Background
Methods
Study population
Mycological study
ELISA identification
Statistical analysis
Results
Demographic features | |
Male/female (%) | 39/34 (53.4%/46.6%) |
Age mean (range) | 5 years (10 month > 18 years) |
Underlying Disease | |
Hematologic disorders | 52 (71.2%) |
Heart surgery | 8 (11%) |
Liver Surgery | 6 (8.2%) |
Immunodeficiency disease | 5 (6.8%) |
AIDS | 1 (1.4%) |
Diabetes | 1(1.4%) |
Site of infection | |
Lung | 38 (52%) |
Liver | 24 (32.9%) |
Heart | 7 (9.6%) |
Sinuses | 5 (6.8%) |
Kidney | 2 (2.7%) |
Fever of unknown origin | 9 (12.3%) |
Antifungal therapy | |
Not used | 30 (41.1%) |
Amphotericin B | 9 (12.3%) |
Itraconazole | 4 (5.5%) |
Voriconazole | 3 (4.1%) |
Fluconazole | 8 (11%) |
Combination therapya | 19 (26%) |
Outcome | |
Alive | 53 (72.6%) |
Death | 20 (27.4%) |
sTREM-1 | Procalcitonin | Lactate dehydrogenase | C-reactive protein | White blood cells | Erythrocyte sedimentation rate | |
---|---|---|---|---|---|---|
AUC | 0.7 | 0.8 | 0.9 | 0.9 | 0.5 | 0.8 |
95% CIa | 0.6% to 0.8% | 0.75% to 0.84% | 0.85% to 97% | 0.85% to 0.94% | 0.45% to 0.58% | 0.73% to 0.85% |
P-value | 0.003 | < 0.0001 | < 0.0001 | < 0.0001 | 0.29 | < 0.0001 |
Cut- off Value | > 190 | > 260 | > 252 | > 7 | ≤ 4930 | > 23 |
Sensitivity | 71.2% | 80.8% | 91.8% | 90.4% | 49.3% | 83.6% |
95% CI | 59% to 81% | 70% to 88.2% | 83.2% to 96.2% | 81% to 96% | 37% to 61% | 73% to 91% |
Specificity | 100% | 100% | 100% | 100% | 100% | 94.4% |
95% CI | 81.5% to100% | 81.5% to100% | 81.5% to100% | 81.5% to100% | 81.5% to100% | 72.7% to 99.9% |
PPVa | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 98.4 |
NPVa | 46.2 | 56.2 | 75 | 72 | 32.7 | 58.6 |