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2020 | OriginalPaper | Buchkapitel

20. Wissenschaftliche Grundlagen der herzchirurgischen Fachliteratur

verfasst von : Brigitta Gahl, Olaf Stanger

Erschienen in: Kompendium der modernen Herzchirurgie beim Erwachsenen

Verlag: Springer Vienna

Zusammenfassung

Die meisten Ärzte lesen mehr oder weniger regelmäßig wissenschaftliche Fachliteratur, um sich über neue Entwicklungen und Erfahrungen in ihrem medizinischen Arbeitsgebiet zu informieren und diese Kenntnisse für die beste und sicherste Behandlung ihrer Patienten zu nutzen. Verständliche, objektive Berichte über Untersuchungsergebnisse, die für medizinische Entscheidungen relevant sind, erhöhen die Behandlungsqualität und kommen den Patienten zugute. In der Realität gibt es jedoch leider viele Artikel, die diesem Ideal nicht entsprechen, weil inadäquate Methoden (Design, Durchführung, Analyse, Interpretation) angewendet oder die Ergebnisse übertrieben dargestellt wurden; dominante Firmeninteressen oder mangelnde Sorgfalt können den Nutzen ebenfalls stark einschränken. Um trotz dieser Hindernisse brauchbare Informationen entnehmen und Zuverlässiges erkennen zu können, helfen gute Methodenkenntnisse. Dieses Kapitel erläutert einige Grundprinzipien und soll den Sinn für das qualitative Beurteilen herzchirurgischer Fachliteratur schärfen. Im Idealfall ist es auch beim Verfassen eines Artikels hilfreich. Es kann und will jedoch kein Lehrbuch über wissenschaftliches Arbeiten ersetzen.
Literatur
Zurück zum Zitat Abraham NS, Young JM, Solomon MJ (2006) A systematic review of reasons for nonentry of eligible patients into surgical randomized controlled trials. Surgery 139:469–483PubMedCrossRef Abraham NS, Young JM, Solomon MJ (2006) A systematic review of reasons for nonentry of eligible patients into surgical randomized controlled trials. Surgery 139:469–483PubMedCrossRef
Zurück zum Zitat Abraham NS, Byrne CJ, Young JM, Solomon MJ (2010) Meta-analysis of well-designed nonrandomized comparative studies of surgical procedures is as good as randomized controlled trials. J Clin Epidemiol 63:238–425PubMedCrossRef Abraham NS, Byrne CJ, Young JM, Solomon MJ (2010) Meta-analysis of well-designed nonrandomized comparative studies of surgical procedures is as good as randomized controlled trials. J Clin Epidemiol 63:238–425PubMedCrossRef
Zurück zum Zitat Annesley TM (2010b) Who, what, when, where, how, and why: the ingredients in the recipe for a succesful methods section. Clin Chem 56:897–901PubMedCrossRef Annesley TM (2010b) Who, what, when, where, how, and why: the ingredients in the recipe for a succesful methods section. Clin Chem 56:897–901PubMedCrossRef
Zurück zum Zitat Annesley TM (2010e) Put your best figure forward: line graphs and scattergrams. Clin Chem 56:1229–1233PubMedCrossRef Annesley TM (2010e) Put your best figure forward: line graphs and scattergrams. Clin Chem 56:1229–1233PubMedCrossRef
Zurück zum Zitat Antunes MJ (2008) Guidelines in real life. Why are they not always enforced? Eur J Cardiothorac Surg 34:935–936PubMedCrossRef Antunes MJ (2008) Guidelines in real life. Why are they not always enforced? Eur J Cardiothorac Surg 34:935–936PubMedCrossRef
Zurück zum Zitat Bekelman JE, Li Y, Gross CP (2003) Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 289:454–465PubMedCrossRef Bekelman JE, Li Y, Gross CP (2003) Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 289:454–465PubMedCrossRef
Zurück zum Zitat Benson K, Hartz AJ (2000) A comparison of observational studies and randomized, controlled trials. N Engl J Med 342:1878–1886PubMedCrossRef Benson K, Hartz AJ (2000) A comparison of observational studies and randomized, controlled trials. N Engl J Med 342:1878–1886PubMedCrossRef
Zurück zum Zitat Benstoem C, Moza A, Autschbach R, Stoppe C, Goetzenich A (2015) Evaluating outcomes used in cardiothoracic interventional research: a systematic review of reviews to develop a core outcome set. PLoS One 10:e0122204PubMedPubMedCentralCrossRef Benstoem C, Moza A, Autschbach R, Stoppe C, Goetzenich A (2015) Evaluating outcomes used in cardiothoracic interventional research: a systematic review of reviews to develop a core outcome set. PLoS One 10:e0122204PubMedPubMedCentralCrossRef
Zurück zum Zitat Braga LH, Farrokhyar F, Bhandari M (2012) Confounding: what it is and how do we deal with it? J Can Chir 55:132–138 Braga LH, Farrokhyar F, Bhandari M (2012) Confounding: what it is and how do we deal with it? J Can Chir 55:132–138
Zurück zum Zitat van den Broek MA, van Dam RM, Malagó M, Dejong CH, van Breukelen GJ, Olde Damink SW (2009) Feasibility of randomized controlled trials in liver surgery using surgery-related mortality or morbidity as endpoint. Br J Surg 96:1005–1014PubMedCrossRef van den Broek MA, van Dam RM, Malagó M, Dejong CH, van Breukelen GJ, Olde Damink SW (2009) Feasibility of randomized controlled trials in liver surgery using surgery-related mortality or morbidity as endpoint. Br J Surg 96:1005–1014PubMedCrossRef
Zurück zum Zitat Chalmers I, Glasziou P (2009) Avoidable waste in the production and reporting of research evidence. Lancet 374:86–89PubMedCrossRef Chalmers I, Glasziou P (2009) Avoidable waste in the production and reporting of research evidence. Lancet 374:86–89PubMedCrossRef
Zurück zum Zitat Chan AW, Altman DG (2005) Epidemiology and reporting of randomised trials published in PubMed jounals. Lancet 365:1159–1162PubMedCrossRef Chan AW, Altman DG (2005) Epidemiology and reporting of randomised trials published in PubMed jounals. Lancet 365:1159–1162PubMedCrossRef
Zurück zum Zitat Chan AW, Hróbjartsson A, Haahr MT, Gøtzsche PC, Altman DG (2004) Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 291:2457–2465PubMedCrossRef Chan AW, Hróbjartsson A, Haahr MT, Gøtzsche PC, Altman DG (2004) Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 291:2457–2465PubMedCrossRef
Zurück zum Zitat Chang L, Dhruva SS, Chu J, Bero LA, Redberg RF (2015) Selective reporting in trials of high risk cardiovascular devices: cross sectional comparison between premarket approval summaries and published reports. Br Med J 350:h2613CrossRef Chang L, Dhruva SS, Chu J, Bero LA, Redberg RF (2015) Selective reporting in trials of high risk cardiovascular devices: cross sectional comparison between premarket approval summaries and published reports. Br Med J 350:h2613CrossRef
Zurück zum Zitat Chen CE, Dhruva SS, Redberg RF (2012) Inclusion of comparative effectiveness data in high-risk cardiovascular device studies at the time of premarket approval. JAMA 308:1740–1742PubMedCrossRef Chen CE, Dhruva SS, Redberg RF (2012) Inclusion of comparative effectiveness data in high-risk cardiovascular device studies at the time of premarket approval. JAMA 308:1740–1742PubMedCrossRef
Zurück zum Zitat Concato J, Shah N, Horwitz RI (2000) Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342:1887–1892PubMedPubMedCentralCrossRef Concato J, Shah N, Horwitz RI (2000) Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342:1887–1892PubMedPubMedCentralCrossRef
Zurück zum Zitat Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA et al (2007) Clinical end points in coronary stent trials: a case for standardized definitions. Circulation 115:2344–2351PubMedCrossRef Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA et al (2007) Clinical end points in coronary stent trials: a case for standardized definitions. Circulation 115:2344–2351PubMedCrossRef
Zurück zum Zitat Da Costa BR, Gahl B, Jüni P (2014) Tools and techniques – statistics: propensity score techniques. EuroIntervention 10:761–767 Da Costa BR, Gahl B, Jüni P (2014) Tools and techniques – statistics: propensity score techniques. EuroIntervention 10:761–767
Zurück zum Zitat Djulbegovic B, Clarke M (2001) Scientific and ethical issues in equivalence trials. JAMA 285:1206–1208PubMedCrossRef Djulbegovic B, Clarke M (2001) Scientific and ethical issues in equivalence trials. JAMA 285:1206–1208PubMedCrossRef
Zurück zum Zitat Ebrahim S, Sohani ZN, Montoya L, Agarwal A, Thorlund K, Mills EJ, Ioannidis JP (2014) Reanalyses of randomized clinical trial data. JAMA 312:1024–1032PubMedCrossRef Ebrahim S, Sohani ZN, Montoya L, Agarwal A, Thorlund K, Mills EJ, Ioannidis JP (2014) Reanalyses of randomized clinical trial data. JAMA 312:1024–1032PubMedCrossRef
Zurück zum Zitat Feinstein AR (1989) Epidemiologic analyses of causation: the unlearned scientific lessons of randomized trials. J Clin Epidemiol 42:481–489PubMedCrossRef Feinstein AR (1989) Epidemiologic analyses of causation: the unlearned scientific lessons of randomized trials. J Clin Epidemiol 42:481–489PubMedCrossRef
Zurück zum Zitat Flacco ME, Manzoli L, Boccia S, Capasso L, Aleksovska K, Rosso A et al (2005) Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor. J Clin Epidemiol 68:811–820CrossRef Flacco ME, Manzoli L, Boccia S, Capasso L, Aleksovska K, Rosso A et al (2005) Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor. J Clin Epidemiol 68:811–820CrossRef
Zurück zum Zitat Garas G, Ibrahim A, Ashrafian H, Ahmed K, Patel V, Okabayashi K et al (2012) Evidence-based surgery: barriers, solutions, and the role of evidence synthesis. World J Surg 36:1723–1731PubMedCrossRef Garas G, Ibrahim A, Ashrafian H, Ahmed K, Patel V, Okabayashi K et al (2012) Evidence-based surgery: barriers, solutions, and the role of evidence synthesis. World J Surg 36:1723–1731PubMedCrossRef
Zurück zum Zitat Garattini S, Bertele V (2007) Non-inferiority trials are unethical because they disregard patients’ interests. Lancet 370:1875–1877PubMedCrossRef Garattini S, Bertele V (2007) Non-inferiority trials are unethical because they disregard patients’ interests. Lancet 370:1875–1877PubMedCrossRef
Zurück zum Zitat Glasziou P, Altman DG, Bossuyt P, Boutron I, Clarke M, Julious S et al (2014) Reducing waste from incomplete or unusable reports of biomedical research. Lancet 383:267–276PubMedCrossRef Glasziou P, Altman DG, Bossuyt P, Boutron I, Clarke M, Julious S et al (2014) Reducing waste from incomplete or unusable reports of biomedical research. Lancet 383:267–276PubMedCrossRef
Zurück zum Zitat Goldfarb M, Drudi L, Almohammadi M, Langlois Y, Noiseux N, Perrault L et al (2015) Outcome reporting in cardiac surgery trials: systematic review and critical appraisal. J Am Heart Assoc 4:e002204PubMedPubMedCentralCrossRef Goldfarb M, Drudi L, Almohammadi M, Langlois Y, Noiseux N, Perrault L et al (2015) Outcome reporting in cardiac surgery trials: systematic review and critical appraisal. J Am Heart Assoc 4:e002204PubMedPubMedCentralCrossRef
Zurück zum Zitat Gotzsche PC (2006) Lessons from and cautions about noninferiority and equivalence randomized trials. JAMA 295:1172–1174PubMedCrossRef Gotzsche PC (2006) Lessons from and cautions about noninferiority and equivalence randomized trials. JAMA 295:1172–1174PubMedCrossRef
Zurück zum Zitat Griffith BP, Hattler BG, Hardesty RL, Kormos RL, Pham SM, Bahnson HA (1995) The need for accurate risk-adjusted measures of outcome in surgery. Lessons learned through coronary artery bypass. Ann Surg 222:593–598PubMedPubMedCentralCrossRef Griffith BP, Hattler BG, Hardesty RL, Kormos RL, Pham SM, Bahnson HA (1995) The need for accurate risk-adjusted measures of outcome in surgery. Lessons learned through coronary artery bypass. Ann Surg 222:593–598PubMedPubMedCentralCrossRef
Zurück zum Zitat Grimes DA, Schulz KF (2002) An overview of clinical research: the lay of the land. Lancet 359:57–61PubMedCrossRef Grimes DA, Schulz KF (2002) An overview of clinical research: the lay of the land. Lancet 359:57–61PubMedCrossRef
Zurück zum Zitat Grunkemeier GL, Jin R, Eijkemans MJ, Takkenberg JJ (2007) Actual and actuarial probabilities of competing risks: apples and lemons. Ann Thorac Surg 83:1586–1592PubMedCrossRef Grunkemeier GL, Jin R, Eijkemans MJ, Takkenberg JJ (2007) Actual and actuarial probabilities of competing risks: apples and lemons. Ann Thorac Surg 83:1586–1592PubMedCrossRef
Zurück zum Zitat Hernán MA, Hernández-Díaz S, Werler MM, Mitchell AA (2002) Causal knowledge as a prerequisite for confounding evaluation: an application to birth defects epidemiology. Am J Epidemiol 155:176–184PubMedCrossRef Hernán MA, Hernández-Díaz S, Werler MM, Mitchell AA (2002) Causal knowledge as a prerequisite for confounding evaluation: an application to birth defects epidemiology. Am J Epidemiol 155:176–184PubMedCrossRef
Zurück zum Zitat Hickey GL, Grant SW, Cosgriff R, Dimarakis I, Pagano D, Kappetein AP, Bridgewater B (2013) Clinical registries: governance, management, analysis and applications. Eur J Cardiothorac Surg 44:605–614PubMedCrossRef Hickey GL, Grant SW, Cosgriff R, Dimarakis I, Pagano D, Kappetein AP, Bridgewater B (2013) Clinical registries: governance, management, analysis and applications. Eur J Cardiothorac Surg 44:605–614PubMedCrossRef
Zurück zum Zitat Hickey GL, Dunning J, Seifert B, Sodeck G, Carr MJ, Burger HU, Beyersdorf F (2015) Statistical and data reporting guidelines for the European Journal of Cardiothoracic Surgery and the Interactive Cardiovascular and Throracic Surgery. Eur J Cardiothorac Surg 48:180–193PubMedCrossRef Hickey GL, Dunning J, Seifert B, Sodeck G, Carr MJ, Burger HU, Beyersdorf F (2015) Statistical and data reporting guidelines for the European Journal of Cardiothoracic Surgery and the Interactive Cardiovascular and Throracic Surgery. Eur J Cardiothorac Surg 48:180–193PubMedCrossRef
Zurück zum Zitat Huebner M, Vach W, le Cessie S (2016) A systematic approach to initial data analysisis good research practice. J Thorac Cardiovasc Surg 151:25–27PubMedCrossRef Huebner M, Vach W, le Cessie S (2016) A systematic approach to initial data analysisis good research practice. J Thorac Cardiovasc Surg 151:25–27PubMedCrossRef
Zurück zum Zitat Ioannides JP (2005a) Why most published research findings are false. PLoS Med 8:e124CrossRef Ioannides JP (2005a) Why most published research findings are false. PLoS Med 8:e124CrossRef
Zurück zum Zitat Ioannides JP (2005b) Contradicted and initially stronger effects in highly cited clinical research. JAMA 294:218–228CrossRef Ioannides JP (2005b) Contradicted and initially stronger effects in highly cited clinical research. JAMA 294:218–228CrossRef
Zurück zum Zitat Jüni P, Nartey L, Reichenbach S, Dieppe PA, Sterchi R, Egger M (2004) Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 364:2021–2029PubMedCrossRef Jüni P, Nartey L, Reichenbach S, Dieppe PA, Sterchi R, Egger M (2004) Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 364:2021–2029PubMedCrossRef
Zurück zum Zitat Kjaergard LL, Als-Nielsen B (2002) Association between competing interests and authors’ conclusions: epidemiological study of randomised clinical trials published in the BMJ. BMJ 325:249PubMedPubMedCentralCrossRef Kjaergard LL, Als-Nielsen B (2002) Association between competing interests and authors’ conclusions: epidemiological study of randomised clinical trials published in the BMJ. BMJ 325:249PubMedPubMedCentralCrossRef
Zurück zum Zitat Lassen K, Hϕye A, Myrmel T (2012) Randomised trials in surgery: the burden of evidence. Rev Recent Clin Trials 7:244–248PubMedCrossRef Lassen K, Hϕye A, Myrmel T (2012) Randomised trials in surgery: the burden of evidence. Rev Recent Clin Trials 7:244–248PubMedCrossRef
Zurück zum Zitat Lundh A, Sismondo S, Lexchin J, Busuioc OA, Bero L (2012) Industry sponsorship and research outcome. Cochrane Database Syst Rev 12:MR000033PubMed Lundh A, Sismondo S, Lexchin J, Busuioc OA, Bero L (2012) Industry sponsorship and research outcome. Cochrane Database Syst Rev 12:MR000033PubMed
Zurück zum Zitat Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311–1315PubMedCrossRef Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311–1315PubMedCrossRef
Zurück zum Zitat McKenna UG, Meadows JA, Brewer NS, Wilson WR, Perrault J (1980) Toxic shock syndrome, a newly recognized disease entity. Report of 11 cases. Mayo Clin Proc 55:663–672PubMed McKenna UG, Meadows JA, Brewer NS, Wilson WR, Perrault J (1980) Toxic shock syndrome, a newly recognized disease entity. Report of 11 cases. Mayo Clin Proc 55:663–672PubMed
Zurück zum Zitat Naylor CD, Guyatt GH (1996) Users’ guides to the medical literature. X. How to use an article reporting variations in the outcomes of health services. The Evidence-Based Medicine Working Group. JAMA 275:554–558PubMedCrossRef Naylor CD, Guyatt GH (1996) Users’ guides to the medical literature. X. How to use an article reporting variations in the outcomes of health services. The Evidence-Based Medicine Working Group. JAMA 275:554–558PubMedCrossRef
Zurück zum Zitat Nuesch E, Reichenbach S, Trelle S, Rutjes AW, Liewald K, Sterchi R et al (2009) The importance of allocation concealment and patient blinding in osteoarthritis trials: a meta-epidemiologic study. Arthritis Rheum 61:1633–1641PubMedCrossRef Nuesch E, Reichenbach S, Trelle S, Rutjes AW, Liewald K, Sterchi R et al (2009) The importance of allocation concealment and patient blinding in osteoarthritis trials: a meta-epidemiologic study. Arthritis Rheum 61:1633–1641PubMedCrossRef
Zurück zum Zitat Piaggio G, Elbourne DR, Pocock SJ, Evans SJ, Altman DG, CONSORT Group (2012) Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA 308:2594–2604PubMedCrossRef Piaggio G, Elbourne DR, Pocock SJ, Evans SJ, Altman DG, CONSORT Group (2012) Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA 308:2594–2604PubMedCrossRef
Zurück zum Zitat Pocock SJ, Clayton TC, Altman DG (2002) Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls. Lancet 359:1686–1689PubMedCrossRef Pocock SJ, Clayton TC, Altman DG (2002) Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls. Lancet 359:1686–1689PubMedCrossRef
Zurück zum Zitat Pollock AV (1989) The rise and fall of the random controlled trial in surgery. Theor Surg 4:163–170 Pollock AV (1989) The rise and fall of the random controlled trial in surgery. Theor Surg 4:163–170
Zurück zum Zitat Porter ME, Larsson S, Lee TH (2016) Standardizing patient outcome measurement. N Engl J Med 374:504–506PubMedCrossRef Porter ME, Larsson S, Lee TH (2016) Standardizing patient outcome measurement. N Engl J Med 374:504–506PubMedCrossRef
Zurück zum Zitat Rahimi K, Malhotra A, Banning A, Jenkinson C (2010) Outcome selection and role of patient reported outcomes in contemporary cardiovascular trials: systematic review. BMJ 341:c5707PubMedPubMedCentralCrossRef Rahimi K, Malhotra A, Banning A, Jenkinson C (2010) Outcome selection and role of patient reported outcomes in contemporary cardiovascular trials: systematic review. BMJ 341:c5707PubMedPubMedCentralCrossRef
Zurück zum Zitat Ramsay CR, Grant AM, Wallace SA, Garthwaite PH, Monk AF, Russell IT (2001) Statistical assessment of the learning curves of health technologies. Health Technol Assess 5:1–79PubMedCrossRef Ramsay CR, Grant AM, Wallace SA, Garthwaite PH, Monk AF, Russell IT (2001) Statistical assessment of the learning curves of health technologies. Health Technol Assess 5:1–79PubMedCrossRef
Zurück zum Zitat Rising K, Bacchetti P, Bero L (2008) Reporting bias in drug trials submitted to the Food and Drug Administration: review of publication and presentation. PLoS Med 5:e217PubMedPubMedCentralCrossRef Rising K, Bacchetti P, Bero L (2008) Reporting bias in drug trials submitted to the Food and Drug Administration: review of publication and presentation. PLoS Med 5:e217PubMedPubMedCentralCrossRef
Zurück zum Zitat Rosenbaum L (2003) Understanding bias-the case for careful study. NEJM 372:1959–1963CrossRef Rosenbaum L (2003) Understanding bias-the case for careful study. NEJM 372:1959–1963CrossRef
Zurück zum Zitat Sackett DL, Richardson WS, Rosenberg W, Haynes RB (1997) Evidence-based medicine: how to practice and teach EBM. Churchill Livingtone, New York Sackett DL, Richardson WS, Rosenberg W, Haynes RB (1997) Evidence-based medicine: how to practice and teach EBM. Churchill Livingtone, New York
Zurück zum Zitat Sacks H, Chalmers TC, Smith H Jr (1982) Randomized versus historical controls for clinical trials. Am J Med 72:233–240PubMedCrossRef Sacks H, Chalmers TC, Smith H Jr (1982) Randomized versus historical controls for clinical trials. Am J Med 72:233–240PubMedCrossRef
Zurück zum Zitat Schulz KF, Chalmers I, Hayes RJ, Altman DG (1995) Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 273:408–412PubMedCrossRef Schulz KF, Chalmers I, Hayes RJ, Altman DG (1995) Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 273:408–412PubMedCrossRef
Zurück zum Zitat Shroyer AL, McDonald GO, Wagner BD, Johnson R, Schade LM, Bell MR, Grover FL (2008) Improving quality of care in cardiac surgery: evaluating risk factors, processes of care, structures of care, and outcomes. Semin Cardiothorac Vasc Anesth 12:140–152PubMedCrossRef Shroyer AL, McDonald GO, Wagner BD, Johnson R, Schade LM, Bell MR, Grover FL (2008) Improving quality of care in cardiac surgery: evaluating risk factors, processes of care, structures of care, and outcomes. Semin Cardiothorac Vasc Anesth 12:140–152PubMedCrossRef
Zurück zum Zitat Solomon MJ, McLeod RS (1995) Should we be performing more randomized controlled trials evaluating surgical operations? Surgery 118:459–467PubMedCrossRef Solomon MJ, McLeod RS (1995) Should we be performing more randomized controlled trials evaluating surgical operations? Surgery 118:459–467PubMedCrossRef
Zurück zum Zitat Solomon MJ, Laxamana A, Devore L, McLeod RS (1994) Randomized controlled trials in surgery. Surgery 115:707–712PubMed Solomon MJ, Laxamana A, Devore L, McLeod RS (1994) Randomized controlled trials in surgery. Surgery 115:707–712PubMed
Zurück zum Zitat Steere AC, Malawista SE, Snydman DR, Shope RE, Andiman WA, Ross MR, Steele FM (1977) Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis Rheum 20:7–17PubMedCrossRef Steere AC, Malawista SE, Snydman DR, Shope RE, Andiman WA, Ross MR, Steele FM (1977) Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis Rheum 20:7–17PubMedCrossRef
Zurück zum Zitat Steinberg SM, Popa MR, Michalek JA, Bethel MJ, Ellison EC (2008) Comparison of risk adjustment methodologies in surgical quality improvement. Surgery 144:662–667PubMedCrossRef Steinberg SM, Popa MR, Michalek JA, Bethel MJ, Ellison EC (2008) Comparison of risk adjustment methodologies in surgical quality improvement. Surgery 144:662–667PubMedCrossRef
Zurück zum Zitat Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction (2012) Third universal definition of myocardial infarction. Circulation 126:2020–2035PubMedCrossRef Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction (2012) Third universal definition of myocardial infarction. Circulation 126:2020–2035PubMedCrossRef
Zurück zum Zitat Van Rij AM, McDonald JR, Pettigrew RA, Putterill MJ, Reddy CK, Wright JJ (1995) CUSUM as an aid to early assessment of the surgical trainee. Br J Surg 82:1500–1503PubMed Van Rij AM, McDonald JR, Pettigrew RA, Putterill MJ, Reddy CK, Wright JJ (1995) CUSUM as an aid to early assessment of the surgical trainee. Br J Surg 82:1500–1503PubMed
Zurück zum Zitat Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, STROBE Initiative et al (2014) Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Int J Surg 12:1500–1524PubMedCrossRef Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, STROBE Initiative et al (2014) Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Int J Surg 12:1500–1524PubMedCrossRef
Zurück zum Zitat Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165:710–718PubMedCrossRef Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165:710–718PubMedCrossRef
Zurück zum Zitat Von Allmen RS, Weiss S, Tevaearai HT, Kuemmerli C, Tinner C, Carrel TP et al (2015) Completeness of follow-up determines validity of study findings: results of a prospective repeated measures cohort study. PLoS One 10:e0140817CrossRef Von Allmen RS, Weiss S, Tevaearai HT, Kuemmerli C, Tinner C, Carrel TP et al (2015) Completeness of follow-up determines validity of study findings: results of a prospective repeated measures cohort study. PLoS One 10:e0140817CrossRef
Zurück zum Zitat Vranckx P, Cutlip DE, Mehran R, Kint PP, Silber S, Windecker S, Serruys PW (2010) Myocardial infarction adjudication in contemporary all-comer stent trials: balancing sensitivity and specificity. Addendum to the historical MI definitions used in stent studies. EuroIntervention 5:871–874PubMedCrossRef Vranckx P, Cutlip DE, Mehran R, Kint PP, Silber S, Windecker S, Serruys PW (2010) Myocardial infarction adjudication in contemporary all-comer stent trials: balancing sensitivity and specificity. Addendum to the historical MI definitions used in stent studies. EuroIntervention 5:871–874PubMedCrossRef
Zurück zum Zitat Wood L, Egger M, Gluud LL, Schulz KF, Juni P, Altman DG (2008) Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ 336:601–605PubMedPubMedCentralCrossRef Wood L, Egger M, Gluud LL, Schulz KF, Juni P, Altman DG (2008) Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ 336:601–605PubMedPubMedCentralCrossRef
Zurück zum Zitat Yordanov Y, Dechartres A, Porcher R, Boutron I, Altman DG, Ravaud P (2015) Avoidable waste of research related to inadequate methods in clinical trials. BMJ 350:h809PubMedPubMedCentralCrossRef Yordanov Y, Dechartres A, Porcher R, Boutron I, Altman DG, Ravaud P (2015) Avoidable waste of research related to inadequate methods in clinical trials. BMJ 350:h809PubMedPubMedCentralCrossRef
Metadaten
Titel
Wissenschaftliche Grundlagen der herzchirurgischen Fachliteratur
verfasst von
Brigitta Gahl
Olaf Stanger
Copyright-Jahr
2020
Verlag
Springer Vienna
DOI
https://doi.org/10.1007/978-3-7091-0451-4_20

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Klinikreform soll zehntausende Menschenleben retten

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Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

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S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.