst von:: Gabriella Chauca Strand, Ulf Strömberg, Anna Forsberg, Carl Bonander

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04.05.2024 | METABOLOMIC EPIDEMIOLOGY

Differences in metabolomic profiles between Black and White women in the U.S.: Analyses from two prospective cohorts

There is growing interest in incorporating metabolomics into public health practice. However, Black women are under-represented in many metabolomics studies. If metabolomic profiles differ between Black and White women, this under-representation …

verfasst von:: Emma E. McGee, Oana A. Zeleznik, Raji Balasubramanian, Jie Hu, Bernard A. Rosner, Jean Wactawski-Wende, Clary B. Clish, Julian Avila-Pacheco, Walter C. Willett, Kathryn M. Rexrode, Rulla M. Tamimi, A. Heather Eliassen

04.05.2024 | COHORT PROFILE

The Chinese keratoconus (CKC) cohort study

The Chinese keratoconus (CKC) cohort study is a population-based longitudinal prospective cohort study in the Chinese population involving a clinical database and biobanks. This ongoing study focuses on the prevention of KC progression and is the …

verfasst von:: Kaili Yang, Xiaotian Liu, Liyan Xu, Yuwei Gu, Qi Fan, Shanshan Yin, Yifan Wang, Yi Yuan, Anqi Chang, Yonghao Zang, Chenchen Yin, Chenjiu Pang, Chongjian Wang, Shengwei Ren

27.04.2024 | REPRODUCTIVE EPIDEMIOLOGY

A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France

Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had …

verfasst von:: Julie Boudet-Berquier, Christophe Demattei, Laurence Guldner, Anne Gallay, Sylvie Manouvrier, Jérémie Botton, Claire Philippat, Fleur Delva, Juliette Bloch, Caroline Semaille, Sylvie Odent, Isabelle Perthus, Hanitra Randrianaivo, Sylvie Babajko, Tiphaine Barjat, Claire Beneteau, Naima Brennetot, Ester Garne, Georges Haddad, Mounia Hocine, Isabelle Lacroix, Klervi Leuraud, Michel Mench, Joan Morris, Sophie Patrier, Arnaud Sartelet, Alain Verloes, Christophe Bonaldi, Mélina Le Barbier, Bertrand Gagnière, Philippe Pépin, Ronan Ollivier, Monique Bitoun, Lisa King, Andrea Guajardo-Villar, Eugenia Gomes, Jean-Claude Desenclos, Nolwenn Regnault, Alexandra Benachi

Open Access 23.04.2024 | COVID-19

Continued decline in the incidence of myocardial infarction beyond the COVID-19 pandemic: a nationwide study of the Swedish population aged 60 and older during 2015–2022

The number of myocardial infarctions declined during the early COVID-19 pandemic but mechanisms behind these declines are poorly understood. COVID-19 infection is also associated with an increased risk of myocardial infarction which could lead to …

verfasst von:: Anna C. Meyer, Marcus Ebeling, Enrique Acosta, Karin Modig

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Open Access 20.04.2024 | Screening

The underestimated preventive effects of flexible sigmoidoscopy screening: re-analysis and meta-analysis of randomized trials

Flexible sigmoidoscopy (FS), which is less invasive, resource intensive and costly than colonoscopy, is among the recommended screening options for colorectal cancer (CRC). Four large randomized trials consistently reported statistically …

verfasst von:: Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister

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Open Access 18.04.2024 | Correction

Correction: Agricultural activities and risk of Alzheimer’s disease: the TRACTOR project, a nationwide retrospective cohort study

verfasst von:: Pascal Petit, Elise Gondard, Gérald Gandon, Olivier Moreaud, Mathilde Sauvée, Vincent Bonneterre

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16.04.2024 | COHORT PROFILE

Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection

There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipients with …

verfasst von:: Valentin Goutaudier, Marta Sablik, Maud Racapé, Olivia Rousseau, Benoit Audry, Nassim Kamar, Marc Raynaud, Olivier Aubert, Béatrice Charreau, Emmanuelle Papuchon, Richard Danger, Laurence Letertre, Lionel Couzi, Emmanuel Morelon, Moglie Le Quintrec, Jean-Luc Taupin, Eric Vicaut, Christophe Legendre, Hoa Le Mai, Vishnu Potluri, Thi-Van-Ha Nguyen, Marie-Eliane Azoury, Alice Pinheiro, Georges Nouadje, Pierre Sonigo, Dany Anglicheau, Ineke Tieken, Serge Vogelaar, Christian Jacquelinet, Peter Reese, Pierre-Antoine Gourraud, Sophie Brouard, Carmen Lefaucheur, Alexandre Loupy, the KTD-Innov Consortium

09.04.2024 | COVID-19

Congenital anomalies during Covid-19: artifact of surveillance or a real TORCH?

Infections in the first trimester of pregnancy can be teratogenic, but the possibility that Covid-19 could lead to birth defects is unclear. We examined whether SARS-CoV-2 infection during pregnancy or exposure to pandemic conditions were …

verfasst von:: Nathalie Auger, Laura Arbour, Antoine Lewin, Émilie Brousseau, Jessica Healy-Profitós, Thuy Mai Luu

Open Access 06.04.2024 | AGING EPIDEMIOLOGY

The AccelerAge framework: a new statistical approach to predict biological age based on time-to-event data

Aging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for …

verfasst von:: Marije Sluiskes, Jelle Goeman, Marian Beekman, Eline Slagboom, Erik van den Akker, Hein Putter, Mar Rodríguez-Girondo

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Open Access 31.03.2024 | DIABETES MELLITUS

Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility

Cigarette smokers are at increased risk of developing type 2 diabetes: Observational studies show a 20-60% elevated risk in smokers [ 1 , 2 ], and Mendelian randomization (MR) studies support a causal relationship [ 3 ]. Smokers differ from …

verfasst von:: Yuxia Wei, Sara Hägg, Jonathan K. L. Mak, Tiinamaija Tuomi, Yiqiang Zhan, Sofia Carlsson

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Open Access 29.03.2024 | REVIEW

Prevalence of functional disorders across Europe: a systematic review and meta-analysis

Functional Disorders (FD) refer to persistent somatic symptoms caused by changes in the functioning of bodily processes. Previous findings suggest that FD are highly prevalent, but overall prevalence rates for FD in European countries are scarce.

verfasst von:: Caroline Rometsch, Giovanni Mansueto, Frederic Maas Genannt Bermpohl, Alexandra Martin, Fiammetta Cosci

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Open Access 16.03.2024 | SOCIAL EPIDEMIOLOGY

Life-course social participation and physical activity in midlife: longitudinal associations in the 1970 British Cohort Study (BCS70)

A hypothesized benefit of social participation is that it encourages people to be more physically active. However, limited evidence exists on the association between social participation over the life-course and physical activity in midlife. We …

verfasst von:: Stergiani Tsoli, Daisy Fancourt, Alice Sullivan, Mark Hamer, George B. Ploubidis, Ichiro Kawachi

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Open Access 29.02.2024 | METHODS

Using the global randomization test as a Mendelian randomization falsification test for the exclusion restriction assumption

Mendelian randomization may give biased causal estimates if the instrument affects the outcome not solely via the exposure of interest (violating the exclusion restriction assumption). We demonstrate use of a global randomization test as a …

verfasst von:: Louise A. C. Millard, George Davey Smith, Kate Tilling

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Open Access 24.02.2024 | CANCER

Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study

Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene …

verfasst von:: Guoqiao Zheng, Subhayan Chattopadhyay, Jan Sundquist, Kristina Sundquist, Jianguang Ji

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Open Access 28.01.2024 | METHODS

Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression

Identifying factors that are causes of disease progression, especially in neurodegenerative diseases, is of considerable interest. Disease progression can be described as a trajectory of outcome over time—for example, a linear trajectory having …

verfasst von:: Michael Lawton, Yoav Ben-Shlomo, Apostolos Gkatzionis, Michele T. Hu, Donald Grosset, Kate Tilling

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Open Access 14.01.2024 | CORRESPONDENCE

Population-based analysis of the number of thrombectomies performed after cerebral ischemic stroke and prognostic factors of mortality in France

Ischemic stroke management with occlusion of large blood vessels in the anterior circulation has been ground broken with the development of mechanical thrombectomy (MT). Indeed, in multiple randomized trials, this new treatment has shown greater …

verfasst von:: Fabien de Oliveira, Lucas Léger, Vincent Costalat, Ihssen Belhadj, Maxime Pastor, Héléne de Forges, Jean-Paul Beregi, Thierry Boudemaghe, Julien Frandon

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12.01.2024 | META-ANALYSIS

Vitamin D and human health: evidence from Mendelian randomization studies

We summarized the current evidence on vitamin D and major health outcomes from Mendelian randomization (MR) studies. PubMed and Embase were searched for original MR studies on vitamin D in relation to any health outcome from inception to September …

verfasst von:: Aiping Fang, Yue Zhao, Ping Yang, Xuehong Zhang, Edward L. Giovannucci

04.01.2024 | CORRESPONDENCE

Re: Statistical inference and effect measures in abstracts of randomized trials, 1975-2021

verfasst von:: Donald B. Macnaughton

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin