Background
Breast cancer affects almost 56,000 women every year in the United Kingdom (UK) [
1] and despite improvements in treatment, approximately 40% of these will require mastectomy [
2]. Seroma formation following mastectomy and/or axillary clearance is common, with reported incidence in the literature varying between 10 and 85% [
3]. Although rarely a serious complication of breast surgery, seroma can cause delayed wound healing, require repeated aspiration with the risk of infection, and may delay the start of adjuvant treatments [
4,
5].
Strategies to reduce the formation of seroma include the use of surgical drains and flap fixation methods such as quilting or tissue glue and external compression which all act by minimising the surgical dead-space and evidence to support the effectiveness of different approaches has been summarised in several systematic reviews [
6‐
10]. Many of these reviews, however, have highlighted the lack of high-quality research to support practice and the need for future well-designed studies in this area.
For future research to be meaningful, it is vital that the study design should reflect current practice and address key uncertainties that are important to patients and the clinical community. We aimed to survey breast surgeons to determine current approaches to the management of seroma in the UK; particularly the use of drains after simple breast cancer surgery to inform the feasibility and design of a future randomised controlled trial (RCT).
Discussion
This survey has demonstrated considerable variation in the management of seromas following mastectomy and axillary surgery in the UK and the need for and potential feasibility of a large-scale pragmatic RCT to establish best practice. It is likely that a future trial would compare the use of drains vs no drains as this is currently the main strategy for reducing seroma development in the UK.
Surgeons’ attitudes to a potential trial in this area reflects the lack of high-quality evidence to support the use of drains following breast cancer surgery. A systematic review [
6] considered seroma formation in 1347 women following mastectomy (± axillary lymph node clearance) with and without suction drainage. The review included two RCTs [
12,
13] and six non-randomised studies [
14‐
19]. The data were found to be at a high risk of bias, heterogeneous with variable use of flap fixation methods and with an inconsistently defined primary outcome of seroma formation. The authors concluded that there was some evidence that drainage following mastectomy and axillary surgery could be safely omitted without increasing seroma formation or complications but highlighted the need for further high-quality research to determine the role of surgical drains following breast cancer surgery including outcomes of importance to patients. These findings were consistent with previous reviews [
9,
20,
21] suggesting that drainage does appear to reduce seroma rates but may be associated with longer hospital stays. However, it should be noted that drain use increasingly may not affect hospital stay as significantly as it has done in the past. The 2021 Getting It Right First Time (GIRFT) report (Using Hospital Episode Statistics, HES Data April 2015-March 2018) [
22], demonstrated that only 20% of mastectomies without reconstruction, were conducted as a day case and that rates vary widely across trusts from 0% to 78.28%. The report recommended that day case mastectomy rates should be increased to 75%. Increasing day case mastectomy has perhaps recently been driven by the COVID-19 pandemic, and the consequent need to avoid hospital stay and risk of infection. In this survey, 77% (58/75) of respondents reported that patients went home on the day of surgery more than 75% of the time (Table
2).
Several recent or ongoing European RCTs, as well as comprehensive literature reviews [
23] have considered techniques to reduce seroma formation and the need for drains after mastectomy. The Dutch SAM trial [
24,
25] (NCT03305757), was a multicentre three arm RCT of flap fixation with sutures or tissue glue and conventional closure, with closed suction drains in all arms. This showed a significant reduction in clinically significant seroma in both flap fixation arms with the greatest reduction in the sutured flap fixation group [
24]. Ongoing RCTs include the single-centre Dutch SARA [
26] (NCT04035590) trial which will compare flap fixation with and without suction drainage; the multicentre Dutch QUILT (NCT05272904—not yet recruiting) trial comparing quilting without a drain and conventional closure; and the multicentre French QUISERMAS trial [
27] (NCT02263651) comparing conventional closure with a drain and flap fixation without a drain. This study completed in 2018 but has yet to report. None of these trials, however, reflect current UK practice or include outcomes of importance of patients. Quilting is not standard practice in the UK, perhaps due to the increased costs associated with the time quilting takes and the use of more expensive self-locking sutures to perform the procedure. In addition, there are perceived concerns regarding compromising skin flap viability, particularly where the skin flaps are thin or in those already deemed to be high risk for complications such as smokers.
Whilst the most common outcome for the trial suggested by surgeons in this survey was the number of symptomatic seromas drained (20% of respondents), this was closely followed by the number of hospital/healthcare provider visits (16% of respondents). Work with our patient and public involvement (PPI) group highlighted that hospital visits were perceived as a major burden to patients. This outcome would comprehensively evaluate drain-related issues, symptomatic seromas; wound complications and patient concerns which may require clinical evaluation while being objective and easy to measure. As such, hospital visits would pragmatically be the most appropriate primary outcome for a future trial.
This is a national practice survey with limitations that require consideration. Firstly, it only includes the views of a relatively small group of UK breast surgeons. From the Getting It Right First Time (GIRFT) report in 2021 [
22], there were 130 breast surgery units in England, but this number varies year to year depending on service mergers and closures. The surgeons who responded, may be more engaged in research and thus may not be representative of the breast surgical community more broadly. Whilst this is possible, the survey has included surgeons from across the UK, in all major geographical areas, with various degrees of experience. Furthermore, this engaged group of surgeons is likely to include those who will open and recruit to any future study. It could therefore be argued that their views are the most relevant as they will determine whether a future study would be successful. It is, however, possible that willing to participate in a future RCT in principle, does not always translate into actual participation in practice.
Despite limitations, this work demonstrates there is a need for a high-quality RCT to determine if, when and in whom closed suction drains are necessary following mastectomy and axillary surgery in the UK. Perhaps more importantly, this is a question that is also meaningful to patients as in the recent James Lind Priority Setting Partnership (PSP) in breast cancer surgery [
28], one in three patient respondents submitted questions related to seroma and the benefits of drains after breast cancer surgery. Overall, this question was ranked as the 11
th most important research priority to patients completing the survey and although it narrowly missed being considered for the top 10 research priorities [
28], it is clearly an area where more research is needed.
Work to design and gain funding for a future trial is now underway. Given the large volume of procedures performed, it is likely that that such a trial would recruit quickly and easily and utilisation of the breast trainee collaborative research network may represent a cost-effective means of delivering the study in a timely fashion [
29‐
31]. If an RCT proves that drains are unnecessary in all or most patients undergoing mastectomy and/or axillary surgery, it will provide the necessary high-quality evidence to change practice. This will reduce NHS costs and the burden on scarce resources, but more importantly, improve patient experiences of breast cancer treatment.
Acknowledgements
List of PUBMed citable collaborators (names as given in the online survey; some who completed did not leave a name). Nick Abbott, Raj Achuthan, Goran Ahmed, Rachel Ainsworth, Laura Arthur, Salena Bains, Zoe Barber, Jeremy Batt, Ashleigh Bell, Jane Carter, Alice Chambers, Anna Conway, Carol-Ann Courtney, Ian Daltrey, Raouf Daoud, Isabella Dash, Rajiv Dave, Julia Dicks, Urszula Donigiewicz, Hiba Fatayer, Daniel Glassman, Nikki Green, Eleanor Gutteridge, Ahmed Hamad, Anita Hargreaves, James Harvey, Shaziya Hassan Ali, Sophie Helme, Julia Henderson, Susan Hignett, Fiona Hoar, Jonathan Horsnell, Thomas Hubbard, Alex Humphreys, Javeria Iqbal, Omotayo Johnson, Meera Joshi, Charlotte Kallaway, Isabella Karat, Baek Kim, Eleftheria Kleidi, Manish Kothari, Chrissie Laban, Kelly Lambert, Siobhan Laws, Alexander Leeper, Serena Ledwidge, Valentina Lefemine, Jonathan Lund, E Jane Macaskill, Mariam Malik, James Mansell, Loaie Maraqa, Yazan Masannat, Julia Massey, Ross McLean, Jennifer McIlhenny, Colin McIlmunn, Louise Merker, Geraldine Mitchell, Jo Mondani, Elizabeth Morrow, Nabila Nasir, Olubunmi Odofin, Caroline Osborne, Polly Partlett, Anna Powell-Chandler, Sreekumar Sundara Rajan, Clare Rogers, Chandeena Roshanlall, Matthew Philip Rowland, Walid Abou Samra, Lucy Satherley, Brendan Skelly, Richard Sutton, Anne Tansley, Marios Konstantinos Tasoulis, Simon Timbrel, Nader Touqan, Alison Waterworth, Lisa Whisker, Kate Williams, Nihal Gonen Yildirim, Charles Zammit.
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