Ausgabe 8/2022
Inhalt (20 Artikel)
Associations between immune-related thyroid dysfunction and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis
Yee-Ming Melody Cheung, Wei Wang, Bradley McGregor, Ole-Petter Riksfjord Hamnvik
Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities
Rosy Njonkou, Christopher M. Jackson, Graeme F. Woodworth, David S. Hersh
The integration of systemic and tumor PD-L1 as a predictive biomarker of clinical outcomes in patients with advanced NSCLC treated with PD-(L)1blockade agents
Carlos Zamora Atenza, Geòrgia Anguera, Mariona Riudavets Melià, Letícia Alserawan De Lamo, Ivana Sullivan, Andrés Barba Joaquin, Jorgina Serra Lopez, M. Angels Ortiz, Maria Mulet, Sílvia Vidal, Margarita Majem
Combination immunotherapy including OncoVEXmGMCSF creates a favorable tumor immune micro-environment in transgenic BRAF murine melanoma
Robyn D. Gartrell, Zoë Blake, Emanuelle M. Rizk, Rolando Perez-Lorenzo, Stuart P. Weisberg, Ines Simoes, Camden Esancy, Yichun Fu, Danielle R. Davari, Luke Barker, Grace Finkel, Manas Mondal, Hanna E. Minns, Samuel W. Wang, Benjamin T. Fullerton, Francisco Lozano, Codruta Chiuzan, Basil Horst, Yvonne M. Saenger
Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice
Mélanie Gaignage, Xuhao Zhang, Julie Stockis, Olivier Dedobbeleer, Camille Michiels, Perrine Cochez, Laure Dumoutier, Pierre G. Coulie, Sophie Lucas
Functional virus-specific memory T cells survey glioblastoma
Jianfang Ning, Noah V. Gavil, Shaoping Wu, Sathi Wijeyesinghe, Eyob Weyu, Jun Ma, Ming Li, Florina-Nicoleta Grigore, Sanjay Dhawan, Alexander G. J. Skorput, Shawn C. Musial, Clark C. Chen, David Masopust, Pamela C. Rosato
Selection of antibody and light exposure regimens alters therapeutic effects of EGFR-targeted near-infrared photoimmunotherapy
Ryuhei Okada, Takuya Kato, Aki Furusawa, Fuyuki Inagaki, Hiroaki Wakiyama, Daiki Fujimura, Shuhei Okuyama, Hideyuki Furumoto, Hiroshi Fukushima, Peter L. Choyke, Hisataka Kobayashi
A real-world study of the efficacy and safety of anti-PD-1 antibodies plus lenvatinib in patients with advanced gallbladder cancer
Bangyou Zuo, Xiaobo Yang, Xu Yang, Jin Bian, Junyu Long, Dongxu Wang, Cong Ning, Yanyu Wang, Ziyu Xun, Yunchao Wang, Xin Lu, Yilei Mao, Xinting Sang, Haitao Zhao
Safety, antitumor activity and biomarkers of sugemalimab in Chinese patients with advanced solid tumors or lymphomas: results from the first-in-human phase 1 trial
Jifang Gong, Junning Cao, Qingyuan Zhang, Nong Xu, Yanqiu Zhao, Baocai Xing, Zhanhui Miao, Yilong Wu, Hongming Pan, Quanli Gao, Xingya Li, Baorui Liu, Wei Li, Zhidong Pei, Hongqiang Xia, Qinzhou Qi, Hangjun Dai, Qingmei Shi, Jianxin Yang, Jin Li, Lin Shen
Novel inhibitor of hematopoietic cell kinase as a potential therapeutic agent for acute myeloid leukemia
Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Juliete Aparecida Francisco da Silva, Guilherme Rossi Assis-Mendonça, Cristiane Okuda Torello, Rodrigo Nato Shiraishi, Fernando Viera Pericole, Karla Priscila Ferro, Adriana Santos Silva Duarte, Eduardo Magalhães Rego, Sara Teresinha Olalla Saad
Prognostic value, DNA variation and immunologic features of a tertiary lymphoid structure-related chemokine signature in clear cell renal cell carcinoma
Wenhao Xu, Chunguang Ma, Wangrui Liu, Aihetaimujiang Anwaier, Xi Tian, Guohai Shi, Yuanyuan Qu, Shiyin Wei, Hailiang Zhang, Dingwei Ye
Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma
Johanna Waidhauser, Pia Nerlinger, Tim Tobias Arndt, Stefan Schiele, Florian Sommer, Sebastian Wolf, Phillip Löhr, Stefan Eser, Gernot Müller, Rainer Claus, Bruno Märkl, Andreas Rank
Efficacy of immunotherapy beyond RECIST progression in advanced melanoma: a real-world evidence
Anna Małgorzata Czarnecka, Paweł Sobczuk, Paweł Rogala, Tomasz Świtaj, Joanna Placzke, Katarzyna Kozak, Anna Mariuk-Jarema, Mateusz Spałek, Monika Dudzisz-Śledź, Paweł Teterycz, Aneta Borkowska, Piotr Rutkowski
Efficacy of an ALDH peptide-based dendritic cell vaccine targeting cancer stem cells
Fei Liao, Jing Zhang, Yangyang Hu, Alireza Hassani Najafabadi, James J. Moon, Max S. Wicha, Bashir Kaspo, Joel Whitfield, Alfred E. Chang, Qiao Li
Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer
Nadja Salomon, Abderaouf Selmi, Christian Grunwitz, Anthony Kong, Eliana Stanganello, Jennifer Neumaier, Jutta Petschenka, Mustafa Diken, Sebastian Kreiter, Özlem Türeci, Ugur Sahin, Fulvia Vascotto
Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells
Emily Cluff, Carina C. Magdaleno, Emyly Fernandez, Trenton House, Srividya Swaminathan, Archana Varadaraj, Narendiran Rajasekaran
Oral administration of a whole glucan particle (WGP)-based therapeutic cancer vaccine targeting macrophages inhibits tumor growth
Liuyang He, Yu Bai, Lei Xia, Jie Pan, Xiao Sun, Zhichao Zhu, Jun Ding, Chunjian Qi, Cui Tang
Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden
Julia Femel, Luuk van Hooren, Melanie Herre, Jessica Cedervall, Falk Saupe, Elisabeth J. M. Huijbers, Danielle R. J. Verboogen, Matthias Reichel, Victor L. Thijssen, Arjan W. Griffioen, Lars Hellman, Anna Dimberg, Anna-Karin Olsson
A phase I dose-escalation, safety/tolerability, and preliminary efficacy study of the intratumoral administration of GEN0101 in patients with advanced melanoma
Eiji Kiyohara, Atsushi Tanemura, Kazuma Sakura, Toshihiro Nakajima, Akira Myoui, Naoya Yamazaki, Yoshio Kiyohara, Ichiro Katayama, Manabu Fujimoto, Yasufumi Kaneda
Immune-related adverse events of COVID-19 vaccination in skin cancer patients receiving immune-checkpoint inhibitor treatment
Sophia B. Strobel, Devayani Machiraju, Katharina A. Kälber, Jessica C. Hassel