Background
Materials and methods
Literature search strategy
Inclusion criteria
Data extraction
Statistical analysis
Network of protein-interaction of IL-6 and IL-10 gene
Results
Study searching and their basic information
Author | Year | Country | Ethnicity | Case | Control | SOC | HWE | Genotype | Sub-type |
---|---|---|---|---|---|---|---|---|---|
-592 | rs1800872 | ||||||||
Chen | 2004 | China | Asian | 77 | 54 | HB | 0.633 | PCR-RFLP | PBC |
Zappala | 1998 | UK | Caucasian | 171 | 141 | HB | 0.071 | PCR | PBC |
Matsushita | 2002 | USA | Caucasian | 94 | 72 | PB | 0.501 | PCR-RFLP | PBC |
Matsushita | 2002 | USA | Caucasian | 65 | 71 | PB | < 0.01 | PCR-RFLP | PBC |
Marcos | 2008 | Spain | Caucasian | 96 | 100 | HB | 0.093 | PCR-RFLP | ALC |
Yao | 2015 | China | Asian | 318 | 318 | PB | < 0.01 | PCR-RFLP | LC |
Barooah | 2020 | India | Asian | 96 | 110 | HB | 0.009 | PCR-RFLP | HCV-LC |
Liu | 2015 | China | Asian | 192 | 192 | HB | < 0.01 | Sequenom Assay Design | Mixed |
Cao | 2016 | China | Asian | 241 | 254 | HB | < 0.01 | PCR-RFLP | LC |
Baghi | 2015 | Iran | Asian | 9 | 102 | PB | 0.664 | PCR-RFLP | HBV-LC |
Cheong | 2005 | South Korea | Asian | 79 | 261 | HB | < 0.01 | PCR | HBV-LC |
Sheneef | 2017 | Egypt | African | 50 | 50 | PB | 0.889 | ARMS-PCR | HCV-LC |
Corchado | 2013 | Korea | Asian | 39 | 49 | HB | 0.187 | PCR | HCV-LC |
Fan | 2004 | China | Asian | 77 | 160 | HB | < 0.01 | PCR-RFLP | PBC |
Khalifa | 2016 | Saudi Arabia | Asian | 109 | 110 | HB | 0.525 | PCR-RFLP | HBV-LC |
Moreira | 2016 | Brazil | Mixed | 37 | 102 | HB | 0.316 | PCR-SSP | HCV-LC |
Wang | 2010 | China | Asian | 50 | 42 | HB | < 0.01 | PCR | HBV-LC |
Jiang | 2009 | China | Asian | 169 | 119 | HB | 0.552 | PCR-RFLP | HBV-LC |
Wu | 2010 | China | Asian | 50 | 96 | HB | 0.125 | PCR-RFLP | HBV-LC |
−819 | rs1800871 | ||||||||
Chen | 2004 | China | Asian | 77 | 54 | HB | 1 | PCR-RFLP | PBC |
Matsushita | 2002 | USA | Caucasian | 94 | 72 | PB | 0.501 | PCR-RFLP | PBC |
Matsushita | 2002 | USA | Caucasian | 65 | 71 | PB | 0.049 | PCR-RFLP | PBC |
Yao | 2015 | China | Asian | 318 | 318 | PB | 0.227 | PCR-RFLP | LC |
Barooah | 2020 | India | Asian | 96 | 110 | HB | 0.474 | PCR-RFLP | HCV-LC |
Liu | 2015 | China | Asian | 192 | 192 | HB | 0.073 | Sequenom Assay Design | Mixed |
Baghi | 2015 | Iran | Asian | 9 | 102 | PB | 0.369 | PCR-RFLP | HBV-LC |
Cheong | 2005 | South Korea | Asian | 79 | 261 | HB | 0.458 | PCR | HBV-LC |
Yang | 2013 | China | Asian | 40 | 64 | PB | 0.821 | ARMS-PCR | ALC |
Fan | 2004 | China | Asian | 77 | 160 | HB | 0.455 | PCR-RFLP | PBC |
Moreira | 2016 | Brazil | Mixed | 37 | 102 | HB | 0.316 | PCR-SSP | HCV-LC |
Wang | 2010 | China | Asian | 50 | 43 | HB | 0.017 | PCR | HBV-LC |
−1082 | rs1800896 | ||||||||
Chen | 2004 | China | Asian | 77 | 54 | HB | 0.611 | PCR-RFLP | PBC |
Bathgate | 2000 | UK | Caucasian | 61 | 330 | HB | 0.003 | sequence | PBC |
Matsushita | 2002 | USA | Caucasian | 94 | 72 | PB | 0.859 | PCR-RFLP | PBC |
Matsushita | 2002 | USA | Caucasian | 65 | 71 | PB | 0.568 | PCR-RFLP | PBC |
Abd El-Baky | 2020 | Egypt | African | 22 | 48 | PB | < 0.01 | TaqMan real-time PCR | HCV-LC |
Yao | 2015 | China | Asian | 318 | 318 | PB | 0.898 | PCR-RFLP | LC |
Barooah | 2020 | India | Asian | 96 | 110 | HB | 0.054 | PCR-RFLP | HCV-LC |
Liu | 2015 | China | Asian | 266 | 532 | HB | < 0.01 | Sequenom Assay Design | Mixed |
Cao | 2016 | China | Asian | 241 | 254 | PB | 0.953 | PCR-RFLP | LC |
Baghi | 2015 | Iran | Asian | 9 | 102 | PB | 0.047 | PCR-RFLP | HBV-LC |
Cheong | 2005 | South Korea | Asian | 79 | 261 | HB | 0.769 | PCR | HBV-LC |
Yang | 2013 | China | Asian | 40 | 64 | PB | 0.452 | ARMS-PCR | ALC |
Sheneef | 2017 | Egypt | African | 50 | 50 | PB | 0.259 | ARMS-PCR | HCV-LC |
Fan | 2004 | China | Asian | 77 | 160 | HB | 0.505 | PCR-RFLP | PBC |
Khalifa | 2016 | Saudi Arabia | Asian | 109 | 110 | HB | 0.267 | PCR-RFLP | HBV-LC |
Moreira | 2016 | Brazil | Mixed | 37 | 102 | HB | 0.973 | PCR-SSP | HCV-LC |
Wang | 2010 | China | Asian | 50 | 42 | HB | 0.874 | PCR | HBV-LC |
Wu | 2010 | China | Asian | 50 | 96 | HB | 0.629 | PCR-RFLP | HBV-LC |
-174G > C | |||||||||
Giannitrapani | 2011 | Italy | Caucasian | 95 | 105 | HB | 0.776 | PCR-RFLP | LC |
Fan | 2004 | China | Asian | 77 | 160 | PB | < 0.01 | SSP | PBC |
Falleti | 2008 | Italy | Caucasian | 219 | 236 | PB | 0.536 | PCR-RFLP | Mixed |
Marcos | 2009 | Spain | Caucasian | 96 | 160 | PB | 0.333 | TaqMan | ALC |
Motawi | 2016 | Egypt | African | 65 | 100 | HB | < 0.01 | PCR-RFLP | HCV-LC |
Moreira | 2016 | Brazil | Mixed | 38 | 100 | HB | 0.718 | PCR-SSP | HCV-LC |
IL6–572 | |||||||||
Park | 2003 | Korea | Asian | 696 | 280 | PB | 0.193 | sequence | HBV-LC |
Falleti | 2008 | Italy | Caucasian | 219 | 236 | PB | 0.249 | PCR-RFLP | Mixed |
Saxenas | 2014 | India | Asian | 63 | 83 | HB | < 0.01 | PCR-RFLP | HBV-LC |
Tang | 2013 | China | Asian | 153 | 265 | HB | 0.529 | TaqMan | HBV-LC |
597G > A | |||||||||
Falleti | 2008 | Italy | Caucasian | 219 | 236 | PB | 0.348 | PCR-RFLP | Mixed |
Saxenas | 2014 | India | Asian | 3 | 138 | HB | 0.613 | PCR-RFLP | HBV-LC |
Quantitative synthesis
IL-10 − 592 polymorphism
Variables | N | Case/ | Allelic contrast | Heterozygote comparison | Dominant model |
---|---|---|---|---|---|
Control | OR(95%CI) Ph P I-squared | OR(95%CI) Ph P I-squared | OR(95%CI) Ph P I-squared | ||
IL-10 -592 | |||||
Total | 19 | 2019/2403 | 1.15 (0.98–1.37)0.000 0.093 65.7% | 1.30 (1.01–1.67)0.006 0.03950.9% | 1.34 (1.04–1.72)0.001 0.02157.5% |
Ethnicity | |||||
Asian | 13 | 1506/1867 | 1.25 (1.01–1.55)0.000 0.042 72.3% | 1.40 (1.03–1.88)0.001 0.02963.1% | 1.47 (1.09–1.99)0.000 0.01368.3% |
Caucasian | 4 | 426/384 | 0.98 (0.78–1.22)0.270 0.840 23.4% | 1.26 (0.74–2.14)0.728 0.399 0.0% | 1.24 (0.76–2.02)0.747 0.395 0.0% |
SOC | |||||
HB | 14 | 1483/1790 | 1.19 (0.95–1.48)0.000 0.125 73.6% | 1.36 (0.98–1.89)0.001 0.06863.5% | 1.40 (1.01–1.96)0.000 0.04668.2% |
PB | 5 | 536/613 | 1.11 (0.93–1.33)0.594 0.234 0.0% | 1.17 (0.88–1.57)0.917 0.277 0.0% | 1.19 (0.91–1.56)0.897 0.208 0.0% |
Disease type | |||||
PBC | 5 | 484/498 | 1.11 (0.91–1.35)0.590 0.319 0.0% | 1.23 (0.85–1.78)0.908 0.281 0.0% | 1.27 (0.89–1.79)0.871 0.184 0.0% |
HBV-LC | 6 | 466/730 | 1.46 (0.86–2.49)0.000 0.163 35.9% | 2.24 (0.95–5.28)0.000 0.06584.0% | 2.26 (0.95–5.38)0.000 0.06586.3% |
HCV-LC | 4 | 222/311 | 0.98 (0.75–1.28)0.161 0.901 41.8% | 0.93 (0.53–1.64)0.531 0.794 0.0% | 0.98 (0.59–1.62)0.572 0.926 0.0% |
-819 | |||||
Total | 12 | 1134/1549 | 1.07 (0.88–1.30)0.017 0.485 52.4% | 1.14 (0.86–1.51)0.072 0.35440.3% | 1.15 (0.86–1.53)0.029 0.35448.8% |
Ethnicity | |||||
Asian | 9 | 938/1304 | 1.05 (0.82–1.34)0.006 0.089 63.0% | 1.18 (0.86–1.64)0.047 0.30449.0% | 1.17 (0.83–1.64)0.016 0.36757.2% |
Caucasian | 2 | 159/143 | 1.28 (0.90–1.83)0.790 0.173 0.0% | 1.23 (0.64–2.34)0.542 0.537 0.0% | 1.33 (0.74–2.39)0.493 0.334 0.0% |
SOC | |||||
HB | 7 | 608/922 | 1.14 (0.88–1.47)0.037 0.321 55.2% | 1.22 (0.78–1.91)0.020 0.38660.2% | 1.23 (0.80–1.91)0.016 0.34361.5% |
PB | 5 | 526/627 | 0.96 (0.68–1.36)0.045 0.832 58.9% | 1.07 (0.81–1.42)0.543 0.614 0.0% | 1.08 (0.83–1.40)0.229 0.556 28.8% |
Disease type | |||||
PBC | 4 | 313/357 | 1.24 (0.97–1.57)0.964 0.082 0.0% | 1.37 (0.95–1.99)0.906 0.095 0.0% | 1.38 (0.97–1.96)0.911 0.071 0.0% |
HBV-LC | 3 | 138/406 | 1.55 (0.55–4.43)0.004 0.409 81.6% | 2.96 (0.70–12.47)0.0320.14070.8% | 2.68 (0.67–10.74)0.0240.16573.2% |
HCV-LC | 2 | 133/212 | 0.92 (0.66–1.27)0.901 0.595 0.0% | 0.65 (0.38–1.14)0.457 0.132 0.0% | 0.71 (0.42–1.20)0.467 0.203 0.0% |
-1082 | |||||
Total | 18 | 1741/2776 | 1.01 (0.85–1.20)0.013 0.892 47.5% | 1.01 (0.82–1.23)0.202 0.941 21.2% | 1.00 (0.80–1.24)0.053 0.971 37.9% |
Ethnicity | |||||
Asian | 12 | 1412/2103 | 0.94 (0.76–1.17)0.018 0.577 51.9% | 1.01 (0.78–1.33)0.092 0.921 37.5% | 0.96 (0.72–1.29)0.024 0.795 50.2% |
Caucasian | 3 | 220/473 | 1.25 (0.94–1.65)0.323 0.122 11.4% | 1.20 (0.78–1.85)0.900 0.409 0.0% | 1.30 (0.86–1.95)0.699 0.213 0.0% |
African | 2 | 72/98 | 1.27 (0.82–1.97)0.817 0.282 0.0% | 1.12 (0.47–2.70)0.241 0.799 27.2% | 1.24 (0.55–2.82)0.269 0.602 18.0% |
SOC | |||||
HB | 10 | 902/1797 | 1.04 (0.89–1.21)0.502 0.601 0.0% | 1.11 (0.90–1.37)0.734 0.319 0.0% | 1.09 (0.90–1.32)0.683 0.380 0.0% |
PB | 8 | 839/979 | 0.99 (0.72–1.36)0.005 0.966 65.8% | 0.86 (0.56–1.33)0.087 0.505 43.7% | 0.87 (0.53–1.42)0.016 0.577 59.3% |
Disease type | |||||
PBC | 5 | 374/687 | 1.30 (1.01–1.68)0.568 0.043 0.0% | 1.32 (0.93–1.89)0.901 0.122 0.0% | 1.39 (0.98–1.95)0.863 0.061 0.0% |
HBV-LC | 5 | 297/611 | 0.97 (0.71–1.32)0.318 0.827 15.2% | 1.30 (0.89–1.90)0.527 0.170 0.0% | 1.15 (0.80–1.67)0.420 0.447 0.0% |
HCV-LC | 4 | 205/310 | 0.98 (0.76–1.28)0.547 0.897 0.0% | 0.81 (0.53–1.24)0.865 0.332 0.0% | 0.85 (0.58–1.26)0.489 0.414 0.0% |
LC | 2 | 559/572 | 0.72 (0.60–0.85)0.987 0.000 0.0% | 0.64 (0.44–0.93)0.865 0.019 0.0% | 0.56 (0.39–0.80)0.892 0.001 0.0% |
IL-6 -174 | |||||
Total | 6 | 590/861 | 1.17 (0.73–1.86)0.002 0.511 77.5% | 1.42 (0.70–2.87)0.000 0.330 78.3% | 1.37 (0.71–2.63)0.001 0.346 77.2% |
Ethnicity | |||||
Caucasian | 3 | 410/501 | 0.89 (0.73–1.09)0.631 0.244 0.0% | 0.87 (0.65–1.15)0.314 0.316 13.7% | 0.86 (0.66–1.12)0.550 0.257 0.0% |
SOC | |||||
HB | 3 | 198/305 | 1.98 (0.55–7.05)0.001 0.294 86.8% | 2.79 (0.41–18.88)0.000 0.294 90.4% | 2.71 (0.47–15.57)0.0000.26589.6% |
PB | 3 | 392/556 | 0.99 (0.63–1.55)0.083 0.961 59.8% | 1.04 (0.76–1.42)0.130 0.800 50.9% | 0.98 (0.73–1.32)0.110 0.916 54.7% |
−572 | |||||
Total | 4 | 1131/864 | 1.15 (0.97–1.36)0.859 0.117 0.0% | 2.23 (0.80–6.21)0.000 0.127 89.2% | 1.60 (0.83–3.06)0.005 0.157 76.3% |
−597 | |||||
Total | 2 | 280/374 | 0.84 (0.66–1.08)0.453 0.168 0.0% | 0.88 (0.63–1.23)0.203 0.462 38.3% | 0.84 (0.61–1.15)0.278 0.283 15.0% |
IL-10 -1082 polymorphism
IL-10-819, IL-6 -174, − 572 and − 597 polymorphisms
Bias diagnosis for publication and sensitivity analysis
Egger’s test | Begg’s test | ||||||
---|---|---|---|---|---|---|---|
Genetic type | Coefficient | Standard error | t | P value | 95%CI of intercept | z | P value |
C-allele vs. A-allele | −0.181 | 1.211 | −0.15 | 0.883 | (−2.736–2.374) | 1.26 | 0.208 |
CA vs. AA | −0.047 | 0.447 | −0.11 | 0.917 | (−0.992–0.897) | 0.35 | 0.726 |
CC + CA vs. AA | −0.047 | 0.51 | −0.09 | 0.927 | (−1.124–1.029) | 0.56 | 0.576 |