Skip to main content
Erschienen in: World Journal of Urology 1/2024

01.12.2024 | Original Article

Factors related to acupuncture response in patients with chronic prostatitis/chronic pelvic pain syndrome: secondary analysis of a randomized controlled trial

verfasst von: Xinlu Wang, Lili Zhu, Min Yang, Yu Chen, Zhishun Liu

Erschienen in: World Journal of Urology | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Acupuncture has been recommended as an effective therapy to improve symptoms of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We conducted this secondary analysis to explore the factors that may influence the response of patients with CP/CPPS to acupuncture.

Methods

This secondary analysis was based on a randomized controlled trial demonstrating the efficacy of acupuncture among patients with CP/CPPS. Responder is defined as a patient with a decrease of  ≥ 6 points in National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total score from baseline at the 32 week. 206 patients who received acupuncture treatment and completed 32-week follow-up were included in this secondary analysis. Descriptive statistics were used to describe the demographic and clinical characteristics of both responders and non-responders in acupuncture group. Logistic regression analysis with bootstrapping was made to identify potential factors that contributed to the effectiveness of acupuncture for treating CP/CPPS. Responders and non-responders were listed as dependent variables.

Results

In this study, 130 (63.11%) patients were assessed as responders. The results showed that men with non-sedentariness (OR 4.170 [95%CI 1.837 to 9.463; P = 0.001]), non-smoking habit (OR 2.824 [95%CI 1.453 to 5.487; P = 0.002]), without comorbidity (OR 8.788 [95%CI 1.912 to 40.295; P = 0.005]), and severe NIH-CPSI total score (OR 0.227 [95%CI 0.114 to 0.450; P < 0.0001]) benefited more from acupuncture intervention.

Conclusion

CP/CPPS patients who are active, non-smokers, without comorbidity, and had severe symptoms may be more likely to respond to acupuncture.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
3.
Zurück zum Zitat Engeler DBA, Berghmans B, et al (2023) EAU guidelines on chronic pelvic pain. European Association of Urology Engeler DBA, Berghmans B, et al (2023) EAU guidelines on chronic pelvic pain. European Association of Urology
10.
Zurück zum Zitat Sun Y, Liu Y, Liu B, Zhou K, Yue Z, Zhang W, Fu W, Yang J, Li N, He L, Zang Z, Su T, Fang J, Ding Y, Qin Z, Song H, Hu H, Zhao H, Mo Q, Zhou J, Wu J, Liu X, Wang W, Pang R, Chen H, Wang X, Liu Z (2021) Efficacy of acupuncture for chronic prostatitis/chronic pelvic pain syndrome : a randomized trial. Ann Intern Med 174:1357–1366. https://doi.org/10.7326/m21-1814CrossRefPubMed Sun Y, Liu Y, Liu B, Zhou K, Yue Z, Zhang W, Fu W, Yang J, Li N, He L, Zang Z, Su T, Fang J, Ding Y, Qin Z, Song H, Hu H, Zhao H, Mo Q, Zhou J, Wu J, Liu X, Wang W, Pang R, Chen H, Wang X, Liu Z (2021) Efficacy of acupuncture for chronic prostatitis/chronic pelvic pain syndrome : a randomized trial. Ann Intern Med 174:1357–1366. https://​doi.​org/​10.​7326/​m21-1814CrossRefPubMed
15.
Zurück zum Zitat Terk MD, Stock RG, Stone NN (1998) Identification of patients at increased risk for prolonged urinary retention following radioactive seed implantation of the prostate. J Urol 160:1379–1382CrossRefPubMed Terk MD, Stock RG, Stone NN (1998) Identification of patients at increased risk for prolonged urinary retention following radioactive seed implantation of the prostate. J Urol 160:1379–1382CrossRefPubMed
19.
Zurück zum Zitat Tremblay MJAPN, Metabolism (2012) Standardized use of the terms "sedentary" and "sedentary behaviours"Sedentary Behaviour Research Network (SBRN). Appl Physiol Nutr Metab 37: 540–542 Tremblay MJAPN, Metabolism (2012) Standardized use of the terms "sedentary" and "sedentary behaviours"Sedentary Behaviour Research Network (SBRN). Appl Physiol Nutr Metab 37: 540–542
20.
Zurück zum Zitat Giubilei G, Mondaini N, Minervini A, Saieva C, Lapini A, Serni S, Bartoletti R, Carini M (2007) Physical activity of men with chronic prostatitis/chronic pelvic pain syndrome not satisfied with conventional treatments–could it represent a valid option? The physical activity and male pelvic pain trial: a double-blind, randomized study. J Urol 177:159–165. https://doi.org/10.1016/j.juro.2006.08.107CrossRefPubMed Giubilei G, Mondaini N, Minervini A, Saieva C, Lapini A, Serni S, Bartoletti R, Carini M (2007) Physical activity of men with chronic prostatitis/chronic pelvic pain syndrome not satisfied with conventional treatments–could it represent a valid option? The physical activity and male pelvic pain trial: a double-blind, randomized study. J Urol 177:159–165. https://​doi.​org/​10.​1016/​j.​juro.​2006.​08.​107CrossRefPubMed
21.
24.
Zurück zum Zitat Xu C, Cheng K, Wu XL, Tai HY, Chai YM, Yang ZW, Sun QH, Qiu XH, Yang XY, Li N, Tan Y, Liu SM, Chen W (2022) Expression Profiling of L5–S2 spinal cord dorsal horn in a rat model of chronic pelvic pain syndrome uncovers potential mechanism of electroacupuncture mediated inflammation and pain responses. J Pain Res 15:2067–2084. https://doi.org/10.2147/jpr.S364972CrossRefPubMedPubMedCentral Xu C, Cheng K, Wu XL, Tai HY, Chai YM, Yang ZW, Sun QH, Qiu XH, Yang XY, Li N, Tan Y, Liu SM, Chen W (2022) Expression Profiling of L5–S2 spinal cord dorsal horn in a rat model of chronic pelvic pain syndrome uncovers potential mechanism of electroacupuncture mediated inflammation and pain responses. J Pain Res 15:2067–2084. https://​doi.​org/​10.​2147/​jpr.​S364972CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Wu XL, Cheng K, Xu C, Chai YM, Yap TH, Yang ZW, Sun QH, Tan Y, Zhang JN, Chen W, Qiu XH, Yang XY, Li N (2022) Effect of electroacupuncture on cyclic adenosine monophosphate-protein kinase A-vanillic acid receptor subtype 1 of the transient receptor potential/PLK-protein kinase C-vanillic acid receptor subtype 1 of the transient receptor potential pathway based on RNA-seq analysis in prostate tissue in rats with chronic prostatitis/chronic pelvic pain syndrome. Front Neurosci 16:938200. https://doi.org/10.3389/fnins.2022.938200CrossRefPubMedPubMedCentral Wu XL, Cheng K, Xu C, Chai YM, Yap TH, Yang ZW, Sun QH, Tan Y, Zhang JN, Chen W, Qiu XH, Yang XY, Li N (2022) Effect of electroacupuncture on cyclic adenosine monophosphate-protein kinase A-vanillic acid receptor subtype 1 of the transient receptor potential/PLK-protein kinase C-vanillic acid receptor subtype 1 of the transient receptor potential pathway based on RNA-seq analysis in prostate tissue in rats with chronic prostatitis/chronic pelvic pain syndrome. Front Neurosci 16:938200. https://​doi.​org/​10.​3389/​fnins.​2022.​938200CrossRefPubMedPubMedCentral
Metadaten
Titel
Factors related to acupuncture response in patients with chronic prostatitis/chronic pelvic pain syndrome: secondary analysis of a randomized controlled trial
verfasst von
Xinlu Wang
Lili Zhu
Min Yang
Yu Chen
Zhishun Liu
Publikationsdatum
01.12.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
World Journal of Urology / Ausgabe 1/2024
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-024-04791-y

Weitere Artikel der Ausgabe 1/2024

World Journal of Urology 1/2024 Zur Ausgabe

Patrone im Penis bringt Urologen in Gefahr

30.05.2024 Operationen am Penis Nachrichten

In Lebensgefahr brachte ein junger Mann nicht nur sich selbst, sondern auch das urologische Team, das ihm zu Hilfe kam: Er hatte sich zur Selbstbefriedigung eine scharfe Patrone in die Harnröhre gesteckt.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.