Introduction
Cardiovascular changes in pregnancy and preeclampsia
Cardiac factors | Hemodynamic factors | Intravascular fluid status | Others |
---|---|---|---|
• Myocardial ischemia • Atrial and ventricular arrhythmias | • Increased intravascular hydrostatic pressure (acute hypertension) • Increased endothelial permeability • Decrease in intravascular oncotic pressure (albumin loss, postpartum autotransfusion) | • Autotransfusion after delivery • Iatrogenic fluid overload • Uterotonics (oxytocin) | • Pain • Anxiety • Labor • Anesthesia |
Clinical features
Diagnosis | Clinical presentation | Role of echocardiography |
---|---|---|
Acute coronary syndrome | • Typical chest pain with localizing ECG changes • Arrhythmias, heart block • Elevated troponin levels | • Identification of regional wall motion abnormalities • Detect complications of myocardial infarction: acute mitral regurgitation, ventricular septal rupture, ventricular wall rupture, and cardiac tamponade |
Arrhythmias | • Palpitations • Syncopal attacks | • Could help rule out structural defects predisposing to arrhythmias (e.g., valvular disease) • Rule out the presence of thrombus in heart chambers |
Valvulopathies | • Worsening of preexisting symptoms in known heart disease patients • New onset dyspnea, orthopnea, paroxysmal nocturnal dyspnea, and palpitations | • Detect structural valvular/septal defects • Pulmonary arterial hypertension • Chamber enlargement • Rule out intracardiac thrombi |
Preeclampsia | • New-onset hypertension after 20 weeks’ gestation associated with proteinuria, adverse conditions, or multi-organ dysfunction | • Identify and grade LV concentric hypertrophy • Detect and quantify LV systolic and diastolic dysfunction |
Peripartum cardiomyopathy | • HF toward the end of pregnancy or postpartum • Diagnosis of exclusion • Elevated natriuretic peptide levels | • LV systolic dysfunction and ejection faction < 45% • Global hypokinesia |
Takotsubo cardiomyopathy | • Ischemic-like chest pain and transient ECG changes • Elevated troponin level | • Identify characteristic apical ballooning with free wall-sparing |
Septic cardiomyopathy | • Systemic features of sepsis • Hypo/hyperthermia • Hypotension • Raised inflammatory markers | • Demonstrate global hypokinesia with a hyperdynamic circulation |
Investigational workup
A | Acceptable and Applicable as it is safe and non-invasive |
B | Can be performed Bedside of the patient (point of care) |
C | Concise examination (parasternal and apical views) and Comfortable for parturients |
D | Diagnose contractility disorders and hypo/hypervolemia and treat accordingly |
E | Embolus (clot, amniotic fluid, and air), assessment of right heart function, and structure |
F | Fetal heart rate monitoring by experienced clinicians |
Management of HF in preeclampsia
Drug | Use in pregnancy | Use during lactation | Potential adverse effects |
---|---|---|---|
Loop diuretics (furosemide) | Compatible | Compatible | Maternal hypovolemia and hypotension, uterine hypoperfusion, decreased breast milk production |
Beta-blockers | Compatible | Compatible | Fetal hypoglycemia, fetal bradycardia |
Nitrates (glyceryl trinitrate) | Compatible | Compatible | Maternal hypotension, uterine hypoperfusion |
ACE inhibitors/ARBs | Incompatible | Compatible | Renal agenesis, oligohydramnios, fetal loss |
Mineralocorticoid receptor antagonists | Incompatible | Compatible | Fetal undervirilization |
Digoxin | Compatible | Compatible | Low birth weight |
Heparin (UFH, LMWH) | Compatible | Compatible | Increased maternal bleeding risk, implication on timing of neuraxial interventions |
Warfarin | Avoid | Compatible | Fetal skeletal deformities, intracranial bleeding, abortion, and stillbirth |
HF with reduced ejection fraction
Initial pharmacotherapy
Vasopressors and inotropes
Mechanical circulatory support and ventricular assist devices
Bromocriptine
Magnesium
HF with preserved ejection fraction
Arrhythmia management
Anticoagulation
Planning of delivery
Analgesia for vaginal delivery
Anesthesia for cesarean delivery
Central neuraxial anesthesia
General anesthesia
Use of uterotonics
Postpartum care
Obstetric critical care
System | Considerations |
---|---|
Respiratory support | - Noninvasive ventilation • Has been used but with caution, keeping in mind the high risk of gastric inflation, regurgitation, and aspiration - Tracheal intubation • Histamine receptor antagonist or proton-pump inhibitor in anticipation, sodium citrate solution, head-up tilt • Cricoid pressure controversial • Preoxygenation can be done using high-flow nasal cannula • Short-handled laryngoscope, ensure optimal positioning including “ramp” for patients with high BMI, and smaller-sized endotracheal tubes - Invasive mechanical ventilation • Plateau pressure — 35-cm H2O, tidal volume 6 mL/kg (ideal body weight) • Optimal PEEP titration with driving pressure ≤ 15-cm H2O • Arterial oxygen partial pressure threshold — 70 mm Hg. Consider using fetal heart rate monitor to monitor for signs of fetal hypoxia if a lower threshold is used • Maternal optimization of oxygenation and ventilation should not routinely include fetal delivery, unless fetal indications are present |
Circulatory support | - In case of any hemodynamic instability, always rule out possible aorto-caval compression - Judicious use of intravenous fluids - Low threshold for initiating invasive monitoring - Evidence-based use of vasodilators, vasopressors, and inotropes - Bedside-focused transthoracic echocardiography to diagnose etiology and initiating appropriate treatment |
Pharmacotherapeutic agents | - Ideal sedative is still elusive - Most sedatives will have depressant actions on the fetus, if birth is planned soon after - Opioid infusions are associated with risk of respiratory depression in the fetus - Midazolam infusions carry risk of acute fetal benzodiazepine withdrawal |
Nutrition | - Most nutrition trials have excluded parturients; hence, appropriate caloric goals are unknown - Prokinetics might be needed in view of impaired gastric emptying |
Prophylaxis for deep venous thrombosis | - All patients to receive prophylaxis unless otherwise contraindicated |
Fetal care | - In the absence of specific maternal indication, cardiotocography is usually not a routine practice if the patient is not laboring - Obstetrician, anesthesiologist, and neonatologist must be kept informed prior and available on standby if delivery is planned in the obstetric critical care unit - Cardiotocogram, uterotonic agents, cesarean kit, and neonatal resuscitation equipment be kept ready |