Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
International Ophthalmology
Erschienen in: International Ophthalmology 6/2023

27.11.2022 | Original Paper

Analysis of risk factors for dry eye disease and effect of diquafosol sodium ophthalmic solution on the tear film after vitrectomy in patients with type 2 diabetes mellitus: a preliminary study

verfasst von: Xing Du, Zhen Yang, Yuanyuan Guo, Shanshan Li, Xu Wang, Yanjuan Sheng, Min Du

Erschienen in: International Ophthalmology | Ausgabe 6/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The purpose of this study was to investigate the risk factors of DM associated dry eye syndrome (DMDES) and to explore the effect of diquafosol sodium ophthalmic solution (DQS) on patients with DMDES after vitrectomy.

Methods

Totally 107 patients (107 eyes) received vitrectomy. The data of age, gender, left/right eye, duration of DM, duration of vitrectomy, fasting blood glucose and glycosylated hemoglobin were collected and analyzed for correlation between these factors and DMDES. Postoperatively, DQS was instilled in experimental group and sodium hyaluronate was instilled in control group. The noninvasive breakup time (NIBUT), tear meniscus height (TMH), Schirmer I test (SIT), corneal fluorescence staining score (CFSS) and ocular surface disease index (OSDI) were recorded before vitrectomy and 1, 2 and 3 months after vitrectomy. All data were used for statistical comparison.

Results

Gender, duration of DM and glycosylated hemoglobin were relevant factors of DMDES (P < 0.05). At 1, 2 and 3 months postoperatively, NIBUT and TMH of experimental group were significantly higher than control group (P < 0.05). Postoperatively, CFSS of experimental group was lower than that before vitrectomy, and CFSS at 2 and 3 months after vitrectomy was significantly different between the two groups (P < 0.05). At 1, 2 and 3 months postoperatively, SIT increased in both groups, but there was no significant difference between the two groups (P > 0.05). OSDI was significantly lower in experimental group at 1, 2 and 3 months postoperatively, compared with that of the control group (P < 0.05).

Conclusion

These results suggest that gender, duration of DM and glycosylated hemoglobin are risk factors for DMDES. Postoperative instillation of DQS can improve the tear film quality in patients with DMDES after vitrectomy.
Literatur
1.
International Diabetes Federation (2021) IDF Diabetes Atlas. 10th ed. International Diabetes Federation
2.
Messmer EM (2015) The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch Arztebl Int 112:71–81PubMedPubMedCentral
3.
Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE et al (2017) TFOS DEWS II pathophysiology report. Ocul Surf 15:438–510PubMedCrossRef
4.
Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ et al (2009) 10-year follow-up of diabetes incidence and weight loss in the diabetes prevention program outcomes study. Lancet 374:1677–1686PubMedCrossRef
5.
Yazdani-Ibn-Taz MK, Han MM, Jonuscheit S, Collier A, Nally JE, Hagan S (2019) Patient-reported severity of dry eye and quality of life in diabetes. Clin Ophthalmol 13:217–224PubMedPubMedCentralCrossRef
6.
Yoo TK, Oh E (2019) Diabetes mellitus is associated with dry eye syndrome: a meta-analysis. Int Ophthalmol 39:2611–2620PubMedCrossRef
7.
Zhang X, Zhao L, Deng S, Sun X, Wang N (2016) Dry eye syndrome in patients with diabetes mellitus: prevalence, etiology, and clinical characteristics. J Ophthalmol 2016:8201053PubMedPubMedCentralCrossRef
8.
Tsubota K, Yokoi N, Shimazaki J, Watanabe H, Dogru M et al (2017) New perspectives on dry eye definition and diagnosis: a consensus report by the asia dry eye society. Ocul Surf 15:65–76PubMedCrossRef
9.
Yokoi N, Kato H, Kinoshita S (2014) Facilitation of tear fluid secretion by 3% diquafosol ophthalmic solution in normal human eyes. Am J Ophthalmol 157:85-92.e81PubMedCrossRef
10.
Miyake H, Kawano Y, Tanaka H, Iwata A, Imanaka T et al (2016) Tear volume estimation using a modified Schirmer test: a randomized, multicenter, double-blind trial comparing 3% diquafosol ophthalmic solution and artificial tears in dry eye patients. Clin Ophthalmol 10:879–886PubMedPubMedCentralCrossRef
11.
Inoue Y, Ochi S (2017) Effects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery. Clin Ophthalmol 11:87–93PubMedCrossRef
12.
Yokoi N, Georgiev GA (2018) Tear film-oriented diagnosis and tear film-oriented therapy for dry eye based on tear film dynamics. Invest Ophthalmol Vis Sci 59:Des13–Des22PubMedCrossRef
13.
Wu D, Chen WQ, Li R, Wang Y (2015) Efficacy and safety of topical diquafosol ophthalmic solution for treatment of dry eye: a systematic review of randomized clinical trials. Cornea 34:644–650PubMedCrossRef
14.
Fujii GY, De Juan E, Jr., Humayun MS, Chang TS, Pieramici DJ, et al. (2002) Initial experience using the transconjunctival sutureless vitrectomy system for vitreoretinal surgery. Ophthalmology 109: 1814-1820
15.
Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M et al (2017) TFOS DEWS II diagnostic methodology report. Ocul Surf 15:539–574PubMedCrossRef
16.
Sang X, Li Y, Yang L, Liu JH, Wang XR et al (2018) Lipid layer thickness and tear meniscus height measurements for the differential diagnosis of evaporative dry eye subtypes. Int J Ophthalmol 11:1496–1502PubMedPubMedCentral
17.
Amparo F, Wang H, Yin J, Marmalidou A, Dana R (2017) Evaluating Corneal Fluorescein Staining Using a Novel Automated Method. Invest Ophthalmol Vis Sci 58: Bio168-bio173.
18.
Asian Dry Eye Society China Branch, Ocular Surface and Tear Disease Group of Ophthalmology Professional Committee of Association of Medical Exchanges Across the Taiwan Straits, Ocular Surface and Dry Eye Group of Ophthalmologist Branch of Chinese Medical Doctor Association (2020) Consensus of Chinese dry eye experts: examination and diagnosis. Chin J Ophthalmol 56:741–747
19.
Wang S, Jia Y, Li T, Wang A, Gao L et al (2019) Dry eye disease is more prevalent in children with diabetes than in those without diabetes. Curr Eye Res 44:1299–1305PubMedCrossRef
20.
Kaiserman I, Kaiserman N, Nakar S, Vinker S (2005) Dry eye in diabetic patients. Am J Ophthalmol 139:498–503PubMedCrossRef
21.
22.
Lane JD, Krumholz DM, Sack RA, Morris C (2006) Tear glucose dynamics in diabetes mellitus. Curr Eye Res 31:895–901PubMedCrossRef
23.
Erdur SK, Aydin R, Ozsutcu M, Olmuscelik O, Eliacik M et al (2017) The relationship between metabolic syndrome, its components, and dry eye: a cross-sectional study. Curr Eye Res 42:1115–1117PubMedCrossRef
24.
McKown RL, Wang N, Raab RW, Karnati R, Zhang Y et al (2009) Lacritin and other new proteins of the lacrimal functional unit. Exp Eye Res 88:848–858PubMedCrossRef
25.
Najafi L, Malek M, Valojerdi AE, Aghili R, Khamseh ME et al (2013) Dry eye and its correlation to diabetes microvascular complications in people with type 2 diabetes mellitus. J Diabetes Complicat 27:459–462CrossRef
26.
Misra SL, Patel DV, McGhee CN, Pradhan M, Kilfoyle D et al (2014) Peripheral neuropathy and tear film dysfunction in type 1 diabetes mellitus. J Diabetes Res 2014:848659PubMedPubMedCentralCrossRef
27.
Kalteniece A, Ferdousi M, Azmi S, Marshall A, Soran H et al (2018) Keratocyte density is reduced and related to corneal nerve damage in diabetic neuropathy. Invest Ophthalmol Vis Sci 59:3584–3590PubMedCrossRef
28.
Achtsidis V, Eleftheriadou I, Kozanidou E, Voumvourakis KI, Stamboulis E et al (2014) Dry eye syndrome in subjects with diabetes and association with neuropathy. Diabetes Care 37:e210-211PubMedCrossRef
29.
Inoue K, Okugawa K, Amano S, Oshika T, Takamura E et al (2005) Blinking and superficial punctate keratopathy in patients with diabetes mellitus. Eye (Lond) 19:418–421PubMedCrossRef
30.
He J, Bazan HE (2012) Mapping the nerve architecture of diabetic human corneas. Ophthalmology 119:956–964PubMedCrossRef
31.
Gunay M, Celik G, Yildiz E, Bardak H, Koc N et al (2016) Ocular surface characteristics in diabetic children. Curr Eye Res 41:1526–1531PubMedCrossRef
32.
Dogru M, Katakami C, Inoue M (2001) Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology 108:586–592PubMedCrossRef
33.
34.
Herbaut A, Liang H, Denoyer A, Baudouin C, Labbé A (2019) Tear film analysis and evaluation of optical quality: a review of the literature. J Fr Ophtalmol 42:e21–e35PubMedCrossRef
35.
36.
Lee JH, Na KS, Kim TK, Oh HY, Lee MY (2019) Effects on ocular discomfort and tear film dynamics of suturing 23-gauge pars plana vitrectomies. Arq Bras Oftalmol 82:214–219PubMedCrossRef
37.
Mani R, Shobha PS, Thilagavathi S, Prema P, Viswanathan N et al (2020) Altered mucins and aquaporins indicate dry eye outcome in patients undergoing Vitreo-retinal surgery. PLoS ONE 15:e0233517PubMedPubMedCentralCrossRef
38.
Sato T, Koh S, Yasukura YI, Kanai M, Noguchi Y et al (2019) Surgical factors affecting changes in ocular surface dynamics in the early postoperative period after 25-gauge vitrectomy. Eye Contact Lens 45:254–259PubMedCrossRef
39.
Moon H, Yoon JH, Hyun SH, Kim KH (2014) Short-term influence of aspirating speculum use on dry eye after cataract surgery: a prospective study. Cornea 33:373–375PubMedCrossRef
40.
Tomita Y, Lee D, Tsubota K, Negishi K, Kurihara T (2021) Updates on the current treatments for diabetic retinopathy and possibility of future oral therapy. J Clin Med 10(20):4666PubMedPubMedCentralCrossRef
41.
Berrocal MH, Acaba-Berrocal L (2021) Early pars plana vitrectomy for proliferative diabetic retinopathy: update and review of current literature. Curr Opin Ophthalmol 32:203–208PubMedCrossRef
42.
Finis D, Ackermann P, Pischel N, König C, Hayajneh J et al (2015) Evaluation of meibomian gland dysfunction and local distribution of meibomian gland atrophy by non-contact infrared meibography. Curr Eye Res 40:982–989PubMedCrossRef
43.
Koh S, Ikeda C, Watanabe S, Oie Y, Soma T et al (2015) Effect of non-invasive tear stability assessment on tear meniscus height. Acta Ophthalmol 93:e135-139PubMedCrossRef
44.
Ngo W, Srinivasan S, Schulze M, Jones L (2014) Repeatability of grading meibomian gland dropout using two infrared systems. Optom Vis Sci 91:658–667PubMedCrossRef
45.
von Kügelgen I (2021) Molecular pharmacology of P2Y receptor subtypes. Biochem Pharmacol 187:114361CrossRef
46.
Hori Y, Kageyama T, Sakamoto A, Shiba T, Nakamura M et al (2017) Comparison of short-term effects of diquafosol and rebamipide on mucin 5AC level on the rabbit ocular surface. J Ocul Pharmacol Ther 33:493–497PubMedCrossRef
47.
Fukuoka S, Arita R (2019) Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study. Sci Rep 9:9091PubMedPubMedCentralCrossRef
48.
Zhang Q, Zhang H, Qin G, Wu Y, Song Y et al (2022) Impact of diquafosol ophthalmic solution on tear film and dry eye symptom in type 2 diabetic dry eye: a pilot study. J Ocul Pharmacol Ther 38:133–140PubMedCrossRef
49.
Yokoi N, Sonomura Y, Kato H, Komuro A, Kinoshita S (2015) Three percent diquafosol ophthalmic solution as an additional therapy to existing artificial tears with steroids for dry-eye patients with Sjögren’s syndrome. Eye (Lond) 29:1204–1212PubMedCrossRef
50.
Utsunomiya T, Kawahara A, Hanada K, Yoshida A (2017) Effects of diquafosol ophthalmic solution on quality of life in dry eye assessed using the dry eye-related quality-of-life score questionnaire: effectiveness in patients while reading and using visual display terminals. Cornea 36:908–914PubMedCrossRef
51.
Yokoi N, Uchino M, Uchino Y, Dogru M, Kawashima M et al (2015) Importance of tear film instability in dry eye disease in office workers using visual display terminals: the Osaka study. Am J Ophthalmol 159:748–754PubMedCrossRef
52.
Byun YS, Yoo YS, Kwon JY, Joo JS, Lim SA et al (2016) Diquafosol promotes corneal epithelial healing via intracellular calcium-mediated ERK activation. Exp Eye Res 143:89–97PubMedCrossRef
53.
Park JH, Moon SH, Kang DH, Um HJ, Kang SS et al (2018) Diquafosol sodium inhibits apoptosis and inflammation of corneal epithelial cells via activation of Erk1/2 and RSK. In vitro and in vivo dry eye model. Invest Ophthalmol Vis Sci 59:5108–5115PubMedCrossRef
54.
Cui L, Li Y, Lee HS, Yang JM, Choi W et al (2018) Effect of diquafosol tetrasodium 3% on the conjunctival surface and clinical findings after cataract surgery in patients with dry eye. Int Ophthalmol 38:2021–2030PubMedCrossRef
55.
Lee JH, Song IS, Kim KL, Yoon SY (2016) Effectiveness and optical quality of topical 3.0% diquafosol versus 0.05% cyclosporine a in dry eye patients following cataract surgery. J Ophthalmol 2016:8150757PubMedPubMedCentralCrossRef
56.
Kim S, Shin J, Lee JE (2021) A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery. Sci Rep 11:9124PubMedPubMedCentralCrossRef
57.
Baek J, Doh SH, Chung SK (2016) The effect of topical diquafosol tetrasodium 3% on dry eye after cataract surgery. Curr Eye Res 41:1281–1285PubMedCrossRef
58.
Nakamura M, Imanaka T, Sakamoto A (2012) Diquafosol ophthalmic solution for dry eye treatment. Adv Ther 29:579–589PubMedCrossRef
Metadaten
Titel
Analysis of risk factors for dry eye disease and effect of diquafosol sodium ophthalmic solution on the tear film after vitrectomy in patients with type 2 diabetes mellitus: a preliminary study
verfasst von
Xing Du
Zhen Yang
Yuanyuan Guo
Shanshan Li
Xu Wang
Yanjuan Sheng
Min Du
Publikationsdatum
27.11.2022
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 6/2023
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-022-02584-z

Weitere Artikel der Ausgabe 6/2023

International Ophthalmology 6/2023 Zur Ausgabe

Original Paper

Global trends and prospects in research of artificial cornea over past 20 years: a bibliometric and visualized analysis

Original Paper

Albuminuria as a biomarker of severity in diabetic retinopathy and in the response to intravitreal treatment in diabetic macular edema

Original Paper

Brachytherapy as a curative option for ocular surface squamous neoplasia

Original Paper

Outcomes of transcutaneous retrobulbar Amphotericin B (TRAMB) as an adjuvant therapy for rhino-orbital-cerebral mucormycosis (ROCM) following COVID-19

Original Paper

Evaluation of the reliability, utility, and quality of the lid loading videos on YouTube

Original Paper

Molecular diagnosis of rhino-orbital mucormycosis in a COVID-19 setting

Neu im Fachgebiet Augenheilkunde

Metastase in der periokulären Region

Metastasen Leitthema

Orbitale und periokuläre metastatische Tumoren galten früher als sehr selten. Aber mit der ständigen Aktualisierung von Medikamenten und Nachweismethoden für die Krebsbehandlung werden neue Chemotherapien und Strahlenbehandlungen eingesetzt. Die …

Staging und Systemtherapie bei okulären und periokulären Metastasen

Metastasen Leitthema

Metastasen bösartiger Erkrankungen sind die häufigsten Tumoren, die im Auge diagnostiziert werden. Sie treten bei ungefähr 5–10 % der Patienten mit soliden Tumoren im Verlauf der Erkrankung auf. Besonders häufig sind diese beim Mammakarzinom und …

CME: Wundheilung nach Trabekulektomie

Trabekulektomie CME-Artikel

Wird ein Glaukom chirurgisch behandelt, ist die anschließende Wundheilung von entscheidender Bedeutung. In diesem CME-Kurs lernen Sie, welche Pathomechanismen der Vernarbung zugrunde liegen, wie perioperativ therapiert und Operationsversagen frühzeitig erkannt werden kann.

„standard operating procedures“ (SOP) – Vorschlag zum therapeutischen Management bei periokulären sowie intraokulären Metastasen

Metastasen Leitthema

Peri- sowie intraokuläre Metastasen sind insgesamt gesehen selten und meist Zeichen einer fortgeschrittenen primären Tumorerkrankung. Die Therapie ist daher zumeist palliativ und selten kurativ. Zudem ist die Therapiefindung sehr individuell. Die …

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen