Ausgabe 1/2021
Inhalt (176 Artikel)
Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency
Dong Il Choi, Myeongwon Kim, Somi Kim, Nam-Kyung Yu, Chuljung Kwak, Hyunhyo Seo, Kyungmin Lee, Bong-Kiun Kaang
Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation
Min Soo Kang, Jin-Hee Han
Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort
Xiao Liang, ShiQiang Cheng, Jing Ye, XiaoMeng Chu, Yan Wen, Li Liu, Xin Qi, YuMeng Jia, Feng Zhang
A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels
Eder Gambeta, Maria A. Gandini, Ivana A. Souza, Laurent Ferron, Gerald W. Zamponi
Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice
Shigeo Miyata, Toshikazu Kakizaki, Kazuyuki Fujihara, Hideru Obinata, Touko Hirano, Junichi Nakai, Mika Tanaka, Shigeyoshi Itohara, Masahiko Watanabe, Kenji F. Tanaka, Manabu Abe, Kenji Sakimura, Yuchio Yanagawa
Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells
So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo, Dong-Hyung Cho
Regulation of behavioral response to stress by microRNA-690
Jungyoung Park, Joonhee Lee, Koeul Choi, Hyo Jung Kang
Roles of palmitoylation in structural long-term synaptic plasticity
Benjun Ji, Małgorzata Skup
The nuclear lamina is a hub for the nuclear function of Jacob
Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz, Anna Karpova
Distinct role of 5′UTR sequences in dendritic trafficking of BDNF mRNA: additional mechanisms for the BDNF splice variants spatial code
Andrea Colliva, Enrico Tongiorgi
Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice
Jinho Kim, Yoo-Hun Suh, Keun-A Chang
Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development
Fengping Dong, Joseph Mao, Miranda Chen, Joy Yoon, Yingwei Mao
Choice-dependent cross-modal interaction in the medial prefrontal cortex of rats
Mengyao Zheng, Jinghong Xu, Les Keniston, Jing Wu, Song Chang, Liping Yu
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150glued
Bo Kyoung Suh, Seol-Ae Lee, Cana Park, Yeongjun Suh, Soo Jeong Kim, Youngsik Woo, Truong Thi My Nhung, Su Been Lee, Dong Jin Mun, Bon Seong Goo, Hyun Sun Choi, So Jung Kim, Sang Ki Park
The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion
Tao Wang, Jin Tao, Yehong Fang, Chao Ma
Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2
Ria Thomas, Elizabeth B. Moloney, Zachary K. Macbain, Penelope J. Hallett, Ole Isacson
Altered functional connectivity between hypothalamus and limbic system in fibromyalgia
Jian Kong, Yiting Huang, Jiao Liu, Siyi Yu, Cheng Ming, Helen Chen, Georgia Wilson, William F. Harvey, Wen Li, Chenchen Wang
Rare functional missense variants in CACNA1H: What can we learn from Writer’s cramp?
Miaozhen Huang, Esther A. R. Nibbeling, Tjerk J. Lagrand, Ivana A. Souza, Justus L. Groen, Maria A. Gandini, Fang-Xiong Zhang, Johannes H. T. M. Koelman, Noam Adir, Richard J. Sinke, Gerald W. Zamponi, Marina A. J. Tijssen, Dineke S. Verbeek
The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells
Qin Ma, Alessandro Didonna
Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15
Kimberly Gomez, Dongzhi Ran, Cynthia L. Madura, Aubin Moutal, Rajesh Khanna
Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons
Kazuhiro Hada, Bolati Wulaer, Taku Nagai, Norimichi Itoh, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Daisuke Mori, Itaru Kushima, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamada
No observed effect on brain vasculature of Alzheimer’s disease-related mutations in the zebrafish presenilin 1 gene
Karissa Barthelson, Morgan Newman, Cameron J. Nowell, Michael Lardelli
Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks
M. Asada-Utsugi, K. Uemura, M. Kubota, Y. Noda, Y. Tashiro, T. M. Uemura, H. Yamakado, M. Urushitani, R. Takahashi, S. Hattori, T. Miyakawa, N. Ageta-Ishihara, K. Kobayashi, M. Kinoshita, A. Kinoshita
Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes
Sangyep Shin, Andrea Santi, Shiyong Huang
iTRAQ-based proteomic profiling reveals protein alterations after traumatic brain injury and supports thyroxine as a potential treatment
Zhongxiang Zhang, Jiangtao Yu, Pengcheng Wang, Lian Lin, Ruining Liu, Rong Zeng, Haoli Ma, Yan Zhao
Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses
Pojeong Park, Heather Kang, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function
Maria A. Gandini, Ivana A. Souza, Laurent Ferron, A. Micheil Innes, Gerald W. Zamponi
2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors
Serena Boccella, Francesca Guida, Monica Iannotta, Fabio Arturo Iannotti, Rosmara Infantino, Flavia Ricciardi, Claudia Cristiano, Rosa Maria Vitale, Pietro Amodeo, Ida Marabese, Carmela Belardo, Vito de Novellis, Salvatore Paino, Enza Palazzo, Antonio Calignano, Vincenzo Di Marzo, Sabatino Maione, Livio Luongo
Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study
Jian Yang, Binbin Zhao, Li Qian, Fengjie Gao, Yanjuan Fan, Xiaoyan He, Qingyan Ma, Lihong Yang, Bin Yan, Wei Wang, Xiancang Ma
Metabolic fingerprints of fear memory consolidation during sleep
Iyo Koyanagi, Kazuhiro Sonomura, Toshie Naoi, Takaaki Ohnishi, Naoko Kaneko, Kazunobu Sawamoto, Taka-Aki Sato, Masanori Sakaguchi
PDK1 is a negative regulator of axon regeneration
Hyemin Kim, Jinyoung Lee, Yongcheol Cho
Extracting single-trial neural interaction using latent dynamical systems model
Namjung Huh, Sung-Phil Kim, Joonyeol Lee, Jeong-woo Sohn
GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter
Chiaki Hoshino, Ayumu Konno, Nobutake Hosoi, Ryosuke Kaneko, Ryo Mukai, Junichi Nakai, Hirokazu Hirai
The IL33 receptor ST2 contributes to mechanical hypersensitivity in mice with neuropathic pain
Junting Huang, Vinicius M. Gadotti, Zizhen Zhang, Gerald W. Zamponi
Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord
Hui Wang, Liang Xu, Chuying Lai, Kaiyu Hou, Junliang Chen, Yaowei Guo, Abhijeet Sambangi, Shreya Swaminathan, Chunming Xie, Zheng Wu, Gong Chen
Proteomic insights into synaptic signaling in the brain: the past, present and future
Yalan Xu, Xiuyue Song, Dong Wang, Yin Wang, Peifeng Li, Jing Li
Long-range GABAergic projections from the nucleus of the solitary tract
Mei-Yu Shi, Lu-Feng Ding, Yu-Hong Guo, Yu-Xiao Cheng, Guo-Qiang Bi, Pak-Ming Lau
Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice
Chunmei Jin, Yeunkum Lee, Hyojin Kang, Kwon Jeong, Joori Park, Yinhua Zhang, Hyae Rim Kang, Ruiying Ma, Hyunyoung Seong, Yoonhee Kim, Hosung Jung, Jin Young Kim, Yoon Ki Kim, Kihoon Han
Correction to: GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior
Yuanyuan Xu, Mike T. Lin, Xiang-ming Zha
Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice
Yujun Guo, Guichang Zou, Keke Qi, Jin Jin, Lei Yao, Yang Pan, Wei Xiong
Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway
Sarayut Phasuk, Tanita Pairojana, Pavithra Suresh, Chee-Hing Yang, Sittiruk Roytrakul, Shun-Ping Huang, Chien-Chang Chen, Narawut Pakaprot, Supin Chompoopong, Sutisa Nudmamud-Thanoi, Ingrid Y. Liu
Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima
Interactions between the amygdala and medial prefrontal cortex as upstream regulators of the hippocampus to reconsolidate and enhance retrieved inhibitory avoidance memory
Hotaka Fukushima, Yue Zhang, Satoshi Kida
AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain
Fei Zeng, Qiaosheng Zhang, Yaling Liu, Guanghao Sun, Anna Li, Robert S. Talay, Jing Wang
Ethosuximide inhibits acute histamine- and chloroquine-induced scratching behavior in mice
Vinicius M. Gadotti, Gerald W. Zamponi
SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity
Unghwi Lee, Seung Hyun Ryu, Sunghoe Chang
Correction to: Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity
Alan Jung Park, Mahesh Shivarama Shetty, Jay M. Baraban, Ted Abel
Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice
Pan Wang, Ke Tu, Peng Cao, Yuefan Yang, Hao Zhang, Xin-Tong Qiu, Ming-Ming Zhang, Xiao-Jun Wu, Hui Yang, Tao Chen
Alterations in the gut microbiota and metabolite profiles in the context of neuropathic pain
Peng Chen, Chen Wang, Yan-na Ren, Zeng-jie Ye, Chao Jiang, Zhi-bing Wu
Correction to: Increase in excitability of hippocampal neurons during novelty-induced hyperlocomotion in dopamine-deficient mice
Masayo Fujita, Yukiko Ochiai, Taishi-Clark Takeda, Yoko Hagino, Kazuto Kobayashi, Kazutaka Ikeda
The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice
Hisako Sugimoto, Takuro Horii, Jun-Na Hirota, Yoshitake Sano, Yo Shinoda, Ayumu Konno, Hirokazu Hirai, Yasuki Ishizaki, Hajime Hirase, Izuho Hatada, Teiichi Furuichi, Tetsushi Sadakata
Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons
Soulmee Koh, Wongyoung Lee, Sang Myun Park, Sung Hyun Kim
The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex
Xin Wang, Wei Jiang, Shuo Luo, Xiaoyu Yang, Changnan Wang, Bingying Wang, Yongjun Dang, Yin Shen, Dengke K. Ma
α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice
Yuto Shiraishi, Keisuke Koga, Ryo Yamagata, Izuho Hatada, Miho Shiratori-Hayashi, Makoto Tsuda
Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder
Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo, Tomoya Takemoto, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Neurodegenerative phosphoprotein signaling landscape in models of SCA3
Anna S. Sowa, Taissia G. Popova, Tina Harmuth, Jonasz J. Weber, Priscila Pereira Sena, Jana Schmidt, Jeannette Hübener-Schmid, Thorsten Schmidt
Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons
Mutsumi Yokota, Soichiro Kakuta, Takahiro Shiga, Kei-ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koike
SGTA associates with intracellular aggregates in neurodegenerative diseases
Shun Kubota, Hiroshi Doi, Shigeru Koyano, Kenichi Tanaka, Hiroyasu Komiya, Atsuko Katsumoto, Shingo Ikeda, Shunta Hashiguchi, Haruko Nakamura, Ryoko Fukai, Keita Takahashi, Misako Kunii, Mikiko Tada, Hideyuki Takeuchi, Fumiaki Tanaka
NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice
Qi-Yu Chen, Xu-Hui Li, Jing-Shan Lu, Yinglu Liu, Jung-Hyun Alex Lee, Yu-Xin Chen, Wantong Shi, Kexin Fan, Min Zhuo
Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior
Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation
Kyung-Ran Kim, Yoonsub Kim, Hyeon-Ju Jeong, Jong-Sun Kang, Sang Hun Lee, Yujin Kim, Suk-Ho Lee, Won-Kyung Ho
Projection-dependent heterogeneity of cerebellar granule cell calcium responses
Jun Kyu Rhee, Heeyoun Park, Taegon Kim, Yukio Yamamoto, Keiko Tanaka-Yamamoto
Correction to: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors
Serena Boccella, Francesca Guida, Monica Iannotta, Fabio Arturo Iannotti, Rosmara Infantino, Flavia Ricciardi, Claudia Cristiano, Rosa Maria Vitale, Pietro Amodeo, Ida Marabese, Carmela Belardo, Vito de Novellis, Salvatore Paino, Enza Palazzo, Antonio Calignano, Vincenzo Di Marzo, Sabatino Maione, Livio Luongo
Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
Yun Lim, Seolsong Kim, Eun-Kyoung Kim
Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Masayasu Okada, Yosuke Kawagoe, Yuta Sato, Motohiro Nozumi, Yuya Ishikawa, Atsushi Tamada, Hiroyuki Yamazaki, Yuko Sekino, Yonehiro Kanemura, Yohei Shinmyo, Hiroshi Kawasaki, Naoko Kaneko, Kazunobu Sawamoto, Yukihiko Fujii, Michihiro Igarashi
Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors
Mingzhao Su, Junhua Liu, Baocong Yu, Kaixing Zhou, Congli Sun, Mengjie Yang, Chunjie Zhao
Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders
Ryo Saito, Chika Miyoshi, Michinori Koebis, Itaru Kushima, Kazuki Nakao, Daisuke Mori, Norio Ozaki, Hiromasa Funato, Masashi Yanagisawa, Atsu Aiba
Correction to: Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice
Pan Wang, Ke Tu, Peng Cao, Yuefan Yang, Hao Zhang, Xin-Tong Qiu, Ming-Ming Zhang, Xiao-Jun Wu, Hui Yang, Tao Chen
Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John
Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice
Kai Qian, Jiaqi Liu, Yiqing Cao, Jing Yang, Shuang Qiu
Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity
Sarayut Phasuk, Sureka Jasmin, Tanita Pairojana, Hsueh-Kai Chang, Kai-Chi Liang, Ingrid Y. Liu
Drosophila Graf regulates mushroom body β-axon extension and olfactory long-term memory
Sungdae Kim, Joohyung Kim, Sunyoung Park, Joong-Jean Park, Seungbok Lee
Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis
Hiroyasu Komiya, Hideyuki Takeuchi, Yuki Ogawa, Kosuke Suzuki, Akihiro Ogasawara, Keita Takahashi, Yasu-Taka Azuma, Hiroshi Doi, Fumiaki Tanaka
FMRP attenuates activity dependent modifications in the mitochondrial proteome
Pernille Bülow, Stephanie A. Zlatic, Peter A. Wenner, Gary J. Bassell, Victor Faundez
Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
Hirotoshi Magota, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Ryo Ukai, Ryo Kiyose, Rie Onodera, Jeffery D. Kocsis, Osamu Honmou
Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice
Tiziana Imbriglio, Remy Verhaeghe, Nico Antenucci, Stefania Maccari, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella
Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation
Boren Lin, Khaled Alganem, Sinead M. O’Donovan, Zhen Jin, FarzanehSadat Naghavi, Olivia A. Miller, Tyler C. Ortyl, Ye Chun Ruan, Robert E. McCullumsmith, Jianyang Du
Activation of spinal dorsal horn astrocytes by noxious stimuli involves descending noradrenergic signaling
Riku Kawanabe, Kohei Yoshihara, Izuho Hatada, Makoto Tsuda
Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)
Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls
Isabel Ellerbrock, Angelica Sandström, Jeanette Tour, Silvia Fanton, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Rouslan Sitnikov, Eva Kosek
Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss
Toru Miwa, Fan-yan Wei, Kazuhito Tomizawa
Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson’s disease
Hui Yung Chin, Michael Lardelli, Lyndsey Collins-Praino, Karissa Barthelson
Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model
Jesús David Urbano-Gámez, Juan José Casañas, Itziar Benito, María Luz Montesinos
Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity
Sang Hun Lee, Vadim Y. Bolshakov, Jie Shen
Optimization of protocols for pre-embedding immunogold electron microscopy of neurons in cell cultures and brains
Jung-Hwa Tao-Cheng, Virginia Crocker, Sandra Lara Moreira, Rita Azzam
Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
Lara Friess, Mathilde Cheray, Lily Keane, Kathleen Grabert, Bertrand Joseph
Multiple synaptic connections into a single cortical pyramidal cell or interneuron in the anterior cingulate cortex of adult mice
Jung-Hyun Alex Lee, Zhuang Miao, Qi-Yu Chen, Xu-Hui Li, Min Zhuo
Cannabinoid receptors distribution in mouse cortical plasma membrane compartments
Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B. Laprairie, Changiz Taghibiglou
The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells
Teiichi Furuichi, Yuko Muto, Tetsushi Sadakata, Yumi Sato, Kanehiro Hayashi, Yoko Shiraishi-Yamaguchi, Yo Shinoda
Reversibility of motor dysfunction in the rat model of NGLY1 deficiency
Makoto Asahina, Reiko Fujinawa, Hiroto Hirayama, Ryuichi Tozawa, Yasushi Kajii, Tadashi Suzuki
Molecular laterality encodes stress susceptibility in the medial prefrontal cortex
Sujin Chae, Jiso Hong, Keunsoo Kang, Anna Shin, Dae-Gun Kim, Sinjeong Lee, Moo-young Kim, Inkyung Jung, Daesoo Kim
Correction to: Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect
Gi Seok Jeong, Joon Young Chang, Ji Soo Park, Seung-A Lee, DoYeun Park, Junsung Woo, Heeyoung An, C. Justin Lee, Sang-Hoon Lee
The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice
Mariko Ito, Masashi Nagase, Suguru Tohyama, Kaori Mikami, Fusao Kato, Ayako M. Watabe
In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons
Yukti Vyas, Yewon Jung, Kevin Lee, Craig C. Garner, Johanna M. Montgomery
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Tertia D. Purves-Tyson, Amelia M. Brown, Christin Weissleder, Debora A. Rothmond, Cynthia Shannon Weickert
Adult neurogenesis mediates forgetting of multiple types of memory in the rat
Gavin A. Scott, Dylan J. Terstege, Andrew J. Roebuck, Kelsea A. Gorzo, Alex P. Vu, John G. Howland, Jonathan R. Epp
Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons
Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak P. Srivastava, Nicholas J. Bray, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Ehsan Pishva, Emma L. Dempster, Katie Lunnon, Jonathan Mill, Eilis Hannon
The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury
Jiyun Peng, Min-Hee Yi, Heejin Jeong, Przemyslaw Peter McEwan, Jiaying Zheng, Gongxiong Wu, Shashank Ganatra, Yi Ren, Jason R. Richardson, Seog Bae Oh, Long-Jun Wu
Autophagy activity contributes to the impairment of social recognition in Epac2−/− mice
Ji-Hye Kwak, You-kyung Lee, Mi-Hee Jun, Mootaek Roh, Hyunhyo Seo, Juhyun Lee, Kyungmin Lee, Jin-A Lee
Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation
Shannon L. Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J. Russo, Gustavo Turecki, Amy M. Gancarz-Kausch, David M. Dietz, Mary Kay Lobo
In vivo imaging of immediate early gene expression dynamics segregates neuronal ensemble of memories of dual events
P. Meenakshi, S. Kumar, J. Balaji
Correction to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
Hyungju Park, Kyung-Seok Han, Jinsoo Seo, Jaekwang Lee, Shashank M. Dravid, Junsung Woo, Heejung Chun, Sukhee Cho, Jin Young Bae, Heeyoung An, Woohyun Koh, Bo-Eun Yoon, Rolando Berlinguer-Palmini, Guido Mannaioni, Stephen F. Traynelis, Yong Chul Bae, Se-Young Choi, C. Justin Lee
Aversive emotion rapidly activates orexin neurons and increases heart rate in freely moving mice
Akira Yamashita, Shunpei Moriya, Ryusei Nishi, Jun Kaminosono, Akihiro Yamanaka, Tomoyuki Kuwaki
Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice
Yutaka Koizumi, Kunio Mizutari, Satoko Kawauchi, Shunichi Sato, Akihiro Shiotani, Seiji Kakehata
Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice
Yong Gyu Kim, Myeong Seong Bak, Ahbin Kim, Yujin Kim, Yun-Cheol Chae, Ye Lee Kim, Yang-Sook Chun, Joon-Yong An, Sang-Beom Seo, Sang Jeong Kim, Yong-Seok Lee
Disrupting the α7nAChR–NR2A protein complex exerts antidepressant-like effects
Anlong Jiang, Ping Su, Shupeng Li, Albert H. C. Wong, Fang Liu
Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John
Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein
Fan Jia, Li Li, Haizhou Liu, Pei Lv, Xiangwei Shi, Yang Wu, Chen Ling, Fuqiang Xu
APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains
Joseph O. Ojo, Jon M. Reed, Gogce Crynen, Prashanthi Vallabhaneni, James Evans, Benjamin Shackleton, Maximillian Eisenbaum, Charis Ringland, Anastasia Edsell, Michael Mullan, Fiona Crawford, Corbin Bachmeier
Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
Moonseok Choi, Sang-Min Lee, Dongsoo Kim, Heh-In Im, Hye-Sun Kim, Yun Ha Jeong
A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen, Claire Desnos
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy
Hao Wu, Yong Liu, Lishuo Liu, Qiang Meng, Changwang Du, Kuo Li, Shan Dong, Yong Zhang, Huanfa Li, Hua Zhang
Correction to: Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice
Tiziana Imbriglio, Remy Verhaeghe, Nico Antenucci, Stefania Maccari, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella
Modeling temperature- and Cav3 subtype-dependent alterations in T-type calcium channel mediated burst firing
Fernando R. Fernandez, Mircea C. Iftinca, Gerald W. Zamponi, Ray W. Turner
Meningitic Escherichia coli α-hemolysin aggravates blood–brain barrier disruption via targeting TGFβ1-triggered hedgehog signaling
Jiyang Fu, Liang Li, Dong Huo, Ruicheng Yang, Bo Yang, Bojie Xu, Xiaopei Yang, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang
Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons
Sun Huang, Stefanie A. Black, Junting Huang, Peter K. Stys, Gerald W. Zamponi
RNA-seq co-expression network analysis reveals anxiolytic behavior of mice with Efnb2 knockout in parvalbumin+ neurons
Ying Sun, Le Ma, Jianhua Chen, Weidi Wang, Shiyu Peng, Ying Cheng, Yu Zhang, Jinghong Chen, Peijun Ju
The role m6A RNA methylation is CNS development and glioma pathogenesis
Ting Pan, Fan Wu, Liwen Li, Shiyan Wu, Fang Zhou, Ping Zhang, Caixing Sun, Liang Xia
Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients
Arpna Srivastava, Krishan Kumar, Jyotirmoy Banerjee, Manjari Tripathi, Vivek Dubey, Devina Sharma, Nitin Yadav, M. C. Sharma, Sanjeev Lalwani, Ramesh Doddamani, P. Sarat Chandra, Aparna Banerjee Dixit
Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
Haiwang Zhang, Youssif Ben Zablah, An Liu, Dongju Lee, Haorui Zhang, Yanghong Meng, Changxi Zhou, Xingde Liu, Yiming Wang, Zhengping Jia
Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons
Tae-Young Ha, Yu Ree Choi, Hye Rin Noh, Seon-Heui Cha, Jae-Bong Kim, Sang Myun Park
Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury
Yuan Yao, Yingshi Ji, Jinghong Ren, Huanyu Liu, Rajesh Khanna, Li Sun
TPEN attenuates amyloid-β25–35-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels
Wen-bo Chen, Yu-xiang Wang, Hong-gang Wang, Di An, Dan Sun, Pan Li, Tao Zhang, Wan-ge Lu, Yan-qiang Liu
Altered hippocampal transcriptome dynamics following sleep deprivation
Marie E. Gaine, Ethan Bahl, Snehajyoti Chatterjee, Jacob J. Michaelson, Ted Abel, Lisa C. Lyons
De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy
Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Ivana A. Souza, Judy Ibrahim, Tomas Vacik, Waseem Mahmoud Fathalla, Jozef Hertecant, Gerald W. Zamponi, Lubica Lacinova, Norbert Weiss
Correction to: Reversibility of motor dysfunction in the rat model of NGLY1 deficiency
Makoto Asahina, Reiko Fujinawa, Hiroto Hirayama, Ryuichi Tozawa, Yasushi Kajii, Tadashi Suzuki
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo
Maxinne Watchon, Luan Luu, Katherine J. Robinson, Kristy C. Yuan, Alana De Luca, Hannah J. Suddull, Madelaine C. Tym, Gilles J. Guillemin, Nicholas J. Cole, Garth A. Nicholson, Roger S. Chung, Albert Lee, Angela S. Laird
Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits
Yang Zhou, Huanyu Lu, Ying Liu, Zaihua Zhao, Qian Zhang, Chong Xue, Yuankang Zou, Zipeng Cao, Wenjing Luo
Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons
Anne-Sophie Racine, François-Xavier Michon, Isabel Laplante, Jean-Claude Lacaille
Modeling PTEN overexpression-induced microcephaly in human brain organoids
Navroop Dhaliwal, Wendy W.Y. Choi, Julien Muffat, Yun Li
Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply
Jens V. Andersen, Emil W. Westi, Emil Jakobsen, Nerea Urruticoechea, Karin Borges, Blanca I. Aldana
Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression
Yujing Chen, Peilin Meng, Shiqiang Cheng, Yumeng Jia, Yan Wen, Xuena Yang, Yao Yao, Chuyu Pan, Chun’e Li, Huijie Zhang, Jingxi Zhang, Zhen Zhang, Feng Zhang
GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis
Brittany A. Mayweather, Sean M. Buchanan, Lee L. Rubin
Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila
Ryuichi Nakajima, Hideo Hagihara, Tsuyoshi Miyakawa
Functional organization of the midbrain periaqueductal gray for regulating aversive memory formation
Li-Feng Yeh, Takaaki Ozawa, Joshua P. Johansen
Multivalent electrostatic pi–cation interaction between synaptophysin and synapsin is responsible for the coacervation
Goeun Kim, Sang-Eun Lee, Seonyoung Jeong, Jeongkun Lee, Daehun Park, Sunghoe Chang
Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events
Yong Gyu Kim, Jae Jin Shin, Sang Jeong Kim
Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain
Fang-bing Shao, Jun-fan Fang, Si-si Wang, Meng-ting Qiu, Dan-ning Xi, Xiao-ming Jin, Jing-gen Liu, Xiao-mei Shao, Zui Shen, Yi Liang, Jian-qiao Fang, Jun-ying Du
Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice
Hui-Hui Miao, Zhuang Miao, Ji-Gang Pan, Xu-Hui Li, Min Zhuo
Arginine vasopressin in the medial amygdala causes greater post-stress recruitment of hypothalamic vasopressin neurons
Wen Han Tong, Samira Abdulai-Saiku, Ajai Vyas
The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain
Sang Ho Yoon, Woo Seok Song, Sung Pyo Oh, Young Sook Kim, Myoung-Hwan Kim
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition
Chelsie A. Kadgien, Anusha Kamesh, Austen J. Milnerwood
Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1
Yana Van Den Herrewegen, Thomas M. Sanderson, Surajit Sahu, Dimitri De Bundel, Zuner A. Bortolotto, Ilse Smolders
Splice-variant specific effects of a CACNA1H mutation associated with writer’s cramp
Ivana A. Souza, Maria A. Gandini, Gerald W. Zamponi
Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery
Yosuke Katsuda, Kenichi Tanaka, Tomohisa Mori, Michiko Narita, Hideyuki Takeshima, Takashige Kondo, Yoshiyuki Yamabe, Misa Matsufuji, Daisuke Sato, Yusuke Hamada, Keisuke Yamaguchi, Toshikazu Ushijima, Eiichi Inada, Naoko Kuzumaki, Masako Iseki, Minoru Narita
Hypoxia with inflammation and reperfusion alters membrane resistance by dynamically regulating voltage-gated potassium channels in hippocampal CA1 neurons
Yoon-Sil Yang, Joon Ho Choi, Jong-Cheol Rah
Rapid generation of conditional knockout mice using the CRISPR-Cas9 system and electroporation for neuroscience research
Hirofumi Nishizono, Yuki Hayano, Yoshihisa Nakahata, Yasuhito Ishigaki, Ryohei Yasuda
Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro
Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, Kousuke Baba, Hitoshi Hashimoto, Yuko Sekino, Tomoaki Shirao, Hideki Mochizuki, Yonehiro Kanemura
Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus
Yi-Hung Chen, Sheng-Yun Xie, Chao-Wei Chen, Dah-Yuu Lu
Ackr3-Venus knock-in mouse lights up brain vasculature
Aliza T. Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L. Kieffer
Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents
Li-Ching Lee, Ming-Tsan Su, Hsing-Ying Huang, Ying-Chun Cho, Ting-Kuang Yeh, Chun-Yen Chang
Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory
Yoonjeong Jeon, Yun Lim, Jiwoo Yeom, Eun-Kyoung Kim
S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS
Junqing Du, Min Yi, Fang Zhou, Wanjun He, Aifen Yang, Mengsheng Qiu, Hao Huang
Bisperoxovanadium promotes motor neuron survival and neuromuscular innervation in amyotrophic lateral sclerosis
Junmei Wang, Lydia Tierney, Ranjeet Mann, Thomas Lonsway, Chandler L. Walker
Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll, Cathryn L. Haigh
Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding
Nan Li, Na Li, Fenghua Xu, Ming Yu, Zichen Qiao, Yu Zhou
Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
Shekhar Kedia, Kousik Mandal, Pallavi Rao Netrakanti, Mini Jose, Sangram S. Sisodia, Deepak Nair
Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices
Giulia Panattoni, Roberta Amoriello, Christian Memo, Agnes Thalhammer, Clara Ballerini, Laura Ballerini
Seasonal regulation of singing-driven gene expression associated with song plasticity in the canary, an open-ended vocal learner
Shin Hayase, Chengru Shao, Masahiko Kobayashi, Chihiro Mori, Wan-chun Liu, Kazuhiro Wada
Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease
Zhaoxiang Zhou, Penghai Ye, Xu-Hui Li, Yuxiang Zhang, Muhang Li, Qi-Yu Chen, Jing-Shan Lu, Man Xue, Yanan Li, Weiqi Liu, Lin Lu, Wantong Shi, Ping-Yi Xu, Min Zhuo
Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
Nadine F. Joseph, Aya Zucca, Jenna L. Wingfield, Isabel Espadas, Damon Page, Sathyanarayanan V. Puthanveettil
Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain
Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori, Akio Wanaka
Correction to: Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes
Adan Hernandez, Chunfeng Tan, Florian Plattner, Aric F. Logsdon, Karine Pozo, Mohammad A. Yousuf, Tanvir Singh, Ryan C. Turner, Brandon P. Lucke-Wold, Jason D. Huber, Charles L. Rosen, James A. Bibb
VMAT2 availability in Parkinson’s disease with probable REM sleep behaviour disorder
Mikaeel Valli, Sang Soo Cho, Carme Uribe, Mario Masellis, Robert Chen, Alexander Mihaescu, Antonio P. Strafella
The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels
Vinicius M. Gadotti, Sun Huang, Gerald W. Zamponi
Avoidance memory requires CaMKII activity to persist after recall
Andressa Radiske, Maria Carolina Gonzalez, Janine I. Rossato, Gênedy Apolinário, João R. de Oliveira, Lia R. M. Bevilaqua, Martín Cammarota
Brain substrates for automatic retrieval of value memory in the primate basal ganglia
Hyoung F. Kim
Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons
Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker, Jeremy H. Herskowitz
Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda, Yu Hayashi
Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus
Jea Kwon, Minwoo Wendy Jang, C. Justin Lee
Retrosplenial cortex in spatial memory: focus on immediate early genes mapping
Edyta Balcerek, Urszula Włodkowska, Rafał Czajkowski
A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro
Chihiro Nakamoto, Yuhei Goto, Yoko Tomizawa, Yuko Fukata, Masaki Fukata, Kasper Harpsøe, David E. Gloriam, Kazuhiro Aoki, Tomonori Takeuchi
Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
Dae Hee Han, Ilgang Hong, Ja Eun Choi, Pojeong Park, Jun-Yeong Baek, HyoJin Park, Soichiro Ide, Masayoshi Mishina, Kazutaka Ikeda, Bong-Kiun Kaang
Enhanced synchronization between prelimbic and infralimbic cortices during fear extinction learning
Mayumi Watanabe, Akira Uematsu, Joshua P. Johansen
Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases
Yanjun Xu, Zhiyu Huang, Xiaoqing Yu, Kaiyan Chen, Yun Fan