Skip to main content

2021 | OriginalPaper | Buchkapitel

Therapie der Anastomoseninsuffizienz in der onkologischen Kolonchirurgie

verfasst von : Stephan M. Freys

Erschienen in: Chirurgie des Kolonkarzinoms

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Die Therapie der Anastomoseninsuffizienz (AI) nach kolorektalen Resektionen wird wesentlich durch eine zeitnahe Diagnostik und das Beherrschen komplexer chirurgischer, interventioneller und endoskopischer Maßnahmen geprägt. Neben den bekannten Faktoren, die das therapeutische Vorgehen beeinflussen – Alter und Komorbidität der Patienten, Lokalisation der Anastomose, Intervallzeitraum zur Primäroperation und Ausmaß der entstandenen Leckage – also Faktoren, die primär vom behandelnden Chirurgen nicht beeinflusst werden können, spielen jedoch der Erfahrungsstand des Chirurgen und die interdisziplinäre kooperative Therapieplanung und -durchführung eine nicht unerhebliche Rolle. Die aufgezeigten Algorithmen für 3 grundsätzlich unterschiedliche klinische Szenarien sollen helfen, Therapieentscheidungen in diesen Problemsituationen auf derzeit aktuellem Stand des Wissens führen zu können.
Literatur
Zurück zum Zitat Akyol AM, McGregor JR, Galloway DJ, George WD (1992) Early postoperative contrast radiology in the assessment of colorectal anastomotic integrity. Int J Colorectal Dis 7:141–143PubMedCrossRef Akyol AM, McGregor JR, Galloway DJ, George WD (1992) Early postoperative contrast radiology in the assessment of colorectal anastomotic integrity. Int J Colorectal Dis 7:141–143PubMedCrossRef
Zurück zum Zitat Almeida AB, Faria G, Moreira H, Pinto-de-Sousa J, Correia-da-Silva P, Maia JC (2012) Elevated serum C-reactive protein as a predictive factor for anastomotic leakage in colorectal surgery. Int J Surg 10:87–91PubMedCrossRef Almeida AB, Faria G, Moreira H, Pinto-de-Sousa J, Correia-da-Silva P, Maia JC (2012) Elevated serum C-reactive protein as a predictive factor for anastomotic leakage in colorectal surgery. Int J Surg 10:87–91PubMedCrossRef
Zurück zum Zitat Alves A, Panis Y, Pocard M, Regimbeau JM, Valleur P (1999) Management of anastomotic leakage after nondiverted large bowel resection. J Am Coll Surg 189:554–559PubMedCrossRef Alves A, Panis Y, Pocard M, Regimbeau JM, Valleur P (1999) Management of anastomotic leakage after nondiverted large bowel resection. J Am Coll Surg 189:554–559PubMedCrossRef
Zurück zum Zitat Ambrosetti P, Robert J, Mathey P, Rohner A (1994) Left-sided colon and colorectal anastomoses: Doppler ultrasound as an aid to assess bowel vascularization. A prospective evaluation of 200 consecutive elective cases. Int J Colorectal Dis 9:211–214 Ambrosetti P, Robert J, Mathey P, Rohner A (1994) Left-sided colon and colorectal anastomoses: Doppler ultrasound as an aid to assess bowel vascularization. A prospective evaluation of 200 consecutive elective cases. Int J Colorectal Dis 9:211–214
Zurück zum Zitat Bell SW, Walker KG, Rickard MJ et al (2003) Anastomotic leakage after curative anterior resection results in a higher prevalence of local recurrence. Br J Surg 90:1261–1266PubMedCrossRef Bell SW, Walker KG, Rickard MJ et al (2003) Anastomotic leakage after curative anterior resection results in a higher prevalence of local recurrence. Br J Surg 90:1261–1266PubMedCrossRef
Zurück zum Zitat Bertram P, Junge K, Schachtrupp A, Götze C, Kunz D, Schumpelick V (2003) Peritoneal release of TNFalpha and IL-6 after elective colorectal surgery and anastomotic leakage. J Invest Surg 16:65–69PubMedCrossRef Bertram P, Junge K, Schachtrupp A, Götze C, Kunz D, Schumpelick V (2003) Peritoneal release of TNFalpha and IL-6 after elective colorectal surgery and anastomotic leakage. J Invest Surg 16:65–69PubMedCrossRef
Zurück zum Zitat Bruce J, Krukowski ZH, Al-Khairy G, Russell EM, Park KG (2001) Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg 88:1157–1168PubMedCrossRef Bruce J, Krukowski ZH, Al-Khairy G, Russell EM, Park KG (2001) Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg 88:1157–1168PubMedCrossRef
Zurück zum Zitat Crafa F, Smolarek S, Missori G, Shalaby M, Quaresima S, Noviello A, Cassini D, Ascenzi P, Franceschilli L, Delrio P et al (2017) Transanal inspection and management of low colorectal anastomosis performed with a new technique: the TICRANT study. Surg Innov 24:483–491PubMedCrossRef Crafa F, Smolarek S, Missori G, Shalaby M, Quaresima S, Noviello A, Cassini D, Ascenzi P, Franceschilli L, Delrio P et al (2017) Transanal inspection and management of low colorectal anastomosis performed with a new technique: the TICRANT study. Surg Innov 24:483–491PubMedCrossRef
Zurück zum Zitat Daams F, Wu Z, Lahaye MJ, Jeekel J, Lange JF (2014) Prediction and diagnosis of colorectal anastomotic leakage: a systematic review of literature. World J Gastrointest Surg 6:14–26PubMedPubMedCentralCrossRef Daams F, Wu Z, Lahaye MJ, Jeekel J, Lange JF (2014) Prediction and diagnosis of colorectal anastomotic leakage: a systematic review of literature. World J Gastrointest Surg 6:14–26PubMedPubMedCentralCrossRef
Zurück zum Zitat Davies AH, Bartolo DC, Richards AE, Johnson CD, McC Mortensen NJ (1988) Intra-operative air testing: an audit on rectal anastomosis. Ann R Coll Surg Engl 70:345–347PubMedPubMedCentral Davies AH, Bartolo DC, Richards AE, Johnson CD, McC Mortensen NJ (1988) Intra-operative air testing: an audit on rectal anastomosis. Ann R Coll Surg Engl 70:345–347PubMedPubMedCentral
Zurück zum Zitat Dekker JW, Liefers GJ, de Mol van Otterloo JC, Putter H, Tollenaar RA (2011) Predicting the risk of anastomotic leakage in left-sided colorectal surgery using a colon leakage score. J Surg Res 166:e27–e34 Dekker JW, Liefers GJ, de Mol van Otterloo JC, Putter H, Tollenaar RA (2011) Predicting the risk of anastomotic leakage in left-sided colorectal surgery using a colon leakage score. J Surg Res 166:e27–e34
Zurück zum Zitat Dixon AR, Holmes JT (1991) Colorectal anastomotic integrity after anterior resection: is there a role for intraoperative testing? J R Coll Surg Edinb 36:35–36PubMed Dixon AR, Holmes JT (1991) Colorectal anastomotic integrity after anterior resection: is there a role for intraoperative testing? J R Coll Surg Edinb 36:35–36PubMed
Zurück zum Zitat Doeksen A, Tanis PJ, Wüst AF, Vrouenraets BC, van Lanschot JJ, van Tets WF (2008) Radiological evaluation of colorectal anastomoses. Int J Colorectal Dis 23:863–868PubMedPubMedCentralCrossRef Doeksen A, Tanis PJ, Wüst AF, Vrouenraets BC, van Lanschot JJ, van Tets WF (2008) Radiological evaluation of colorectal anastomoses. Int J Colorectal Dis 23:863–868PubMedPubMedCentralCrossRef
Zurück zum Zitat DuBrow RA, David CL, Curley SA (1995) Anastomotic leaks after low anterior resection for rectal carcinoma: evaluation with CT and barium enema. AJR Am J Roentgenol 165:567–571PubMedCrossRef DuBrow RA, David CL, Curley SA (1995) Anastomotic leaks after low anterior resection for rectal carcinoma: evaluation with CT and barium enema. AJR Am J Roentgenol 165:567–571PubMedCrossRef
Zurück zum Zitat den Dulk M, Noter SL, Hendriks ER, Brouwers MA, van der Vlies CH, Oostenbroek RJ, Menon AG, Steup WH, van de Velde CJ (2009) Improved diagnosis and treatment of anastomotic leakage after colorectal surgery. Eur J Surg Oncol 35:420–426CrossRef den Dulk M, Noter SL, Hendriks ER, Brouwers MA, van der Vlies CH, Oostenbroek RJ, Menon AG, Steup WH, van de Velde CJ (2009) Improved diagnosis and treatment of anastomotic leakage after colorectal surgery. Eur J Surg Oncol 35:420–426CrossRef
Zurück zum Zitat Eckmann C, Kujath P, Kraus M, Schwandner O, Bruch HP, Shekarriz H (2005) Therapeutic strategy for anastomotic leakage following low anterior resection. Viszeralchirurgie 40:17–21CrossRef Eckmann C, Kujath P, Kraus M, Schwandner O, Bruch HP, Shekarriz H (2005) Therapeutic strategy for anastomotic leakage following low anterior resection. Viszeralchirurgie 40:17–21CrossRef
Zurück zum Zitat Eckmann C, Kujath P, Schiedeck TH, Shekarriz H, Bruch HP (2004) Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approach. Int J Colorectal Dis 19:128–133PubMedCrossRef Eckmann C, Kujath P, Schiedeck TH, Shekarriz H, Bruch HP (2004) Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approach. Int J Colorectal Dis 19:128–133PubMedCrossRef
Zurück zum Zitat Ellebaek Pedersen M, Qvist N, Bisgaard C, Kelly U, Bernhard A, Møller Pedersen S (2009) Peritoneal microdialysis. Early diagnosis of anastomotic leakage after low anterior resection for rectosigmoid cancer. Scand J Surg 98:148–154 Ellebaek Pedersen M, Qvist N, Bisgaard C, Kelly U, Bernhard A, Møller Pedersen S (2009) Peritoneal microdialysis. Early diagnosis of anastomotic leakage after low anterior resection for rectosigmoid cancer. Scand J Surg 98:148–154
Zurück zum Zitat Fouda E, El Nakeeb A, Magdy A, Hammad EA, Othman G, Farid M (2011) Early detection of anastomotic leakage after elective low anterior resection. J Gastrointest Surg 15:137–144PubMedCrossRef Fouda E, El Nakeeb A, Magdy A, Hammad EA, Othman G, Farid M (2011) Early detection of anastomotic leakage after elective low anterior resection. J Gastrointest Surg 15:137–144PubMedCrossRef
Zurück zum Zitat Gouya H, Oudjit A, Leconte M, Coste J, Vignaux O, Dousset B, Legmann P (2012) CT antegrade colonography to assess proctectomy and temporary diverting ileostomy complications before early ileostomy takedown in patients with low rectal endometriosis. Am J Roentgenol 198:98–105CrossRef Gouya H, Oudjit A, Leconte M, Coste J, Vignaux O, Dousset B, Legmann P (2012) CT antegrade colonography to assess proctectomy and temporary diverting ileostomy complications before early ileostomy takedown in patients with low rectal endometriosis. Am J Roentgenol 198:98–105CrossRef
Zurück zum Zitat Haynes IG, Goldman M, Silverman SH, Alexander-Williams J, Keighley MR (1986) Water-soluble contrast enema after colonic anastomosis. Lancet 1:675–676PubMedCrossRef Haynes IG, Goldman M, Silverman SH, Alexander-Williams J, Keighley MR (1986) Water-soluble contrast enema after colonic anastomosis. Lancet 1:675–676PubMedCrossRef
Zurück zum Zitat Herwig R, Glodny B, Kühle C, Schlüter B, Brinkmann OA, Strasser H, Senninger N, Winde G (2002) Early identification of peritonitis by peritoneal cytokine measurement. Dis Colon Rectum 45:514–521PubMedCrossRef Herwig R, Glodny B, Kühle C, Schlüter B, Brinkmann OA, Strasser H, Senninger N, Winde G (2002) Early identification of peritonitis by peritoneal cytokine measurement. Dis Colon Rectum 45:514–521PubMedCrossRef
Zurück zum Zitat Hirano Y, Omura K, Tatsuzawa Y, Shimizu J, Kawaura Y, Watanabe G (2006) Tissue oxygen saturation during colorectal surgery measured by near-infrared spectroscopy: pilot study to predict anastomotic complications. World J Surg 30:457–461PubMedCrossRef Hirano Y, Omura K, Tatsuzawa Y, Shimizu J, Kawaura Y, Watanabe G (2006) Tissue oxygen saturation during colorectal surgery measured by near-infrared spectroscopy: pilot study to predict anastomotic complications. World J Surg 30:457–461PubMedCrossRef
Zurück zum Zitat Hoffmann J, Jensen RH, Shokouh-Amiri MH, Damm P (1988) Clinical value of water-soluble contrast enema in assessing the integrity of left colonic anastomoses. J R Coll Surg Edinb 33:23–24PubMed Hoffmann J, Jensen RH, Shokouh-Amiri MH, Damm P (1988) Clinical value of water-soluble contrast enema in assessing the integrity of left colonic anastomoses. J R Coll Surg Edinb 33:23–24PubMed
Zurück zum Zitat Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA (2007) Anastomotic leaks after intestinal anastomosis: it’s later than you think. Ann Surg 245:254–258PubMedPubMedCentralCrossRef Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA (2007) Anastomotic leaks after intestinal anastomosis: it’s later than you think. Ann Surg 245:254–258PubMedPubMedCentralCrossRef
Zurück zum Zitat Ishihara S, Watanabe T, Nagawa H (2008) Intraoperative colonoscopy for stapled anastomosis in colorectal surgery. Surg Today 38:1063–1065PubMedCrossRef Ishihara S, Watanabe T, Nagawa H (2008) Intraoperative colonoscopy for stapled anastomosis in colorectal surgery. Surg Today 38:1063–1065PubMedCrossRef
Zurück zum Zitat Ito M, Sugito M, Kobayashi A, Nishizawa Y, Tsunoda Y, Saito N (2008) Relationship between multiple numbers of stapler firings during rectal division and anastomotic leakage after laparoscopic rectal resection. Int J Colorectal Dis 23:703–707PubMedCrossRef Ito M, Sugito M, Kobayashi A, Nishizawa Y, Tsunoda Y, Saito N (2008) Relationship between multiple numbers of stapler firings during rectal division and anastomotic leakage after laparoscopic rectal resection. Int J Colorectal Dis 23:703–707PubMedCrossRef
Zurück zum Zitat Junger W, Junger WG, Miller K, Bahrami S, Redl H, Schlag G, Moritz E (1996) Early detection of anastomotic leaks after colorectal surgery by measuring endotoxin in the drainage fluid. Hepatogastroenterology 43:1523–1529PubMed Junger W, Junger WG, Miller K, Bahrami S, Redl H, Schlag G, Moritz E (1996) Early detection of anastomotic leaks after colorectal surgery by measuring endotoxin in the drainage fluid. Hepatogastroenterology 43:1523–1529PubMed
Zurück zum Zitat Kalady MF, Mantyh CR, Petrofski J, Ludwig KA (2008) Routine contrast imaging of low pelvic anastomosis prior to closure of defunctioning ileostomy: is it necessary? J Gastrointest Surg 12:1227–1231PubMedCrossRef Kalady MF, Mantyh CR, Petrofski J, Ludwig KA (2008) Routine contrast imaging of low pelvic anastomosis prior to closure of defunctioning ileostomy: is it necessary? J Gastrointest Surg 12:1227–1231PubMedCrossRef
Zurück zum Zitat Karliczek A, Benaron DA, Baas PC, Zeebregts CJ, Wiggers T, van Dam GM (2010) Intraoperative assessment of microperfusion with visible light spectroscopy for prediction of anastomotic leakage in colorectal anastomoses. Colorectal Dis 12:1018–1025PubMedCrossRef Karliczek A, Benaron DA, Baas PC, Zeebregts CJ, Wiggers T, van Dam GM (2010) Intraoperative assessment of microperfusion with visible light spectroscopy for prediction of anastomotic leakage in colorectal anastomoses. Colorectal Dis 12:1018–1025PubMedCrossRef
Zurück zum Zitat Keskin M, Bayram O, Bulut T, Balik E (2015) Effectiveness of endoluminal vacuum-assisted closure therapy (endosponge) for the treatment of pelvic anastomotic leakage after colorectal surgery. Surg Laparosc Endosc Percutan Tech 25(6):505–508 Keskin M, Bayram O, Bulut T, Balik E (2015) Effectiveness of endoluminal vacuum-assisted closure therapy (endosponge) for the treatment of pelvic anastomotic leakage after colorectal surgery. Surg Laparosc Endosc Percutan Tech 25(6):505–508
Zurück zum Zitat Kudszus S, Roesel C, Schachtrupp A, Höer JJ (2010) Intraoperative laser fluorescence angiography in colorectal surgery: a non-invasive analysis to reduce the rate of anastomotic leakage. Langenbecks Arch Surg 395:1025–1030PubMedCrossRef Kudszus S, Roesel C, Schachtrupp A, Höer JJ (2010) Intraoperative laser fluorescence angiography in colorectal surgery: a non-invasive analysis to reduce the rate of anastomotic leakage. Langenbecks Arch Surg 395:1025–1030PubMedCrossRef
Zurück zum Zitat Kuehn F, Janisch F, Schwandner F, Alsfasser G, Schiffmann L, Gock M, Klar E (2016) Endoscopic Vacuum Therapy in Colorectal Surgery. J Gastrointest Surg 20(2):328–334PubMedCrossRef Kuehn F, Janisch F, Schwandner F, Alsfasser G, Schiffmann L, Gock M, Klar E (2016) Endoscopic Vacuum Therapy in Colorectal Surgery. J Gastrointest Surg 20(2):328–334PubMedCrossRef
Zurück zum Zitat Kulu Y, Ulrich A, Bruckner T et al (2013) Validation of the International Study Group of Rectal Cancer definition and severity grading of anastomotic leakage. Surgery 153:753–761PubMedCrossRef Kulu Y, Ulrich A, Bruckner T et al (2013) Validation of the International Study Group of Rectal Cancer definition and severity grading of anastomotic leakage. Surgery 153:753–761PubMedCrossRef
Zurück zum Zitat Kumar RR, Kim JT, Haukoos JS et al (2006) Factors affecting the successful management of intra-abdominal abscesses with anti-biotics and the need for percutaneous drainage. Dis Colon Rectum 49:183–189PubMedCrossRef Kumar RR, Kim JT, Haukoos JS et al (2006) Factors affecting the successful management of intra-abdominal abscesses with anti-biotics and the need for percutaneous drainage. Dis Colon Rectum 49:183–189PubMedCrossRef
Zurück zum Zitat Lanthaler M, Biebl M, Mittermair R, Ofner D, Nehoda H (2008) Intraoperative colonoscopy for anastomosis assessment in laparoscopically assisted left-sided colon resection: is it worthwhile? J Laparoendosc Adv Surg Tech A 18:27–31PubMedCrossRef Lanthaler M, Biebl M, Mittermair R, Ofner D, Nehoda H (2008) Intraoperative colonoscopy for anastomosis assessment in laparoscopically assisted left-sided colon resection: is it worthwhile? J Laparoendosc Adv Surg Tech A 18:27–31PubMedCrossRef
Zurück zum Zitat Law WL, Choi HK, Lee YM et al (2007) Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy. J Gastrointest Surg 11:8–15PubMedCrossRef Law WL, Choi HK, Lee YM et al (2007) Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy. J Gastrointest Surg 11:8–15PubMedCrossRef
Zurück zum Zitat Li VK, Wexner SD, Pulido N, Wang H, Jin HY, Weiss EG, Nogeuras JJ, Sands DR (2009) Use of routine intraoperative endoscopy in elective laparoscopic colorectal surgery: can it further avoid anastomotic failure? Surg Endosc 23:2459–2465PubMedCrossRef Li VK, Wexner SD, Pulido N, Wang H, Jin HY, Weiss EG, Nogeuras JJ, Sands DR (2009) Use of routine intraoperative endoscopy in elective laparoscopic colorectal surgery: can it further avoid anastomotic failure? Surg Endosc 23:2459–2465PubMedCrossRef
Zurück zum Zitat Markham NI, Greatorex RA, Everett WG (1987) The value and significance of the limited barium enema examination following restorative resection for carcinoma of the rectum. Ann R Coll Surg Engl 69:116–118PubMedPubMedCentral Markham NI, Greatorex RA, Everett WG (1987) The value and significance of the limited barium enema examination following restorative resection for carcinoma of the rectum. Ann R Coll Surg Engl 69:116–118PubMedPubMedCentral
Zurück zum Zitat Matthiessen P, Henriksson M, Hallböök O, Grunditz E, Norén B, Arbman G (2008) Increase of serum C-reactive protein is an early indicator of subsequent symptomatic anastomotic leakage after anterior resection. Colorectal Dis 10:75–80PubMedCrossRef Matthiessen P, Henriksson M, Hallböök O, Grunditz E, Norén B, Arbman G (2008) Increase of serum C-reactive protein is an early indicator of subsequent symptomatic anastomotic leakage after anterior resection. Colorectal Dis 10:75–80PubMedCrossRef
Zurück zum Zitat Matthiessen P, Strand I, Jansson K, Törnquist C, Andersson M, Rutegård J, Norgren L (2007) Is early detection of anastomotic leakage possible by intraperitoneal microdialysis and intra- peritoneal cytokines after anterior resection of the rectum for cancer? Dis Colon Rectum 50:1918–1927PubMedCrossRef Matthiessen P, Strand I, Jansson K, Törnquist C, Andersson M, Rutegård J, Norgren L (2007) Is early detection of anastomotic leakage possible by intraperitoneal microdialysis and intra- peritoneal cytokines after anterior resection of the rectum for cancer? Dis Colon Rectum 50:1918–1927PubMedCrossRef
Zurück zum Zitat McDermott FD, Heeney A, Kelly ME, Steele RJ, Carlson GL, Winter DC (2015) Systematic review of pre-operative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg 102:462–479PubMedCrossRef McDermott FD, Heeney A, Kelly ME, Steele RJ, Carlson GL, Winter DC (2015) Systematic review of pre-operative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg 102:462–479PubMedCrossRef
Zurück zum Zitat Midura EF, Hanseman D, Davis BR et al (2015) Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum 58:333–338PubMedCrossRef Midura EF, Hanseman D, Davis BR et al (2015) Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum 58:333–338PubMedCrossRef
Zurück zum Zitat Milito G, Lisi G, Venditti D, Campanelli M, Aronadio E, Grande S, Cabry F, Grande M (2017) Endoluminal vacuum therapy as treatment for anastomotic colorectal leakage. Surg Technol Int 30:125–130PubMed Milito G, Lisi G, Venditti D, Campanelli M, Aronadio E, Grande S, Cabry F, Grande M (2017) Endoluminal vacuum therapy as treatment for anastomotic colorectal leakage. Surg Technol Int 30:125–130PubMed
Zurück zum Zitat Miller K, Arrer E, Leitner C (1996) Early detection of anastomotic leaks after low anterior resection of the rectum. Dis Colon Rectum 39:1081–1085PubMedCrossRef Miller K, Arrer E, Leitner C (1996) Early detection of anastomotic leaks after low anterior resection of the rectum. Dis Colon Rectum 39:1081–1085PubMedCrossRef
Zurück zum Zitat Moghadamyeghaneh Z, Hanna MH, Alizadeh RF, Carmichael JC, Mills S, Pigazzi A, Stamos MJ (2016) Contemporary management of anastomotic leak after colon surgery: assessing the need for reoperation. Am J Surg. 211(6):1005–1013PubMedCrossRef Moghadamyeghaneh Z, Hanna MH, Alizadeh RF, Carmichael JC, Mills S, Pigazzi A, Stamos MJ (2016) Contemporary management of anastomotic leak after colon surgery: assessing the need for reoperation. Am J Surg. 211(6):1005–1013PubMedCrossRef
Zurück zum Zitat Mussetto A, Arena R, Buzzi A, Fuccio L, Dari S, Brancaccio ML, Triossi O (2017) Long-term efficacy of vacuum-assisted therapy (Endo-SPONGE®) in large anastomotic leakages following anterior rectal resection. Ann Gastroenterol 30(6):649–653PubMedPubMedCentral Mussetto A, Arena R, Buzzi A, Fuccio L, Dari S, Brancaccio ML, Triossi O (2017) Long-term efficacy of vacuum-assisted therapy (Endo-SPONGE®) in large anastomotic leakages following anterior rectal resection. Ann Gastroenterol 30(6):649–653PubMedPubMedCentral
Zurück zum Zitat Nesbakken A, Nygaard K, Lunde OC, Blücher J, Gjertsen Ø, Dullerud R (2005) Anastomotic leak following mesorectal excision for rectal cancer: true incidence and diagnostic challenges. Colorectal Dis 7:576–581PubMedCrossRef Nesbakken A, Nygaard K, Lunde OC, Blücher J, Gjertsen Ø, Dullerud R (2005) Anastomotic leak following mesorectal excision for rectal cancer: true incidence and diagnostic challenges. Colorectal Dis 7:576–581PubMedCrossRef
Zurück zum Zitat Nicksa GA, Dring RV, Johnson KH, Sardella WV, Vignati PV, Cohen JL (2007) Anastomotic leaks: what is the best diagnostic imaging study? Dis Colon Rectum 50:197–203PubMedCrossRef Nicksa GA, Dring RV, Johnson KH, Sardella WV, Vignati PV, Cohen JL (2007) Anastomotic leaks: what is the best diagnostic imaging study? Dis Colon Rectum 50:197–203PubMedCrossRef
Zurück zum Zitat Phitayakorn R, Delaney CP, Reynolds HL, Champagne BJ, Heriot AG, Neary P, Senagore AJ (2008) International anastomotic leak study group. Standardized algorithms for management of anastomotic leaks and related abdominal and pelvic abscesses after colorectal surgery. World J Surg 32:1147–1156 Phitayakorn R, Delaney CP, Reynolds HL, Champagne BJ, Heriot AG, Neary P, Senagore AJ (2008) International anastomotic leak study group. Standardized algorithms for management of anastomotic leaks and related abdominal and pelvic abscesses after colorectal surgery. World J Surg 32:1147–1156
Zurück zum Zitat Platell C, Barwood N, Dorfmann G, Makin G (2007) The incidence of anastomotic leaks in patients undergoing colorectal surgery. Colorectal Dis 9:71–79PubMedCrossRef Platell C, Barwood N, Dorfmann G, Makin G (2007) The incidence of anastomotic leaks in patients undergoing colorectal surgery. Colorectal Dis 9:71–79PubMedCrossRef
Zurück zum Zitat Platt JJ, Ramanathan ML, Crosbie RA, Anderson JH, McKee RF, Horgan PG, McMillan DC (2012) C-reactive protein as a predictor of postoperative infective complications after curative resection in patients with colorectal cancer. Ann Surg Oncol 19:4168–4177PubMedCrossRef Platt JJ, Ramanathan ML, Crosbie RA, Anderson JH, McKee RF, Horgan PG, McMillan DC (2012) C-reactive protein as a predictor of postoperative infective complications after curative resection in patients with colorectal cancer. Ann Surg Oncol 19:4168–4177PubMedCrossRef
Zurück zum Zitat Power N, Atri M, Ryan S, Haddad R, Smith A (2007) CT assessment of anastomotic bowel leak. Clin Radiol 62:37–42PubMedCrossRef Power N, Atri M, Ryan S, Haddad R, Smith A (2007) CT assessment of anastomotic bowel leak. Clin Radiol 62:37–42PubMedCrossRef
Zurück zum Zitat Rahbari NN, Weitz J, Hohenberger W et al (2010) Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery 147:339–351PubMedCrossRef Rahbari NN, Weitz J, Hohenberger W et al (2010) Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery 147:339–351PubMedCrossRef
Zurück zum Zitat Ricciardi R, Roberts PL, Marcello PW, Hall JF, Read TE, Schoetz DJ (2009) Anastomotic leak testing after colorectal resection: what are the data? Arch Surg 144:407–411; (discussion 411–2) Ricciardi R, Roberts PL, Marcello PW, Hall JF, Read TE, Schoetz DJ (2009) Anastomotic leak testing after colorectal resection: what are the data? Arch Surg 144:407–411; (discussion 411–2)
Zurück zum Zitat Rickert A, Willeke F, Kienle P et al (2010) Management and outcome of anastomotic leakage after colonic surgery. Colorectal Dis 12:e216-223PubMedCrossRef Rickert A, Willeke F, Kienle P et al (2010) Management and outcome of anastomotic leakage after colonic surgery. Colorectal Dis 12:e216-223PubMedCrossRef
Zurück zum Zitat Ruggiero R, Sparavigna L, Docimo G, et al (2011) Post-operative peritonitis due to anastomotic dehiscence after colonic resection. Multicentric experience, retrospective analysis of risk factors and review of the literature. Ann Ital Chir 82:369–375 Ruggiero R, Sparavigna L, Docimo G, et al (2011) Post-operative peritonitis due to anastomotic dehiscence after colonic resection. Multicentric experience, retrospective analysis of risk factors and review of the literature. Ann Ital Chir 82:369–375
Zurück zum Zitat Sakanoue Y, Nakao K, Shoji Y, Yanagi H, Kusunoki M, Utsunomiya J (1993) Intraoperative colonoscopy. Surg Endosc 7:84–87PubMedCrossRef Sakanoue Y, Nakao K, Shoji Y, Yanagi H, Kusunoki M, Utsunomiya J (1993) Intraoperative colonoscopy. Surg Endosc 7:84–87PubMedCrossRef
Zurück zum Zitat Sammour T, Cohen L, Karunatillake AI, Lewis M, Lawrence MJ, Hunter A, Moore JW, Thomas ML (2017) Validation of an online risk calculator for the prediction of anastomotic leak after colon cancer surgery and preliminary exploration of artificial intelligence-based analytics. Tech Coloproctol 21(11):869–877PubMedCrossRef Sammour T, Cohen L, Karunatillake AI, Lewis M, Lawrence MJ, Hunter A, Moore JW, Thomas ML (2017) Validation of an online risk calculator for the prediction of anastomotic leak after colon cancer surgery and preliminary exploration of artificial intelligence-based analytics. Tech Coloproctol 21(11):869–877PubMedCrossRef
Zurück zum Zitat Schmidt O, Merkel S, Hohenberger W (2003) Anastomotic leakage after low rectal stapler anastomosis: significance of intraoperative anastomotic testing. Eur J Surg Oncol 29:239–243PubMedCrossRef Schmidt O, Merkel S, Hohenberger W (2003) Anastomotic leakage after low rectal stapler anastomosis: significance of intraoperative anastomotic testing. Eur J Surg Oncol 29:239–243PubMedCrossRef
Zurück zum Zitat Severini A, Civelli EM, Uslenghi E, Cozzi G, Salvetti M, Milella M, Gallino G, Bonfanti G, Belli F, Leo E (2000) Diagnostic and interventional radiology in the post-operative period and follow-up of patients after rectal resection with coloanal anastomosis. Eur Radiol 10:1101–1105PubMedCrossRef Severini A, Civelli EM, Uslenghi E, Cozzi G, Salvetti M, Milella M, Gallino G, Bonfanti G, Belli F, Leo E (2000) Diagnostic and interventional radiology in the post-operative period and follow-up of patients after rectal resection with coloanal anastomosis. Eur Radiol 10:1101–1105PubMedCrossRef
Zurück zum Zitat Shamiyeh A, Szabo K, Ulf Wayand W, Zehetner J (2012) Intraoperative endoscopy for the assessment of circular-stapled anastomosis in laparoscopic colon surgery. Surg Laparosc Endosc Percutan Tech 22:65–67PubMedCrossRef Shamiyeh A, Szabo K, Ulf Wayand W, Zehetner J (2012) Intraoperative endoscopy for the assessment of circular-stapled anastomosis in laparoscopic colon surgery. Surg Laparosc Endosc Percutan Tech 22:65–67PubMedCrossRef
Zurück zum Zitat Smith S, McGeehin W, Kozol RA, Giles D (2007) The efficacy of intraoperative methylene blue enemas to assess the integ- rity of a colonic anastomosis. BMC Surg 7:15PubMedPubMedCentralCrossRef Smith S, McGeehin W, Kozol RA, Giles D (2007) The efficacy of intraoperative methylene blue enemas to assess the integ- rity of a colonic anastomosis. BMC Surg 7:15PubMedPubMedCentralCrossRef
Zurück zum Zitat Sparreboom CL, Wu ZQ, Ji JF, Lange JF (2016) Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances. World J Gastroenterol 22(32):7226–7235PubMedPubMedCentralCrossRef Sparreboom CL, Wu ZQ, Ji JF, Lange JF (2016) Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances. World J Gastroenterol 22(32):7226–7235PubMedPubMedCentralCrossRef
Zurück zum Zitat Tsujinaka S, Kawamura YJ, Konishi F, Maeda T, Mizokami K (2008) Pelvic drainage for anterior resection revisited: use of drains in anastomotic leaks. ANZ J Surg 78:461–465PubMedCrossRef Tsujinaka S, Kawamura YJ, Konishi F, Maeda T, Mizokami K (2008) Pelvic drainage for anterior resection revisited: use of drains in anastomotic leaks. ANZ J Surg 78:461–465PubMedCrossRef
Zurück zum Zitat Uğraş B, Giriş M, Erbil Y, Gökpinar M, Citlak G, Işsever H, Bozbora A, Oztezcan S (2008) Early prediction of anastomotic leakage after colorectal surgery by measuring peritoneal cytokines: prospective study. Int J Surg 6:28–35PubMedCrossRef Uğraş B, Giriş M, Erbil Y, Gökpinar M, Citlak G, Işsever H, Bozbora A, Oztezcan S (2008) Early prediction of anastomotic leakage after colorectal surgery by measuring peritoneal cytokines: prospective study. Int J Surg 6:28–35PubMedCrossRef
Zurück zum Zitat Vallance A, Wexner S, Berho M, Cahill R, Coleman M, Haboubi N, Heald RJ, Kennedy RH, Moran B, Mortensen N, Motson RW, Novell R, O’Connell PR, Ris F, Rockall T, Senapati A, Windsor A, Jayne DG (2017) A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery. Colorectal Dis 19(1):O1–O12PubMedCrossRef Vallance A, Wexner S, Berho M, Cahill R, Coleman M, Haboubi N, Heald RJ, Kennedy RH, Moran B, Mortensen N, Motson RW, Novell R, O’Connell PR, Ris F, Rockall T, Senapati A, Windsor A, Jayne DG (2017) A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery. Colorectal Dis 19(1):O1–O12PubMedCrossRef
Zurück zum Zitat Vignali A, Gianotti L, Braga M, Radaelli G, Malvezzi L, Di Carlo V (2000) Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak. Dis Colon Rectum 43:76–82PubMedCrossRef Vignali A, Gianotti L, Braga M, Radaelli G, Malvezzi L, Di Carlo V (2000) Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak. Dis Colon Rectum 43:76–82PubMedCrossRef
Zurück zum Zitat Walker KG, Bell SW, Rickard MJ et al (2004) Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer. Ann Surg 240:255–259PubMedPubMedCentralCrossRef Walker KG, Bell SW, Rickard MJ et al (2004) Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer. Ann Surg 240:255–259PubMedPubMedCentralCrossRef
Zurück zum Zitat Warschkow R, Beutner U, Steffen T, Müller SA, Schmied BM, Güller U, Tarantino I (2012) Safe and early discharge after colorectal surgery due to C-reactive protein: a diagnostic meta-analysis of 1832 patients. Ann Surg 256:245–250PubMedCrossRef Warschkow R, Beutner U, Steffen T, Müller SA, Schmied BM, Güller U, Tarantino I (2012) Safe and early discharge after colorectal surgery due to C-reactive protein: a diagnostic meta-analysis of 1832 patients. Ann Surg 256:245–250PubMedCrossRef
Zurück zum Zitat Weidenhagen R, Gruetzner KU, Wiecken T, Spelsberg F, Jauch K-W (2008) Endoscopic vacuum-assisted closure of anas- tomotic leakage following anterior resection of the rec- tum: a new method. Surg Endosc 22:1818–1825PubMedCrossRef Weidenhagen R, Gruetzner KU, Wiecken T, Spelsberg F, Jauch K-W (2008) Endoscopic vacuum-assisted closure of anas- tomotic leakage following anterior resection of the rec- tum: a new method. Surg Endosc 22:1818–1825PubMedCrossRef
Zurück zum Zitat Wheeler JM, Gilbert JM (1999) Controlled intraoperative water testing of left-sided colorectal anastomoses: are ileostomies avoidable? Ann R Coll Surg Engl 81:105–108PubMedPubMedCentral Wheeler JM, Gilbert JM (1999) Controlled intraoperative water testing of left-sided colorectal anastomoses: are ileostomies avoidable? Ann R Coll Surg Engl 81:105–108PubMedPubMedCentral
Zurück zum Zitat Woeste G, Müller C, Bechstein WO, Wullstein C (2010) Increased serum levels of C-reactive protein precede anastomotic leakage in colorectal surgery. World J Surg 34:140–146PubMedCrossRef Woeste G, Müller C, Bechstein WO, Wullstein C (2010) Increased serum levels of C-reactive protein precede anastomotic leakage in colorectal surgery. World J Surg 34:140–146PubMedCrossRef
Zurück zum Zitat Yamamoto T, Umegae S, Matsumoto K, Saniabadi AR (2011) Peritoneal cytokines as early markers of peritonitis follow- ing surgery for colorectal carcinoma: a prospective study. Cytokine 53:239–242PubMedCrossRef Yamamoto T, Umegae S, Matsumoto K, Saniabadi AR (2011) Peritoneal cytokines as early markers of peritonitis follow- ing surgery for colorectal carcinoma: a prospective study. Cytokine 53:239–242PubMedCrossRef
Zurück zum Zitat Yu XQ, Zhao B, Zhou WP, Han LZ, Cai GH, Fang ZW, Peng YH, Yuan B (2016) Utility of colon leakage score in left-sided colorectal surgery. J Surg Res 202(2):398–402PubMedCrossRef Yu XQ, Zhao B, Zhou WP, Han LZ, Cai GH, Fang ZW, Peng YH, Yuan B (2016) Utility of colon leakage score in left-sided colorectal surgery. J Surg Res 202(2):398–402PubMedCrossRef
Metadaten
Titel
Therapie der Anastomoseninsuffizienz in der onkologischen Kolonchirurgie
verfasst von
Stephan M. Freys
Copyright-Jahr
2021
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-60453-3_27

Chirurginnen nehmen sich Zwischenfälle im OP besonders zu Herzen

05.06.2024 Allgemeine Chirurgie Nachrichten

Selbstverschuldete Fehler oder unerwartete Komplikationen machen jungen Chirurginnen und Operateuren mit Migrationshintergrund offenbar besonders zu schaffen. Benötigt werden routinemäßige Programme zum Umgang mit Zwischenfällen im OP.

Schützt auch die medikamentöse Gewichtsreduktion vor Krebs?

03.06.2024 ASCO 2024 Kongressbericht

Offenbar muss es nicht immer die bariatrische Chirurgie sein, wenn es darum geht, durch deutlichen Gewichtsverlust auch das Krebsrisiko günstig zu beeinflussen. Eine große Kohortenanalyse zur Behandlung mit GLP-1-Agonisten wurde dazu auf der ASCO-Tagung vorgestellt.

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Häusliche Gewalt Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.