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European Archives of Oto-Rhino-Laryngology

Erschienen in:

21.10.2023 | Review Article

Tranexamic acid in bleeding reduction and operative time of nasal surgeries: systematic review and meta-analysis

verfasst von: Paulo Eduardo Goncalves, Francisco Jose Silva Ferreira, Alice Santos Lima, Dandara Carvalho Moreira, Bruno Fernandes de Oliveira Santos, Nelson Almeida D’Avila Melo, André Beer-Furlan, Arthur Maynart Pereira Oliveira

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2024

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Abstract

Purpose

Our study goal is to review the efficacy of tranexamic acid in reducing blood loss and operative time in nasal surgeries.

Methods

We included randomized clinical trials using oral or intravenous tranexamic acid, excluded non-randomized studies, topic administration, coagulopathy, and using other drugs interfering in the coagulation cascade. Online databases, National Library of Medicine (MEDLINE-PubMED), Latin American and Caribbean Literature on Health Sciences (Lilacs), Cochrane Library, Embase and Google Scholar were used to perform the search. The review was registered in PROSPERO by no CRD42022310977. Two authors, independently, selected the articles meeting the inclusion criteria. They extracted the data and used RevMan 5 software to perform the meta-analysis.

Results

Our search resulted in 16 RCTs that were included in the meta-analysis totalizing 1108 patients. Studies were evaluated resulting in a low risk of bias for the five domains. The use of tranexamic acid resulted in significant reduction in duration of surgery (DOS) and intraoperative blood loss (IBL) had significant reduction. The level of evidence according to GRADE System was high in all studies and variables.

Conclusion

Tranexamic acid has an important role in reducing intraoperative blood loss and duration of surgery. Our study has some limitations due to the low number of RCTs available in the literature.

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Titel: Tranexamic acid in bleeding reduction and operative time of nasal surgeries: systematic review and meta-analysis
verfasst von: Paulo Eduardo Goncalves
Francisco Jose Silva Ferreira
Alice Santos Lima
Dandara Carvalho Moreira
Bruno Fernandes de Oliveira Santos
Nelson Almeida D’Avila Melo
André Beer-Furlan
Arthur Maynart Pereira Oliveira
Publikationsdatum: 21.10.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2024
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08291-4

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Tranexamic acid in bleeding reduction and operative time of nasal surgeries: systematic review and meta-analysis