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02.10.2023 | Original Article

Relationship between serum uric acid in early pregnancy and gestational diabetes mellitus: a prospective cohort study

verfasst von: Yanbei Duo, Shuoning Song, Yuemei Zhang, Xiaolin Qiao, Jiyu Xu, Jing Zhang, Zhenyao Peng, Yan Chen, Xiaorui Nie, Qiujin Sun, Xianchun Yang, Ailing Wang, Wei Sun, Yong Fu, Yingyue Dong, Zechun Lu, Tao Yuan, Weigang Zhao

Erschienen in: Endocrine | Ausgabe 3/2024

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Abstract

Purpose

The association between serum uric acid (UA) and gestational diabetes mellitus (GDM) was still unclear. Serum UA levels in pregnancy differed from that in non-pregnancy. This study aimed to investigate the changes of serum UA in early pregnancy, and to explore the association of serum UA with the risk of GDM.

Methods

A prospective double-center study including 873 singleton pregnant women was conducted in Beijing, China since 2019 (clinical trial number: NCT03246295). Seventy-eight healthy non-pregnant women were selected to compare the changes of biomarkers in pregnancy. Spearman correlation and logistic regression analysis were performed to measure the relationship between serum UA in early pregnancy and GDM.

Results

The incidence of GDM in our cohort was 20.27%(177/873). Compared with non-pregnant women, serum UA and creatinine decreased significantly during early pregnancy. Serum UA concentration in early pregnancy was significantly higher in GDM women than that in normal glucose tolerance (NGT) women [217.0(192.9, 272.0) μmol/l vs. 201.9(176.0, 232.0) μmol/l, p < 0.001]. After adjusted for confounding factors, elevated serum UA remained as an independent risk factor for GDM. The risk of GDM increased when serum UA was above 240 μmol/l (adjusted OR 1.964, 95% CI 1.296–2.977, p < 0.001), and stronger relationships between serum UA and GDM were observed in pregnant women aged over 35 years old and preBMI ≥ 24 kg/m².

Conclusion

The normal range of serum UA and creatinine in pregnant women were lower than those in non-pregnant women. It is essential to monitor serum UA concentrations since early pregnancy to alert and prevent GDM, especially in older and heavier pregnant women.

Clinical trial number

NCT03246295.

Nur mit Berechtigung zugänglich

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Titel: Relationship between serum uric acid in early pregnancy and gestational diabetes mellitus: a prospective cohort study
verfasst von: Yanbei Duo
Shuoning Song
Yuemei Zhang
Xiaolin Qiao
Jiyu Xu
Jing Zhang
Zhenyao Peng
Yan Chen
Xiaorui Nie
Qiujin Sun
Xianchun Yang
Ailing Wang
Wei Sun
Yong Fu
Yingyue Dong
Zechun Lu
Tao Yuan
Weigang Zhao
Publikationsdatum: 02.10.2023
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 3/2024
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-023-03544-y

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Relationship between serum uric acid in early pregnancy and gestational diabetes mellitus: a prospective cohort study