Despite evidence supporting the effectiveness of prehabilitation as a new preoperative care pathway to optimise perioperative outcomes, its implementation into routine health care is widely pending. Frail patients might particularly benefit from prehabilitation interventions, but facilitating and hindering factors need to be considered in the implementation process. Thus, our aim was to derive a programme theory on what prehabilitation programmes work for frail patients in what circumstances and why.
Methods
Following Pawson’s realist review approach, preliminary programme theories on facilitators and barriers were established. General and topic-specific databases were searched systematically for facilitators and barriers to the implementation of prehabilitation for frail patients. Articles were included if they dealt with multimodal prehabilitation programmes prior to surgery in a frail population and if they contained information on facilitators and barriers during the implementation process in the full text. Based on these articles, refined programme theories were generated.
Results
From 2,609 unique titles, 34 were retained for the realist synthesis. Facilitating factors included the individualisation of prehabilitation programmes to meet the patients’ needs and abilities, multimodality, adaption to the local setting and health care system, endorsement by an ambassador and sharing of responsibilities among a multidisciplinary team. Central barriers for frail patients were transportation, lack of social support, and inadequate, overwhelming information provision.
Conclusions
Implementing prehabilitation as a new care pathway for frail patients requires organisational readiness and adaptability to the local setting. On an individual level, a clear understanding of responsibilities and of the intervention’s goal among patients and providers are necessary. Added attention must be paid to the individualisation to fit the needs and restrictions of frail patients. This makes prehabilitation a resource-intense, but promising intervention for frail surgery patients.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Abkürzungen
ADLs
activities of daily living
CEO
Chief Executive Officer
CMO
context-mechanism-outcome
CMOC
context-mechanism-outcome configurations
PEDro
Physiotherapy Evidence Database
PICOSH
Population, Intervention, Comparison/Control, Outcome, Study design, Healthcare context
RCT
randomised controlled trial
TDF
Theoretical Domains Framework
Contributions to the literature
Prehabilitation is a new care pathway aiming to make patients fit for an upcoming surgery. Frail patients might particularly benefit from prehabilitation.
To support future implementation of prehabilitation for frail patients, this realist review looked at what works, for whom, in what circumstances and why based on the existing literature in the field.
A total of 34 documents were found and used to create refined programme theories on the facilitators and barriers to implementation.
Based on the review’s findings, we present evidence-based recommendations for stakeholders seeking to implement prehabilitation for frail surgical patients, adding to the existing literature at a meta-level.
Background
Rationale for review
Prehabilitation is an intervention prior to surgery that aims to improve modifiable risk factors as well as the overall functional capacity of a patient, thereby increasing the ability to cope with the stress of surgery [1]. It extends the rehabilitation phase to pre-surgery and is thus a way of targeting risk factors that can have an adverse impact on the surgical outcome [2]. Prehabilitation is usually multimodal, meaning different types of therapy such as physiotherapy, occupational therapy, and nutritional counselling, amongst others, are combined to prepare individuals for the upcoming intervention [3]. Evidence suggests that the various modes of preoperative intervention can have a positive effect on postoperative outcomes such as length of stay or postoperative complications [4‐7] and it has been postulated that especially high-risk individuals, such as elderly, frail or comorbid patients, might benefit from prehabilitation [8].
Anzeige
Frailty is defined as a multidimensional geriatric syndrome, which displays as individuals being more vulnerable to internal and external stressors along with a lack of individual reserve capacity [9]. Frailty is prevalent among 4 to 59 % of community-dwelling elderly, increasing with age, and is more prevalent among women [10]. Because frailty is associated with surgical morbidity and mortality, but is generally a modifiable risk factor [11], an improvement of the frailty status of patients prior to surgery through prehabilitation can have a positive impact on lives post-surgery [12]. The evidence from randomised trials on prehabilitation for frail patients is currently limited with only a small number of trials completed and published yet, such as Carli et al. 2020 [13] and McIsaac et al. 2022 [14]. Although these trials found no significant effects, prehabilitation reduced the prevalence of (severe) complications [13, 14].
The implementation of prehabilitation into routine care, i.e. the systematic uptake of evidence-based practices into standard practice [15], is still widely pending [16]. One reason for the lagging implementation process may be that prehabilitation is an intervention within a complex adaptive system [17], meaning it depends on the patients’ behaviour and on multidisciplinary cooperation between different health care professions and disciplines. Complex interventions are usually context-specific, and many factors determine whether the implementation will be successful and show results comparable to those observed under clinical trial conditions [17, 18]. When the complex intervention addresses a population with specific needs, like frail patients, even more factors apply due to the complexity of the population itself.
The aim of this realist review was to derive a theory on what prehabilitation programmes work for frail patients in what circumstances and why. Our objectives were to identify facilitators and barriers to the implementation of prehabilitation programmes for frail patients prior to elective surgery, and thereby inform future implementation of prehabilitation into routine care.
Methods
We chose Pawson’s realist review approach [19] as it is the gold standard method for investigating what “What works, for whom, in what circumstances and why?”. To report the realist review process and findings, the Realist and Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) publication standards [20, 21] (Appendix A) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Checklist [22, 23] (Appendix B) were used. The review protocol was registered at PROSPERO prior to conducting the systematic literature searches (CRD42022335282). No changes were made to the review process as documented in the registration on PROSPERO.
Anzeige
Realist review design
Realist reviews present an evidence-based method to derive implementation determinants. Pawson's realist review approach [19] is theory-driven and aims to provide an understanding on the successes and challenges of complex interventions by taking the context and working mechanisms into account [24]. Realist reviews start with creating a preliminary programme theory by investigating the relations between contexts, mechanisms, and outcomes in which a specific intervention or programme is implemented. The preliminary programme theory is then refined based on the evidence. Contexts describe the circumstances, in which an intervention is implemented, whereas mechanisms describe how the intervention will work given the specific context. The outcome results from the context-mechanism interaction. The body of context-mechanism-outcome configurations (CMOC) forms the programme theory.
Development of preliminary programme theories
To give adequate consideration to the complex nature of prehabilitation [17], preliminary programme theories on prehabilitation were developed in an iterative process without regard for specific target populations. To that end, an initial exploratory literature search on prehabilitation using medical subject headings and free text as search terms was performed primarily in PubMed. This background search was used for familiarisation with the literature and the main concepts of the intervention. These searches as well as backward citation searches aimed to specifically identify publications that reference determinants of successful implementation of prehabilitation.
Two context-mechanism-outcome (CMO) configurations, one for facilitators and one for barriers, were identified from individual articles and documented in detail. These CMO configurations were further condensed into the preliminary programme theories, which formed the basis for testing and refinement throughout the realist review process. The preliminary programme theories were extensively discussed within the multidisciplinary research team that is experienced in both prehabilitation and frailty.
Searching processes
For the systematic literature search, the databases MEDLINE via Pubmed, Embase via Ovid, Cochrane Library, and PEDro were searched on June 7, 2022. The databases were selected to be complementary and as extensive as possible within the scope of this realist review. Furthermore, forward and backward reference searching was conducted using Google Scholar. For grey literature, ProQuest Dissertations & Theses global was searched to identify relevant dissertations, and as an additional source for grey/non-academic literature, the first one hundred results of a Google search (in private search mode and sorted according to relevance) were screened.
The search strategy was developed for MEDLINE using PubMed and then translated to fit the other databases. The strategy included various term combinations to account for the prehabilitative intervention (e.g., “prehab*” or “preoperative exercise”) as well as the frail patient group (e.g., “frail*” or “geriatric*”). Because facilitators and barriers are not always explicitly named as such or might not be mentioned in the title, abstract or keywords, no search terms targeting these concepts were included in the search. The search strategies can be found in Appendix C. All search results from the database searches were imported to and stored in the literature management software EndNote 20 [25].
Selection and appraisal of documents
The in- and exclusion criteria are detailed in Table 1. Documents were included for full-text screening if they dealt with prehabilitation programmes prior to surgery. To define prehabilitation, we used a slightly modified version of the Gurlit et al. 2019 definition: “a multidisciplinary approach to the care of patients awaiting surgery and nonsurgical procedures to reduce vulnerability and to increase resilience to periinterventional and postinterventional risks, accelerate and improve outcomes and quality of life, and reduce healthcare costs” [26]. Originally, this definition includes multimodality, but to widen the scope of this realist review, we decided to also accept unimodal programmes if they went beyond medication or supplement intake. At the title-and-abstract-screening stage, we included all references that appeared to focus on prehabilitation and frailty. At the full-text-screening stage, articles were only included if they actually focused on prehabilitation and frailty and also contained information on any challenges, problems, supportive or helpful factors for the implementation of prehabilitation programmes for frail patients.
Table 1
Review inclusion and exclusion criteria
Inclusion criteria
P – population
Frail patients who had to undergo surgery; prehabilitation patients had to include frail individuals; term frail/frailty had to be used in the article, or a structured/standardised frailty assessment had to be conducted, e.g., concept of frailty by Fried et al. [27]
I – intervention
Prehabilitation programme
C – comparator
Experimental studies could include a comparison group, but this was not a condition of inclusion. Observational studies and other article types did not have to include a comparison group.
O – outcomes
Facilitators and barriers to the implementation of prehabilitation for frail patients into routine health care. These can be considered from different perspectives such as the patients, the surgeons, the institutions, or the therapists carrying out the prehabilitation programme.
S – study design
No restriction on study design, includes non-empirical sources, or publication type, i.e., grey literature like dissertations, opinion papers etc.
H – healthcare context
Any healthcare setting that provides prehabilitation to frail patients, including ambulatory, inpatient, or partially inpatient, or community settings. Home-based interventions, including tele-medical interventions, were also included.
Exclusion criteria
- Publication language other than English or German
- Study registration records and other documentation (e.g., conference abstracts) of ongoing studies on the (cost-)effectiveness and/or safety of prehabilitation
- Programmes that were comprised of medication or supplement intake only as well as mere educational programmes
- Prehabilitation programmes prior to chemotherapy or other non-surgical interventions
- Articles were excluded if they did not contain information that hints at challenges, problems, supportive or helpful factors for the implementation of prehabilitation programmes for frail patients
Articles were included regardless of publication type (full-text article, conference abstract) and publication date. Only articles written in English or German (authors’ first language) were included for there were no resources for translating articles. Empirical research of any study design (experimental or observational) or data type (quantitative, qualitative or mixed methods), was considered for inclusion. Grey literature, such as dissertations and theses, and other article types were also included. Study registration records and other documentation (e.g., conference abstracts) of ongoing studies on the (cost-) effectiveness or safety of prehabilitation were excluded since for this evaluation, implementation results were relevant.
The research tool Rayyan was used to remove duplicate records and for screening database results [28]. A randomly selected 10%-sample of the search results was screened by title and abstract by two reviewers (AFS, TR) independently. As an agreement rate of more than 80% between reviewers was achieved after the first 10%-sample, the remaining results were screened by one reviewer, who consulted with members of the review team in case of uncertainty. For full-text screening, a new random 10%-sample of the full texts was selected and screened by the two independent reviewers (AFS, TR) until they achieved sufficient agreement (≥ 80%). An agreement rate of 92% was achieved after screening two 10%-samples (excluding conference abstracts or articles where the full text was not yet available). The remaining full texts were screened by one reviewer, again consulting with members of the review team in case of uncertainty. Screening of full texts was conducted along the above PICOSH scheme, noting the reason for exclusion in order of the acronym (e.g., “population” if the focus was not on frail patients).
Anzeige
Data extraction
Data was extracted by one reviewer (AFS) using Microsoft Word. The selection of data items represents items the reviewers considered relevant to the implementation process and included:
1)
Document type and study design (if applicable)
2)
Study description (if applicable): location, study period, sample size, sample characteristics
3)
Description of the context: disease focus, surgery type, frailty assessment and description of prehabilitation
4)
Quotations on barriers
5)
Quotations on facilitators
6)
Conflict of interest and funding
Analysis and synthesis
Included articles were read and re-read to identify their contributions to the refinement of the preliminary programme theories in respect to the target population of frail patients. Particular attention was paid to facilitating factors and barriers identified in the preliminary programme theories. Contributions from the included articles could both be supporting or disconfirming the preliminary programme theories. The analysis was not limited to these preliminary concepts and additional context-mechanism-outcome configurations for facilitators and barriers unique to frail patients could be added. Contributions from the included literature were classified and manually color-coded, then summarised to overarching concepts [29]. Results were presented graphically in tables.
Relevance and rigour of the included literature
Unlike systematic reviews and meta-analyses, realist reviews do not include standardised quality assessments of the literature, but consider even study fragments and not only studies as a whole when evaluating its quality and relevance [30]. Relevance relates to the contribution each selected study makes to the synthesis of the programme theories [30]. Rigour was not judged using standardised checklists but as a non-standardised judgement of how pieces of evidence within the review are used [30].
Anzeige
In this realist review, only articles that contained information on facilitators and/or barriers were included, making all of them relevant to theory-building. The variation in the quality of information provided in the articles translates to the rigour of the study. Rigour, in this review, was assessed by looking at the type of study design and at the context, in which the insights on facilitators and barriers were gained. We differentiated between insights gained from real life situations, in which prehabilitation was implemented (higher rigour), and artificial study situations (lesser rigour). Similarly, we differentiated between the different study designs. Observational studies in real health system settings as well as qualitative interviews that provide first-hand information on context-specific factors affecting the implementation process were considered of higher rigour than systematic reviews, which provide more generalised information, although both types of information can be helpful in the synthesis process. Information from editorials or opinion pieces, on the other hand, should be considered with more caution as the quality of the information can vary with the expertise of the author, and were thus regarded of less rigour.
Results
Preliminary programme theories
Two preliminary programme theories describing five CMOCs for facilitators and five CMOCs for barriers to the implementation of prehabilitation programmes built the basis for the review process (see tables and supporting quotations in Appendix D and E). Amongst others, the CMOCs covered the themes of information provision, patient-centredness, programme adaptability, and multidisciplinary providers.
Search results
Figure 1 shows the screening process, starting with 2,170 unique results from database searches, which were then screened by title and abstract. 127 results met the criteria for full-text screening, of which 34 provided information on facilitators and barriers to the implementation of prehabilitation programmes for frail patients and were thus included in the review [26, 31‐63]. Three documents could not be accessed as full texts and were thus excluded [64‐66]. The full list of documents excluded after full-text screening can be found in Appendix F.
Fig. 1
Document flow diagram
×
Document characteristics
Table 2 provides an overview of the 34 included documents that provide the basis for data synthesis and refinement of the preliminary programme theories to arrive at CMO-configurations for prehabilitation implementation for frail patients. Of the 34 included documents, which were published between 2003 and 2022, four were qualitative, exploratory studies, seven narrative reviews or perspective articles, five randomised clinical trials, eight non-randomised studies, two letters to the editor, as well as two editorials and six systematic reviews. Most of the included publications covered colorectal cancer (n=8) or cardiac disease (n=5). Eight did not define a disease focus. The prehabilitation interventions ranged from unimodal exercise interventions (n=8) to a combined exercise and nutrition intervention (n=6) to multimodal (n=2) or were not defined (n=18).
comorbidity (Chronic Obstructive Pulmonary Disease, Diabetes Mellitus), chemotherapy in the last half year, severe osteoarthrosis, heart failure, or other recent surgery limiting functional capacity
personalised, supervised, and home-based multimodal programme prescribed by a kinesiologist, a nutritionist, and a psychology-trained nurse; programme started after the baseline visit and continued for 4weeks before surgery
Study article (Non-randomised pilot observational study)
Netherlands
February 2017 – February 2018
14
≥ 70 years who underwent a resection for colorectal cancer
Colorectal cancer
Colorectal cancer surgery
Fried criteria, Clinical Frailty Scale, Short Physical Performance Battery (SPPB), KATZ – Independence of Activities of Daily Living (KATZ-ADL-6 questionnaire)
daily elderly-adapted computer-supported strength training workout (home-based) and two protein-rich meals
patient undergoing colorectal surgery for cancer; frail or prefrail; able to attend exercise training in the regional city; and age ≥ 50
Colorectal cancer
Colorectal surgery
Edmonton Frail Scale
4-week supervised exercise program with dietary advice; three 1 h exercise sessions per week on non-consecutive days to increase muscular strength and cardiorespiratory/aerobic function
physically frail, community-living persons, aged 75 years or older
Not defined
Not defined
rapid gait (i.e., walking back and forth over a 3-m course as quickly as possible) and a single chair stand (i.e., standing up from a hard-back chair with arms folded)
home-based physical therapy including progressive balance and conditioning exercises, using Thera-Bands
Study article (Single-blind, randomised clinical pilot trial)
Netherlands
July 2007 – November 2008
21
Frail elderly with hip osteoarthritis awaiting total hip replacement
Hip osteoarthritis
Total hip arthroplasty
Clinical Frailty Scale
supervised exercise twice a week (60 minutes each) at an outpatient department of physiotherapy; additionally encouraged to exercise at home; strength and aerobic training, functional physical activities for daily living
All-comers were included in the analysis because all potential liver transplant candidates received an exercise prescription at their initial PT evaluation
Liver disease
Liver transplantation
Liver Frailty Index
individualised exercise prescription, mainly as home-based exercise workouts; on rare occasions, home health physical therapy or outpatient physical therapy (at a facility close to home) was recommended
Study article (Single-blind pilot randomised controlled trial)
Netherlands
Unknown
30
elective total hip arthroplasty (minimum waiting period of 3 weeks), osteoarthritis as underlying diagnosis for total hip arthroplasty, age older than 65 years; frail patients
End-stage hip osteoarthritis
Total hip arthroplasty
Identification of Seniors at Risk
home-based programme supervised by an experienced physical therapist to train functional activities and walking capacity
4-week prehabilitation programme that includes a blood flow restriction exercise combined with daily consumption of a sports nutrition cocktail; use of a mobile app as a home-based strategyd
personalised, supervised, and home-based multimodal programme prescribed by a kinesiologist, a nutritionist, and a psychology-trained nurse; programme started after the baseline visit and continued for 4 weeks before surgery
Study article (stratified RCT and systematic review)
Hong Kong
July 3, 2019 – December 31, 2020
RCT: 63 (recruitment ongoing), later 153
frail patients (pre-frail to moderately frail) undergoing elective cardiac surgery; non-participants were defined as: inability to regularly attend, or indecisive/refusal to participate
Cardiac disease
Cardiac surgery
Clinical Frailty Scale
preoperative exercise training twice a week to optimise physical and psychosocial fitness at a dedicated room with gymnasium equipment at the Day Surgery Centre
Anzeige
Main findings
The refined programme theories contain six CMOCs for facilitators and five CMOCs for barriers to the implementation of prehabilitation programmes built (see Tables 3 and 4 and supporting quotations in Appendix G). Of note, some facilitators and barriers can be seen as pairs of antagonists where the presence of one factor may be beneficial, but its absence negatively impacts the outcome.
Table 3
Refined programme theories for facilitators to the implementation of prehabilitation for frail patients into routine health care
CMOC
Context
+ Mechanism
= Outcome
References
1 Well-timed and appropriate information provision
If information about the prehabilitation intervention is provided
• in an understandable, “intuitive and user-friendly”([58], p. 7) way,
• in a way that emphasises the “value of physical activity and the need to exercise”([33], p. 5) and stresses how prehabilitation helps “perform ADLs [activities of daily living]”([31], p. 449)
• at an early time point, “since it helps demystify the reason for the intervention”([39], p. 324)
then this enacts
• an understanding of the benefits
• facilitation of exercise
• increased willingness and interest in active participation
resulting in
• patient empowerment
• increased adherence and motivation
• awareness and understanding of one’s own active role in improvement
• is a “one-size-fits-all intervention”([38], p. 13),
• is not adaptable to the individual capabilities, needs and mobility of the patient, e.g., if there is “inflexibility of ‘prescribed’ prehabilitation”([44], p. 11), and
• is not adapted to the local setting
then this enacts
• excessive demand on the patients (feeling overwhelmed),
• extra stresses,
• dissatisfaction with the intervention
resulting in
• low compliance or drop out,
• inability to participate in or even access the intervention (e.g., due to long distances),
If there is a “lack of physician support, attributed to a lack of conviction regarding the benefit of prehabilitation”([51], p. 21) and if patients feel like a burden to their family and friends, especially due to transportation needs
then this enacts
• lack of focus on the intervention,
• emotional/psychological stress, and
• uncertainty about the importance of the intervention
As part of the refinement process, a CMOC on “Guidance and (social) support” was added in the programme theory on facilitators. This theme had emerged as a unique domain which might greatly affect the feasibility of prehabilitation among frail patients. The themes covered by the refined CMOCs are described in detail in the following paragraphs.
Information provision
Information provision (when, how and by whom) impacts whether patients feel overwhelmed, can process the information, and understand their own role in the intervention. Although it is recommended to approach prospective patients as early as possible to allow for sufficient time for prehabilitation, it is often overwhelming for patients to process information after receiving their diagnosis and need for surgery, leading to limited willingness to participate [33, 42]. Information should suit the patients’ prior knowledge about the components of prehabilitation, conveyed in an understandable way and emphasise the importance of prehabilitation for activities of daily living [31, 44]. Comprehending the intervention and its benefits, especially for their independence in daily activities after surgery, leads to the patients’ understanding of their own role in affecting the outcome of surgery. This improves compliance and increases motivation and adherence to the prehabilitation programme [33, 35].
Patient-centredness and programme adaptability
Adaptability is one of the most important features for successful prehabilitation implementation, especially for frail individuals, who are generally more limited in their mobility and tasks they can do independently. If a prehabilitation programme is a “one-size-fits-all intervention” ([38], p. 13) and not adaptable to the individual capabilities, needs and mobility, this can lead to excessive demand, leaving the frail patients feeling overwhelmed [44, 48]. Individualising exercises, nutrition and psychological advice and adapting them to the lifestyles and degree of frailty is important to ensure compliance and a feeling of comfort and attainability for the patients.
The possibility to complete the intervention at home is helpful for frail patients because of their limited mobility: transportation is a significant barrier for participation. Dependency on others to be transported to participate in sessions makes patients feel like a burden and prevents regular attendance or any participation [31, 42, 45, 48, 49, 52, 54, 56, 59]. Despite less supervision, support by a health care professional and equipment being available in the patients’ homes, home programmes can significantly increase accessibility and is often preferred by patients [31, 37, 41, 43, 58]. Video-conferencing and digital tools like wearable fitness trackers or health apps are helpful in remote monitoring of the patients [38, 43, 56].
Guidance and (social) support
Frail patients need significant support, both by professionals and their social networks, to successfully participate in prehabilitation programmes. Physician support is needed to reduce patients’ uncertainty about the importance of the intervention. Professionals should monitor the patient’s activities, set goals and rewards together with the patients to make them feel directed within the prehabilitation programme [36, 44, 48, 53, 56, 59, 61].
Because of their limited independence, frail patients often strongly rely on their social network, especially for transportation, making support by friends and family important [42]. Without social support, participating in a prehabilitation programme can be emotionally and psychologically stressful, leading to difficulties in adherence and compliance, limited success in and benefit from the programme, or even increased drop-out or non-participation rates.
Integration into and adaption of the setting
For the prehabilitation programme to be successful across different settings, it needs be integrated into the local setting, which depends on factors such as contextual readiness, expressed as leadership support, but also flexibility in hospital and surgery culture as well as available resources [34]. Diffusion and promotion by an ambassador, who is well respected and trusted within the local setting, can increase acceptance [26, 44]. Low cost prehabilitation programmes can facilitate the uptake in settings where financial resources are scarce [33, 61]. For successful integration into the perioperative patient pathway, changes in the organisation processes will be needed to be adopted by all involved stakeholders [26, 44].
Resources
Multimodal prehabilitation is a resource-intensive intervention [34, 50, 51, 56]. The resource intensity is determined by the degree of support a patient needs to complete the program and if it is a home-based or centre-based intervention. The availability of human and financial resources can vary by location as well as the time frame available for the intervention prior to surgery depending on the urgency of the diagnosis and waitlists [37, 62]. A difficulty in prehabilitation implementation is that it is an intervention, which does not show immediate effects, however needs significant funding up front [44], making investment difficult to obtain. If prehabilitation is implemented despite resource constraints, it can put an additional strain on personnel and the quality of care provided [61].
Multidisciplinary team approach
The adoption of prehabilitation programmes into the perioperative trajectory depends on a multidisciplinary and interprofessional team approach, because such an intervention among frail and multimorbid patients requires a holistic approach to adequately address their needs [51]. Only if all involved healthcare professionals have the same understanding of the way prehabilitation should be integrated into the health care setting and the intervention is perceived as valuable by all players, can patients benefit from well-integrated, multimodal care that produces the best outcomes [26]. Patient selection as well as the timing and individual design of the intervention require discussions and cooperation between different providers so that frail patients get the maximum benefit from prehabilitation. If there are no predefined guidelines for prehabilitation, e.g., including a minimum duration, the referral to the intervention could be disturbed and tensions among professionals along the care pathway can arise, sabotaging prehabilitation goals.
Clear patient pathway
A clear patient pathway is facilitated if there are specific and early entry points that follow clear and accepted referral guidelines. It is important that not only the selection criteria for patients to participate in prehabilitation are clear, but that patients enter the prehabilitation programme as early as possible to allow for sufficient time for the intervention before the date of surgery [26, 39, 48]. Ideally, the patient pathway should allow for the flexibility regarding the duration between diagnosis including indication for surgery and the procedure [44]. Clear guidelines, and at the same time, a degree of flexibility, enact a smooth referral between different healthcare professionals, allowing for shared accountability for the success of the intervention. Ultimately, this helps to optimally use existing resources and to maximise the benefits of the prehabilitation programme.
Conflict of interest & funding of the included documents
Information on funding and conflict of interest can be found in Appendix H. Six of the included documents declared that there was no funding and no conflict of interest to report [26, 38, 51, 53, 56, 61]. Six documents did not report their funding and potential conflict of interest and should be considered with caution [32, 35, 39, 41, 62, 63]. Eleven documents, which either did not report a conflict of interest or reported no conflict of interest, received research grants or sponsoring by different national research institutions (non-profit funding), whereas seven documents reported a combination of “none” and “not reported” for conflict of interest and funding [21, 36, 40, 46, 50, 59, 60]. Four other documents declared a conflict of interest, including a CEO position in a firm providing services used in the study [58], a consulting position and intellectual property ownership [47], and financial contributions by medical firms unrelated to the research [34, 37]. The former can be considered problematic as this direct involvement can compromise the evaluation of the study, whereas the readers should be aware of the two latter declarations, however, are not of the same degree of conflict as the first.
Relevance and rigour of the included documents
Out of the 34 included documents, five were classified as being of less rigour because they express personal opinions (letters to the editor, editorials) and the quality of these contributions vary with expertise of the authors. Eight documents provide context-specific insights with high rigour that were obtained through observations and interviews, whereas the remaining 21 documents provided more generalised information that was obtained through reviews.
In terms of relevance, all documents were considered relevant as they added to the analysis of barriers and facilitators to the implementation of prehabilitation for frail patients. However, the documents had varying degrees of relevance based on the type of information they provided. Ten documents were conducted in a controlled experimental setting, not reflecting real-world experiences, which made them less relevant than five other documents that brought insights from real-life settings through observation and interviews. 17 publications provided generalised information that can be considered more relevant to answer questions regarding implementation than those from controlled settings, however, cannot provide the same relevance as context-specific experiences. An overview of judgements of relevance and rigour for each publication can be found in Appendix I.
Discussion
Summary of findings
This realist review provides insights on facilitator and barriers for the implementation of prehabilitation programmes for frail patients who are planning to undergo elective surgery. Six facilitating factors and five barriers were identified, which can be seen as pairs of antagonists whose presence is beneficial, while the absence has negative impact. Most facilitating and hindering factors for the implementation of prehabilitation programmes apply to both frail and non-frail patient groups. For the successful implementation of prehabilitation programmes, the organisational readiness must be given. This includes resources, such as reimbursement, staff, premises, as well as the willingness to implement new and clear referral guidelines and to integrate prehabilitation into the patient pathway. This also necessitates a common understanding and purpose among the health care providers who are part of the multimodal prehabilitation team. Additionally, health care professionals should adapt their communication to fit frail patients. The timing and manner of information provision is also essential to effectively reach and not overwhelm patients and is complicated by the time available until surgery.
Frail patients are limited in their independence, physically, mentally, or both, and require special guidance and support to be able to complete a prehabilitation programme. Support by family and friends plays a vital role, because prehabilitation can be psychologically and physically stressful. Central to the individualisation for frail people is the possibility to participate in a home-based intervention as transportation to attend centre-based programmes is one of the most significant barriers to implementing prehabilitation for frail people. Home-based prehabilitation, however, still needs to provide sufficient support and should ideally be multimodal. In addition, home-based prehabilitation can also be limiting when space is restricted or if monitoring is not feasible [54].
Comparison with existing literature
The findings from this realist review are in line with factors that are frequently named in theoretical implementation science frameworks. Wisdom et al. [67] reviewed 20 theoretical adoption frameworks for the implementation process of complex interventions and found 28 factors on five levels of adoption: Socio-political and External Influence, Organisation Characteristics, Innovation Characteristics, Staff/Individual Characteristics, and Client Characteristics [67]. The facilitators and barriers identified in this realist review fit within these five levels of adoption and are also comparable to factors within the levels of adoption. For example, the factor “Leadership and Champion of Innovation”, part of “Organization Characteristics”, claims that organisational leadership when promoting an innovation is an essential component for successful pre-adoption and adoption [67]. The importance of an ambassador is also recognised in this review.
Findings related to frail patients’ perceptions of and problems with prehabilitation in this review were primarily gained from the qualitative studies by Agasi-Idenburg et al. [33] and Heil et al. [44]. A commonly used framework for qualitative studies on health behaviour change is the Theoretical Domains Framework (TDF), which contains 14 domains that guide the assessment of behaviour change as a result of an intervention [68]. This framework can be helpful to analyse findings from stakeholder interviews. Barnes et al. 2023 conducted a qualitative study that was published after our date of last search [69] using TDF to identify barriers and facilitators to participation in exercise prehabilitation before cancer surgery for older adults with frailty. Their study was nested into the RCT by McIsaac et al. 2020 [14] and found that home-based prehabilitation programs are manageable for frail patients with adequate support and can lead to self-perceived health benefits [69]. Similar to our study, Barnes et al. 2023 found that the need for individualisation, adoptability and variety is a key determinant for the success of prehabilitation interventions among frail patients [69].
Strengths and limitations
The strengths of this realist review include that it was registered prior to conducting the research. Furthermore, by drawing on quantitative, qualitative, and review data, this realist review combines multiple perspectives and experiences to create program theories that can be applied to many situations of prehabilitation implementation. The search strategy produced a broad range of publications and there was no restriction on the publication date so that early as well as very recent studies on prehabilitation were included. Different geographical and health care settings and a variety of prehabilitation approaches were included, so that many different factors impacting implementation are covered in this review.
Limitations posed by the review methods include that, although the search approach aimed to be as comprehensive as possible, literature adding to the issue might have been missed. Only texts in English and German were included, which could have introduced a language bias. Additionally, three full texts were not accessible and subsequently had to be excluded [64‐66]. Due to limited resources, screening was performed independently and in duplicate only in a subset and (following high agreement) continued by one person. Also, data was only extracted by one researcher, which might have introduced errors. Lastly, the assessment of relevance and rigour is subjective to a certain degree, leaving room for debate to what extent each of the included articles provide quality information on facilitators and barriers of the implementation of prehabilitation for frail patients.
The included literature itself also poses some limitations. For one thing, the included articles vary methodologically, and multiple definitions of frailty are used, which can lead to a different understanding of the patients’ limitations, and thus, a different ability to complete a prehabilitation programme. Additionally, the content and intensity of the prehabilitation interventions varied or were not defined, which complicates the interpretation and generisability of results.
Conclusions
We identified several context-mechanism-outcome-configurations for facilitators and barriers to the implementation of prehabilitation programmes prior to elective surgery for frail patients. The resulting programme theories show that, when designing the prehabilitation programme, it is key that the intervention is individualised to fit the capacities and needs of the frail patient. This should be done in cooperation with the patients and their social environment. Furthermore, adequate information provision by health care professionals leads to an understanding of the importance of the intervention and the patients’ role in improving their outcomes, which can be enforced by regular communication with the patient and family. When introducing the prehabilitation programme into routine care, change management activities are required to transform the care pathway. Organisational readiness must include resources, commitment and endorsement by the multidisciplinary team, a clear referral system and clear distribution of responsibilities along the patient pathway. While it is important to learn from the successes and failures of other prehabilitation programmes, the programme must be adapted to the local setting, e.g. after a pilot phase with thorough evaluation.
Acknowledgements
Not applicable.
Declarations
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
AFS performed the research as part of her master’s thesis and declares no financial conflict of interest. JK, SJS, CS and TR are involved in an ongoing randomized clinical trial on prehabilitation in the frail elderly (PRAEP-GO; ClinicalTrials.gov identifier NCT04418271) funded by the Innovationsfonds des Gemeinsamen Bundesausschusses.
JK declares no financial conflict of interest.
Furthermore, SJS received grants and non-financial support from Reactive Robotics GmbH (Munich, Germany), ASP GmbH (Attendorn, Germany), STIMIT AG (Biel, Switzerland), ESICM (Geneva, Switzerland), grants, personal fees and non-financial support from Fresenius Kabi Deutschland GmbH (Bad Homburg, Germany), grants from the Innovationsfond of The Federal Joint Committee (G-BA), personal fees from Springer Verlag GmbH (Vienna, Austria) for educational purposes and Advanz Pharma GmbH (Bielefeld, Germany), non-financial support from national and international societies (and their congress organizers) in the field of anesthesiology and intensive care medicine, outside the submitted work. Dr. Schaller holds stocks in small amounts from Alphabeth Inc., Bayer AG and Siemens AG; these holdings have not affected any decisions regarding his research or this study.
CS reports grants from Innovationsfonds des Gemeinsamen Bundesausschusses, Bundesministerium für Bildung und Forschung, Bundesministerium für Gesundheit/Robert Koch-Institut, Deutsche Forschungsgemeinschaft, Deutsches Zentrum für Luft- und Raumfahrt e. V., Einstein Stiftung Berlin, Inneruniversitäre Forschungsförderung, European Society of Anaesthesiology and Intensive Care, Baxter Deutschland GmbH, Cytosorbents Europe GmbH, Edwards Lifesciences Germany GmbH, Fresenius Medical Care, Grünenthal GmbH, Masimo Europe Ltd., Pfizer Pharma GmbH, Dr. F. Köhler Chemie GmbH, Sintetica GmbH, Stifterverband für die deutsche Wissenschaft e.V./Phillips, Stiftung Charité, AGUETTANT Deutschland GmbH, AbbVie Deutschland GmbH & Co. KG, Amomed Pharma GmbH, InTouch Health, Copra System GmbH, Correvio GmbH, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Deutsche Gesellschaft für Anästhesiologie & Intensivmedizin, Stifterverband für die deutsche Wissenschaft e.V./Metronic, Philips Electronics Nederland BV, Drägerwerk AG & Co. KGaA; personal fees from Georg Thieme Verlag, all outside the submitted work.
TR received honorary fees for commissioned research by the Statutory Health Insurance Medical Review Board outside the submitted work.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
