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01.08.2023 | Original articles

Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?

verfasst von: Emrullah Kızıltunç, MD, Associate Professor of Cardiology, Sabire Gökalp, MD, Gürsel Biberoğlu, MD, Professor of Pediatric Metabolism and Nutrition, Yakup Yalçın, MD, Burcu Cihan, MD, Rıdvan M Öktem, MD, Assistant Professor of Pediatric Metabolism and Nutrition, Aslı İnci, MD, Associate Professor of Pediatric Metabolism and Nutrition, Leyla Tümer, MD, Professor of Pediatric Metabolism and Nutrition, Mehmet R Yalçın, MD, Professor of Cardiology, Adnan Abacı, MD, Professor of Cardiology

Erschienen in: Herz | Ausgabe 1/2024

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Abstract

Background

Lipid metabolism is considerably complex and there can be many critical steps in atherogenesis. The association between lysosomal acid lipase (LAL) activity and coronary artery disease (CAD) has not been elucidated in detail. We aimed to evaluate the association between LAL activity with the presence and severity of CAD in patients who are seen in daily clinical practice.

Methods

Patients who underwent coronary angiography were divided into groups according to the angiography results. Syntax scores and Gensini scores were calculated. The LAL activity was measured from dried blood spots.

Results

Median LAL activity values were similar in all study groups (normal coronary arteries: 0.40 nmol/punch/h; non-obstructive CAD: 0.44 nmol/punch/h; obstructive chronic CAD: 0.40 nmol/punch/h; obstructive acute coronary syndrome: 0.48 nmol/punch/h) and there was no correlation between coronary atherosclerotic burden and LAL activity (correlation coefficients Syntax score and LAL: −0.032; Gensini score and LAL: −0.030). In addition, no relationship between serum lipid levels and LAL activity was detected.

Conclusion

The presence of CAD and its severity is not associated with the LAL activity in patients encountered in daily clinical practice.

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Titel: Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?
verfasst von: Emrullah Kızıltunç, MD, Associate Professor of Cardiology
Sabire Gökalp, MD
Gürsel Biberoğlu, MD, Professor of Pediatric Metabolism and Nutrition
Yakup Yalçın, MD
Burcu Cihan, MD
Rıdvan M Öktem, MD, Assistant Professor of Pediatric Metabolism and Nutrition
Aslı İnci, MD, Associate Professor of Pediatric Metabolism and Nutrition
Leyla Tümer, MD, Professor of Pediatric Metabolism and Nutrition
Mehmet R Yalçın, MD, Professor of Cardiology
Adnan Abacı, MD, Professor of Cardiology
Publikationsdatum: 01.08.2023
Verlag: Springer Medizin
Erschienen in: Herz / Ausgabe 1/2024
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-023-05200-7

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