Endocrine OnlineFirst articles

31.05.2024 | Original Article

Continuous glucose monitoring profile in COVID-19 patients with and without diabetes receiving methylprednisolone

Evidence based on multiple randomized trials and guidelines indicates that early systemic glucocorticoid therapy can improve clinical outcomes and reduce mortality in hospitalized patients with coronavirus disease 2019 (COVID-19) who require …

verfasst von:: Xingxing He, Guangchen Duan, Jingyi Lu, Yaxin Wang, Jinghao Cai, Yiqing Tong, Wei Wu, Xiaojing Ma, Qiming Feng, Jian Zhou

31.05.2024 | Original Article

Alteration in gut microbial characteristics of patients with acromegaly

Acromegaly is a rare disorder characterized by hypersecretion of growth hormone (GH) and its peripheral target hormone insulin-like growth factor-1 (IGF-1) [ 1 ]. The majority of patients with acromegaly have GH-secreting pituitary adenomas …

verfasst von:: Afruz Babayeva, Ceren Ozkul, Meric Coskun, Arzu Uzun, Mehmet Muhittin Yalcin, Meltem Yalinay, Mujde Akturk, Fusun Balos Toruner, Mehmet Ayhan Karakoc, Ilhan Yetkin, Alev Eroglu Altinova

Open Access 30.05.2024 | Original Article

Utility of time in tight range (TITR) in evaluating metabolic control in pediatric and adult patients with type 1 diabetes in treatment with advanced hybrid closed-loop systems

In the last century, there have been continuous advances in the treatment of diabetes, with technological advancements gaining special relevance in recent decades. One of the most notable technological milestones is the interstitial glucose …

verfasst von:: Pilar Bahillo-Curieses, Pablo Fernández Velasco, Paloma Pérez-López, Ana María Vidueira Martínez, María de la O Nieto de la Marca, Gonzalo Díaz-Soto

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Open Access 30.05.2024 | Meta-Analysis

Adherence to the dietary approaches to stop hypertension diet reduces the risk of diabetes mellitus: a systematic review and dose-response meta-analysis

Type 2 diabetes mellitus (DM) represents a major global health problem, which has become a severe, chronic, non-communicable disease after cardio-cerebrovascular diseases [ 1 ]. According to the statistics reported by the International Diabetes …

verfasst von:: Xiyan Quan, Xiaoming Shen, Chun Li, Yayuan Li, Tiangang Li, Baifan Chen

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30.05.2024 | Original Article

Associations of four surrogate insulin resistance indexes with non-alcoholic steatohepatitis in Chinese patients with obesity: a cross-sectional study

In the past, obesity and its co-morbidities were considered intractable health problems in Western countries. However, as Asian countries urbanize, sedentary lifestyles and excessive nutrient intake create a hidden danger for the obesity epidemic.

verfasst von:: Jinfeng Xiao, Xinxin Zhang, Lina Chang, Hong Yu, Longhao Sun, Chonggui Zhu, Qing He

29.05.2024 | Original Article

DXA-derived lumbar bone strain index corrected for kyphosis is associated with vertebral fractures and trabecular bone score in acromegaly

In acromegaly, assessment of skeletal health and prediction of fractures may be a challenge, since skeletal alterations caused by growth hormone (GH) hypersecretion are not generally captured by dual-energy X-ray absorptiometry (DXA) measurement …

verfasst von:: Simona Jaafar, Giacomo Cristofolini, Emanuela Morenghi, Luca Rinaudo, Maria Francesca Birtolo, Elisa Sala, Emanuele Ferrante, Roberta Mungari, Elisabetta Lavezzi, Lorenzo Leonardi, Pasquala Ragucci, Fabio M. Ulivieri, Luca Balzarini, Giovanna Mantovani, Andrea G. Lania, Gherardo Mazziotti

29.05.2024 | Original Article

Survival benefit of postoperative radioiodine therapy among patients with intermediate-risk differentiated thyroid carcinoma

The incidence of thyroid cancer is declining from 2014 to 2018 due to recent changes in clinical practice designed to mitigate over-detection. However, it is estimated that about 43,800 people will be diagnosed in the United States in 2022 [ 1 – 3 …

verfasst von:: Jinwen Wang, Yaqian Mao, Liantao Li, Jixing Liang, Huibin Huang, Wei Lin, Gang Chen, Junping Wen

29.05.2024 | Research

A machine learning-based diagnosis modeling of IgG4 Hashimoto’s thyroiditis

Hashimoto’s thyroiditis (HT) is a common form of autoimmune thyroid disease, with a prevalence up to 2% and showing an increasing trend. The production of specific autoantibodies to thyroglobulin (Tg) and thyroperoxidase (TPO) is one of the most …

verfasst von:: Chenxu Zhao, Zhiming Sun, Yang Yu, Yiwei Lou, Liyuan Liu, Ge Li, Jumei Liu, Lei Chen, Sainan Zhu, Yu Huang, Yang Zhang, Ying Gao

28.05.2024 | Original Article

Single-cell transcriptome analysis reveals the regulatory functions of islet exocrine cells after short-time obesogenic diet

Pancreatic islets include multiple distinct cell types, such as α, β, δ, pancreatic polypeptide, ductal, endothelium, and acinar cells, which are responsible for energy metabolism and glucose homeostasis [ 1 ]. Cells with different functions …

verfasst von:: Qianqian Sun, Huiyu Tang, Huan Zhu, Yanyan Liu, Min Zhang, Chenghang Che, Bing Xiang, Shuang Wang

Open Access 28.05.2024 | Brief Report

Wnt/β-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma

verfasst von:: Diana Diaz, Kensey Bergdorf, Matthew A. Loberg, Courtney J. Phifer, George J. Xu, Quanhu Sheng, Sheau-Chiann Chen, Jamal M. Byrant, Megan L. Tigue, Heather Hartmann, Sarah L. Rohde, James L. Netterville, Naira Baregamian, Jeremy A. Goettel, Fei Ye, Ethan Lee, Vivian L. Weiss

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27.05.2024 | Meta- Analysis

Value of radiofrequency ablation for treating locally recurrent thyroid cancer: a systematic review and meta-analysis for 2-year follow-up

Thyroid cancer has been the most common endocrine malignancy in recent decades, the incidence of thyroid cancer increased from 7.25 per 100,000 person-years in 2000 to 13.48 per 100,000 person-years in 2018 in United States [ 1 ]. Most thyroid …

verfasst von:: Zhen Yang, Mingbo Zhang, Lin Yan, Jing Xiao, Yingying Li, Xinyang Li, Yukun Luo

27.05.2024 | Original Article

Muscle function, exercise capacity, physical activity level and cardiovascular disease risk factor knowledge in patients with prolactinoma

Prolactinoma is the most commonly observed type of secretory pituitary adenoma [ 1 ]. High prolactin (PRL) levels increase sympathetic tone and mediate chronotropic responses and vasoconstrictive effects, which have been associated with increased …

verfasst von:: Ayşegül Erkoç, İmdat Eroğlu, Tomris Erbas, Ebru Calik Kutukcu

Open Access 27.05.2024 | Original Article

Small RNA sequencing reveals snoRNAs and piRNA-019825 as novel players in diabetic kidney disease

Diabetic kidney disease (DKD) is one of the most common complications in type 2 diabetes. Nonetheless, while some develop complications early in the disease, others will never. The mechanisms underlying DKD are not fully understood though [ 1 ].

verfasst von:: L. M. ’t Hart, J. A. de Klerk, G. A. Bouland, J. H. D. Peerlings, M. T. Blom, S. J. Cramer, R. Bijkerk, J. W. J. Beulens, R. C. Slieker

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27.05.2024 | Brief Report

Primary resistance to selpercatinib in a patient with advanced medullary thyroid cancer

Selpercatinib, a selective RET kinase inhibitor, has demonstrated remarkable efficacy in treating patients with advanced medullary (MTC) and differentiated thyroid cancer with RET alterations. Primary resistance to selpercatinib is a very uncommon …

verfasst von:: Fabian Pitoia, Pierpaolo Trimboli, Erika Abelleira

24.05.2024 | Correction

Correction to: Androgen-induced upregulation of CFTR in pancreatic β-cell contributes to hyperinsulinemia in PCOS model

verfasst von:: Mengzhu Sun, Yong Wu, Chun Yuan, Jingya Lyu, Xinyi Zhao, Ye Chun Ruan, Jinghui Guo, Hui Chen, Wen Qing Huang

Open Access 24.05.2024 | Original Article

Quality of life, diabetes-related stress and treatment satisfaction are correlated with glycemia risk index (GRI), time in range and hypoglycemia/hyperglycemia components in type 1 diabetes

Data provided by continuous glucose monitoring (CGM) systems have become the preferred form of blood glucose monitoring to achieve adequate control in patients with type 1 diabetes (T1D) [ 1 – 3 ]. It is well known that the use of these devices …

verfasst von:: Gonzalo Díaz-Soto, Paloma Pérez-López, Pablo Férnandez-Velasco, Pilar Bahillo-Curieses, María de la O Nieto de la Marca, Rebeca Jimenez, Daniel de Luis

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Open Access 23.05.2024 | Original Article

Effects of metformin on the glucose regulation, lipid levels and gut microbiota in high-fat diet with streptozotocin induced type 2 diabetes mellitus rats

The recent rise in high-salt, high-fat, and high-sugar diets has led to a gradual annual increase in the incidence of diabetes, posing a threat to human health [ 1 ]. Type 2 diabetes mellitus (T2DM) accounts for 95% of all diabetes cases. The …

verfasst von:: Xuan Zhou, Jian Zhou, Qingfeng Ban, Mei Zhang, Bo Ban

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23.05.2024 | Original Article

Association between the triglyceride-glucose index and thyroid disorders: a cross-sectional survey and Mendelian randomization analysis

Insulin resistance refers to the insensitivity of tissues (such as muscle, fat, and liver) to insulin [ 1 ]. Insulin resistance is considered a key predictor of hypertension, hypertriglyceridemia, abdominal obesity and impaired glucose tolerance [ …

verfasst von:: Chenyu Zhang, Haoyu Wang, Yongze Li, Xichang Wang, Yutong Han, Xiaotong Gao, Yaxin Lai, Chuyuan Wang, Weiping Teng, Zhongyan Shan

Open Access 22.05.2024 | Original Paper

Cardiac magnetic resonance reveals biventricular impairment in Cushing’s syndrome: a multicentre case-control study

Cushing’s syndrome (CS), or chronic hypercortisolism, is associated with increased mortality mostly due to cardiovascular disease [ 1 , 2 ], with infectious diseases and coexisting comorbidities also playing a role [ 1 – 9 ]. Older age at …

verfasst von:: Tiziana Feola, Alessia Cozzolino, Dario De Alcubierre, Riccardo Pofi, Nicola Galea, Carlo Catalano, Chiara Simeoli, Nicola Di Paola, Federica Campolo, Rosario Pivonello, Andrea M. Isidori, Elisa Giannetta

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21.05.2024 | Original Article

Ten years’ real-life experience on the use of multikinase inhibitors in patients with advanced differentiated thyroid cancer

Up to 15% of differentiated thyroid cancer (DTC) patients exhibit an aggressive disease, resulting in the development of distant metastases [ 1 ]. Approximately two-thirds of these patients do not respond to radioactive iodine (RAI) treatment which …

verfasst von:: Fernando Jerkovich, Soledad Capalbo, Erika Abelleira, Fabián Pitoia

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