Erschienen in:
13.05.2022 | COVID-19 | Original Paper
Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patients
verfasst von:
Verónica Rico-Caballero, Mariana Fernández, Juan C. Hurtado, M. Angeles Marcos, Celia Cardozo, Laia Albiach, Daiana Agüero, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena De la Mora, Nicole Garcia-Pouton, Ana Gonzalez-Cordón, Gerard Dueñas, Marta Hernandez-Meneses, Alexy Inciarte, Montse Laguno, Lorna Leal, Irene Macaya, Miguel J. Martínez, Genoveva Cuesta, Fernanda Meira, Laura Morata, Pedro Puerta-Alcalde, John Rojas, Berta Torres, Pedro Castro, Jose Muñoz, Josep Mensa, José Antonio Martínez, Gemma Sanjuan, Jordi Vila, Felipe García, Carolina Garcia-Vidal, Alex Soriano, COVID-19-Researcher Group
Erschienen in:
Infection
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Ausgabe 5/2022
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Abstract
Purpose
Assess the impact of viral load estimated by cycle threshold (Ct) of reverse transcription real time-polymerase chain reaction (rRT-PCR) and the days from symptoms onset on mortality in hospitalized patients with COVID19.
Methods
Retrospective observational study of 782 patients with a positive rRT-PCR from a nasopharyngeal swab was performed within the first 24 h from admission. Demographic data, clinical manifestations and laboratory parameters were collected. Uni- and multivariate analyses were performed to identify factors associated with mortality at 60 days.
Results
Ct was divided into three groups and the mortality rate decreased from 27.3 to 20.7% and 9.8% for Ct values of ≤ 20, 21–25 and > 25, respectively (P = 0.0001). The multivariate analysis identified as predictors of mortality, a Ct value < 20 (OR 3.13, CI 95% 1.38–7.10), between 21–25 (OR 2.47, CI 95% 1.32–4.64) with respect to a Ct value > 25. Days from symptoms onset is a variable associated with mortality as well (DSOA) ≤ 6 (OR 1.86, CI 95% 1.00–3.46), among other factors. Patients requiring hospital admission within 6 DSOA with a Ct value ≤ 25 had the highest mortality rate (28%).
Conclusions
The inclusion of Ct values and DSOA in the characterization of study populations could be a useful tool to evaluate the efficacy of antivirals.