Präzisionsmedizin in der Hypertoniebehandlung

Zurück zum Zitat Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G, Januszewicz A, Muiesan ML, Tsioufis K, Agabiti-Rosei E, Algharably EAE, Azizi M, Benetos A, Borghi C, Hitij JB, Cifkova R, Coca A, Cornelissen V, Cruickshank JK, Cunha PG, Danser AHJ, Pinho RM de, Delles C, Dominiczak AF, Dorobantu M, Doumas M, Fernández-Alfonso MS, Halimi J-M, Járai Z, Jelaković B, Jordan J, Kuznetsova T, Laurent S, Lovic D, Lurbe E, Mahfoud F, Manolis A, Miglinas M, Narkiewicz K, Niiranen T, Palatini P, Parati G, Pathak A, Persu A, Polonia J, Redon J, Sarafidis P, Schmieder R, Spronck B, Stabouli S, Stergiou G, Taddei S, Thomopoulos C, Tomaszewski M, van de Borne P, Wanner C, Weber T, Williams B, Zhang Z-Y, Kjeldsen SE. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023. Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G, Januszewicz A, Muiesan ML, Tsioufis K, Agabiti-Rosei E, Algharably EAE, Azizi M, Benetos A, Borghi C, Hitij JB, Cifkova R, Coca A, Cornelissen V, Cruickshank JK, Cunha PG, Danser AHJ, Pinho RM de, Delles C, Dominiczak AF, Dorobantu M, Doumas M, Fernández-Alfonso MS, Halimi J-M, Járai Z, Jelaković B, Jordan J, Kuznetsova T, Laurent S, Lovic D, Lurbe E, Mahfoud F, Manolis A, Miglinas M, Narkiewicz K, Niiranen T, Palatini P, Parati G, Pathak A, Persu A, Polonia J, Redon J, Sarafidis P, Schmieder R, Spronck B, Stabouli S, Stergiou G, Taddei S, Thomopoulos C, Tomaszewski M, van de Borne P, Wanner C, Weber T, Williams B, Zhang Z-Y, Kjeldsen SE. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023.

Zurück zum Zitat Käyser SC, Schalk BWM, Grauw WJC de, Schermer TR, Akkermans RP, Lenders JWM, Deinum J, Biermans MCJ. Is the plasma aldosterone-to-renin ratio associated with blood pressure response to treatment in general practice? Fam Pract. 2019; 36: 154-161. Käyser SC, Schalk BWM, Grauw WJC de, Schermer TR, Akkermans RP, Lenders JWM, Deinum J, Biermans MCJ. Is the plasma aldosterone-to-renin ratio associated with blood pressure response to treatment in general practice? Fam Pract. 2019; 36: 154-161.

Zurück zum Zitat Suonsyrjä T, Hannila-Handelberg T, Paavonen KJ, Miettinen HE, Donner K, Strandberg T, Tikkanen I, Tilvis R, Pentikäinen PJ, Kontula K, Hiltunen TP. Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES Study. J Hypertens. 2008; 26: 1250-1256. Suonsyrjä T, Hannila-Handelberg T, Paavonen KJ, Miettinen HE, Donner K, Strandberg T, Tikkanen I, Tilvis R, Pentikäinen PJ, Kontula K, Hiltunen TP. Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES Study. J Hypertens. 2008; 26: 1250-1256.

Zurück zum Zitat Parthasarathy HK, Alhashmi K, McMahon AD, Struthers AD, McInnes GT, Ford I, Connell JM, MacDonald TM. Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. J Hypertens. 2010; 28: 170-177. Parthasarathy HK, Alhashmi K, McMahon AD, Struthers AD, McInnes GT, Ford I, Connell JM, MacDonald TM. Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. J Hypertens. 2010; 28: 170-177.

Zurück zum Zitat Mehanna M, McDonough CW, Smith SM, Gong Y, Gums JG, Chapman AB, Johnson JA, McIntyre L, Cooper-DeHoff RM. Metabolomics Signature of Plasma Renin Activity and Linkage with Blood Pressure Response to Beta Blockers and Thiazide Diuretics in Hypertensive European American Patients. Metabolites. 2021; 11. Mehanna M, McDonough CW, Smith SM, Gong Y, Gums JG, Chapman AB, Johnson JA, McIntyre L, Cooper-DeHoff RM. Metabolomics Signature of Plasma Renin Activity and Linkage with Blood Pressure Response to Beta Blockers and Thiazide Diuretics in Hypertensive European American Patients. Metabolites. 2021; 11.

Zurück zum Zitat Irvin MR et al. Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group. Am J Hypertens. 2019; 32: 1146-1153. Irvin MR et al. Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group. Am J Hypertens. 2019; 32: 1146-1153.

Zurück zum Zitat Sánez Tähtisalo H, Ruotsalainen S, Mars N, Porthan K, Oikarinen L, Virolainen J, Fyhrquist F, Ripatti S, Kontula KK, Hiltunen TP. Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses. Sci Rep. 2020; 10: 11940. Sánez Tähtisalo H, Ruotsalainen S, Mars N, Porthan K, Oikarinen L, Virolainen J, Fyhrquist F, Ripatti S, Kontula KK, Hiltunen TP. Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses. Sci Rep. 2020; 10: 11940.

Zurück zum Zitat Xiao Z-L, Yang M, Chen X-B, Xie X-M, Chen M-F. Personalized antihypertensive treatment guided by pharmacogenomics in China. Cardiovasc Diagn Ther. 2022; 12: 635-645. Xiao Z-L, Yang M, Chen X-B, Xie X-M, Chen M-F. Personalized antihypertensive treatment guided by pharmacogenomics in China. Cardiovasc Diagn Ther. 2022; 12: 635-645.

Zurück zum Zitat Wu C, Smit E, Peralta CA, Sarathy H, Odden MC. Functional Status Modifies the Association of Blood Pressure with Death in Elders: Health and Retirement Study. J Am Geriatr Soc. 2017; 65: 1482-1489. Wu C, Smit E, Peralta CA, Sarathy H, Odden MC. Functional Status Modifies the Association of Blood Pressure with Death in Elders: Health and Retirement Study. J Am Geriatr Soc. 2017; 65: 1482-1489.

Zurück zum Zitat Ku E, Lipkowitz MS, Appel LJ, Parsa A, Gassman J, Glidden DV, Smogorzewski M, Hsu C-Y. Strict blood pressure control associates with decreased mortality risk by APOL1 genotype. Kidney Int. 2017; 91: 443-450. Ku E, Lipkowitz MS, Appel LJ, Parsa A, Gassman J, Glidden DV, Smogorzewski M, Hsu C-Y. Strict blood pressure control associates with decreased mortality risk by APOL1 genotype. Kidney Int. 2017; 91: 443-450.