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Journal of Bone and Mineral Metabolism

01.02.2024 | Invited Review

Association of chronic liver disease with bone diseases and muscle weakness

verfasst von: Chisato Saeki, Mitsuru Saito, Akihito Tsubota

Erschienen in: Journal of Bone and Mineral Metabolism

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Abstract

The liver is a vital organ involved in nutrient metabolism, hormone regulation, immunity, cytokine production, and gut homeostasis. Impairment in liver function can result in malnutrition, chronic inflammation, decreased anabolic hormone levels, and dysbiosis. These conditions eventually cause an imbalance in osteoblast and osteoclast activities, resulting in bone loss. Osteoporosis is a frequent complication of chronic liver disease (CLD) that adversely affects quality of life and increases early mortality. Sarcopenia is another common complication of CLD characterized by progressive loss of skeletal muscle mass and function. Assessment criteria for sarcopenia specific to liver disease have been established, and sarcopenia has been reported to be associated with an increase in the risk of liver disease-related events and mortality in patients with CLD. Owing to their similar risk factors and underlying pathophysiological mechanisms, osteoporosis and sarcopenia often coexist (termed osteosarcopenia), progress in parallel, and further exacerbate the conditions mentioned above. Therefore, comprehensive management of these musculoskeletal disorders is imperative. This review summarizes the clinical implications and characteristics of osteoporosis, extending to sarcopenia and osteosarcopenia, in patients with CLD caused by different etiologies.
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Metadaten
Titel
Association of chronic liver disease with bone diseases and muscle weakness
verfasst von
Chisato Saeki
Mitsuru Saito
Akihito Tsubota
Publikationsdatum
01.02.2024
Verlag
Springer Nature Singapore
Erschienen in
Journal of Bone and Mineral Metabolism
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-023-01488-x

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