Ausgabe 3/2022
Inhalt (12 Artikel)
Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells
Rachel E. Nicoletto, Clyde M. Ofner III
Roles of DNA polymerase ζ in the radiotherapy sensitivity and oxidative stress of lung cancer cells
Xialin Chen, Rong Ji, Jianjiang Liu, Xueying Jin, Hong Zhu, Jianfang Wang, Ming Chen
Correlation between pharmacokinetic parameters of 5-fluorouracil and related metabolites and adverse reactions in East-Asian patients with advanced colorectal cancer
Zhiqiang Tong, Mengfei Cheng, Yang Yu, Jiuhang Yu, Yichuang Yin, Jiahui Liu, Shuo Zhang, Shuai Jiang, Mei Dong
Repurposed antipsychotic chlorpromazine inhibits colorectal cancer and pulmonary metastasis by inducing G2/M cell cycle arrest, apoptosis, and autophagy
Fuyan Xu, Huizhi Xi, Mengya Liao, Yiqian Zhang, Hongbo Ma, Mengling Wu, Qiang Xue, Hongbao Sun, Yiwen Zhang, Yong Xia
Differential tumor inhibitory effects induced by HER3 extracellular subdomain-specific mouse monoclonal antibodies
Danesh Hassani, Mahmood Jeddi-Tehrani, Parisa Yousefi, Samaneh Mansouri-Fard, Maryam Mobini, Hengameh Ahmadi-Zare, Forough Golsaz-Shirazi, Mohammad Mehdi Amiri, Fazel Shokri
Efficacy and safety exposure–response analyses of entrectinib in patients with advanced or metastatic solid tumors
Francois Mercier, Nassim Djebli, Mario González-Sales, Felix Jaminion, Georgina Meneses-Lorente
Pharmacokinetics and pharmacodynamics of MEDI0680, a fully human anti-PD-1 monoclonal antibody, in patients with advanced malignancies
Xuyang Song, Anis A. Khan, Diansong Zhou, Nairouz Elgeioushi, Farzana Walcott, Song Ren, Megan Gibbs
Prediction of drug–drug interaction potential mediated by transporters between dasatinib and metformin, pravastatin, and rosuvastatin using physiologically based pharmacokinetic modeling
Ming Chang, Sai Bathena, Lisa J. Christopher, Hong Shen, Amit Roy
Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients
Ravi Ramalingam, Harpreet Kaur, Julius Xavier Scott, Latha M. Sneha, Ganeshprasad Arunkumar, Arathi Srinivasan, Solomon F. D. Paul
Isoprenylcysteine carboxyl methyltransferase is critical for glioblastoma growth and survival by activating Ras/Raf/Mek/Erk
Weifeng Wan, Wenfeng Xiao, Wen Pan, Ligang Chen, Zhiyong Liu, Jianguo Xu
Cabozantinib with or without Panitumumab for RAS wild-type metastatic colorectal cancer: impact of MET amplification on clinical outcomes and circulating biomarkers
Jingquan Jia, Lauren Howard, Yingmiao Liu, Mark D. Starr, John C. Brady, Donna Niedzwiecki, John H. Strickler, Andrew B. Nixon
A phase I study of AZD2171 and Temsirolimus in patients with advanced gynecological malignancies
Susana M. Campos, Suzanne Berlin, Carolyn N. Krasner, Christin Whalen, Tina Atkinson, Kristin Meegan, Lauren Pereira, Karin Tyburski, Weixiu Lou, Hang Lee, Neil Horowitz, Richard T. Penson