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Erschienen in: Current Diabetes Reports 8/2023

05.06.2023

Challenges and Opportunities in Diagnosis and Management of Cardiometabolic Risk in Adolescents

verfasst von: Dedeepya Konuthula, Marcia M. Tan, Deborah L. Burnet

Erschienen in: Current Diabetes Reports | Ausgabe 8/2023

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Abstract

Purpose of Review

This review aims to elucidate the limitations of diagnosing metabolic syndrome in adolescents as well as challenges and opportunities in the identification and reduction of cardiometabolic risk in this population.

Recent Findings

There are multiple criticisms of how we define and approach obesity in clinical practice and scientific research, and weight stigma further complicates the process of making and communicating weight-related diagnoses. While the goal of diagnosing and managing metabolic syndrome in adolescents would be to identify individuals at elevated future cardiometabolic risk and intervene to reduce the modifiable component of this risk, there is evidence that identifying cardiometabolic risk factor clustering may be more useful in adolescents than establishing a cutoff-based diagnosis of metabolic syndrome. It has also become clear that many heritable factors and social and structural determinants of health contribute more to weight and body mass index than do individual behavioral choices about nutrition and physical activity. Promoting cardiometabolic health equity requires that we intervene on the obesogenic environment and mitigate the compounding effects of weight stigma and systemic racism.

Summary

The existing options to diagnose and manage future cardiometabolic risk in children and adolescents are flawed and limited. While striving to improve population health through policy and societal interventions, there are opportunities to intervene at all levels of the socioecological model in order to decrease future morbidity and mortality from the chronic cardiometabolic diseases associated with central adiposity in both children and adults. More research is needed to identify the most effective interventions.
Literatur
4.
8.
Zurück zum Zitat Mechanick J, Hurley D, Garvey W. Adiposity-based chronic disease as a new diagnostic term: the American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement. Endocr Pract. 2017;23(3). https://doi.org/10.4158/EP161688.PS. Mechanick J, Hurley D, Garvey W. Adiposity-based chronic disease as a new diagnostic term: the American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement. Endocr Pract. 2017;23(3). https://​doi.​org/​10.​4158/​EP161688.​PS.
9.
Zurück zum Zitat • Nieto-Martínez R, González-Rivas J, Mechanick J. Cardiometabolic risk: new chronic care models. JPEN J Parenter Enteral Nutr. 2021;45(S2). https://doi.org/10.1002/jpen.2264. (Describes a new Cardiometabolic-Based Chronic Disease (CMBCD) care model for cardiometabolic risk.) • Nieto-Martínez R, González-Rivas J, Mechanick J. Cardiometabolic risk: new chronic care models. JPEN J Parenter Enteral Nutr. 2021;45(S2). https://​doi.​org/​10.​1002/​jpen.​2264. (Describes a new Cardiometabolic-Based Chronic Disease (CMBCD) care model for cardiometabolic risk.)
19.
Zurück zum Zitat Bradbury D, Chisholm A, Watson P, Bundy C, Bradbury N, Birtwistle S. Barriers and facilitators to health care professionals discussing child weight with parents: a meta-synthesis of qualitative studies. Br J Health Psychol. 2018;23(3). https://doi.org/10.1111/bjhp.12312. Bradbury D, Chisholm A, Watson P, Bundy C, Bradbury N, Birtwistle S. Barriers and facilitators to health care professionals discussing child weight with parents: a meta-synthesis of qualitative studies. Br J Health Psychol. 2018;23(3). https://​doi.​org/​10.​1111/​bjhp.​12312.
20.
33.
Zurück zum Zitat Ross R, Neeland I, Yamashita S, Shai I, Seidell J, Magni P et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol. 2020;16(3). https://doi.org/10.1038/s41574-019-0310-7. Ross R, Neeland I, Yamashita S, Shai I, Seidell J, Magni P et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol. 2020;16(3). https://​doi.​org/​10.​1038/​s41574-019-0310-7.
34.
35.
Zurück zum Zitat Inokuchi M, Matsuo N, Takayama J, Hasegawa T. Population-based waist circumference reference values in Japanese children (0–6 years): comparisons with Dutch, Swedish and Turkish preschool children. J Pediatr Endocrinol Metab: JPEM. 2020;34(3). https://doi.org/10.1515/jpem-2020-0418. Inokuchi M, Matsuo N, Takayama J, Hasegawa T. Population-based waist circumference reference values in Japanese children (0–6 years): comparisons with Dutch, Swedish and Turkish preschool children. J Pediatr Endocrinol Metab: JPEM. 2020;34(3). https://​doi.​org/​10.​1515/​jpem-2020-0418.
36.
Zurück zum Zitat Garvey W, Mechanick J, Brett E, Garber A, Hurley D, Jastreboff A, et al. American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines for Medical Care of Patients with Obesity. Endocr Pract. 2016;22 Suppl 3. https://doi.org/10.4158/EP161365.GL Garvey W, Mechanick J, Brett E, Garber A, Hurley D, Jastreboff A, et al. American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines for Medical Care of Patients with Obesity. Endocr Pract. 2016;22 Suppl 3. https://​doi.​org/​10.​4158/​EP161365.​GL
42.
43.
Zurück zum Zitat Steinberger J, Daniels S. Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation. 2003;107(10). https://doi.org/10.1161/01.cir.0000060923.07573.f2. Steinberger J, Daniels S. Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation. 2003;107(10). https://​doi.​org/​10.​1161/​01.​cir.​0000060923.​07573.​f2.
44.
Zurück zum Zitat Adolescents EPoIGfCHaRRiCa, National Heart L, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics. 2011;128 Suppl 5(Suppl 5). https://doi.org/10.1542/peds.2009-2107C. Adolescents EPoIGfCHaRRiCa, National Heart L, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics. 2011;128 Suppl 5(Suppl 5). https://​doi.​org/​10.​1542/​peds.​2009-2107C.
57.
Zurück zum Zitat Israel B, Schulz A, Parker E, Becker A. Critical issues in developing and following community-based participatory research principles. In: Minkler M, Wallerstein N, editors. Community-Based Participatory Research for Health. San Francisco: Jossey-Bass; 2008. p. 47–62. Israel B, Schulz A, Parker E, Becker A. Critical issues in developing and following community-based participatory research principles. In: Minkler M, Wallerstein N, editors. Community-Based Participatory Research for Health. San Francisco: Jossey-Bass; 2008. p. 47–62.
58.
Zurück zum Zitat Sallis J, Owen N, Fisher E. Ecological models of health behavior. In: Glanz K, Rimer B, Viswanath K, editors. Health behavior and health education. 4th ed. San Francisco: John Wiley & Sons; 2008. p. 465–85. Sallis J, Owen N, Fisher E. Ecological models of health behavior. In: Glanz K, Rimer B, Viswanath K, editors. Health behavior and health education. 4th ed. San Francisco: John Wiley & Sons; 2008. p. 465–85.
59.
Zurück zum Zitat Wallerstein N, Duran B. The conceptual, historical and practice roots of community-based participatory research and related participatory traditions. In: Minkler M, Wallerstein N, editors. Community-based participatory research for health. 1st ed. San Francisco: Jossey-Bass; 2003. p. 27–52. Wallerstein N, Duran B. The conceptual, historical and practice roots of community-based participatory research and related participatory traditions. In: Minkler M, Wallerstein N, editors. Community-based participatory research for health. 1st ed. San Francisco: Jossey-Bass; 2003. p. 27–52.
60.
62.
Zurück zum Zitat •• Kumanyika S. Advancing health equity efforts to reduce obesity: changing the course. Ann Rev Nutr. 2022;42. https://doi.org/10.1146/annurev-nutr-092021-050805. (Highlights how numerous inequities across the lifespan lead to disparities in obesity prevalence with a focus on Black Americans and provides recommendations for equity.) •• Kumanyika S. Advancing health equity efforts to reduce obesity: changing the course. Ann Rev Nutr. 2022;42. https://​doi.​org/​10.​1146/​annurev-nutr-092021-050805. (Highlights how numerous inequities across the lifespan lead to disparities in obesity prevalence with a focus on Black Americans and provides recommendations for equity.)
64.
Zurück zum Zitat Felitti V, Anda R, Nordenberg D, Williamson D, Spitz A, Edwards V, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998;14(4). https://doi.org/10.1016/s0749-3797(98)00017-8. Felitti V, Anda R, Nordenberg D, Williamson D, Spitz A, Edwards V, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998;14(4). https://​doi.​org/​10.​1016/​s0749-3797(98)00017-8.
70.
Zurück zum Zitat Jones C. The impact of racism on health. Ethn Dis. 2002;12(1). Jones C. The impact of racism on health. Ethn Dis. 2002;12(1).
77.
Zurück zum Zitat Kumanyika S. The sociocultural context for obesity prevention and treatment in children and adolescents: influences of ethnicity and gender. In: Freemark M (ed) Pediatric Obesity: Etiology, Pathogenesis and Treatment. Springer International Publishing; 2018. p. 695–713 Kumanyika S. The sociocultural context for obesity prevention and treatment in children and adolescents: influences of ethnicity and gender. In: Freemark M (ed) Pediatric Obesity: Etiology, Pathogenesis and Treatment. Springer International Publishing; 2018. p. 695–713
88.
Zurück zum Zitat Resnicow K, Harris D, Wasserman R, Schwartz R, Perez-Rosas V, Mihalcea R, et al. Advances in motivational interviewing for pediatric obesity: results of the brief motivational interviewing to reduce body mass index trial and future directions. Pediatr Clin North Am. 2016;63(3). https://doi.org/10.1016/j.pcl.2016.02.008. Resnicow K, Harris D, Wasserman R, Schwartz R, Perez-Rosas V, Mihalcea R, et al. Advances in motivational interviewing for pediatric obesity: results of the brief motivational interviewing to reduce body mass index trial and future directions. Pediatr Clin North Am. 2016;63(3). https://​doi.​org/​10.​1016/​j.​pcl.​2016.​02.​008.
89.
Zurück zum Zitat Christie D, Channon S. The potential for motivational interviewing to improve outcomes in the management of diabetes and obesity in paediatric and adult populations: a clinical review. Diabetes Obes Metab. 2014;16(5). https://doi.org/10.1111/dom.12195. Christie D, Channon S. The potential for motivational interviewing to improve outcomes in the management of diabetes and obesity in paediatric and adult populations: a clinical review. Diabetes Obes Metab. 2014;16(5). https://​doi.​org/​10.​1111/​dom.​12195.
92.
Zurück zum Zitat Weir K. Family-based behavioral treatment is key to addressing childhood obesity. Monit Psychol. 2019;50(4):30. Weir K. Family-based behavioral treatment is key to addressing childhood obesity. Monit Psychol. 2019;50(4):30.
94.
95.
Zurück zum Zitat Yuksel H, Şahin F, Maksimovic N, Drid P, Bianco A. School-based intervention programs for preventing obesity and promoting physical activity and fitness: a systematic review. Int J Environ Res Public Health. 2020;17(1).https://doi.org/10.3390/ijerph17010347. Yuksel H, Şahin F, Maksimovic N, Drid P, Bianco A. School-based intervention programs for preventing obesity and promoting physical activity and fitness: a systematic review. Int J Environ Res Public Health. 2020;17(1).https://​doi.​org/​10.​3390/​ijerph17010347.
97.
Zurück zum Zitat Choudhry S, McClinton-Powell L, Solomon M, Davis D, Lipton R, Darukhanavala A et al. Power-up: a collaborative after-school program to prevent obesity in African American children. Prog Community Health Partnersh. 2011;5(4). Choudhry S, McClinton-Powell L, Solomon M, Davis D, Lipton R, Darukhanavala A et al. Power-up: a collaborative after-school program to prevent obesity in African American children. Prog Community Health Partnersh. 2011;5(4).
104.
107.
Zurück zum Zitat Wilfley D, Staiano A, Altman M, Lindros J, Lima A, Hassink S et al. Improving access and systems of care for evidence-based childhood obesity treatment: conference key findings and next steps. Obesity (Silver Spring, Md). 2017;25(1). https://doi.org/10.1002/oby.21712. Wilfley D, Staiano A, Altman M, Lindros J, Lima A, Hassink S et al. Improving access and systems of care for evidence-based childhood obesity treatment: conference key findings and next steps. Obesity (Silver Spring, Md). 2017;25(1). https://​doi.​org/​10.​1002/​oby.​21712.
112.
Zurück zum Zitat StateofChildhoodObesity. Meeting the Moment - Learning From Leaders at the Forefront of Change.2022 11–15. StateofChildhoodObesity. Meeting the Moment - Learning From Leaders at the Forefront of Change.2022 11–15.
Metadaten
Titel
Challenges and Opportunities in Diagnosis and Management of Cardiometabolic Risk in Adolescents
verfasst von
Dedeepya Konuthula
Marcia M. Tan
Deborah L. Burnet
Publikationsdatum
05.06.2023
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 8/2023
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-023-01513-3

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