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01.09.2011 | Schwerpunkt

Genetische Anfälligkeit für Infektionen

verfasst von: S.J. Ott, Prof. Dr. S. Schreiber

Erschienen in: Die Innere Medizin | Ausgabe 9/2011

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Zusammenfassung

Infektionserkrankungen zählen zu den führenden Ursachen für Morbidität und Mortalität weltweit. Die klinische Manifestation von Infektionserkrankungen ist sehr variabel; das Spektrum an Krankheitsverläufen reicht von asymptomatischen Infektionen und leichten Erkrankungen bis hin zu rasch progressiven und tödlichen Verläufen. Eine erbliche Komponente wurde zunächst in Zwillingsstudien gezeigt. Epidemiologische und genetische Studien konnten im Verlauf konkrete Gene und Polymorphismen für die meisten relevanten Infektionserkrankungen identifizieren. Verlässliche genetische Marker, die eine Empfänglichkeit oder Resistenz gegenüber Infektionen, die Krankheitsprogression und das Therapieansprechen prognostizieren, sind notwendig für die Definition von Risikopopulationen und die Therapieplanung. Genetische Untersuchungen können dazu beitragen, Zielstrukturen für neue Therapiestrategien und antimikrobielle Wirkstoffe zu finden. Die vorliegende Arbeit beschreibt den Einfluss genetischer Faktoren für einige wichtige Infektionserkrankungen und gibt Beispiele für eine erfolgreiche Umsetzung genetischer Forschung in die praktische Medizin.

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Titel: Genetische Anfälligkeit für Infektionen
verfasst von: S.J. Ott
Prof. Dr. S. Schreiber
Publikationsdatum: 01.09.2011
Verlag: Springer-Verlag
Erschienen in: Die Innere Medizin / Ausgabe 9/2011
Print ISSN: 2731-7080
Elektronische ISSN: 2731-7099
DOI: https://doi.org/10.1007/s00108-011-2858-8

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