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Erschienen in: Herz 5/2013

01.08.2013 | CME Zertifizierte Fortbildung

Myokardrevaskularisation

verfasst von: Prof. Dr. H. Möllmann, S. Szardien, J. Kempfert, H. Nef, C. Liebetrau, T. Walther, C. Hamm

Erschienen in: Herz | Ausgabe 5/2013

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Zusammenfassung

Die koronare Herzkrankheit (KHK) zählt zu den häufigsten Erkrankungen der westlichen Welt und ist aufgrund der weiter steigenden Prävalenz von zentraler sozioökonomischer Bedeutung. Bis zur Einführung der perkutanen Koronarintervention (PCI) konnte die KHK neben der medikamentösen Therapie nur operativ behandelt werden. Die In-Stent-Restenose ist ein zentrales Problem nach Stentimplantation; durch die Verwendung neuer Stentmaterialien und -beschichtungen konnte die Häufigkeit dieser Komplikation jedoch entscheidend gesenkt werden. Heutzutage stehen daher mit der operativen Myokardrevaskularisation und der PCI 2 gleichwertige Therapieverfahren zur Verfügung. Welches Therapieverfahren für den Patienten geeignet ist, hängt u. a. von der Anzahl der erkrankten Gefäße, der Komplexität der Stenosen, von Begleiterkrankungen und dem Allgemeinzustand des Patienten ab. Das Behandlungsregime sollte anhand der Leitlinien der Europäischen und der Deutschen Gesellschaft für Kardiologie ausgerichtet werden, bei komplexen oder grenzwertigen Befunden empfiehlt sich die Besprechung des individuellen Therapiekonzepts in einer interdisziplinären Fallkonferenz.
Literatur
1.
Zurück zum Zitat Murray CJ, Lopez AD (1997) Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet 349:1498–1504PubMedCrossRef Murray CJ, Lopez AD (1997) Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet 349:1498–1504PubMedCrossRef
2.
Zurück zum Zitat Robert-Koch-Institut (Hrsg) (2006) Gesundheit in Deutschland. Gesundheitsberichterstattung des Bundes. Robert-Koch-Institut, Berlin Robert-Koch-Institut (Hrsg) (2006) Gesundheit in Deutschland. Gesundheitsberichterstattung des Bundes. Robert-Koch-Institut, Berlin
3.
Zurück zum Zitat Scholte op Reimer WJM, Gitt AK, Boersma E, Simoons ML (Hrsg) (2006) Cardiovascular diseases in Europe. Euro Heart Survey – 2006. European Society of Cardiology, Sophia Antipolis Scholte op Reimer WJM, Gitt AK, Boersma E, Simoons ML (Hrsg) (2006) Cardiovascular diseases in Europe. Euro Heart Survey – 2006. European Society of Cardiology, Sophia Antipolis
4.
Zurück zum Zitat Buuren F van (2010) 25. Bericht über die Leistungszahlen der Herzkatheterlabore in der Bundesrepublik Deutschland. Kardiologe 4:502–508CrossRef Buuren F van (2010) 25. Bericht über die Leistungszahlen der Herzkatheterlabore in der Bundesrepublik Deutschland. Kardiologe 4:502–508CrossRef
5.
Zurück zum Zitat Gummert JF, Funkat A, Beckmann A et al (2009) Cardiac surgery in Germany during 2008. A report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 57:315–323PubMedCrossRef Gummert JF, Funkat A, Beckmann A et al (2009) Cardiac surgery in Germany during 2008. A report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 57:315–323PubMedCrossRef
6.
Zurück zum Zitat Wijns W, Kolh P, Danchin N et al (2010) Guidelines on myocardial revascularization. Eur Heart J 31:2501–2555 Wijns W, Kolh P, Danchin N et al (2010) Guidelines on myocardial revascularization. Eur Heart J 31:2501–2555
7.
Zurück zum Zitat Bluemke DA, Achenbach S, Budoff M et al (2008) Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention, and the Councils on Clinical Cardiology and Cardiovascular Disease in the Young. Circulation 118:586–606PubMedCrossRef Bluemke DA, Achenbach S, Budoff M et al (2008) Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention, and the Councils on Clinical Cardiology and Cardiovascular Disease in the Young. Circulation 118:586–606PubMedCrossRef
8.
Zurück zum Zitat Schroeder S, Achenbach S, Bengel F et al (2008) Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. Eur Heart J 29:531–556CrossRef Schroeder S, Achenbach S, Bengel F et al (2008) Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. Eur Heart J 29:531–556CrossRef
9.
Zurück zum Zitat Sarno G, Decraemer I, Vanhoenacker PK et al (2009) On the inappropriateness of noninvasive multidetector computed tomography coronary angiography to trigger coronary revascularization: a comparison with invasive angiography. JACC Cardiovasc Interv 2:550–557PubMedCrossRef Sarno G, Decraemer I, Vanhoenacker PK et al (2009) On the inappropriateness of noninvasive multidetector computed tomography coronary angiography to trigger coronary revascularization: a comparison with invasive angiography. JACC Cardiovasc Interv 2:550–557PubMedCrossRef
10.
Zurück zum Zitat Cheitlin MD, Alpert JS, Armstrong WF et al (1997) ACC/AHA Guidelines for the clinical application of echocardiography. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Clinical Application of Echocardiography). Developed in collaboration with the American Society of Echocardiography. Circulation 95:1686–1744PubMedCrossRef Cheitlin MD, Alpert JS, Armstrong WF et al (1997) ACC/AHA Guidelines for the clinical application of echocardiography. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Clinical Application of Echocardiography). Developed in collaboration with the American Society of Echocardiography. Circulation 95:1686–1744PubMedCrossRef
11.
Zurück zum Zitat Marwick TH (1998) Current status of stress echocardiography for diagnosis and prognostic assessment of coronary artery disease. Coron Artery Dis 9:411–426PubMedCrossRef Marwick TH (1998) Current status of stress echocardiography for diagnosis and prognostic assessment of coronary artery disease. Coron Artery Dis 9:411–426PubMedCrossRef
12.
Zurück zum Zitat Schinkel AF, Bax JJ, Geleijnse ML et al (2003) Noninvasive evaluation of ischaemic heart disease: myocardial perfusion imaging or stress echocardiography? Eur Heart J 24:789–800CrossRef Schinkel AF, Bax JJ, Geleijnse ML et al (2003) Noninvasive evaluation of ischaemic heart disease: myocardial perfusion imaging or stress echocardiography? Eur Heart J 24:789–800CrossRef
13.
Zurück zum Zitat Ritchie JL, Bateman TM, Bonow RO et al (1995) Guidelines for clinical use of cardiac radionuclide imaging. Report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Committee on Radionuclide Imaging), developed in collaboration with the American Society of Nuclear Cardiology. J Am Coll Cardiol 25:521–547 Ritchie JL, Bateman TM, Bonow RO et al (1995) Guidelines for clinical use of cardiac radionuclide imaging. Report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Committee on Radionuclide Imaging), developed in collaboration with the American Society of Nuclear Cardiology. J Am Coll Cardiol 25:521–547
14.
Zurück zum Zitat Underwood SR, Anagnostopoulos C, Cerqueira M et al (2004) Myocardial perfusion scintigraphy: the evidence. Eur J Nucl Med Mol Imaging 31:261–291PubMedCrossRef Underwood SR, Anagnostopoulos C, Cerqueira M et al (2004) Myocardial perfusion scintigraphy: the evidence. Eur J Nucl Med Mol Imaging 31:261–291PubMedCrossRef
15.
Zurück zum Zitat Nandalur KR, Dwamena BA, Choudhri AF et al (2007) Diagnostic performance of stress cardiac magnetic resonance imaging in the detection of coronary artery disease: a meta-analysis. J Am Coll Cardiol 50:1343–1353 Nandalur KR, Dwamena BA, Choudhri AF et al (2007) Diagnostic performance of stress cardiac magnetic resonance imaging in the detection of coronary artery disease: a meta-analysis. J Am Coll Cardiol 50:1343–1353
16.
Zurück zum Zitat Fox K, Garcia MA, Ardissino D et al (2006) Guidelines on the management of stable angina pectoris: executive summary: the task force on the management of stable angina pectoris of the European Society of Cardiology. Eur Heart J 27:1341–1381 Fox K, Garcia MA, Ardissino D et al (2006) Guidelines on the management of stable angina pectoris: executive summary: the task force on the management of stable angina pectoris of the European Society of Cardiology. Eur Heart J 27:1341–1381
17.
Zurück zum Zitat Gould KL, Kirkeeide RL, Buchi M (1990) Coronary flow reserve as a physiologic measure of stenosis severity. J Am Coll Cardiol 15:459–474 Gould KL, Kirkeeide RL, Buchi M (1990) Coronary flow reserve as a physiologic measure of stenosis severity. J Am Coll Cardiol 15:459–474
18.
Zurück zum Zitat Pijls NH, Schaardenburgh P van, Manoharan G et al (2007) Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER study. J Am Coll Cardiol 49:2105–2111 Pijls NH, Schaardenburgh P van, Manoharan G et al (2007) Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER study. J Am Coll Cardiol 49:2105–2111
19.
Zurück zum Zitat Tonino PA, De Bruyne B, Pijls NH et al (2009) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 360:213–224 Tonino PA, De Bruyne B, Pijls NH et al (2009) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 360:213–224
20.
Zurück zum Zitat Hamm CW, Bassand JP, Agewall S et al (2011) ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32:2999–3054 Hamm CW, Bassand JP, Agewall S et al (2011) ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32:2999–3054
21.
Zurück zum Zitat Diercks DB, Peacock WF, Hiestand BC et al (2006) Frequency and consequences of recording an electrocardiogram >10 min after arrival in an emergency room in non-ST-segment elevation acute coronary syndromes (from the CRUSADE Initiative). Am J Cardiol 97:437–442PubMedCrossRef Diercks DB, Peacock WF, Hiestand BC et al (2006) Frequency and consequences of recording an electrocardiogram >10 min after arrival in an emergency room in non-ST-segment elevation acute coronary syndromes (from the CRUSADE Initiative). Am J Cardiol 97:437–442PubMedCrossRef
22.
Zurück zum Zitat Van de Werf F, Bax J, Betriu A et al (2008) Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 29:2909–2945CrossRef Van de Werf F, Bax J, Betriu A et al (2008) Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 29:2909–2945CrossRef
23.
Zurück zum Zitat Parisi AF, Folland ED, Hartigan P (1992) A comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease. Veterans Affairs ACME Investigators. N Engl J Med 326:10–16 Parisi AF, Folland ED, Hartigan P (1992) A comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease. Veterans Affairs ACME Investigators. N Engl J Med 326:10–16
24.
Zurück zum Zitat Boden WE, O’Rourke RA, Teo KK et al (2007) Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 356:1503–1516 Boden WE, O’Rourke RA, Teo KK et al (2007) Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 356:1503–1516
25.
Zurück zum Zitat Davies RF, Goldberg AD, Forman S et al (1997) Asymptomatic Cardiac Ischemia Pilot (ACIP) study two-year follow-up: outcomes of patients randomized to initial strategies of medical therapy versus revascularization. Circulation 95:2037–2043PubMedCrossRef Davies RF, Goldberg AD, Forman S et al (1997) Asymptomatic Cardiac Ischemia Pilot (ACIP) study two-year follow-up: outcomes of patients randomized to initial strategies of medical therapy versus revascularization. Circulation 95:2037–2043PubMedCrossRef
26.
Zurück zum Zitat Bucher HC, Hengstler P, Schindler C, Guyatt GH (2000) Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomised controlled trials. BMJ 321:73–77PubMedCrossRef Bucher HC, Hengstler P, Schindler C, Guyatt GH (2000) Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomised controlled trials. BMJ 321:73–77PubMedCrossRef
27.
Zurück zum Zitat Holmes DR Jr, Leon MB, Moses JW et al (2004) Analysis of 1-year clinical outcomes in the SIRIUS trial: a randomized trial of a sirolimus-eluting stent versus a standard stent in patients at high risk for coronary restenosis. Circulation 109:634–640PubMedCrossRef Holmes DR Jr, Leon MB, Moses JW et al (2004) Analysis of 1-year clinical outcomes in the SIRIUS trial: a randomized trial of a sirolimus-eluting stent versus a standard stent in patients at high risk for coronary restenosis. Circulation 109:634–640PubMedCrossRef
28.
Zurück zum Zitat Morice MC, Serruys PW, Sousa JE et al (2002) A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 346:1773–1780 Morice MC, Serruys PW, Sousa JE et al (2002) A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 346:1773–1780
29.
Zurück zum Zitat Stone GW, Ellis SG, Cox DA et al (2004) One-year clinical results with the slow-release, polymer-based, paclitaxel-eluting TAXUS stent: the TAXUS-IV trial. Circulation 109:1942–1947PubMedCrossRef Stone GW, Ellis SG, Cox DA et al (2004) One-year clinical results with the slow-release, polymer-based, paclitaxel-eluting TAXUS stent: the TAXUS-IV trial. Circulation 109:1942–1947PubMedCrossRef
30.
Zurück zum Zitat Stettler C, Wandel S, Allemann S et al (2007) Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet 370:937–948PubMedCrossRef Stettler C, Wandel S, Allemann S et al (2007) Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet 370:937–948PubMedCrossRef
31.
Zurück zum Zitat Kirtane AJ, Gupta A, Iyengar S et al (2009) Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies. Circulation 119:3198–3206PubMedCrossRef Kirtane AJ, Gupta A, Iyengar S et al (2009) Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies. Circulation 119:3198–3206PubMedCrossRef
32.
Zurück zum Zitat Scheller B, Hehrlein C, Bocksch W et al (2006) Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter. N Engl J Med 355:2113–2124 Scheller B, Hehrlein C, Bocksch W et al (2006) Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter. N Engl J Med 355:2113–2124
33.
Zurück zum Zitat Tatoulis J, Buxton BF, Fuller JA (2004) Patencies of 2127 arterial to coronary conduits over 15 years. Ann Thorac Surg 77:93–101PubMedCrossRef Tatoulis J, Buxton BF, Fuller JA (2004) Patencies of 2127 arterial to coronary conduits over 15 years. Ann Thorac Surg 77:93–101PubMedCrossRef
34.
Zurück zum Zitat Puskas J, Cheng D, Knight J et al (2005) Off-pump versus conventional coronary artery bypass grafting: a meta-analysis and consensus statement from the 2004 ISMICS Consensus Conference. Innovations (Phila) 1:3–27 Puskas J, Cheng D, Knight J et al (2005) Off-pump versus conventional coronary artery bypass grafting: a meta-analysis and consensus statement from the 2004 ISMICS Consensus Conference. Innovations (Phila) 1:3–27
35.
Zurück zum Zitat Emmert MY, Seifert B, Wilhelm M et al (2011) Aortic no-touch technique makes the difference in off-pump coronary artery bypass grafting. J Thorac Cardiovasc Surg 142:1499–1506 Emmert MY, Seifert B, Wilhelm M et al (2011) Aortic no-touch technique makes the difference in off-pump coronary artery bypass grafting. J Thorac Cardiovasc Surg 142:1499–1506
36.
Zurück zum Zitat Jones ML, Qiu S, Sudarshan C (2010) Perioperative outcomes in hybrid versus conventional surgical coronary artery revascularisation. Interact Cardiovasc Thorac Surg 11:292–296PubMedCrossRef Jones ML, Qiu S, Sudarshan C (2010) Perioperative outcomes in hybrid versus conventional surgical coronary artery revascularisation. Interact Cardiovasc Thorac Surg 11:292–296PubMedCrossRef
37.
Zurück zum Zitat Kappetein AP, Feldman TE, Mack MJ et al (2011) Comparison of coronary bypass surgery with drug-eluting stenting for the treatment of left main and/or three-vessel disease: 3-year follow-up of the SYNTAX trial. Eur Heart J 32:2125–2134CrossRef Kappetein AP, Feldman TE, Mack MJ et al (2011) Comparison of coronary bypass surgery with drug-eluting stenting for the treatment of left main and/or three-vessel disease: 3-year follow-up of the SYNTAX trial. Eur Heart J 32:2125–2134CrossRef
38.
Zurück zum Zitat Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361:13–20PubMedCrossRef Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361:13–20PubMedCrossRef
39.
Zurück zum Zitat Steg PG, Bonnefoy E, Chabaud S et al (2003) Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty: data from the CAPTIM randomized clinical trial. Circulation 108:2851–2856PubMedCrossRef Steg PG, Bonnefoy E, Chabaud S et al (2003) Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty: data from the CAPTIM randomized clinical trial. Circulation 108:2851–2856PubMedCrossRef
40.
Zurück zum Zitat Widimsky P, Budesinsky T, Vorac D et al (2003) Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial – PRAGUE-2. Eur Heart J 24:94–104CrossRef Widimsky P, Budesinsky T, Vorac D et al (2003) Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial – PRAGUE-2. Eur Heart J 24:94–104CrossRef
41.
Zurück zum Zitat Rastan AJ, Eckenstein JI, Hentschel B et al (2006) Emergency coronary artery bypass graft surgery for acute coronary syndrome: beating heart versus conventional cardioplegic cardiac arrest strategies. Circulation 114:I477–I485PubMedCrossRef Rastan AJ, Eckenstein JI, Hentschel B et al (2006) Emergency coronary artery bypass graft surgery for acute coronary syndrome: beating heart versus conventional cardioplegic cardiac arrest strategies. Circulation 114:I477–I485PubMedCrossRef
42.
Zurück zum Zitat Lorusso R, Gelsomino S, Carella R et al (2010) Impact of prophylactic intra-aortic balloon counter-pulsation on postoperative outcome in high-risk cardiac surgery patients: a multicentre, propensity-score analysis. Eur J Cardiothorac Surg 38:585–591PubMedCrossRef Lorusso R, Gelsomino S, Carella R et al (2010) Impact of prophylactic intra-aortic balloon counter-pulsation on postoperative outcome in high-risk cardiac surgery patients: a multicentre, propensity-score analysis. Eur J Cardiothorac Surg 38:585–591PubMedCrossRef
43.
Zurück zum Zitat Theroux P, Ouimet H, McCans J et al (1988) Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 319:1105–1111 Theroux P, Ouimet H, McCans J et al (1988) Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 319:1105–1111
44.
Zurück zum Zitat Theroux P, Waters D, Qiu S et al (1993) Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina. Circulation 88:2045–2048PubMedCrossRef Theroux P, Waters D, Qiu S et al (1993) Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina. Circulation 88:2045–2048PubMedCrossRef
45.
Zurück zum Zitat Baigent C, Blackwell L, Collins R et al (2009) Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373:1849–1860PubMedCrossRef Baigent C, Blackwell L, Collins R et al (2009) Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373:1849–1860PubMedCrossRef
46.
Zurück zum Zitat Mehta SR, Tanguay JF, Eikelboom JW et al (2010) Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS7): a randomised factorial trial. Lancet 376:1233–1243PubMedCrossRef Mehta SR, Tanguay JF, Eikelboom JW et al (2010) Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS7): a randomised factorial trial. Lancet 376:1233–1243PubMedCrossRef
47.
Zurück zum Zitat Yusuf S, Zhao F, Mehta SR et al (2001) Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345:494–502 Yusuf S, Zhao F, Mehta SR et al (2001) Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345:494–502
48.
Zurück zum Zitat Yusuf S, Mehta SR, Zhao F et al (2003) Early and late effects of clopidogrel in patients with acute coronary syndromes. Circulation 107:966–972PubMedCrossRef Yusuf S, Mehta SR, Zhao F et al (2003) Early and late effects of clopidogrel in patients with acute coronary syndromes. Circulation 107:966–972PubMedCrossRef
49.
Zurück zum Zitat Fox KA, Mehta SR, Peters R et al (2004) Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial. Circulation 110:1202–1208PubMedCrossRef Fox KA, Mehta SR, Peters R et al (2004) Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial. Circulation 110:1202–1208PubMedCrossRef
50.
Zurück zum Zitat Wiviott SD, Trenk D, Frelinger AL et al (2007) Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial. Circulation 116:2923–2932PubMedCrossRef Wiviott SD, Trenk D, Frelinger AL et al (2007) Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial. Circulation 116:2923–2932PubMedCrossRef
51.
Zurück zum Zitat Gurbel PA, Bliden KP, Butler K et al (2009) Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation 120:2577–2585PubMedCrossRef Gurbel PA, Bliden KP, Butler K et al (2009) Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation 120:2577–2585PubMedCrossRef
52.
Zurück zum Zitat Wiviott SD, Braunwald E, McCabe CH et al (2007) Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 357:2001–2015 Wiviott SD, Braunwald E, McCabe CH et al (2007) Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 357:2001–2015
53.
Zurück zum Zitat Wallentin L, Becker RC, Budaj A et al (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361:1045–1057 Wallentin L, Becker RC, Budaj A et al (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361:1045–1057
54.
Zurück zum Zitat Stone GW, Bertrand ME, Moses JW et al (2007) Routine upstream initiation vs deferred selective use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: the ACUITY Timing trial. JAMA 297:591–602PubMedCrossRef Stone GW, Bertrand ME, Moses JW et al (2007) Routine upstream initiation vs deferred selective use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: the ACUITY Timing trial. JAMA 297:591–602PubMedCrossRef
55.
Zurück zum Zitat Giugliano RP, White JA, Bode C et al (2009) Early versus delayed, provisional eptifibatide in acute coronary syndromes. N Engl J Med 360:2176–2190 Giugliano RP, White JA, Bode C et al (2009) Early versus delayed, provisional eptifibatide in acute coronary syndromes. N Engl J Med 360:2176–2190
56.
Zurück zum Zitat White HD, Ohman EM, Lincoff AM et al (2008) Safety and efficacy of bivalirudin with and without glycoprotein IIb/IIIa inhibitors in patients with acute coronary syndromes undergoing percutaneous coronary intervention 1-year results from the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. J Am Coll Cardiol 52:807–814 White HD, Ohman EM, Lincoff AM et al (2008) Safety and efficacy of bivalirudin with and without glycoprotein IIb/IIIa inhibitors in patients with acute coronary syndromes undergoing percutaneous coronary intervention 1-year results from the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. J Am Coll Cardiol 52:807–814
57.
Zurück zum Zitat Hulten E, Jackson JL, Douglas K et al (2006) The effect of early, intensive statin therapy on acute coronary syndrome: a meta-analysis of randomized controlled trials. Arch Intern Med 166:1814–1821PubMedCrossRef Hulten E, Jackson JL, Douglas K et al (2006) The effect of early, intensive statin therapy on acute coronary syndrome: a meta-analysis of randomized controlled trials. Arch Intern Med 166:1814–1821PubMedCrossRef
58.
Zurück zum Zitat Cannon CP, Braunwald E, McCabe CH et al (2004) Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 350:1495–1504 Cannon CP, Braunwald E, McCabe CH et al (2004) Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 350:1495–1504
Metadaten
Titel
Myokardrevaskularisation
verfasst von
Prof. Dr. H. Möllmann
S. Szardien
J. Kempfert
H. Nef
C. Liebetrau
T. Walther
C. Hamm
Publikationsdatum
01.08.2013
Verlag
Urban & Vogel
Erschienen in
Herz / Ausgabe 5/2013
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI
https://doi.org/10.1007/s00059-013-3917-9

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Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

Update Kardiologie

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