Background
Methods
Study design and patients
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Simple (AS): large atrial septal defect, ventricular septal defect, large arterial duct
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Multiple (AM): association of at least two simple lesions
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Complex (AC): anomalous pulmonary venous return, atrioventricular canal, aortopulmonary window, truncus arteriosus
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Complex (BC): tetralogy of Fallot, tricuspid atresia, pulmonary atresia, Ebstein anomaly, unilateral absence of a pulmonary artery, anomalous systemic venous return
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interrupted aortic arch
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transposition of the Great Arteries with ventricular septal defect
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combination of complex lesions:
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Double outlet right ventricle plus interrupted aortic arch
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Double outlet right ventricle plus anomalous pulmonary venous return plus Coarctation of the aorta
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Major aortopulmonary collateral arteries plus ventricular septal defect
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univentricular heart
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primary pulmonary hypertension
Assessments and data collection
Statistical analysis
Results
Characteristics of the patient population
Characteristic | Descriptive statistics | |
---|---|---|
CHD patients (n = 128) | ||
Prophylaxis | 100% | |
Presence of a syndrome | 25 (19.53%) | |
CHD diagnosis | ||
AS | 54 (42.19%) | |
AM | 17 (13.28%) | |
AC | 21 (16.41%) | |
BC | 10 (7.81%) | |
CC | 21 (16.41%) | |
DM | 3 (2.34%) | |
NA | 2 (1.56%) | |
Hospitalization | 27 (21.09%) |
Impact of palivizumab prophylaxis on hospitalization
Characteristic | Hospitalization days 8.53 (± 12.15) | Ratio (95%CI) | p-value |
---|---|---|---|
CHD diagnosis | 0.0005 | ||
No | 6.16 (± 2.29) | 1 | |
Increased pulmonary flow (AS + AM + AC) | 11.71 (± 7.27) | 1.9 (1.41: 2.55) | |
RSS | rho = 0.35 | 1.2 (1.06: 1.35) | 0.0100 |
PICU | 0.0001 | ||
No | 6.18 (2.94) | 1 | |
Yes | 17 (7.07) | 2.75 (1.77: 4.20) | |
Neonatology | 9.4 (2.7) | 1.52 (1.07: 2.13) |
Ratio (95%CI) | p-value | |
---|---|---|
PICU | < 0.0001 | |
No | 1 | |
Yes | 1.77 (1.10:2.84) | |
Neonatology | 1.62 (1.16: 2.23) | |
CHD diagnosis | 0.0036 | |
No | 1 | |
Increased pulmonary flow (AS + AM + AC) | 1.66 (1.19:2.27) |
Outcome | Hospitalized patients (n = 77) | p-value | |
---|---|---|---|
Control group (n = 50) | CHD patients (n = 27) | ||
Hospitalization (days) | 6.16 (± 2.29) | 14.45 (± 21.7) | < 0.0001a |
PICU | 0.0010b | ||
No | 45 (90%) | 10 (71.43%) | |
Yes | 0 (0%) | 4 (28.57%) | |
Neonatology | 5 (10%) | 0 (0%) | |
RSS | 2.34 (± 0.92) | 3.18 (± 0.87) | 0.1211a |
Presence of a syndrome | 0 (0%) | 8 (29.63%) | |
Coexisting syndrome among CHD hospitalized patients (n = 27) | |||
Hospitalization (days) | - | Absence 15 (± 2.88) Presence 13.17 (± 6.77) | 0.7662c |