Introduction
Methods
Patients
Data collection
Statistical analysis
Results
Demographics
Total (N = 327) | pre-attack symptoms |
p-
value | pre-episode symptoms |
p-
value | |||
---|---|---|---|---|---|---|---|
None (n = 58) | Yes(n = 269) | None(n = 259) | Yes(n = 68) | ||||
Age | 33.0 (28.0–39.0) | 31.0 (27.0–38.0) | 33.0 (28.0–39.0) | 0.210 | 32.0 (28.0–38.0) | 34.0 (28.0–39.0) | 0.141 |
Gender | 0.734 | 0.091 | |||||
Male | 269 (82.3%) | 47 (81.0%) | 222 (82.5%) | 218 (84.2%) | 51 (75.0%) | ||
Female | 58 (17.7%) | 11 (19.0%) | 47 (17.5%) | 41 (15.8%) | 17 (25.0%) | ||
Smoking history | 144 (44.0%) | 18 (31.0%) | 126 (46.8%) | 0.037* | 110 (42.5%) | 34 (50.0%) | 0.324 |
Drinking history | 109 (33.3%) | 13 (22.4%) | 96 (35.7%) | 0.064 | 85 (32.8%) | 24 (35.3%) | 0.774 |
Diagnosis | 0.722 | 0.915 | |||||
eCH | 318 (97.2%) | 56 (96.6%) | 262 (97.4%) | 252 (97.3%) | 66 (97.1%) | ||
cCH | 9 (2.8%) | 2 (3.4%) | 7 (2.6%) | 7 (2.7%) | 2 (2.9%) | ||
Duration (years) | 10.0 (5.0–15.0) | 8.0 (2.8–15.0) | 10.0 (5.0–15.0) | 0.328 | 10.0 (5.0–15.0) | 10.0 (7.0–15.0) | 0.026* |
Family history of CH | 19 (5.8%) | 2 (3.4%) | 17 (6.3%) | 0.414 | 15 (5.8%) | 4 (5.9%) | 0.996 |
Coexisting other types | 47 (14.4%) | 6 (10.3%) | 41 (15.2%) | 0.185 | 35 (13.5%) | 12 (17.6%) | 0.234 |
Number of headache locations | 3.0 (2.0–4.0) | 2.0 (1.0–3.0) | 3.0 (2.0–4.0) | 0.009* | 3.0 (2.0–4.0) | 3.0 (2.0–4.0) | 0.362 |
VAS | 9.0 (8.0–10.0) | 8.5 (7.5–10.0) | 9.0 (8.0–10.0) | 0.025* | 9.0 (8.0–10.0) | 9.5 (8.5–10.0) | 0.046* |
Duration of episode | 0.089 | 0.364 | |||||
Less than 2 weeks | 34 (10.4%) | 12 (20.7%) | 22 (8.2%) | 30 (11.6%) | 4 (5.9%) | ||
From 2 weeks to less than 1 month | 77 (23.5%) | 14 (24.1%) | 63 (23.4%) | 57 (22.0%) | 20 (29.4%) | ||
From 1 to 2 months | 164 (50.2%) | 24 (41.4%) | 140 (52.1%) | 127 (49.0%) | 37 (54.4%) | ||
More than 2 months | 43 (13.1%) | 5 (8.6%) | 38 (14.1%) | 37 (14.3%) | 6 (8.8%) | ||
First experience of cluster | 9 (2.8%) | 3 (5.2%) | 6 (2.2%) | 8 (3.1%) | 1 (1.5%) | ||
Frequency of episode | 0.996 | 0.092 | |||||
Less than 1 time/year | 136 (41.6%) | 24 (41.4%) | 112 (41.6%) | 108 (41.7%) | 28 (41.2%) | ||
1 time/year | 121 (37.0%) | 22 (37.9%) | 99 (36.8%) | 101 (39.0%) | 20 (29.4%) | ||
More than 1 time/year | 70 (21.4%) | 12 (20.7%) | 58 (21.6%) | 50 (19.3%) | 20 (29.4%) |
Clinical characteristics
Pre-attack symptoms
Univariable analysis | Multivariable analysis | |||||
---|---|---|---|---|---|---|
OR | 95% CI |
p-value | OR | 95% CI |
p-value | |
Age | 1.023 | 0.990–1.057 | 0.177 | |||
Gender(male) | 0.905 | 0.437–1.873 | 0.787 | |||
Smoking history | 1.958 | 1.069–3.588 | 0.030* | 2.067 | 1.089–3.924 | 0.026* |
Drinking history | 1.921 | 0.987–3.737 | 0.055 | |||
Diagnosis(eCH) | 0.748 | 0.151–3.697 | 0.722 | |||
Duration (years) | 1.018 | 0.979–1.058 | 0.371 | |||
Family history of CH | 1.889 | 0.424–8.411 | 0.404 | |||
Coexisting other types | 1.558 | 0.629–3.864 | 0.338 | |||
Number of headache locations | 1.310 | 1.071–1.603 | 0.009* | 1.204 | 0.980–1.478 | 0.077 |
VAS | 1.277 | 1.025–1.592 | 0.030* | 1.169 | 0.912–1.497 | 0.217 |
Duration of episode | ||||||
Less than 2 weeks | 2.152 | 0.855–5.416 | 0.104 | |||
From 2 weeks to less than 1 month | 2.810 | 1.214–6.501 | 0.016* | |||
From 1 to 2 months | 3.539 | 1.089–11.498 | 0.036* | |||
More than 2 months | 0.957 | 0.201–4.557 | 0.955 | |||
First experience of cluster | (Ref) | (Ref) | ||||
Number of triggers | 1.828 | 1.325–2.520 | 0.001* | 1.798 | 1.264–2.558 | 0.001* |
Number of mitigating factors | 1.643 | 1.067–2.531 | 0.024* | 1.340 | 0.842–2.132 | 0.217 |
Number of non-CAS symptoms | 1.206 | 1.043–1.394 | 0.011* | 1.151 | 0.975–1.360 | 0.097 |
Pre-attack symptom | Total (N = 269) | Smoking history |
P-value | |
---|---|---|---|---|
No (N = 143) | Yes (N = 126) | |||
Head and facial discomfort | 200 (74.3%) | 104 (72.7%) | 96 (76.2%) | 0.070 |
Neck stiffness | 87 (32.3%) | 48 (33.6%) | 39 (31.0%) | 0.862 |
Anxiety and upset | 81 (30.1%) | 39 (27.3%) | 42 (33.3%) | 0.102 |
Unwillingness to talk | 79 (29.4%) | 36 (25.2%) | 43 (34.1%) | 0.033 |
Others | 57 (21.2%) | 35 (24.5%) | 22 (17.5%) | 0.363 |
Phonophobia | 56 (20.8%) | 26 (18.2%) | 30 (23.8%) | 0.114 |
Yawning | 52 (19.3%) | 30 (21.0%) | 22 (17.5%) | 0.784 |
Irritability | 52 (19.3%) | 23 (16.1%) | 29 (23.0%) | 0.063 |
Photophobia | 47 (17.5%) | 22 (15.4%) | 25 (19.8%) | 0.172 |
Drowsiness | 40 (14.9%) | 21 (14.7%) | 19 (15.1%) | 0.638 |
Fatigue | 39 (14.5%) | 20 (14.0%) | 19 (15.1%) | 0.530 |
Concentration changes | 38 (14.1%) | 19 (13.3%) | 19 (15.1%) | 0.431 |
Sweating | 35 (13.0%) | 13 (9.1%) | 22 (17.5%) | 0.018 |
Osmophobia | 30 (11.2%) | 13 (9.1%) | 17 (13.5%) | 0.144 |
Dysesthesia | 26 (9.7%) | 10 (7.0%) | 16 (12.7%) | 0.061 |
Fidgeting | 26 (9.7%) | 11 (7.7%) | 15 (11.9%) | 0.144 |
CASs | 25 (9.3%) | 14 (9.8%) | 11 (8.7%) | 0.997 |
Frustration | 23 (8.6%) | 7 (4.9%) | 16 (12.7%) | 0.011 |
Poor appetite | 23 (8.6%) | 9 (6.3%) | 14 (11.1%) | 0.199 |
Dizziness | 22 (8.2%) | 7 (4.9%) | 15 (11.9%) | 0.018 |
Nausea | 21 (7.8%) | 11 (7.7%) | 10 (7.9%) | 0.732 |
Palpitation | 16 (6.0%) | 6 (4.2%) | 10 (7.9%) | 0.127 |
Thirst | 15 (5.6%) | 9 (6.3%) | 6 (4.8%) | 0.747 |
Ear swelling | 12 (4.5%) | 5 (3.5%) | 7 (5.6%) | 0.309 |
Sensation of cold | 10 (3.7%) | 4 (2.8%) | 6 (4.8%) | 0.302 |
Diarrhea | 9 (3.3%) | 6 (4.2%) | 3 (2.4%) | 0.512 |
Diuresis | 6 (2.2%) | 1 (0.7%) | 5 (4.0%) | 0.050 |
Overactivity | 5 (1.9%) | 5 (3.5%) | 0 | 0.046 |
Edema | 5 (1.9%) | 3 (2.1%) | 2 (1.6%) | 0.855 |
Food craving | 4 (1.5%) | 2 (1.4%) | 2 (1.6%) | 0.809 |
Dysphasia | 2 (0.7%) | 0 | 2 (1.6%) | 0.110 |
Constipation | 2 (0.7%) | 1 (0.7%) | 1 (0.8%) | 0.865 |
Pre-episode symptoms
Univariable analysis | Multivariable analysis | |||||
---|---|---|---|---|---|---|
OR | 95% CI |
p-value | OR | 95% CI |
p-value | |
Age | 1.025 | 0.997–1.054 | 0.081 | |||
Gender(male) | 1.772 | 0.932–3.369 | 0.081 | |||
Smoking history | 1.355 | 0.793–2.314 | 0.267 | |||
Drinking history | 1.117 | 0.637–1.957 | 0.700 | |||
Diagnosis(eCH) | 1.091 | 0.221–5.375 | 0.915 | |||
Duration (years) | 1.035 | 1.003–1.068 | 0.033* | 1.020 | 0.986–1.056 | 0.255 |
Family history of CH | 1.017 | 0.326–3.169 | 0.977 | |||
Coexisting other types | 1.371 | 0.669–2.812 | 0.389 | |||
Number of headache locations | 0.932 | 0.792–1.097 | 0.399 | |||
VAS | 1.273 | 1.001–1.619 | 0.049* | 1.189 | 0.928–1.524 | 0.171 |
Duration of episode | ||||||
Less than 2 weeks | 2.035 | 0.693–5.976 | 0.196 | |||
From 2 weeks to less than 1 month | 1.735 | 0.628–4.793 | 0.288 | |||
From 1 to 2 months | 0.784 | 0.207–2.968 | 0.720 | |||
More than 2 months | 0.725 | 0.074–7.125 | 0.783 | |||
First experience of cluster | (Ref) | (Ref) | ||||
Number of triggers | 1.482 | 1.202–1.826 | 0.001* | 1.372 | 1.100–1.712 | 0.005* |
Number of mitigating factors | 1.433 | 1.027–2.001 | 0.035* | 1.245 | 0.876–1.771 | 0.222 |
Number of non-CAS symptoms | 1.060 | 0.932–1.206 | 0.373 |