Skip to main content
Erschienen in: Current Pain and Headache Reports 11/2023

23.08.2023 | Neuromodulation (A Abd-Elsayed, Section Editor)

Neuromodulation for the Sphenopalatine Ganglion—a Narrative Review

verfasst von: Taehong Lim, Stephen Anderson, Robert Stocum, Karen Ren, Winston Singleton, Jayesh Vallabh, Kristen Noon, Tristan Weaver

Erschienen in: Current Pain and Headache Reports | Ausgabe 11/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

To provide an integrated overview of the current state of knowledge of neuromodulation for the sphenopalatine ganglion (SPG) by reviewing relevant and significant literature.

Recent Findings

There are several case reports and clinical trials evaluating neuromodulation for the SPG. We identified two blinded, randomized clinical trials for patients with chronic cluster headache. The randomized trials and additional studies demonstrated the long-term safety, efficacy, and cost-effectiveness of neuromodulation for the SPG.

Summary

Recent studies in Europe and the USA suggest that SPG neuromodulation is a novel modality with clinical importance for treating acute cluster headaches and reducing the frequency of attacks.
Literatur
1.
Zurück zum Zitat Ho KWD, Przkora R, Kumar S. Sphenopalatine ganglion: block, radiofrequency ablation and neurostimulation - a systematic review. J Headache Pain. 2017;18(1):118.CrossRefPubMedPubMedCentral Ho KWD, Przkora R, Kumar S. Sphenopalatine ganglion: block, radiofrequency ablation and neurostimulation - a systematic review. J Headache Pain. 2017;18(1):118.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Robbins MS, Robertson CE, Kaplan E, Ailani J, Charleston L, Kuruvilla D, et al. The sphenopalatine ganglion: anatomy, pathophysiology, and therapeutic targeting in headache. Headache J Head Face Pain. 2016;56(2):240–58.CrossRef Robbins MS, Robertson CE, Kaplan E, Ailani J, Charleston L, Kuruvilla D, et al. The sphenopalatine ganglion: anatomy, pathophysiology, and therapeutic targeting in headache. Headache J Head Face Pain. 2016;56(2):240–58.CrossRef
3.
Zurück zum Zitat Hainer BL, Matheson EM. Approach to acute headache in adults. Am Fam Physician. 2013;87(10):682–7.PubMed Hainer BL, Matheson EM. Approach to acute headache in adults. Am Fam Physician. 2013;87(10):682–7.PubMed
4.
Zurück zum Zitat Goadsby PJ. Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. Lancet Neurol. 2002;1(4):251–7.CrossRefPubMed Goadsby PJ. Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. Lancet Neurol. 2002;1(4):251–7.CrossRefPubMed
5.
Zurück zum Zitat Tepper SJ, Caparso A. Sphenopalatine ganglion (SPG): stimulation mechanism, safety, and efficacy. Headache. 2017;57(Suppl 1):14–28.CrossRefPubMed Tepper SJ, Caparso A. Sphenopalatine ganglion (SPG): stimulation mechanism, safety, and efficacy. Headache. 2017;57(Suppl 1):14–28.CrossRefPubMed
6.
Zurück zum Zitat Sluder G. The role of the sphenopalatine ganglion in nasal headaches. NY State J Med. 1908. Sluder G. The role of the sphenopalatine ganglion in nasal headaches. NY State J Med. 1908.
8.
Zurück zum Zitat Jürgens TP, May A. Role of sphenopalatine ganglion stimulation in cluster headache. Curr Pain Headache Rep. 2014;18(7):433.CrossRefPubMed Jürgens TP, May A. Role of sphenopalatine ganglion stimulation in cluster headache. Curr Pain Headache Rep. 2014;18(7):433.CrossRefPubMed
9.
Zurück zum Zitat Devoghel JC. Cluster headache and sphenopalatine block. Acta Anaesthesiol Belg. 1981;32(1):101–7.PubMed Devoghel JC. Cluster headache and sphenopalatine block. Acta Anaesthesiol Belg. 1981;32(1):101–7.PubMed
10.
Zurück zum Zitat Hardebo JE, Elner A. Nerves and vessels in the pterygopalatine fossa and symptoms of cluster headache. Headache. 1987;27(10):528–32.CrossRefPubMed Hardebo JE, Elner A. Nerves and vessels in the pterygopalatine fossa and symptoms of cluster headache. Headache. 1987;27(10):528–32.CrossRefPubMed
11.
Zurück zum Zitat Piagkou M, Demesticha T, Troupis T, Vlasis K, Skandalakis P, Makri A, et al. The pterygopalatine ganglion and its role in various pain syndromes: from anatomy to clinical practice: PPG and its role in pain syndromes. Pain Pract. 2012;12(5):399–412.CrossRefPubMed Piagkou M, Demesticha T, Troupis T, Vlasis K, Skandalakis P, Makri A, et al. The pterygopalatine ganglion and its role in various pain syndromes: from anatomy to clinical practice: PPG and its role in pain syndromes. Pain Pract. 2012;12(5):399–412.CrossRefPubMed
13.
Zurück zum Zitat Fontaine D, Lazorthes Y, Mertens P, Blond S, Géraud G, Fabre N, et al. Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain. 2010;11(1):23–31.CrossRefPubMed Fontaine D, Lazorthes Y, Mertens P, Blond S, Géraud G, Fabre N, et al. Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain. 2010;11(1):23–31.CrossRefPubMed
14.
Zurück zum Zitat Silberstein SD, Dodick DW, Saper J, Huh B, Slavin KV, Sharan A, et al. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia Int J Headache. 2012;32(16):1165–79.CrossRef Silberstein SD, Dodick DW, Saper J, Huh B, Slavin KV, Sharan A, et al. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia Int J Headache. 2012;32(16):1165–79.CrossRef
15.
Zurück zum Zitat Oshinsky ML, Murphy AL, Hekierski H, Cooper M, Simon BJ. Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia. Pain. 2014;155(5):1037–42.CrossRefPubMedPubMedCentral Oshinsky ML, Murphy AL, Hekierski H, Cooper M, Simon BJ. Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia. Pain. 2014;155(5):1037–42.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Wolter T, Kiemen A, Kaube H. High cervical spinal cord stimulation for chronic cluster headache. Cephalalgia Int J Headache. 2011;31(11):1170–80.CrossRef Wolter T, Kiemen A, Kaube H. High cervical spinal cord stimulation for chronic cluster headache. Cephalalgia Int J Headache. 2011;31(11):1170–80.CrossRef
18.
Zurück zum Zitat Barker AT, Shields K. Transcranial magnetic stimulation: basic principles and clinical applications in migraine. Headache. 2017;57(3):517–24.CrossRefPubMed Barker AT, Shields K. Transcranial magnetic stimulation: basic principles and clinical applications in migraine. Headache. 2017;57(3):517–24.CrossRefPubMed
19.
Zurück zum Zitat Magis D, Sava S, d’Elia TS, Baschi R, Schoenen J. Safety and patients’ satisfaction of transcutaneous Supraorbital NeuroStimulation (tSNS) with the Cefaly® device in headache treatment: a survey of 2,313 headache sufferers in the general population. J Headache Pain. 2013;14(1):95.CrossRefPubMedPubMedCentral Magis D, Sava S, d’Elia TS, Baschi R, Schoenen J. Safety and patients’ satisfaction of transcutaneous Supraorbital NeuroStimulation (tSNS) with the Cefaly® device in headache treatment: a survey of 2,313 headache sufferers in the general population. J Headache Pain. 2013;14(1):95.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Ramsey RR, Ryan JL, Hershey AD, Powers SW, Aylward BS, Hommel KA. Treatment adherence in patients with headache: a systematic review. Headache. 2014;54(5):795–816.CrossRefPubMedPubMedCentral Ramsey RR, Ryan JL, Hershey AD, Powers SW, Aylward BS, Hommel KA. Treatment adherence in patients with headache: a systematic review. Headache. 2014;54(5):795–816.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Ibarra E. Neuromodulación del ganglio esfenopalatino para aliviar los síntomas de la cefalea en racimos: reporte de un caso. Dolor. 2007;12–8. Ibarra E. Neuromodulación del ganglio esfenopalatino para aliviar los síntomas de la cefalea en racimos: reporte de un caso. Dolor. 2007;12–8.
22.
Zurück zum Zitat Tepper SJ, Rezai A, Narouze S, Steiner C, Mohajer P, Ansarinia M. Acute treatment of intractable migraine with sphenopalatine ganglion electrical stimulation. Headache. 2009;49(7):983–9.CrossRefPubMed Tepper SJ, Rezai A, Narouze S, Steiner C, Mohajer P, Ansarinia M. Acute treatment of intractable migraine with sphenopalatine ganglion electrical stimulation. Headache. 2009;49(7):983–9.CrossRefPubMed
23.
Zurück zum Zitat Ansarinia M, Rezai A, Tepper SJ, Steiner CP, Stump J, Stanton-Hicks M, et al. Electrical stimulation of sphenopalatine ganglion for acute treatment of cluster headaches. Headache. 2010;50(7):1164–74.CrossRefPubMed Ansarinia M, Rezai A, Tepper SJ, Steiner CP, Stump J, Stanton-Hicks M, et al. Electrical stimulation of sphenopalatine ganglion for acute treatment of cluster headaches. Headache. 2010;50(7):1164–74.CrossRefPubMed
24.
Zurück zum Zitat Schoenen J, Jensen RH, Lantéri-Minet M, Láinez MJ, Gaul C, Goodman AM, et al. Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study. Cephalalgia. 2013;33(10):816–30. Schoenen J, Jensen RH, Lantéri-Minet M, Láinez MJ, Gaul C, Goodman AM, et al. Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study. Cephalalgia. 2013;33(10):816–30.
25.
Zurück zum Zitat Jürgens TP, Barloese M, May A, Láinez JM, Schoenen J, Gaul C, et al. Long-term effectiveness of sphenopalatine ganglion stimulation for cluster headache. Cephalalgia. 2017;37(5):423–34.CrossRefPubMed Jürgens TP, Barloese M, May A, Láinez JM, Schoenen J, Gaul C, et al. Long-term effectiveness of sphenopalatine ganglion stimulation for cluster headache. Cephalalgia. 2017;37(5):423–34.CrossRefPubMed
26.
Zurück zum Zitat Barloese MCJ, Jürgens TP, May A, Lainez JM, Schoenen J, Gaul C, et al. Cluster headache attack remission with sphenopalatine ganglion stimulation: experiences in chronic cluster headache patients through 24 months. J Headache Pain. 2016;17(1):67.CrossRefPubMedPubMedCentral Barloese MCJ, Jürgens TP, May A, Lainez JM, Schoenen J, Gaul C, et al. Cluster headache attack remission with sphenopalatine ganglion stimulation: experiences in chronic cluster headache patients through 24 months. J Headache Pain. 2016;17(1):67.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Barloese M, Petersen A, Stude P, Jürgens T, Jensen RH, May A. Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. J Headache Pain. 2018;19(1):6.CrossRefPubMedPubMedCentral Barloese M, Petersen A, Stude P, Jürgens T, Jensen RH, May A. Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. J Headache Pain. 2018;19(1):6.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Goadsby PJ, Sahai-Srivastava S, Kezirian EJ, Calhoun AH, Matthews DC, McAllister PJ, et al. Safety and efficacy of sphenopalatine ganglion stimulation for chronic cluster headache: a double-blind, randomised controlled trial. Lancet Neurol. 2019;18(12):1081–90.CrossRefPubMed Goadsby PJ, Sahai-Srivastava S, Kezirian EJ, Calhoun AH, Matthews DC, McAllister PJ, et al. Safety and efficacy of sphenopalatine ganglion stimulation for chronic cluster headache: a double-blind, randomised controlled trial. Lancet Neurol. 2019;18(12):1081–90.CrossRefPubMed
29.
Zurück zum Zitat Pietzsch JB, Garner A, Gaul C, May A. Cost-effectiveness of stimulation of the sphenopalatine ganglion (SPG) for the treatment of chronic cluster headache: a model-based analysis based on the Pathway CH-1 study. J Headache Pain. 2015;16(1):48.CrossRefPubMedPubMedCentral Pietzsch JB, Garner A, Gaul C, May A. Cost-effectiveness of stimulation of the sphenopalatine ganglion (SPG) for the treatment of chronic cluster headache: a model-based analysis based on the Pathway CH-1 study. J Headache Pain. 2015;16(1):48.CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Pietzsch JB, Weber SA, Lund N, Gaul C. Changes in medication cost observed in chronic cluster headache patients treated with sphenopalatine ganglion (SPG) stimulation: analysis based on 1-year data from the Pathway R-1 Registry. Cephalalgia Int J Headache. 2018;38(8):1455–62.CrossRef Pietzsch JB, Weber SA, Lund N, Gaul C. Changes in medication cost observed in chronic cluster headache patients treated with sphenopalatine ganglion (SPG) stimulation: analysis based on 1-year data from the Pathway R-1 Registry. Cephalalgia Int J Headache. 2018;38(8):1455–62.CrossRef
31.
Zurück zum Zitat Khan S, Schoenen J, Ashina M. Sphenopalatine ganglion neuromodulation in migraine: what is the rationale? Cephalalgia Int J Headache. 2014;34(5):382–91.CrossRef Khan S, Schoenen J, Ashina M. Sphenopalatine ganglion neuromodulation in migraine: what is the rationale? Cephalalgia Int J Headache. 2014;34(5):382–91.CrossRef
32.
Zurück zum Zitat Fontaine D, Santucci S, Lanteri-Minet M. Managing cluster headache with sphenopalatine ganglion stimulation: a review. J Pain Res. 2018;16(11):375–81.CrossRef Fontaine D, Santucci S, Lanteri-Minet M. Managing cluster headache with sphenopalatine ganglion stimulation: a review. J Pain Res. 2018;16(11):375–81.CrossRef
34.
35.
Zurück zum Zitat Goadsby PJ, Rezai AR, Dodick DW. The need for continued care after sponsor closure – Authors’ reply. Lancet Neurol. 2020;19(3):205–6.CrossRefPubMed Goadsby PJ, Rezai AR, Dodick DW. The need for continued care after sponsor closure – Authors’ reply. Lancet Neurol. 2020;19(3):205–6.CrossRefPubMed
Metadaten
Titel
Neuromodulation for the Sphenopalatine Ganglion—a Narrative Review
verfasst von
Taehong Lim
Stephen Anderson
Robert Stocum
Karen Ren
Winston Singleton
Jayesh Vallabh
Kristen Noon
Tristan Weaver
Publikationsdatum
23.08.2023
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 11/2023
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-023-01132-3

Weitere Artikel der Ausgabe 11/2023

Current Pain and Headache Reports 11/2023 Zur Ausgabe

Anesthetic Techniques in Pain Management (D Wang, Section Editor)

SPECT/CT Scan: A New Diagnostic Tool in Pain Medicine

Chronic Daily Headache (S-J Wang and S-P Chen, Section Editors)

Non-Pharmacological Treatment for Chronic Migraine

Hot Topics in Pain and Headache (N Rosen, Section Editor)

Does Tension Headache Have a Central or Peripheral Origin? Current State of Affairs

Secondary Headache (M Robbins, Section Editor)

Spontaneous Intracranial Hypotension in Pregnancy

Uncommon and/or Unusual Headaches and Syndromes (F Cohen, Section Editor)

Primary Cough Headache

Blutdrucksenkung schon im Rettungswagen bei akutem Schlaganfall?

31.05.2024 Apoplex Nachrichten

Der optimale Ansatz für die Blutdruckkontrolle bei Patientinnen und Patienten mit akutem Schlaganfall ist noch nicht gefunden. Ob sich eine frühzeitige Therapie der Hypertonie noch während des Transports in die Klinik lohnt, hat jetzt eine Studie aus China untersucht.

Ähnliche Überlebensraten nach Reanimation während des Transports bzw. vor Ort

29.05.2024 Reanimation im Kindesalter Nachrichten

Laut einer Studie aus den USA und Kanada scheint es bei der Reanimation von Kindern außerhalb einer Klinik keinen Unterschied für das Überleben zu machen, ob die Wiederbelebungsmaßnahmen während des Transports in die Klinik stattfinden oder vor Ort ausgeführt werden. Jedoch gibt es dabei einige Einschränkungen und eine wichtige Ausnahme.

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Häusliche Gewalt Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.