Skip to main content
Erschienen in: Clinical Oral Investigations 1/2024

01.01.2024 | Research

The capability of regenerative endodontics to promote the complete root formation in immature permanent teeth with different initial pre-operative conditions

verfasst von: Xijun Jiang, He Liu

Erschienen in: Clinical Oral Investigations | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To describe the potential possibility of complete root formation after regenerative endodontic procedures (REPs) in immature permanent teeth with different initial pre-operative conditions.

Materials and methods

Children who underwent REPs in the Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, China, from January 2013 to December 2022 were enrolled. Whether the tooth achieved complete root formation was determined using post-operative periapical radiography. The potential possibility of complete root formation after REPs in immature permanent teeth with different initial conditions is discussed.

Results

A total of 428 teeth from 401 patients were included, of which 258 (60.2%) achieved complete root formation. In cases that achieved complete root formation, the most serious type of trauma was avulsion, the teeth with the worst initial root development were less than one-third of the development (stages 6–7), and the longest duration of the presence of apical lesions in the tooth before the first visit was more than 180 days. There is a significant difference in the root formation of teeth with different initial developmental stages and diagnoses.

Conclusions

The active period of continued root formation was 5–21 months post-operatively. The higher the initial stage of root development and the shorter the duration of the presence of apical lesions in the tooth before the first visit, the greater the possibility of root formation. However, complete root formation may still be expected after REPs in severely injured immature permanent teeth and teeth with poor initial pre-operative root development conditions (less than stage 7) at the first visit. This is also true for teeth with long-term and large-scale apical lesions.
Literatur
1.
Zurück zum Zitat Chrepa V et al (2020) Clinical outcomes of immature teeth treated with regenerative endodontic procedures-a San Antonio study. J Endod 46(8):1074–1084CrossRefPubMed Chrepa V et al (2020) Clinical outcomes of immature teeth treated with regenerative endodontic procedures-a San Antonio study. J Endod 46(8):1074–1084CrossRefPubMed
2.
Zurück zum Zitat Diogenes A, Ruparel NB, Shiloah Y, Hargreaves KM (2016) Regenerative endodontics: a way forward. J Am Dent Assoc 147:372–380CrossRefPubMed Diogenes A, Ruparel NB, Shiloah Y, Hargreaves KM (2016) Regenerative endodontics: a way forward. J Am Dent Assoc 147:372–380CrossRefPubMed
3.
Zurück zum Zitat Smith AJ et al (2016) Exploiting the bioactive properties of the dentin-pulp complex in regenerative endodontics. J Endod 17:47–56CrossRef Smith AJ et al (2016) Exploiting the bioactive properties of the dentin-pulp complex in regenerative endodontics. J Endod 17:47–56CrossRef
4.
Zurück zum Zitat Diogenes A, Hargreaves KM (2017) Microbial modulation of stem cells and future directions in regenerative endodontics. J Endod 43:S95–S101CrossRefPubMed Diogenes A, Hargreaves KM (2017) Microbial modulation of stem cells and future directions in regenerative endodontics. J Endod 43:S95–S101CrossRefPubMed
5.
Zurück zum Zitat Banchs F, Trope M (2004) Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? J Endod 30(4):196–200CrossRefPubMed Banchs F, Trope M (2004) Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? J Endod 30(4):196–200CrossRefPubMed
6.
Zurück zum Zitat Petrino JA et al (2001) Challenges in regenerative endodontics: a case series. J Endod 36:536–541CrossRef Petrino JA et al (2001) Challenges in regenerative endodontics: a case series. J Endod 36:536–541CrossRef
7.
Zurück zum Zitat Nosrat A, Seifi A, Asgary (2011) Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial. J Endod 37:562–567CrossRefPubMed Nosrat A, Seifi A, Asgary (2011) Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial. J Endod 37:562–567CrossRefPubMed
8.
Zurück zum Zitat Nosrat A, Homayounfar N, Oloomi K (2012) Drawbacks and unfavorable outcomes of regenerative endodontic treatments of necrotic immature teeth: a literature review and report of a case. J Endod 38:1428–1434CrossRefPubMed Nosrat A, Homayounfar N, Oloomi K (2012) Drawbacks and unfavorable outcomes of regenerative endodontic treatments of necrotic immature teeth: a literature review and report of a case. J Endod 38:1428–1434CrossRefPubMed
9.
Zurück zum Zitat Jiang XJ, Liu H, Peng CF (2017) Clinical and radiographic assessment of the efficacy of a collagen membrane in regenerative endodontics: a randomized, controlled clinical trial. J Endod 43:1465–1471CrossRefPubMed Jiang XJ, Liu H, Peng CF (2017) Clinical and radiographic assessment of the efficacy of a collagen membrane in regenerative endodontics: a randomized, controlled clinical trial. J Endod 43:1465–1471CrossRefPubMed
10.
Zurück zum Zitat Chen MY et al (2012) Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to revascularization procedures. Int Endod J 45:294–305CrossRefPubMed Chen MY et al (2012) Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to revascularization procedures. Int Endod J 45:294–305CrossRefPubMed
11.
Zurück zum Zitat Shah N et al (2008) Efficacy of revascularization to induce apexification/apexogensis in infected, nonvital, immature teeth: a pilot clinical study. J Endod 34:919–925CrossRefPubMed Shah N et al (2008) Efficacy of revascularization to induce apexification/apexogensis in infected, nonvital, immature teeth: a pilot clinical study. J Endod 34:919–925CrossRefPubMed
12.
Zurück zum Zitat Ding RY et al (2009) Pulp revascularization of immature teeth with apical periodontitis: a clinical study. J Endod 35:745–749CrossRefPubMed Ding RY et al (2009) Pulp revascularization of immature teeth with apical periodontitis: a clinical study. J Endod 35:745–749CrossRefPubMed
13.
Zurück zum Zitat Nosrat A, Seifi A, Asgary S (2001) Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial. J Endod 37:562–567CrossRef Nosrat A, Seifi A, Asgary S (2001) Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial. J Endod 37:562–567CrossRef
14.
Zurück zum Zitat Jadhav G, Shah N, Logani A (2012) Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: a pilot clinical study. J Endod 38:1581–1587CrossRefPubMed Jadhav G, Shah N, Logani A (2012) Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: a pilot clinical study. J Endod 38:1581–1587CrossRefPubMed
15.
Zurück zum Zitat Zhujiang A, Kim SG (2016) Regenerative endodontic treatment of an immature necrotic molar with arrested root development by using recombinant human platelet-derived growth factor: a case report. J Endod 42:72–75CrossRefPubMed Zhujiang A, Kim SG (2016) Regenerative endodontic treatment of an immature necrotic molar with arrested root development by using recombinant human platelet-derived growth factor: a case report. J Endod 42:72–75CrossRefPubMed
16.
Zurück zum Zitat Nagy MM et al (2014) Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols. J Endod 40:192–198CrossRefPubMed Nagy MM et al (2014) Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols. J Endod 40:192–198CrossRefPubMed
17.
Zurück zum Zitat Jeeruphan T et al (2012) Mahidol study 1: comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: a retrospective study. J Endod 38:1330–1336CrossRefPubMed Jeeruphan T et al (2012) Mahidol study 1: comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: a retrospective study. J Endod 38:1330–1336CrossRefPubMed
18.
Zurück zum Zitat Chan EK et al (2017) Longitudinal cohort study of regenerative endodontic treatment for immature necrotic permanent teeth. J Endod 43:395–400CrossRefPubMed Chan EK et al (2017) Longitudinal cohort study of regenerative endodontic treatment for immature necrotic permanent teeth. J Endod 43:395–400CrossRefPubMed
19.
Zurück zum Zitat Silujjai J, Linsuwanont P (2017) Treatment outcomes of apexification or revascularization in nonvital immature permanent teeth: a retrospective study. J Endod 43:238–245CrossRefPubMed Silujjai J, Linsuwanont P (2017) Treatment outcomes of apexification or revascularization in nonvital immature permanent teeth: a retrospective study. J Endod 43:238–245CrossRefPubMed
20.
Zurück zum Zitat Jiang X, Liu H, Peng C (2022) Continued root development of immature permanent teeth after regenerative endodontics with or without a collagen membrane: a randomized, controlled clinical trial. Int J Paediatr Dent 32(2):284–293CrossRefPubMed Jiang X, Liu H, Peng C (2022) Continued root development of immature permanent teeth after regenerative endodontics with or without a collagen membrane: a randomized, controlled clinical trial. Int J Paediatr Dent 32(2):284–293CrossRefPubMed
22.
Zurück zum Zitat Jiang XJ, Liu H (2020) An uncommon type of segmental root development after REPs. Int Endod J 53:1728–1741CrossRefPubMed Jiang XJ, Liu H (2020) An uncommon type of segmental root development after REPs. Int Endod J 53:1728–1741CrossRefPubMed
23.
Zurück zum Zitat Nolla CM (1960) The development of the permanent teeth. J Dent Child 27:254–266 Nolla CM (1960) The development of the permanent teeth. J Dent Child 27:254–266
24.
Zurück zum Zitat Lin J et al (2017) Regenerative endodontics versus apexification in immature permanent teeth with apical periodontitis: a prospective randomized controlled study. J Endod 43:1821–1827CrossRefPubMed Lin J et al (2017) Regenerative endodontics versus apexification in immature permanent teeth with apical periodontitis: a prospective randomized controlled study. J Endod 43:1821–1827CrossRefPubMed
25.
Zurück zum Zitat Galler KM (2016) Clinical procedures for REPs: current knowledge and considerations. Int Endod J 49:926–936CrossRefPubMed Galler KM (2016) Clinical procedures for REPs: current knowledge and considerations. Int Endod J 49:926–936CrossRefPubMed
26.
Zurück zum Zitat Chrepa V et al (2017) Survival of the apical papilla and its resident stem cells in a case of advanced pulpal necrosis and apical periodontitis. J Endod 43:561–567CrossRefPubMed Chrepa V et al (2017) Survival of the apical papilla and its resident stem cells in a case of advanced pulpal necrosis and apical periodontitis. J Endod 43:561–567CrossRefPubMed
27.
Zurück zum Zitat Saoud TM et al (2014) Clinical and radiographic outcomes of traumatized immature permanent necrotic teeth after revascularization/REPs therapy. J Endod 40:1946–1952CrossRefPubMedPubMedCentral Saoud TM et al (2014) Clinical and radiographic outcomes of traumatized immature permanent necrotic teeth after revascularization/REPs therapy. J Endod 40:1946–1952CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Chueh L et al (2009) Regenerative endodontic treatment for necrotic immature permanent teeth. J Endod 35:160–164CrossRefPubMed Chueh L et al (2009) Regenerative endodontic treatment for necrotic immature permanent teeth. J Endod 35:160–164CrossRefPubMed
29.
Zurück zum Zitat Vishwanat L et al (2017) Effect of bacterial biofilm on the osteogenic differentiation of stem cells of apical papilla. J Endod 43:916–922CrossRefPubMed Vishwanat L et al (2017) Effect of bacterial biofilm on the osteogenic differentiation of stem cells of apical papilla. J Endod 43:916–922CrossRefPubMed
30.
Zurück zum Zitat Verma P et al (2017) Effect of residual bacteria on the outcome of pulp regeneration in vivo. J Dent Res 96:100–106CrossRefPubMed Verma P et al (2017) Effect of residual bacteria on the outcome of pulp regeneration in vivo. J Dent Res 96:100–106CrossRefPubMed
Metadaten
Titel
The capability of regenerative endodontics to promote the complete root formation in immature permanent teeth with different initial pre-operative conditions
verfasst von
Xijun Jiang
He Liu
Publikationsdatum
01.01.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 1/2024
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-023-05403-6

Weitere Artikel der Ausgabe 1/2024

Clinical Oral Investigations 1/2024 Zur Ausgabe

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Update Zahnmedizin

Bestellen Sie unseren kostenlosen Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.