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Clinical Reviews in Allergy & Immunology

30.04.2024 | Review

Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions

verfasst von: Yuzhuo Liu, Wei Lv, Weiqing Wang

Erschienen in: Clinical Reviews in Allergy & Immunology

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Abstract

Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway. Researches of CRS have progressed from phenotype-based to endotype-based, looking more deeply into molecular biomarkers, signaling pathways, and immune microenvironment. Single-cell RNA sequencing is an effective tool in analyzing composition, function, and interaction of cells in disease microenvironment at transcriptome level, showing great advantage in analyzing potential biomarkers, pathogenesis, and heterogeneity of chronic airway inflammation in an unbiased manner. In this article, we will review the latest advances in scRNA-seq studies of CRS to provide new perspectives for the diagnosis and treatment of this heterogeneous disease.
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Metadaten
Titel
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
verfasst von
Yuzhuo Liu
Wei Lv
Weiqing Wang
Publikationsdatum
30.04.2024
Verlag
Springer US
Erschienen in
Clinical Reviews in Allergy & Immunology
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-024-08992-6

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