Background
Methods
Patient samples
Data collection
Statistical analysis
Results
The levels of serum lipids and BMI among the OSCC, OPMD and control groups
Control (n = 200) | OSCC (n = 187) | OPMD (n = 145) | |
---|---|---|---|
Gender (n) | |||
Male | 116 | 117 | 42 |
Female | 84 | 70 | 103 |
Age | 52.83 ± 11.52 | 61.33 ± 10.98 | 51.70 ± 13.89 |
TC (mmol/L) | 4.43 ± 0.91 | 4.51 ± 0.94 | 4.68 ± 0.87 |
TG (mmol/L) | 1.31 ± 0.71 | 1.40 ± 0.96 | 1.32 ± 0.67 |
HDL-C (mmol/L) | 1.18 ± 0.28 | 1.19 ± 0.32 | 1.49 ± 0.59 |
LDL-C (mmol/L) | 2.46 ± 0.71 | 2.55 ± 0.78 | 2.38 ± 0.75 |
Apo-A (g/L) | 1.32 ± 0.23 | 1.28 ± 0.30 | 1.49 ± 0.22 |
Apo-B (g/L) | 0.91 ± 0.28 | 0.88 ± 0.29 | 0.97 ± 0.38 |
Lpa (mg/L) | 196.05 ± 232.33 | 202.75 ± 261.60 | 172.30 ± 244.95 |
BMI (kg/m2) | 23.34 ± 3.08 | 23.12 ± 3.31 | 23.81 ± 3.36 |
Control | OSCC | OPMD |
P1
|
P2
|
P3
| |
---|---|---|---|---|---|---|
TC (mmol/L) | 4.24 ± 2.69 | 4.31 ± 1.37 | 4.45 ± 1.20 | 0.766 | 0.104 | 0.400 |
TG (mmol/L) | 1.46 ± 2.83 | 1.62 ± 1.37 | 1.50 ± 1.32 | 0.260 | 0.927 | 0.551 |
HDL-C (mmol/L) | 0.85 ± 1.13 | 0.82 ± 0.55 | 1.12 ± 0.48 | 0.757 |
< 0.01*
|
< 0.01*
|
LDL-C (mmol/L) | 2.64 ± 2.12 | 2.77 ± 1.09 | 2.56 ± 0.96 | 0.234 | 0.607 | 0.052 |
Apo-A (g/L) | 1.27 ± 0.71 | 1.23 ± 0.41 | 1.40 ± 0.36 | 0.240 |
< 0.01*
|
< 0.01*
|
Apo-B (g/L) | 0.91 ± 0.85 | 0.88 ± 0.41 | 0.98 ± 0.48 | 0.544 | 0.114 |
0.015*
|
Lpa (mg/L) | 175.83 ± 720.54 | 178.71 ± 358.96 | 154.01 ± 333.67 | 0.993 | 0.711 | 0.682 |
BMI (kg/m2) | 22.79 ± 9.48 | 22.48 ± 4.65 | 23.28 ± 4.33 | 0.641 | 0.363 | 0.097 |
Comparison of serum lipids and BMI according to different clinicopathological parameters of OSCC
Parameter(n) | TC (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | Apo-A (g/L) | Apo-B (g/L) | Lpa (mg/L) | BMI (kg/m2) |
---|---|---|---|---|---|---|---|---|
Gender | ||||||||
Male (117) | 4.42 ± 0.98 | 1.48 ± 1.57 | 1.17 ± 0.36 | 2.49 ± 0.82 | 1.23 ± 0.31 | 0.86 ± 0.31 | 186.44 ± 224.46 | 22.70 ± 3.18 |
Female (70) | 4.65 ± 0.86 | 1.42 ± 0.67 | 1.23 ± 0.25 | 2.66 ± 0.71 | 1.35 ± 0.25 | 0.91 ± 0.24 | 230.00 ± 313.95 | 23.83 ± 3.43 |
P
| 0.094 | 0.752 | 0.166 | 0.169 |
0.011*
| 0.353 | 0.272 |
0.023*
|
Age | ||||||||
< 60(72) | 4.54 ± 0.81 | 1.71 ± 1.72 | 1.11 ± 0.32 | 2.59 ± 0.73 | 1.26 ± 0.36 | 0.90 ± 0.28 | 217.68 ± 252.73 | 23.08 ± 3.40 |
≥ 60(115) | 4.48 ± 1.02 | 1.31 ± 0.94 | 1.24 ± 0.31 | 2.53 ± 0.82 | 1.29 ± 0.25 | 0.87 ± 0.29 | 193.40 ± 267.66 | 23.14 ± 3.27 |
P
| 0.694 | 0.073 |
0.006*
| 0.607 | 0.519 | 0.410 | 0.538 | 0.903 |
TNM stage | ||||||||
I(33) | 4.62 ± 1.06 | 1.63 ± 2.22 | 1.26 ± 0.37 | 2.58 ± 0.85 | 1.25 ± 0.31 | 0.86 ± 0.29 | 140.42 ± 123.13 | 23.13 ± 3.88 |
II(50) | 4.48 ± 0.80 | 1.40 ± 0.89 | 1.21 ± 0.31 | 2.50 ± 0.69 | 1.32 ± 0.35 | 0.87 ± 0.29 | 231.84 ± 318.15 | 23.46 ± 3.25 |
III(43) | 4.50 ± 0.79 | 1.61 ± 1.39 | 1.20 ± 0.30 | 2.53 ± 0.71 | 1.33 ± 0.27 | 0.89 ± 0.27 | 200.93 ± 202.01 | 23.10 ± 3.16 |
IV(61) | 4.48 ± 1.08 | 1.31 ± 0.76 | 1.13 ± 0.32 | 2.60 ± 0.88 | 1.21 ± 0.25 | 0.89 ± 0.30 | 213.90 ± 299.77 | 22.86 ± 3.20 |
P
| 0.905 | 0.573 | 0.267 | 0.895 | 0.141 | 0.933 | 0.460 | 0.827 |
N classification | ||||||||
(-) (119) | 4.51 ± 0.87 | 1.47 ± 1.37 | 1.22 ± 0.32 | 2.52 ± 0.72 | 1.30 ± 0.33 | 0.88 ± 0.28 | 190.40 ± 240.41 | 23.21 ± 3.36 |
(+) (68) | 4.50 ± 1.06 | 1.45 ± 1.19 | 1.14 ± 0.33 | 2.61 ± 0.88 | 1.24 ± 0.23 | 0.88 ± 0.30 | 224.35 ± 295.71 | 22.96 ± 3.25 |
P
| 0.950 | 0.906 | 0.095 | 0.464 | 0.222 | 0.998 | 0.395 | 0.627 |
Location | ||||||||
Tongue (87) | 4.62 ± 1.05 | 1.40 ± 0.88 | 1.21 ± 0.34 | 2.60 ± 0.89 | 1.32 ± 0.33 | 0.91 ± 0.30 | 196.28 ± 275.99 | 22.99 ± 3.12 |
Buccal (42) | 4.43 ± 0.85 | 1.48 ± 1.38 | 1.17 ± 0.25 | 2.54 ± 0.66 | 1.24 ± 0.24 | 0.87 ± 0.31 | 258.50 ± 334.63 | 23.77 ± 3.12 |
Lip (7) | 3.89 ± 0.60 | 1.44 ± 0.73 | 1.01 ± 0.23 | 2.20 ± 0.63 | 1.11 ± 0.24 | 0.76 ± 0.22 | 98.43 ± 98.30 | 22.26 ± 3.57 |
Palate (10) | 4.42 ± 0.71 | 2.72 ± 3.89 | 1.24 ± 0.55 | 2.28 ± 0.65 | 1.29 ± 0.47 | 0.77 ± 0.24 | 258.00 ± 193.10 | 22.98 ± 3.93 |
Gingiva (34) | 4.60 ± 0.80 | 1.24 ± 0.66 | 1.24 ± 0.30 | 2.68 ± 0.71 | 1.28 ± 0.20 | 0.89 ± 0.25 | 148.12 ± 130.82 | 23.13 ± 3.92 |
Mandible (7) | 3.78 ± 0.76 | 1.36 ± 0.56 | 0.95 ± 0.21 | 2.15 ± 0.53 | 1.08 ± 0.18 | 0.79 ± 0.21 | 239.29 ± 214.67 | 21.90 ± 2.80 |
P
| 0.100 | 0.058 | 0.203 | 0.326 | 0.175 | 0.508 | 0.402 | 0.679 |
Comparison of serum lipids and BMI according to different clinicopathological parameters of OPMD
Parameter(n) | TC (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | Apo-A (g/L) | Apo-B (g/L) | Lpa (mg/L) | BMI (kg/m2) |
---|---|---|---|---|---|---|---|---|
Gender | ||||||||
Male (42) | 4.43 ± 0.94 | 1.37 ± 0.77 | 1.33 ± 0.53 | 2.31 ± 0.82 | 1.39 ± 0.023 | 1.00 ± 0.39 | 155.43 ± 204.57 | 23.83 ± 3.73 |
Female (103) | 4.78 ± 0.82 | 1.31 ± 0.63 | 1.55 ± 0.61 | 2.42 ± 0.72 | 1.54 ± 0.20 | 0.96 ± 0.37 | 179.18 ± 260.23 | 23.80 ± 3.22 |
P
| 0.024* | 0.628 | 0.036* | 0.413 | < 0.001* | 0.517 | 0.598 | 0.966 |
Age | ||||||||
< 60(101) | 4.63 ± 0.85 | 1.32 ± 0.67 | 1.36 ± 0.41 | 2.48 ± 0.69 | 1.51 ± 0.21 | 0.96 ± 0.36 | 164.05 ± 229.74 | 23.53 ± 3.49 |
≥ 60(44) | 4.80 ± 0.90 | 1.35 ± 0.67 | 1.79 ± 0.81 | 2.17 ± 0.84 | 1.45 ± 0.24 | 0.99 ± 0.41 | 191.25 ± 278.68 | 24.44 ± 2.99 |
P
| 0.282 | 0.807 | 0.001* | 0.039* | 0.149 | 0.662 | 0.541 | 0.135 |
Disease | ||||||||
OLP (105) | 4.70 ± 0.92 | 1.28 ± 0.63 | 1.33 ± 0.29 | 2.57 ± 0.70 | 1.53 ± 0.21 | 0.96 ± 0.38 | 173.73 ± 260.80 | 23.45 ± 3.42 |
OLK (40) | 4.64 ± 0.71 | 1.43 ± 0.75 | 1.90 ± 0.91 | 1.91 ± 0.66 | 1.40 ± 0.22 | 1.00 ± 0.38 | 168.55 ± 200.38 | 24.75 ± 3.02 |
P
| 0.725 | 0.241 | < 0.001* | < 0.001* | 0.001* | 0.599 | 0.910 | 0.037* |
Type (OLP) | ||||||||
Reticular (45) | 4.72 ± 1.01 | 1.30 ± 0.69 | 1.30 ± 0.28 | 2.64 ± 0.75 | 1.51 ± 020 | 1.00 ± 0.33 | 153.67 ± 184.01 | 22.83 ± 3.58 |
Erosive (60) | 4.68 ± 0.86 | 1.27 ± 0.59 | 1.35 ± 0.30 | 2.51 ± 0.66 | 1.55 ± 0.21 | 0.93 ± 0.41 | 188.78 ± 306.76 | 23.91 ± 3.26 |
P
| 0.826 | 0.804 | 0.350 | 0.351 | 0.268 | 0.330 | 0.497 | 0.110 |
Regression analysis of lipid levels and BMI values of OSCC and OPMD
Predictors | Odds Ratios | 95%CI |
P
|
---|---|---|---|
Gender | |||
male | 1 | ||
female | 0.98 | 0.62–1.55 | 0.924 |
Age | 1.07 | 1.05–1.09 |
< 0.001*
|
BMI (kg/m2) | |||
18.5–23.9 | 1 | ||
< 18.5 | 1.75 | 0.66–4.77 | 0.261 |
> 23.9 | 0.8 | 0.50–1.27 | 0.345 |
TC (mmol/L) | |||
0-5.2 | 1 | ||
> 5.2 | 1.62 | 0.66–4.08 | 0.293 |
TG (mmol/L) | |||
0.4–1.81 | 1 | ||
< 0.4 | 0.35 | 0.01–3.79 | 0.433 |
> 1.81 | 1.53 | 0.85–2.79 | 0.16 |
HDL-C (mmol/L) | |||
1.07–1.9 | 1 | ||
< 1.07 | 1.01 | 0.60–1.70 | 0.96 |
> 1.9 | 1.07 | 0.26–4.59 | 0.922 |
LDL-C (mmol/L) | |||
0-3.1 | 1 | ||
> 3.1 | 0.88 | 0.37–2.05 | 0.761 |
Apo-A (g/L) | |||
1-1.6 | 1 | ||
< 1 | 2.33 | 1.04–5.44 |
0.043
*
|
> 1.6 | 0.78 | 0.34–1.75 | 0.548 |
Apo-B (g/L) | |||
0.1–1.81 | 1 | ||
> 1.81 | 0.76 | 0.19–2.92 | 0.696 |
Lpa (mg/L) | |||
0-300 | 1 | ||
> 300 | 0.87 | 0.50–1.51 | 0.627 |
Predictors | Odds Ratios | 95%CI |
P
|
---|---|---|---|
Gender | |||
male | 1 | ||
female | 2.54 | 1.55–4.21 |
< 0.001
*
|
Age | 0.98 | 0.96–1.00 | 0.064 |
BMI (kg/m2) | |||
18.5–23.9 | 1 | ||
< 18.5 | 0.3 | 0.08–1.01 | 0.06 |
> 23.9 | 0.98 | 0.59–1.63 | 0.941 |
TC (mmol/L) | |||
0-5.2 | 1 | ||
> 5.2 | 2.89 | 0.99–9.85 | 0.066 |
TG (mmol/L) | |||
0.4–1.81 | 1 | ||
< 0.4 | 0.21 | 0.01–1.83 | 0.199 |
> 1.81 | 1.27 | 0.66–2.45 | 0.469 |
HDL-C (mmol/L) | |||
1.07–1.9 | 1 | ||
< 1.07 | 0.68 | 0.36–1.26 | 0.224 |
> 1.9 | 5.01 | 1.57–19.09 |
0.01
*
|
LDL-C (mmol/L) | |||
0-3.1 | 1 | ||
> 3.1 | 0.35 | 0.10–1.05 | 0.077 |
Apo-A (g/L) | |||
1-1.6 | 1 | ||
< 1 | 0.54 | 0.10–2.09 | 0.409 |
> 1.6 | 2.25 | 1.16–4.46 |
0.018
*
|
Apo-B (g/L) | |||
0.1–1.81 | 1 | ||
> 1.81 | 2.05 | 0.58–7.39 | 0.262 |
Lpa (mg/L) | |||
0-300 | 1 | ||
> 300 | 0.82 | 0.44–1.51 | 0.53 |