Skip to main content
Erschienen in: InFo Hämatologie + Onkologie 3/2023

21.03.2023 | Knochentumoren | Schwerpunkt

Schwerpunkt "Knochentumoren"

Systemische Therapie von Osteosarkomen*

verfasst von: Prof. Dr. med. Stefan Bielack, Priv.-Doz. Dr. med. Peter Reichardt, Prof. Dr. med. Lars Lindner, Dr. med. Stefanie Hecker-Nolting

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 3/2023

Einloggen, um Zugang zu erhalten

Auszug

Osteosarkome sind die häufigsten primär malignen Knochentumorerkrankungen. Ihre gut etablierte Standardtherapie besteht aus einer kompletten Tumoroperation, die in eine intensive prä- und postoperative Chemotherapie eingebettet wird. Allerdings ließen sich die Heilungsraten unter dieser Standardtherapie schon seit langem nicht mehr steigern. Der vorliegende Beitrag fokussiert daher auf die Frage, ob sich durch neuere und zielgerichtete Behandlungsansätze diese prognostische Stagnation zukünftig durchbrechen lassen wird. …
Literatur
1.
Zurück zum Zitat Ekhtiari S et al. First case of osteosarcoma in a dinosaur: a multimodal diagnosis. Lancet Oncol. 2020;21(8):1021-2 Ekhtiari S et al. First case of osteosarcoma in a dinosaur: a multimodal diagnosis. Lancet Oncol. 2020;21(8):1021-2
2.
Zurück zum Zitat Jaffe N et al. Osteosarcoma: evolution of treatment paradigms. Sarcoma. 2013;2013:203531 Jaffe N et al. Osteosarcoma: evolution of treatment paradigms. Sarcoma. 2013;2013:203531
3.
Zurück zum Zitat Meazza C, Asaftei SD. State-of-the-art, approved therapeutics for the pharmacological management of osteosarcoma. Expert Opin Pharmacother. 2021;22(15):1995-2006 Meazza C, Asaftei SD. State-of-the-art, approved therapeutics for the pharmacological management of osteosarcoma. Expert Opin Pharmacother. 2021;22(15):1995-2006
4.
Zurück zum Zitat Hecker-Nolting S et al. Bone sarcoma: success through interdisciplinary collaboration. J Child Orthop. 2021;15(4):331-6 Hecker-Nolting S et al. Bone sarcoma: success through interdisciplinary collaboration. J Child Orthop. 2021;15(4):331-6
5.
Zurück zum Zitat Bielack SS et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 2002;20(3):776-90 Bielack SS et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 2002;20(3):776-90
7.
Zurück zum Zitat Strauss SJ et al. Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2021;32(12):1520-36 Strauss SJ et al. Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2021;32(12):1520-36
8.
Zurück zum Zitat Ferrari S et al. EURO-B.O.S.S.: A European study on chemotherapy in bone-sarcoma patients aged over 40: outcome in primary high-grade osteosarcoma. Tumori. 2018;104(1):30-6 Ferrari S et al. EURO-B.O.S.S.: A European study on chemotherapy in bone-sarcoma patients aged over 40: outcome in primary high-grade osteosarcoma. Tumori. 2018;104(1):30-6
9.
Zurück zum Zitat Anninga JK et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011;47(16):2431-45 Anninga JK et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011;47(16):2431-45
10.
Zurück zum Zitat Meyers PA et al. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival—a report from the children's oncology group. J Clin Oncol. 2008;26(4):633-8 Meyers PA et al. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival—a report from the children's oncology group. J Clin Oncol. 2008;26(4):633-8
11.
Zurück zum Zitat No authors listed (2011) Mifamurtide: osteosarcoma: ineffective and harmful. Prescrire Int. 2011;20(115):89 No authors listed (2011) Mifamurtide: osteosarcoma: ineffective and harmful. Prescrire Int. 2011;20(115):89
12.
Zurück zum Zitat Smeland S et al. Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American osteosarcoma study) cohort. Eur J Cancer. 2019;109:36-50 Smeland S et al. Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American osteosarcoma study) cohort. Eur J Cancer. 2019;109:36-50
13.
Zurück zum Zitat Marina NM et al. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol. 2016;17(10):1396-408 Marina NM et al. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol. 2016;17(10):1396-408
14.
Zurück zum Zitat Bielack SS et al. Methotrexate, doxorubicin, and cisplatin (MAP) plus maintenance pegylated interferon alfa-2b versus MAP alone in patients with resectable high-grade Osteosarcoma and good Histologic response to preoperative MAP: first results of the EURAMOS-1 good response randomized controlled trial. J Clin Oncol. 2015;33(20):2279-87 Bielack SS et al. Methotrexate, doxorubicin, and cisplatin (MAP) plus maintenance pegylated interferon alfa-2b versus MAP alone in patients with resectable high-grade Osteosarcoma and good Histologic response to preoperative MAP: first results of the EURAMOS-1 good response randomized controlled trial. J Clin Oncol. 2015;33(20):2279-87
15.
Zurück zum Zitat Le Deley MC et al. SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients. Eur J Cancer. 2007;43(4):752-61 Le Deley MC et al. SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients. Eur J Cancer. 2007;43(4):752-61
16.
Zurück zum Zitat Piperno-Neumann S et al. Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol. 2016;17(8):1070-80 Piperno-Neumann S et al. Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol. 2016;17(8):1070-80
17.
Zurück zum Zitat Benjamin RS. Osteosarcoma: better treatment through better trial design. Lancet Oncol. 2015;16(1):12-3 Benjamin RS. Osteosarcoma: better treatment through better trial design. Lancet Oncol. 2015;16(1):12-3
18.
Zurück zum Zitat Lagmay JP et al. Outcome of patients with recurrent osteosarcoma enrolled in seven phase II trials through children's cancer group, pediatric oncology group, and children's oncology group: learning from the past to move forward. J Clin Oncol. 2016;34(25):3031-8 Lagmay JP et al. Outcome of patients with recurrent osteosarcoma enrolled in seven phase II trials through children's cancer group, pediatric oncology group, and children's oncology group: learning from the past to move forward. J Clin Oncol. 2016;34(25):3031-8
19.
Zurück zum Zitat Bielack SS et al. Update zum Osteosarkom - CME-Test Teil 1. J Oncol. 2021;6:1-4 Bielack SS et al. Update zum Osteosarkom - CME-Test Teil 1. J Oncol. 2021;6:1-4
20.
Zurück zum Zitat Pappo AS et al. A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: results of a sarcoma alliance for research through collaboration study. Cancer. 2014;120:2448-56 Pappo AS et al. A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: results of a sarcoma alliance for research through collaboration study. Cancer. 2014;120:2448-56
21.
Zurück zum Zitat Anderson PM et al. A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma. Pediatr Blood Cancer. 2016;63(10):1761-70 Anderson PM et al. A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma. Pediatr Blood Cancer. 2016;63(10):1761-70
22.
Zurück zum Zitat Tawbi HA et al. Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol. 2017;18(11):1493-501 Tawbi HA et al. Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol. 2017;18(11):1493-501
23.
Zurück zum Zitat Le Cesne A et al. Programmed cell death 1 (PD-1) targeting in patients with advanced osteosarcomas: results from the PEMBROSARC study. Eur J Cancer. 2019;119:151-7 Le Cesne A et al. Programmed cell death 1 (PD-1) targeting in patients with advanced osteosarcomas: results from the PEMBROSARC study. Eur J Cancer. 2019;119:151-7
24.
Zurück zum Zitat Boye K et al. Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial. Cancer Immunol Immunother. 2021;70(9):2617-24 Boye K et al. Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial. Cancer Immunol Immunother. 2021;70(9):2617-24
25.
Zurück zum Zitat Davoli T et al. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017;355(6322):eaaf8399 Davoli T et al. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017;355(6322):eaaf8399
26.
Zurück zum Zitat Grignani G et al. A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian sarcoma group study. Ann Oncol. 2012;23(2):508-16 Grignani G et al. A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian sarcoma group study. Ann Oncol. 2012;23(2):508-16
27.
Zurück zum Zitat Grignani G et al. Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial. Lancet Oncol. 2015;16(1):98-107 Grignani G et al. Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial. Lancet Oncol. 2015;16(1):98-107
28.
Zurück zum Zitat Duffaud F et al. Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study. Lancet Oncol. 2019;20(1):120-33 Duffaud F et al. Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study. Lancet Oncol. 2019;20(1):120-33
29.
Zurück zum Zitat Davis LE et al. Randomized double-blind phase II study of regorafenib in patients with metastatic osteosarcoma. J Clin Oncol. 2019;37(16):1424-31 Davis LE et al. Randomized double-blind phase II study of regorafenib in patients with metastatic osteosarcoma. J Clin Oncol. 2019;37(16):1424-31
30.
Zurück zum Zitat Xie L et al. Apatinib for advanced osteosarcoma after failure of standard multimodal therapy: an open label phase II clinical trial. Oncologist. 2019;24(7):e542-e550 Xie L et al. Apatinib for advanced osteosarcoma after failure of standard multimodal therapy: an open label phase II clinical trial. Oncologist. 2019;24(7):e542-e550
31.
Zurück zum Zitat Italiano A, Mir O, Mathoulin-Pelissier S, Penel N, Piperno-Neumann S, Bompas E et al. Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 21(3):446-55 Italiano A, Mir O, Mathoulin-Pelissier S, Penel N, Piperno-Neumann S, Bompas E et al. Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 21(3):446-55
32.
Zurück zum Zitat van Tilburg CM et al. The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets. Cancer Discov. 2021;11(11):2764-79 van Tilburg CM et al. The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets. Cancer Discov. 2021;11(11):2764-79
33.
Zurück zum Zitat Duchman KR et al. Prognostic factors for survival in patients with high-grade osteosarcoma using the surveillance, epidemiology, and end results (SEER) program database. Cancer Epidemiol. 2015;39(4):593-9 Duchman KR et al. Prognostic factors for survival in patients with high-grade osteosarcoma using the surveillance, epidemiology, and end results (SEER) program database. Cancer Epidemiol. 2015;39(4):593-9
35.
Zurück zum Zitat Seidensaal K et al. The role of combined ion-beam radiotherapy (CIBRT) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma. Radiother Oncol. 2021;159:8-16 Seidensaal K et al. The role of combined ion-beam radiotherapy (CIBRT) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma. Radiother Oncol. 2021;159:8-16
36.
Zurück zum Zitat Bielack et al. Osteosarcomas in older adults: A report from the Cooperative Osteosarcoma Study Group. J Geriatr Oncol. 2023;14(3):101445 Bielack et al. Osteosarcomas in older adults: A report from the Cooperative Osteosarcoma Study Group. J Geriatr Oncol. 2023;14(3):101445
37.
Zurück zum Zitat Meltzer PS, Helman LJ. New horizons in the treatment of osteosarcoma. N Engl J Med. 2021;385(22):2066-76 Meltzer PS, Helman LJ. New horizons in the treatment of osteosarcoma. N Engl J Med. 2021;385(22):2066-76
38.
Zurück zum Zitat Mirabello L et al. Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma. JAMA Oncol. 6(5):724-34 Mirabello L et al. Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma. JAMA Oncol. 6(5):724-34
39.
Zurück zum Zitat Plana A et al. Pediatric cancer data commons: federating and democratizing data for childhood cancer research. JCO Clin Cancer Inform. 2021;5:1034-43 Plana A et al. Pediatric cancer data commons: federating and democratizing data for childhood cancer research. JCO Clin Cancer Inform. 2021;5:1034-43
Metadaten
Titel
Schwerpunkt "Knochentumoren"
Systemische Therapie von Osteosarkomen*
verfasst von
Prof. Dr. med. Stefan Bielack
Priv.-Doz. Dr. med. Peter Reichardt
Prof. Dr. med. Lars Lindner
Dr. med. Stefanie Hecker-Nolting
Publikationsdatum
21.03.2023
Verlag
Springer Medizin
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 3/2023
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-023-9846-8

Weitere Artikel der Ausgabe 3/2023

InFo Hämatologie + Onkologie 3/2023 Zur Ausgabe

Neues aus der Forschung

Bosutinib langfristig effektiv

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

28.05.2024 Nebenwirkungen der Krebstherapie Nachrichten

Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.