nach oben

Erschienen in:

2019 | OriginalPaper | Buchkapitel

25. Periphere T- und NK-Zell Lymphome

verfasst von : Prof. Dr. Dr. h.c. Hans Konrad Müller-Hermelink, Dr. Qunpei Yang, Prof. Dr. Eva Geissinger

Erschienen in: Pathologie

Verlag: Springer Berlin Heidelberg

Einloggen, um Zugang zu erhalten

Zusammenfassung

Maligne Non Hodgkin Lymphome (NHL) des T- und NK-Zell Systems machen zwar in westlichen Ländern nur rund 9 % aller NHL aus. Aufgrund der vielen morphologisch, klinisch und genetisch unterschiedlichen Entitäten erfordern sie jedoch trotz der relativen Seltenheit eine komplexe und detaillierte Diagnostik. Erst in der heute gültigen WHO Klassifikation wurde ihre Beziehung und Ableitung von unterschiedlichen T- und NK-Zell Populationen systematisch molekular und phänotypisch begründet und diagnostische und differenzialdiagnostische Strategien realisiert. Dieses Kapitel bietet einen funktionell begründeten Einstieg in die pathologische Diagnostik dieser Lymphome und setzt den Schwerpunkt auf die primär im Lymphknoten lokalisierten Entitäten, da verschiedene extranodale Entitäten mit primär intestinalem, lienalem oder kutanem Organbefall oder mit primär leukämischem Bild in den jeweiligen Organkapiteln behandelt werden.

Agostinelli C, Hartmann S, Klapper W, Korkolopoulou P, Righi S, Marafioti T, Piccaluga PP, Patsouris E, Hansmann ML, Lennert K, Pileri SA (2011) Peripheral T cell lymphomas with follicular T helper phenotype: a new basket or a distinct entity? Revising Karl Lennert’s personal archive. Histopathology 59:679–691PubMedCrossRef

Almire C, Bertrand P, Ruminy P, Maingonnat C, Wlodarska I, Martin-Subero JI, Siebert R, Tilly H, Bastard C (2007) PVRL2 is translocated to the TRA@ locus in t(14;19)(q11;q13)-positive peripheral T-cell lymphomas. Genes Chromosomes Cancer 46: 1011–1018PubMedCrossRef

Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K, Nakamura S (2005) Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified. Am J Surg Pathol 29:1284–1293PubMedCrossRef

Attygalle AD, Cabecadas J, Gaulard P, Jaffe ES, de Jong D, Ko YH, Said J, Klapper W (2014) Peripheral T-cell and NK-cell lymphomas and their mimics; taking a step forward - report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology. Histopathology 64:171–199CrossRefPubMed

Attygalle AD, Feldman AL, Dogan A (2013) ITK/SYK translocation in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 37:1456–1457PubMedCrossRef

Attygalle AD, Kyriakou C, Dupuis J, Grogg KL, Diss TC, Wotherspoon AC, Chuang SS, Cabecadas J, Isaacson PG, Du MQ, Gaulard P, Dogan A (2007) Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 31:1077–1088PubMedCrossRef

Bacon CM, Paterson JC, Liu H, Payne K, Munson P, Du MQ, Marafioti T (2008) Peripheral T-cell lymphoma with a follicular growth pattern: derivation from follicular helper T cells and relationship to angioimmunoblastic T-cell lymphoma. Br J Haematol 143:439–441PubMedCrossRef

Ballester B, Ramuz O, Gisselbrecht C, Doucet G, Loi L, Loriod B, Bertucci F, Bouabdallah R, Devilard E, Carbuccia N, Mozziconacci MJ, Birnbaum D, Brousset P, Berger F, Salles G, Briere J, Houlgatte R, Gaulard P, Xerri L (2006) Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas. Oncogene 25:1560–1570PubMedCrossRef

Barry TS, Jaffe ES, Sorbara L, Raffeld M, Pittaluga S (2003) Peripheral T-cell lymphomas expressing CD30 and CD15. Am J Surg Pathol 27:1513–1522PubMedCrossRef

10.

Bellei M, Sabattini E, Pesce EA, Ko YH, Kim WS, Cabrera ME, Martinez V, Dlouhy I, Paes RP, Barrese T, Vassallo J, Tarantino V, Vose J, Weisenburger D, Rudiger T, Federico M, Pileri S (2016) Pitfalls and major issues in the histologic diagnosis of peripheral T-cell lymphomas: results of the central review of 573 cases from the T-Cell Project, an international, cooperative study. Hematol Oncol 35(4):630–636PubMedCrossRef

11.

Benharroch D, Meguerian-Bedoyan Z, Lamant L, Amin C, Brugieres L, Terrier-Lacombe MJ, Haralambieva E, Pulford K, Pileri S, Morris SW, Mason DY, Delsol G (1998) ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91:2076–2084PubMed

12.

Bjorkstrom NK, Ljunggren HG, Michaelsson J (2016) Emerging insights into natural killer cells in human peripheral tissues. Nat Rev Immunol 16:310–320PubMedCrossRef

13.

Bonzheim I, Geissinger E, Roth S, Zettl A, Marx A, Rosenwald A, Muller-Hermelink HK, Rudiger T (2004) Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. Blood 104:3358–3360PubMedCrossRef

14.

Brody GS, Deapen D, Taylor CR, Pinter-Brown L, House-Lightner SR, Andersen JS, Carlson G, Lechner MG, Epstein AL (2015) Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases. Plast Reconstr Surg 135:695–705PubMedCrossRef

15.

Brugieres L, Quartier P, Le Deley MC, Pacquement H, Perel Y, Bergeron C, Schmitt C, Landmann J, Patte C, Terrier-Lacombe MJ, Delsol G, Hartmann O (2000) Relapses of childhood anaplastic large-cell lymphoma: treatment results in a series of 41 children – a report from the French Society of Pediatric Oncology. Ann Oncol 11:53–58PubMedCrossRef

16.

Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, Parrens M, Martin A, Xerri L, Brousset P, Chan LC, Chan WC, Gaulard P, Mak TW (2012) IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood 119:1901–1903PubMedPubMedCentralCrossRef

17.

Chan JK, Lamant L, Algar E, Delsol G, Tsang WY, Lee KC, Tiedemann K, Chow CW (2008) ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood 112:2965–2968PubMedCrossRef

18.

Chen X, Cherian S (2013) Immunophenotypic characterization of T-cell prolymphocytic leukemia. Am J Clin Pathol 140:727–735PubMedCrossRef

19.

Chiarle R, Simmons WJ, Cai H, Dhall G, Zamo A, Raz R, Karras JG, Levy DE, Inghirami G (2005) Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat Med 11:623–629PubMedCrossRef

20.

Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Huh J (2009) Distinct features of angioimmunoblastic T-cell lymphoma with bone marrow involvement. Am J Clin Pathol 131:640–646CrossRefPubMed

21.

Clemens MW, Medeiros LJ, Butler CE, Hunt KK, Fanale MA, Horwitz S, Weisenburger DD, Liu J, Morgan EA, Kanagal-Shamanna R, Parkash V, Ning J, Sohani AR, Ferry JA, Mehta-Shah N, Dogan A, Liu H, Thormann N, Di Napoli A, Lade S, Piccolini J, Reyes R, Williams T, McCarthy CM, Hanson SE, Nastoupil LJ, Gaur R, Oki Y, Young KH, Miranda RN (2016) Complete surgical excision is essential for the management of patients with breast implant-associated anaplastic large-cell lymphoma. J Clin Oncol 34:160–168PubMedCrossRef

22.

Crescenzo R, Abate F, Lasorsa E, Tabbo F, Gaudiano M, Chiesa N, Di Giacomo F, Spaccarotella E, Barbarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficarra E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Tzankov A, Ponzoni M, Paulli M, Weisenburger D, Chan WC, Iqbal J, Piris MA, Zamo A, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Shultz LD, Mevellec L, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G (2015) Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell 27:516–532PubMedPubMedCentralCrossRef

23.

Cuadros M, Dave SS, Jaffe ES, Honrado E, Milne R, Alves J, Rodriguez J, Zajac M, Benitez J, Staudt LM, Martinez-Delgado B (2007) Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas. J Clin Oncol 25:3321–3329PubMedCrossRef

24.

de Jong D, Vasmel WL, de Boer JP, Verhave G, Barbe E, Casparie MK, van Leeuwen FE (2008) Anaplastic large-cell lymphoma in women with breast implants. JAMA, Bd. 300, S 2030–2035

25.

de Leval L, Parrens M, Le Bras F, Jais JP, Fataccioli V, Martin A, Lamant L, Delarue R, Berger F, Arbion F, Bossard C, Copin MC, Canioni D, Charlotte F, Damaj G, Dartigues P, Fabiani B, Ledoux-Pilon A, Montagne K, Molina T, Patey M, Tas P, Peoch M, Petit B, Petrella T, Picquenot JM, Rousset T, Rousselet MC, Soubeyran I, Thiebault S, Tournilhac O, Xerri L, Gisselbrecht C, Haioun C, Delsol G, Gaulard P (2015) Angioimmunoblastic T-cell lymphoma is the most common T-cell lymphoma in two distinct French information data sets. Haematologica 100:e361–364PubMedPubMedCentralCrossRef

26.

de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Briere J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (2007) The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood 109:4952–4963PubMedCrossRef

27.

de Leval L, Savilo E, Longtine J, Ferry JA, Harris NL (2001) Peripheral T-cell lymphoma with follicular involvement and a CD4+/bcl-6+ phenotype. Am J Surg Pathol 25:395–400PubMedCrossRef

28.

Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M (2010) The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Cancer Res 70:6193–6204PubMedCrossRef

29.

Dogan A, Attygalle AD, Kyriakou C (2003) Angioimmunoblastic T-cell lymphoma. Br J Haematol 121:681–691PubMedCrossRef

30.

Dogan A, Gaulard P, Jaffe ES, Ralfkiaer E, Muller-Hermelink HK (2008) Angioimmunoblastic T-cell lymphoma. In: Swerdlow SH (Hrsg) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, Lyon, S 309–311

31.

Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ (2006) Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 30:802–810PubMedPubMedCentralCrossRef

32.

Dunleavy K, Wilson WH, Jaffe ES (2007) Angioimmunoblastic T cell lymphoma: pathobiological insights and clinical implications. Curr Opin Hematol 14:348–353CrossRefPubMed

33.

Feldman AL, Dogan A, Smith DI, Law ME, Ansell SM, Johnson SH, Porcher JC, Ozsan N, Wieben ED, Eckloff BW, Vasmatzis G (2011) Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood 117: 915–919CrossRefPubMed

34.

Feldman AL, Law M, Remstein ED, Macon WR, Erickson LA, Grogg KL, Kurtin PJ, Dogan A (2009) Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas. Leukemia 23:574–580CrossRefPubMed

35.

Fujiwara SI, Yamashita Y, Nakamura N, Choi YL, Ueno T, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Abe M, Ozawa K, Mano H (2008) High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays. Leukemia 22:1891–1898CrossRefPubMed

36.

Gafencu GA, Selicean SE, Petrushev B, Cucuianu A, Dima D, Frinc I, Irimie A, Pileczki V, Berindan-Neagoe I, Berce C, Buiga R, Tomuleasa C (2016) Clinicopathological analysis of a case series of peripheral T-cell lymphomas, not otherwise specified, of lymphoepithelioid variant (Lennert’s lymphoma). A Central European single-center study. Human Pathol 53:192–194CrossRef

37.

Gascoyne RD, Aoun P, Wu D, Chhanabhai M, Skinnider BF, Greiner TC, Morris SW, Connors JM, Vose JM, Viswanatha DS, Coldman A, Weisenburger DD (1999) Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood 93:3913–3921PubMed

38.

Geissinger E, Bonzheim I, Krenacs L, Roth S, Reimer P, Wilhelm M, Muller-Hermelink HK, Rudiger T (2006) Nodal peripheral T-cell lymphomas correspond to distinct mature T-cell populations. J Pathol 210:172–180CrossRefPubMed

39.

Geissinger E, Odenwald T, Lee SS, Bonzheim I, Roth S, Reimer P, Wilhelm M, Muller-Hermelink HK, Rudiger T (2004) Nodal peripheral T-cell lymphomas and, in particular, their lymphoepithelioid (Lennert’s) variant are often derived from CD8(+) cytotoxic T-cells. Virchows Arch 445: 334–343

40.

Geissinger E, Sadler P, Roth S, Grieb T, Puppe B, Muller N, Reimer P, Vetter-Kauczok CS, Wenzel J, Bonzheim I, Rudiger T, Muller-Hermelink HK, Rosenwald A (2010) Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations. Haematologica 95:1697–1704PubMedPubMedCentralCrossRef

41.

Godde-Salz E, Feller AC, Lennert K (1987) Chromosomal abnormalities in lymphogranulomatosis X (LgrX)/angioimmunoblastic lymphadenopathy (AILD). Leuk Res 11:181–190CrossRefPubMed

42.

Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB (2015) The burgeoning family of unconventional T cells. Nat Immunol 16:1114–1123CrossRefPubMed

43.

Goto N, Tsurumi H, Sawada M, Kanemura N, Hara T, Kasahara S, Kito Y, Takada K, Sato Y, Yoshino T, Moriwaki H, Takami T (2011) Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma: a case report with a review of the Literature. Pathol Int 61:326–330CrossRefPubMed

44.

Grogg KL, Attygalle AD, Macon WR, Remstein ED, Kurtin PJ, Dogan A (2006) CXCL13, a chemokine highly upregulated in germinal center T-helper cells, distinguishes angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified. Modern Pathol. Expression 19:1101–1107

45.

Grogg KL, Morice WG, Macon WR (2007) Spectrum of bone marrow findings in patients with angioimmunoblastic T-cell lymphoma. Br J Haematol 137:416–422PubMedCrossRef

46.

Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC et al (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361–1392PubMed

47.

Hartmann S, Agostinelli C, Klapper W, Korkolopoulou P, Koch K, Marafioti T, Piccaluga PP, Patsouris E, Pileri S, Hansmann ML (2011) Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: what is Lennert’s lymphoma nowadays? Histopathology 59:1173–1182CrossRefPubMed

48.

Hatano B, Fukushima T, Honda M, Hayashi T, Tsuda N, Ohshima K, Tsuchiya T, Kikuchi M (2002) Peripheral T-cell lymphoma with a nodular growth pattern. Pathol Int 52:400–405CrossRefPubMed

49.

Hernandez L, Pinyol M, Hernandez S, Bea S, Pulford K, Rosenwald A, Lamant L, Falini B, Ott G, Mason DY, Delsol G, Campo E (1999) TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations. Blood 94:3265–3268PubMed

50.

Hu S, Young KH, Konoplev SN, Medeiros LJ (2012) Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas. Human Pathol 43:1789–1798CrossRef

51.

Huang Y, Moreau A, Dupuis J, Streubel B, Petit B, Le Gouill S, Martin-Garcia N, Copie-Bergman C, Gaillard F, Qubaja M, Fabiani B, Roncador G, Haioun C, Delfau-Larue M-H, Marafioti T, Chott A, Gaulard P (2009) Peripheral T-cell lymphomas with a follicular growth pattern are derived from follicular helper T cells (TFH) and may show overlapping features with angioimmunoblastic T-cell lymphomas. Am J Surg Pathol 33:682–690PubMedPubMedCentralCrossRef

52.

Ikonomou IM, Tierens A, Troen G, Aamot HV, Heim S, Lauritzsen GF, Valerhaugen H, Delabie J (2006) Peripheral T-cell lymphoma with involvement of the expanded mantle zone. Virchows Arch 449:78–87CrossRefPubMed

53.

Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM (2014) Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma. Blood 123:2915–2923PubMedPubMedCentralCrossRef

54.

Dogan A, Gaulard P, Jaffe ES, Müller-Hermelink HK, de Leval L (2017) Angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper origin. In: Swerlow SH, Campo E, Harris NL, Jaffe ES, Pileri S, Stein H, Thiele J (Hrsg.) WHO classification of Tumours of haemopoietic and lymphoid tissues. International Agency for Research on Cancer. Lyon, 407–412

55.

Jiang L, Jones D, Medeiros LJ, Orduz YR, Bueso-Ramos CE (2005) Peripheral T-cell lymphoma with a “follicular” pattern and the perifollicular sinus phenotype. Am J Clin Pathol 123:448–455CrossRefPubMed

56.

Kaneko Y, Frizzera G, Edamura S, Maseki N, Sakurai M, Komada Y, Sakurai M, Tanaka H, Sasaki M, Suchi T et al (1989) A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis. Blood, Bd. 73, S 806–813

57.

Keech JA Jr., Creech BJ (1997) Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg 100:554–555CrossRefPubMed

58.

Khokhar FA, Payne WD, Talwalkar SS, Jorgensen JL, Bueso-Ramos CE, Medeiros LJ, Vega F (2010) Angioimmunoblastic T-cell lymphoma in bone marrow: a morphologic and immunophenotypic study. Human Pathol 41:79–87CrossRef

59.

Kim B, Roth C, Chung KC, Young VL, van Busum K, Schnyer C, Mattke S (2011) Anaplastic large cell lymphoma and breast implants: a systematic review. Plast Reconstr Surg 127:2141–2150CrossRefPubMed

60.

King RL, Dao LN, McPhail ED, Jaffe ES, Said J, Swerdlow SH, Sattler CA, Ketterling RP, Sidhu JS, Hsi ED, Karikehalli S, Jiang L, Gibson SE, Ondrejka SL, Nicolae A, Macon WR, Dasari S, Parrilla Castellar E, Feldman AL (2016) Morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 rearrangements. Am J Surg Pathol 40:36–43PubMedPubMedCentralCrossRef

61.

Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O’Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J (2012) MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491:717–723PubMedCrossRef

62.

Kurita D, Miyoshi H, Yoshida N, Sasaki Y, Kato S, Niino D, Sugita Y, Hatta Y, Takei M, Makishima M, Ohshima K (2016) A clinicopathologic study of Lennert lymphoma and possible prognostic factors: the importance of follicular helper T-cell markers and the association with angioimmunoblastic t-cell lymphoma. Am J Surg Pathol 40:1249–1260PubMedCrossRef

63.

Lamant L, Dastugue N, Pulford K, Delsol G, Mariame B (1999) A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation. Blood 93: 3088–3095

64.

Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M, Rajcan-Separovic E, Raghab J, Delsol G, Espinos E (2003) Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma. Genes Chromosomes Cancer 37:427–432PubMedCrossRef

65.

Laurent C, Delas A, Gaulard P, Haioun C, Moreau A, Xerri L, Traverse-Glehen A, Rousset T, Quintin-Roue I, Petrella T, Emile JF, Amara N, Rochaix P, Chenard-Neu MP, Tasei AM, Menet E, Chomarat H, Costes V, Andrac-Meyer L, Michiels JF, Chassagne-Clement C, de Leval L, Brousset P, Delsol G, Lamant L (2016) Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes. Ann Oncol 27:306–314CrossRefPubMed

66.

Lee SH, Kim JS, Kim J, Kim SJ, Kim WS, Lee S, Ko YH, Yoo HY (2015) A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patients. Haematologica 100:e505–e507PubMedPubMedCentralCrossRef

67.

Lee SS, Rudiger T, Odenwald T, Roth S, Starostik P, Muller-Hermelink HK (2003) Angioimmunoblastic T cell lymphoma is derived from mature T-helper cells with varying expression and loss of detectable CD4. Int J Cancer 103:12–20PubMedCrossRef

68.

Lemonnier F, Couronne L, Parrens M, Jais JP, Travert M, Lamant L, Tournillac O, Rousset T, Fabiani B, Cairns RA, Mak T, Bastard C, Bernard OA, de Leval L, Gaulard P (2012) Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters. Blood 120:1466–1469PubMedCrossRef

69.

Lepretre S, Buchonnet G, Stamatoullas A, Lenain P, Duval C, d’Anjou J, Callat MP, Tilly H, Bastard C (2000) Chromosome abnormalities in peripheral T-cell lymphoma. Cancer Genet Cytogenet 117:71–79PubMedCrossRef

70.

Macon WR, Williams ME, Greer JP, Cousar JB (1995) Paracortical nodular T-cell lymphoma. Identification of an unusual variant of peripheral T-cell lymphoma. Am J Surg Pathol 19:297–303CrossRefPubMed

71.

Mahadevan D, Spier C, Croce DK, Miller S, George B, Riley C, Warner S, Grogan TM, Miller TP (2005) Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures. Mol Cancer Ther 4:1867–1879CrossRefPubMed

72.

Martin-Subero JI, Wlodarska I, Bastard C, Picquenot JM, Hoppner J, Giefing M, Klapper W, Siebert R (2006) Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma. Blood 108: 401–402. Author Reply 108:402–403

73.

Martinez-Delgado B, Cuadros M, Honrado E, Ruiz de la Parte A, Roncador G, Alves J, Castrillo JM, Rivas C, Benitez J (2005) Differential expression of NF-kappaB pathway genes among peripheral T-cell lymphomas. Leukemia 19:2254–2263PubMedCrossRef

74.

Michel T, Poli A, Cuapio A, Briquemont B, Iserentant G, Ollert M, Zimmer J (2016) Human CD56bright NK Cells: An Update. J Immunol 196:2923–2931PubMedCrossRef

75.

Miyoshi H, Sato K, Niino D, Arakawa F, Kimura Y, Kiyasu J, Takeuchi M, Yoshida M, Okada Y, Nakamura Y, Sugita Y, Ohshima K (2012) Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders. Am J Clin Pathol 137:879–889PubMedCrossRef

76.

Mori L, Lepore M, De Libero G (2016) The immunology of CD1- and MR1-restricted T cells. Ann Rev. Immunol 34:479–510CrossRef

77.

Moroch J, Copie-Bergman C, de Leval L, Plonquet A, Martin-Garcia N, Delfau-Larue MH, Molinier-Frenkel V, Belhadj K, Haioun C, Audouin J, Swerdlow SH, Marafioti T, Gaulard P (2012) Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics. Am J Surg Pathol 36:1636–1646PubMedCrossRef

78.

Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma. Science, Bd. 263, S 1281–1284

79.

Nagao R, Kikuti YY, Carreras J, Kikuchi T, Miyaoka M, Matsushita H, Kojima M, Ando K, Sakata-Yanagimoto M, Chiba S, Nakamura N (2016) Clinicopathologic analysis of angioimmunoblastic T-cell lymphoma with or without RHOA G17V mutation using formalin-fixed paraffin-embedded sections. Am J Surg Pathol 40:1041–1050PubMedCrossRef

80.

Nagel S, Leich E, Quentmeier H, Meyer C, Kaufmann M, Drexler HG, Zettl A, Rosenwald A, MacLeod RA (2008) Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma. Leukemia 22:387–392PubMedCrossRef

81.

Nelson M, Horsman DE, Weisenburger DD, Gascoyne RD, Dave BJ, Loberiza FR, Ludkovski O, Savage KJ, Armitage JO, Sanger WG (2008) Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma. Br J Haematol 141:461–469PubMedCrossRef

82.

Nicolae A, Pittaluga S, Venkataraman G, Vijnovich-Baron A, Xi L, Raffeld M, Jaffe ES (2013) Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist. Am J Surg Pathol 37:816–826PubMedPubMedCentralCrossRef

83.

Odejide O, Weigert O, Lane AA, Toscano D, Lunning MA, Kopp N, Kim S, van Bodegom D, Bolla S, Schatz JH, Teruya-Feldstein J, Hochberg E, Louissaint A, Dorfman D, Stevenson K, Rodig SJ, Piccaluga PP, Jacobsen E, Pileri SA, Harris NL, Ferrero S, Inghirami G, Horwitz SM, Weinstock DM (2014) A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood 123:1293–1296PubMedPubMedCentralCrossRef

84.

Onaindia A, Martinez N, Montes-Moreno S, Almaraz C, Rodriguez-Pinilla SM, Cereceda L, Revert JB, Ortega C, Tardio A, Gonzalez L, Garcia S, Camacho FI, Gonzalez-Vela C, Piris MA (2016) CD30 expression by B and T cells: a frequent finding in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma-not otherwise specified. Am J Surg Pathol 40:378–385PubMedCrossRef

85.

Ondrejka SL, Grzywacz B, Bodo J, Makishima H, Polprasert C, Said JW, Przychodzen B, Maciejewski JP, Hsi ED (2016) Angioimmunoblastic T-cell lymphomas with the RHOA p.Gly17Val mutation have classic clinical and pathologic features. Am J Surg Pathol 40:335–341PubMedCrossRef

86.

Ortiz-Muchotrigo N, Rodriguez-Pinilla SM, Ramos R, Montes-Moreno S, Gonzalez-Lopez MA, Armesto-Perez A, Roncador G, Piris MA (2009) Follicular T-cell lymphoma: description of a case with characteristic findings suggesting it is a different condition from AITL. Histopathology 54:902–904PubMedCrossRef

87.

Palomero T, Couronne L, Khiabanian H, Kim MY, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas C, Balbin M, Bastard C, Bhagat G, Piris MA, Campo E, Bernard OA, Rabadan R, Ferrando AA (2014) Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet 46:166–170PubMedPubMedCentralCrossRef

88.

Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, Sidhu JS, Hsi ED, Karikehalli S, Jiang L, Vasmatzis G, Gibson SE, Ondrejka S, Nicolae A, Grogg KL, Allmer C, Ristow KM, Wilson WH, Macon WR, Law ME, Cerhan JR, Habermann TM, Ansell SM, Dogan A, Maurer MJ, Feldman AL (2014) ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood 124:1473–1480PubMedPubMedCentralCrossRef

89.

Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J (2013) Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun 4:2142PubMedCrossRef

90.

Patsouris E, Noel H, Lennert K (1989) Angioimmunoblastic lymphadenopathy--type of T-cell lymphoma with a high content of epithelioid cells. Histopathology and comparison with lymphoepithelioid cell lymphoma. Am J Surg Pathol 13:262–275PubMedCrossRef

91.

Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C, Ruland J (2010) The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med 207:1031–1044PubMedPubMedCentralCrossRef

92.

Piccaluga PP, Agostinelli C, Califano A, Rossi M, Basso K, Zupo S, Went P, Klein U, Zinzani PL, Baccarani M, Dalla Favera R, Pileri SA (2007) Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets. J Clin Invest 117:823–834PubMedPubMedCentralCrossRef

93.

Piccaluga PP, Agostinelli C, Zinzani PL, Baccarani M, Dalla Favera R, Pileri SA (2005) Expression of platelet-derived growth factor receptor alpha in peripheral T-cell lymphoma not otherwise specified. Lancet Oncol 6:440PubMedCrossRef

94.

Quintanilla-Martinez L, Fend F, Moguel LR, Spilove L, Beaty MW, Kingma DW, Raffeld M, Jaffe ES (1999) Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. Am J Surg Pathol 23:1233–1240CrossRefPubMed

95.

Rashidi A, Fisher SI (2015) T-cell chronic lymphocytic leukemia or small-cell variant of T-cell prolymphocytic leukemia: a historical perspective and search for consensus. Eur J Haematol 95:199–210PubMedCrossRef

96.

Ree HJ, Kadin ME, Kikuchi M, Ko YH, Go JH, Suzumiya J, Kim DS (1998) Angioimmunoblastic lymphoma (AILD-type T-cell lymphoma) with hyperplastic germinal centers. Am J Surg Pathol 22:643–655PubMedCrossRef

97.

Rimokh R, Magaud JP, Berger F, Samarut J, Coiffier B, Germain D, Mason DY (1989) A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma („Ki-1 lymphoma“). Br J Haematol 71: 31–36PubMedCrossRef

98.

Rodriguez-Pinilla SM, Atienza L, Murillo C, Perez-Rodriguez A, Montes-Moreno S, Roncador G, Perez-Seoane C, Dominguez P, Camacho FI, Piris MA (2008) Peripheral T-cell lymphoma with follicular T-cell markers. Am J Surg Pathol 32:1787–1799PubMedCrossRef

99.

Rohr J, Guo S, Huo J, Bouska A, Lachel C, Li Y, Simone PD, Zhang W, Gong Q, Wang C, Cannon A, Heavican T, Mottok A, Hung S, Rosenwald A, Gascoyne R, Fu K, Greiner TC, Weisenburger DD, Vose JM, Staudt LM, Xiao W, Borgstahl GE, Davis S, Steidl C, McKeithan T, Iqbal J, Chan WC (2015) Recurrent activating mutations of CD28 in peripheral T-cell lymphomas. Leukemia 31:357

100.

Roncador G, Garcia Verdes-Montenegro JF, Tedoldi S, Paterson JC, Klapper W, Ballabio E, Maestre L, Pileri S, Hansmann ML, Piris MA, Mason DY, Marafioti T (2007) Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma. Haematologica, Bd. 92, S 1059–1066

101.

Rosenwald A, Ott G, Pulford K, Katzenberger T, Kuhl J, Kalla J, Ott MM, Mason DY, Muller-Hermelink HK (1999) t(1;2)(q21;p23) and t(2;3)(p23;q21): two novel variant translocations of the t(2;5)(p23;q35) in anaplastic large cell lymphoma. Blood, Bd. 94, S 362–364

102.

Rudiger T, Geissinger E, Muller-Hermelink HK (2006) ’Normal counterparts’ of nodal peripheral T-cell lymphoma. Hematol Oncol 24:175–180PubMedCrossRef

103.

Rudiger T, Ichinohasama R, Ott MM, Muller-Deubert S, Miura I, Ott G, Muller-Hermelink HK (2000) Peripheral T-cell lymphoma with distinct perifollicular growth pattern: a distinct subtype of T-cell lymphoma? Am J Surg Pathol 24:117–122CrossRefPubMed

104.

Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S (2014) Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet 46:171–175PubMedCrossRef

105.

Schatz JH, Horwitz SM, Teruya-Feldstein J, Lunning MA, Viale A, Huberman K, Socci ND, Lailler N, Heguy A, Dolgalev I, Migliacci JC, Pirun M, Palomba ML, Weinstock DM, Wendel HG (2015) Targeted mutational profiling of peripheral T-cell lymphoma not otherwise specified highlights new mechanisms in a heterogeneous pathogenesis. Leukemia 29:237–241PubMedCrossRef

106.

Schlegelberger B, Weber-Matthiesen K, Sterry W, Bartels H, Sonnen R, Maschmeyer G, Feller AC, Grote W (1994) Combined immunophenotyping and karyotyping in peripheral T cell lymphomas demonstrating different clonal and nonclonal chromosome aberrations in T helper cells. Leuk Lymphoma 15:113–125PubMedCrossRef

107.

Schwab U, Stein H, Gerdes J, Lemke H, Kirchner H, Schaadt M, Diehl V (1982) Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin’s disease and a subset of normal lymphoid cells. Nature 299:65–67PubMedCrossRef

108.

Shin SY, Jang S, Park CJ, Chi HS, Lee KH, Huh J, Seo EJ (2012) A rare case of Lennert’s type peripheral T-cell lymphoma with t(14;19)(q11.2;q13.3). International journal of laboratory. hematology, Bd. 34, S 328–332

109.

Soudais C, Samassa F, Sarkis M, Le Bourhis L, Bessoles S, Blanot D, Herve M, Schmidt F, Mengin-Lecreulx D, Lantz O (2015) In vitro and in vivo analysis of the gram-negative bacteria-derived riboflavin precursor derivatives activating mouse MAIT cells. J Immunol 194:4641–4649PubMedCrossRef

110.

Stansfeld AG, Diebold J, Noel H, Kapanci Y, Rilke F, Kelenyi G, Sundstrom C, Lennert K, van Unnik JA, Mioduszewska O et al (1988) Updated Kiel classification for lymphomas. Lancet 1:292–293CrossRefPubMed

111.

Stein H, Mason DY, Gerdes J, O’Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H et al (1985) The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848–858PubMed

112.

Strauss-Albee DM, Blish CA (2016) Human NK Cell Diversity in Viral Infection: Ramifications of Ramification. Front Immunol 7:66PubMedPubMedCentralCrossRef

113.

Streubel B, Vinatzer U, Willheim M, Raderer M, Chott A (2006) Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. Leukemia 20: 313–318CrossRef

114.

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127:2375–2390PubMedPubMedCentralCrossRef

115.

Tan BT, Warnke RA, Arber DA (2006) The frequency of B- and T-cell gene rearrangements and epstein-barr virus in T-cell lymphomas: a comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferations. J Mol Diagn 8:466–475PubMedPubMedCentralCrossRef

116.

Thorns C, Bastian B, Pinkel D, Roydasgupta R, Fridlyand J, Merz H, Krokowski M, Bernd HW, Feller AC (2007) Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach. Genes Chromosomes Cancer 46:37–44PubMedCrossRef

117.

Tort F, Pinyol M, Pulford K, Roncador G, Hernandez L, Nayach I, Kluin-Nelemans HC, Kluin P, Touriol C, Delsol G, Mason D, Campo E (2001) Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma. Lab. Invest, Bd. 81, S 419–426

118.

Touriol C, Greenland C, Lamant L, Pulford K, Bernard F, Rousset T, Mason DY, Delsol G (2000) Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like). Blood 95:3204–3207PubMed

119.

Toya T, Nannya Y, Hangaishi A, Shiseki M, Shimoyama T, Sakamaki H, Motoji T, Usuki K, Nakamura F, Kurokawa M (2016) Prognostic relevance of CD20 expression in peripheral T-cell lymphomas: a multi-center retrospective study. Leuk Lymphoma 57:961–964PubMedCrossRef

120.

Trinei M, Lanfrancone L, Campo E, Pulford K, Mason DY, Pelicci PG, Falini B (2000) A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma. Cancer Res 60: 793–798

121.

Tu MM, Mahmoud AB, Makrigiannis AP (2016) Licensed and Unlicensed NK Cells: Differential Roles in Cancer and Viral Control. Front Immunol 7:166PubMedPubMedCentralCrossRef

122.

Uherova P, Ross CW, Finn WG, Singleton TP, Kansal R, Schnitzer B (2002) Peripheral T-cell lymphoma mimicking marginal zone B-cell lymphoma. Mod Pathol 15:420–425PubMedCrossRef

123.

van Krieken JH, Langerak AW, Macintyre EA, Kneba M, Hodges E, Sanz RG, Morgan GJ, Parreira A, Molina TJ, Cabecadas J, Gaulard P, Jasani B, Garcia JF, Ott M, Hannsmann ML, Berger F, Hummel M, Davi F, Bruggemann M, Lavender FL, Schuuring E, Evans PA, White H, Salles G, Groenen PJ, Gameiro P, Pott C, Dongen JJ (2007) Improved reliability of lymphoma diagnostics via PCR-based clonality testing: report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 21:201–206PubMedCrossRef

124.

Vasmatzis G, Johnson SH, Knudson RA, Ketterling RP, Braggio E, Fonseca R, Viswanatha DS, Law ME, Kip NS, Ozsan N, Grebe SK, Frederick LA, Eckloff BW, Thompson EA, Kadin ME, Milosevic D, Porcher JC, Asmann YW, Smith DI, Kovtun IV, Ansell SM, Dogan A, Feldman AL (2012) Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas. Blood 120:2280–2289PubMedPubMedCentralCrossRef

125.

Vinuesa CG, Linterman MA, Yu D, MacLennan IC (2016) Follicular Helper T Cells. Ann Rev. Immunol 34:335–368CrossRef

126.

Vose J, Armitage J, Weisenburger D (2008) International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 26:4124–4130PubMedCrossRef

127.

Wang C, McKeithan TW, Gong Q, Zhang W, Bouska A, Rosenwald A, Gascoyne RD, Wu X, Wang J, Muhammad Z, Jiang B, Rohr J, Cannon A, Steidl C, Fu K, Li Y, Hung S, Weisenburger DD, Greiner TC, Smith L, Ott G, Rogan EG, Staudt LM, Vose J, Iqbal J, Chan WC (2015) IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma. Blood 126:1741–1752PubMedPubMedCentralCrossRef

128.

Wang T, Feldman AL, Wada DA, Lu Y, Polk A, Briski R, Ristow K, Habermann TM, Thomas D, Ziesmer SC, Wellik LE, Lanigan TM, Witzig TE, Pittelkow MR, Bailey NG, Hristov AC, Lim MS, Ansell SM, Wilcox RA (2014) GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features. Blood 123:3007–3015PubMedPubMedCentralCrossRef

129.

Weisenburger DD, Savage KJ, Harris NL, Gascoyne RD, Jaffe ES, MacLennan KA, Rudiger T, Pileri S, Nakamura S, Nathwani B, Campo E, Berger F, Coiffier B, Kim WS, Holte H, Federico M, Au WY, Tobinai K, Armitage JO, Vose JM, International Peripheral Tc L (2011) Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project. Blood 117:3402–3408PubMedCrossRef

130.

Willenbrock K, Brauninger A, Hansmann ML (2007) Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein-Barr virus-infected cells in early cases. Br J Haematol 138:733–739PubMedCrossRef

131.

Wlodarska I, De Wolf-Peeters C, Falini B, Verhoef G, Morris SW, Hagemeijer A, Van den Berghe H (1998) The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma. Blood, Bd. 92, S 2688–2695

132.

Yoo HY, Sung MK, Lee SH, Kim S, Lee H, Park S, Kim SC, Lee B, Rho K, Lee JE, Cho KH, Kim W, Ju H, Kim J, Kim SJ, Kim WS, Lee S, Ko YH (2014) A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat Genet 46:371–375PubMedCrossRef

133.

Zamo A, Chiarle R, Piva R, Howes J, Fan Y, Chilosi M, Levy DE, Inghirami G (2002) Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 21:1038–1047CrossRefPubMed

134.

Zeng Y, Feldman AL (2016) Genetics of anaplastic large cell lymphoma. Leuk Lymphoma 57:21–27CrossRefPubMed

135.

Zettl A, Lee SS, Rudiger T, Starostik P, Marino M, Kirchner T, Ott M, Muller-Hermelink HK, Ott G (2002) Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified. Am J Clin Pathol 117: 368–379CrossRefPubMed

136.

Zettl A, Rudiger T, Konrad MA, Chott A, Simonitsch-Klupp I, Sonnen R, Muller-Hermelink HK, Ott G (2004) Genomic profiling of peripheral T-cell lymphoma, unspecified, and anaplastic large T-cell lymphoma delineates novel recurrent chromosomal alterations. Am J Pathol 164:1837–1848PubMedPubMedCentralCrossRef

Titel: Periphere T- und NK-Zell Lymphome
verfasst von: Prof. Dr. Dr. h.c. Hans Konrad Müller-Hermelink
Dr. Qunpei Yang
Prof. Dr. Eva Geissinger
Verlag: Springer Berlin Heidelberg
Buch: Pathologie
Print ISBN: 978-3-540-85183-7

Electronic ISBN: 978-3-540-85184-4

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-540-85184-4_25

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

25. Periphere T- und NK-Zell Lymphome

Zusammenfassung

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren