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Erschienen in: DNP – Die Neurologie & Psychiatrie 4/2023

01.08.2023 | Apoplex | Fortbildung

Zufallsbefund stummer Hirninfarkt

Mit primärprophylaktischen Maßnahmen die Prognose verbessern

verfasst von: Clara-Sophie Kossel, PD Dr. med. Joji B. Kuramatsu, Dr. med. Jochen A. Sembill

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 4/2023

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Moderne Bildgebungstechniken ermöglichen einen immer präziseren Einblick in das Gehirn von Patientinnen und Patienten. Nicht selten werden dabei umschriebene Läsionen entdeckt - klinisch asymptomatisch und am ehesten ischämisch bedingt. Warum sich eine tiefere Auseinandersetzung mit diesen stummen Hirninfarkten lohnt.
Literatur
1.
Zurück zum Zitat Meinel TR, Kaesmacher J, Roten L et al. Covert brain infarction. Stroke. 2020;51(8):2597-606 Meinel TR, Kaesmacher J, Roten L et al. Covert brain infarction. Stroke. 2020;51(8):2597-606
2.
Zurück zum Zitat Fanning JP, Wesley AJ, Wong AA et al. Emerging spectra of silent brain infarction. Stroke. 2014;45(11):3461-71 Fanning JP, Wesley AJ, Wong AA et al. Emerging spectra of silent brain infarction. Stroke. 2014;45(11):3461-71
3.
Zurück zum Zitat Vermeer SE, Longstreth WT Jr. et al. Silent brain infarcts: a systematic review. Lancet Neurol. 2007;6(7):611-9 Vermeer SE, Longstreth WT Jr. et al. Silent brain infarcts: a systematic review. Lancet Neurol. 2007;6(7):611-9
4.
Zurück zum Zitat Smith EE, Saposnik G, Biessels GJ et al. Prevention of stroke in patients with silent cerebrovascular disease: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2017;48(2):e44-71 Smith EE, Saposnik G, Biessels GJ et al. Prevention of stroke in patients with silent cerebrovascular disease: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2017;48(2):e44-71
5.
Zurück zum Zitat van Veluw SJ, Shih AY, Smith EE et al. Detection, risk factors, and functional consequences of cerebral microinfarcts. Lancet Neurol. 2017;16(9):730-40 van Veluw SJ, Shih AY, Smith EE et al. Detection, risk factors, and functional consequences of cerebral microinfarcts. Lancet Neurol. 2017;16(9):730-40
6.
Zurück zum Zitat Carey CL, Kramer JH, Josephson SA et al. Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly. Stroke. 2008;39(2):397-402 Carey CL, Kramer JH, Josephson SA et al. Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly. Stroke. 2008;39(2):397-402
7.
Zurück zum Zitat Sun Y-w, Qin L-d, Zhou Y et al. Abnormal functional connectivity in patients with vascular cognitive impairment, no dementia: a resting-state functional magnetic resonance imaging study. Behav Brain Res. 2011;223(2):388-94 Sun Y-w, Qin L-d, Zhou Y et al. Abnormal functional connectivity in patients with vascular cognitive impairment, no dementia: a resting-state functional magnetic resonance imaging study. Behav Brain Res. 2011;223(2):388-94
8.
Zurück zum Zitat Schulz M, Malherbe C, Cheng B et al. Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature. BMC Medicine. 2021;19(1):103 Schulz M, Malherbe C, Cheng B et al. Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature. BMC Medicine. 2021;19(1):103
9.
Zurück zum Zitat Azeem F, Durrani R, Zerna C et al. Silent brain infarctions and cognition decline: systematic review and meta-analysis. J Neurol. 2020;267(2):502-12 Azeem F, Durrani R, Zerna C et al. Silent brain infarctions and cognition decline: systematic review and meta-analysis. J Neurol. 2020;267(2):502-12
10.
Zurück zum Zitat Leung LY, Bartz TM, Rice K et al. Blood pressure and heart rate measures associated with increased risk of covert brain infarction and worsening leukoaraiosis in older adults. Arterioscler Thromb Vasc Biol. 2017;37(8):1579-86 Leung LY, Bartz TM, Rice K et al. Blood pressure and heart rate measures associated with increased risk of covert brain infarction and worsening leukoaraiosis in older adults. Arterioscler Thromb Vasc Biol. 2017;37(8):1579-86
11.
Zurück zum Zitat Kohara K, Fujisawa M, Ando F et al. MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study. Stroke. 2003;34(5):1130-5 Kohara K, Fujisawa M, Ando F et al. MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study. Stroke. 2003;34(5):1130-5
12.
Zurück zum Zitat Longstreth WT Jr., Bernick C, Manolio TA et al. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol. 1998;55(9):1217-25 Longstreth WT Jr., Bernick C, Manolio TA et al. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol. 1998;55(9):1217-25
13.
Zurück zum Zitat Kwon HM, Kim BJ, Lee SH et al. Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people. Stroke. 2006;37(2):466-70 Kwon HM, Kim BJ, Lee SH et al. Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people. Stroke. 2006;37(2):466-70
14.
Zurück zum Zitat Park K, Yasuda N, Toyonaga S et al. Significant associations of metabolic syndrome and its components with silent lacunar infarction in middle aged subjects. J Neurol Neurosurg Psychiatry. 2008;79(6):719-21 Park K, Yasuda N, Toyonaga S et al. Significant associations of metabolic syndrome and its components with silent lacunar infarction in middle aged subjects. J Neurol Neurosurg Psychiatry. 2008;79(6):719-21
15.
Zurück zum Zitat Traenka C, Engelter ST, Brown MM et al. Silent brain infarcts on diffusion-weighted imaging after carotid revascularisation: a surrogate outcome measure for procedural stroke? A systematic review and meta-analysis. Eur Stroke J. 2019;4(2):127-43 Traenka C, Engelter ST, Brown MM et al. Silent brain infarcts on diffusion-weighted imaging after carotid revascularisation: a surrogate outcome measure for procedural stroke? A systematic review and meta-analysis. Eur Stroke J. 2019;4(2):127-43
16.
Zurück zum Zitat Finn C, Giambrone AE, Gialdini G et al. The association between carotid artery atherosclerosis and silent brain infarction: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis. 2017;26(7):1594-601 Finn C, Giambrone AE, Gialdini G et al. The association between carotid artery atherosclerosis and silent brain infarction: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis. 2017;26(7):1594-601
17.
Zurück zum Zitat Baradaran H, Gialdini G, Mtui E et al. Silent brain infarction in patients with asymptomatic carotid artery atherosclerotic disease. Stroke. 2016;47(5):1368-70 Baradaran H, Gialdini G, Mtui E et al. Silent brain infarction in patients with asymptomatic carotid artery atherosclerotic disease. Stroke. 2016;47(5):1368-70
18.
Zurück zum Zitat Gensicke H, Ahlhelm F, Jung S et al. New ischaemic brain lesions in cervical artery dissection stratified to antiplatelets or anticoagulants. Eur J Neurol. 2015;22(5):859-65, e61 Gensicke H, Ahlhelm F, Jung S et al. New ischaemic brain lesions in cervical artery dissection stratified to antiplatelets or anticoagulants. Eur J Neurol. 2015;22(5):859-65, e61
19.
Zurück zum Zitat Meschia JF, Bushnell C, Boden-Albala B et al. Guidelines for the primary prevention of stroke. Stroke. 2014;45(12):3754-832 Meschia JF, Bushnell C, Boden-Albala B et al. Guidelines for the primary prevention of stroke. Stroke. 2014;45(12):3754-832
20.
Zurück zum Zitat Reid CM, Storey E, Wong TY et al. Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurol. 2012;12:3 Reid CM, Storey E, Wong TY et al. Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurol. 2012;12:3
21.
Zurück zum Zitat Kleindorfer DO, Towfighi A, Chaturvedi S et al. Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021;52(7):e364-467 Kleindorfer DO, Towfighi A, Chaturvedi S et al. Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021;52(7):e364-467
22.
Zurück zum Zitat Kozberg MG, Perosa V, Gurol ME et al. A practical approach to the management of cerebral amyloid angiopathy. Int J Stroke. 2021;16(4):356-69 Kozberg MG, Perosa V, Gurol ME et al. A practical approach to the management of cerebral amyloid angiopathy. Int J Stroke. 2021;16(4):356-69
23.
Zurück zum Zitat Katsanos AH, Lioutas VA, Charidimou A et al. Statin treatment and accrual of covert cerebral ischaemia on neuroimaging: a systematic review and meta-analysis of randomized trials. Eur J Neurol. 2020;27(6):1023-7 Katsanos AH, Lioutas VA, Charidimou A et al. Statin treatment and accrual of covert cerebral ischaemia on neuroimaging: a systematic review and meta-analysis of randomized trials. Eur J Neurol. 2020;27(6):1023-7
24.
Zurück zum Zitat Goff DC, Lloyd-Jones DM, Bennett G et al. 2013 ACC/AHA Guideline on the assessment of cardiovascular risk. Circulation. 2014;129(25_suppl_2):49-73 Goff DC, Lloyd-Jones DM, Bennett G et al. 2013 ACC/AHA Guideline on the assessment of cardiovascular risk. Circulation. 2014;129(25_suppl_2):49-73
25.
Zurück zum Zitat Grundy SM, Stone NJ, Bailey AL et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Circulation. 2019;139(25):e1082-143 Grundy SM, Stone NJ, Bailey AL et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Circulation. 2019;139(25):e1082-143
26.
Zurück zum Zitat Aboyans V, Ricco J-B, Bartelink M-LEL et al. 2017 ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS): document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries. Endorsed by the European Stroke Organization (ESO), the task force for the diagnosis and treatment of peripheral arterial diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). European Heart Journal. 2017;39(9):763-816 Aboyans V, Ricco J-B, Bartelink M-LEL et al. 2017 ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS): document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries. Endorsed by the European Stroke Organization (ESO), the task force for the diagnosis and treatment of peripheral arterial diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). European Heart Journal. 2017;39(9):763-816
27.
Zurück zum Zitat Eckstein HH, Kühnl A, Berkefeld J et al. Diagnosis, treatment and follow-up in extracranial carotid stenosis. Dtsch Arztebl International. 2020;117(47):801-7 Eckstein HH, Kühnl A, Berkefeld J et al. Diagnosis, treatment and follow-up in extracranial carotid stenosis. Dtsch Arztebl International. 2020;117(47):801-7
Metadaten
Titel
Zufallsbefund stummer Hirninfarkt
Mit primärprophylaktischen Maßnahmen die Prognose verbessern
verfasst von
Clara-Sophie Kossel
PD Dr. med. Joji B. Kuramatsu
Dr. med. Jochen A. Sembill
Publikationsdatum
01.08.2023

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