European Journal of Nuclear Medicine and Molecular Imaging OnlineFirst articles

28.05.2024 | Editorial

Rapid advancements in PET/MR: the 4th chinese PET/MR academic symposium

verfasst von:: Min Zhang, Rui Guo, Hanzhong Wang, Jun Zhao, Biao Li

28.05.2024 | Original Article

Individual cerebellar metabolic connectome in patients with MTLE and NTLE associated with surgical prognosis

Focal epilepsy, the prevailing type of epilepsy, manifests as seizures that either involve a single focus or can occur in multiple foci [ 1 ]. The primary method of treating epilepsy is through long-term administration of antiseizure medications …

verfasst von:: Yongxiang Tang, Haoyue Zhu, Ling Xiao, Rong Li, Honghao Han, Weiting Tang, Ding Liu, Chunyao Zhou, Dingyang Liu, Zhiquan Yang, Luo Zhou, Bo Xiao, Axel Rominger, Kuangyu Shi, Shuo Hu, Li Feng

25.05.2024 | Original Article

End of induction [18F]FDG PET is prognostic for progression-free survival and overall survival in follicular lymphoma patients enrolled in the FOLL12 trial

Follicular lymphoma (FL) is the most common type of indolent lymphoma [ 1 ], characterized by a relatively favourable response to initial therapy, especially after the introduction of rituximab [ 2 – 4 ]. However, FL is associated with a …

verfasst von:: Luca Guerra, Stephane Chauvie, Federico Fallanca, Fabrizio Bergesio, Luigi Marcheselli, Rexhep Durmo, Simona Peano, Antonella Franceschetto, Lavinia Monaco, Emiliano Barbieri, Marco Ladetto, Gerardo Musuraca, Patrizia Tosi, Benedetta Bianchi, Silvia Anna Maria Bolis, Vincenzo Pavone, Annalisa Chiarenza, Annalisa Arcari, Catello Califano, Alessia Bari, Massimo Massaia, Annarita Conconi, Pellegrino Musto, Donato Mannina, Giovanni Roti, Sara Galimberti, Guido Gini, Flavio Falcinelli, Umberto Vitolo, Sara Veronica Usai, Piero Maria Stefani, Adalberto Ibatici, Anna Marina Liberati, Elsa Pennese, Tommasina Perrone, Annibale Versari, Stefano Luminari, on behalf of Fondazione Italiana Linfomi (FIL)

25.05.2024 | Original Article

Models using comprehensive, lesion-level, longitudinal [68Ga]Ga-DOTA-TATE PET-derived features lead to superior outcome prediction in neuroendocrine tumor patients treated with [177Lu]Lu-DOTA-TATE

The introduction of peptide receptor radionuclide therapy (PRRT) has improved the standard of care for neuroendocrine tumor (NET) patients [ 1 , 2 ]. However, NET patients benefit differently from PRRT. For example, Werner et al. reported that in a …

verfasst von:: Victor Santoro-Fernandes, Brayden Schott, Ali Deatsch, Quinton Keigley, Thomas Francken, Renuka Iyer, Christos Fountzilas, Scott Perlman, Robert Jeraj

24.05.2024 | Editorial

Why and how optical molecular imaging should further be catalyzed by nuclear medicine and molecular imaging: report from the EANM piloting group

verfasst von:: J. Vonk, R. A.J.O. Dierckx, S. Keereweer, A.L. Vahrmeijer, F.A. Verburg, S. Kruijff

24.05.2024 | Correction

Correction to: Development and validation of [18 F]-PSMA-1007 PET-based radiomics model to predict biochemical recurrence-free survival following radical prostatectomy

verfasst von:: Tiancheng Li, Mimi Xu, Shuye Yang, Guolin Wang, Yinuo Liu, Kaifeng Liu, Kui Zhao, Xinhui Su

Open Access 24.05.2024 | Original Article

PET imaging of Aspergillus infection using Zirconium-89 labeled anti-β-glucan antibody fragments

Invasive fungal infections (IFIs) are life-threatening diseases mainly seen in immunocompromised and immunodeficient patients [ 1 , 2 ]. Aspergillus fumigatus ( A. fumigatus ) is the most common IFI pathogen, affecting over 250,000 patients …

verfasst von:: Jianhao Lai, Swati Shah, Neysha Martinez-Orengo, Rekeya Knight, Eyob Alemu, Mitchell L. Turner, Benjamin Wang, Anna Lyndaker, Jianfeng Shi, Falguni Basuli, Dima A. Hammoud

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24.05.2024 | Original Article

Development and evaluation of albumin binder-conjugated heterodimeric radiopharmaceuticals targeting integrin αvβ3 and CD13 for cancer therapy

Angiogenesis plays a crucial role in tumor growth, progression, and metastasis by fulfilling the increasing demand for oxygen and nutrients [ 1 ]. Targeting neovascularization has emerged as a promising strategy in cancer diagnosis and treatment [ …

verfasst von:: Biao Yang, Changyu Shan, Xiangming Song, Xiaoying Lv, Yu Long, Dexing Zeng, Rui An, Xiaoli Lan, Yongkang Gai

24.05.2024 | Editorial

Patient communication of nuclear imaging results: do nuclear medicine practitioners have a role to play?

Nuclear medicine practitioners are faced with the responsibility of communicating imaging examination results to clinicians involved directly in the management of patients referred to them for imaging studies, but do they have a role in …

verfasst von:: Sandra Gonzalez, Frédéric Comte, Jean-Marc Israël, Fabrice Rezungles, Pierre Le Coz, David Taïeb

Open Access 22.05.2024 | Original Article

Lutetium [177Lu]-DOTA-TATE in gastroenteropancreatic-neuroendocrine tumours: rationale, design and baseline characteristics of the Italian prospective observational (REAL-LU) study

Neuroendocrine tumours (NETs) constitute a heterogeneous group of rare malignant neoplasms originating from the neuroendocrine cell system [ 1 – 3 ]. The presentation, prognosis, molecular features, clinical behaviour and location of NETs are …

verfasst von:: Secondo Lastoria, Marcello Rodari, Maddalena Sansovini, Sergio Baldari, Antonio D’Agostini, Anna Rita Cervino, Angelina Filice, Matteo Salgarello, Germano Perotti, Alberto Nieri, Davide Campana, Riccardo Emanuele Pellerito, Elena Pomposelli, Valeria Gaudieri, Giovanni Storto, Chiara Maria Grana, Alberto Signore, Giuseppe Boni, Francesco Dondi, Gabriele Simontacchi, Ettore Seregni

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Open Access 21.05.2024 | Image of the Month

Concomitant metastatic head-and-neck cancer and pancreatic cancer assessed by αvβ6-integrin PET/CT using 68Ga-Trivehexin: incidental detection of a brain metastasis

verfasst von:: Jana Rehm, Robert Winzer, Johannes Notni, Sebastian Hempel, Marius Distler, Gunnar Folprecht, Jörg Kotzerke

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21.05.2024 | Original Article

Chelator boosted tumor-retention and pharmacokinetic properties: development of 64Cu labeled radiopharmaceuticals targeting neurotensin receptor

Lung cancer is the most common cancer and the leading cause of cancer-related death in both men and women worldwide [ 1 ]. The estimated number of deaths from lung and bronchus cancer in 2021 for both sexes is 131,880, accounting for 21.7% of all …

verfasst von:: Tao Zhang, Xinrui Ma, Muyun Xu, Jinghua Cai, Jianhua Cai, Yanguang Cao, Zhihao Zhang, Xin Ji, Jian He, German Oscar Fonseca Cabrera, Xuedan Wu, Weiling Zhao, Zhanhong Wu, Jin Xie, Zibo Li

21.05.2024 | Editorial

STING-targeted PET imaging: unveiling tumor immunogenicity post-chemotherapy in colorectal cancer

verfasst von:: Chao Li, Rachel J. Saladin, Weibo Cai, Weiyu Chen

20.05.2024 | Image of the Month

Successful radioiodine redifferentiation with selpercatinib in RET fusion-positive papillary thyroid carcinoma

verfasst von:: Daniela Weiler, MD, Maria del Sol Pérez Lago, MD

Open Access 20.05.2024 | Original Article

Optimization and impact of sensitivity mode on abbreviated scan protocols with population-based input function for parametric imaging of [18F]-FDG for a long axial FOV PET scanner

Hybrid positron emission tomography (PET)/computed tomography (CT) systems have been accepted as standard-of-care imaging modality in oncology, cardiology and neurology [ 1 , 2 ]. The standardised uptake value (SUV), determined from a static image …

verfasst von:: W. Lan, H. Sari, A. Rominger, C. la Fougère, F. P. Schmidt

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20.05.2024 | Original Article

[68Ga]Ga-FAPI-04 PET/MR imaging strategy in management of Krukenberg tumors (KTs) from gastric signet-ring-cell carcinoma: to overcome limitation of [68Ga]Ga-FAPI-04 PET imaging in KTs

Ovarian metastases of signet ring cell cancer (SRCC) are referred to as Krukenberg tumors (KTs) and account for approximately 1–2% of all ovarian cancers [ 1 ]. The stomach is the most common primary site for Krukenberg tumors, followed by the …

verfasst von:: Tingting Wang, Gan Huang, Haitao Zhao, Lianghua Li, Yanying Shen, Weihua Lou, Jianjun Liu

18.05.2024 | Short Communication

[68Ga]Ga-FAPI-46 PET/CT for penile cancer – a feasibility study

Penile cancer (PeCa) is a rare disease in industrial countries with a worldwide incidence of 0.08/100.000 [ 1 ]. 5-year overall survival is 95% for localized disease and drops to 35–80% in pN + patients [ 2 ]. Patients with ≥ pT1b and cN0 status on …

verfasst von:: Lennert Eismann, Stephan T. Ledderose, Benazir Enzinger, Elena Berg, Thilo Westhofen, Severin Rodler, Gerald B. Schulz, Johannes Toms, Adrien Holzgreve, Franz J. Gildehaus, Matthias Brendel, Clemens C. Cyran, Marcus Unterrainer, Christian G. Stief, Peter Bartenstein, Boris Schlenker, Lena M. Unterrainer

Open Access 17.05.2024 | Image of the Month

Distinct [18F]FDG-PET imaging features of a newly recognized and yet uncharacterized RDD-ECD overlap disease entity

verfasst von:: Martin W. Huellner, Marco M. Bühler, Viktor H. Kölzer, Perparim Limani, Wiebke Rösler

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Open Access 17.05.2024 | Original Article

Assessment of cerebral drug occupancy in humans using a single PET-scan: A [11C]UCB-J PET study

About 1% of the global population suffers from epilepsy [ 1 ], and for approximately 30% of the patients, anti-seizure medication (ASM) does not lead to seizure freedom [ 2 ]. Levetiracetam (LEV) is a very commonly used ASM approved for the …

verfasst von:: Maja R. Marstrand-Joergensen, Gjertrud L. Laurell, Susan Herrmann, Arafat Nasser, Annette Johansen, Anton Lund, Thomas L. Andersen, Gitte M. Knudsen, Lars H. Pinborg

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16.05.2024 | Original Article

FAPI PET uptake patterns after invasive medical interventions: a single center retrospective analysis

Fibroblasts are the most common component of connective tissues and are found throughout the body [ 1 ]. In normal tissues, they are resting mesenchymal cells in the extracellular matrix (ECM). Normal activated fibroblasts (NAF) aid in repair and …

verfasst von:: Peter George Maliha, Masatoshi Hotta, Andrea Farolfi, Tristan Grogan, Rejah Alano, Andrea Limon, Ethan Lam, Giuseppe Carlucci, Shadfar Bahri, Ali Salavati, Matthias Benz, Daniel Silverman, Pawan Gupta, Andrew Quon, Martin Allen-Auerbach, Johannes Czernin, Jeremie Calais

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