Background
Methods
Study design
Study participants
Inclusion criteria
Exclusion criteria
Study variables and groups
Definition of AIS’s initial symptoms
ODT calculation method
Statistical analysis
Results
Overview of ODT in patients with AIS (Table 1)
ODT ≤ 3 h, % | ODT>3 h, % | P value | ||
---|---|---|---|---|
Number of cases | 763, 21.83% | 2732, 78.17% | ||
Gender | Male | 520, 68.15% | 1841, 67.39% | 0.690 |
Female | 243, 31.85% | 891, 32.61% | ||
Age, y | 67.02 ± 11.22 | 65.51 ± 11.58 | 0.011 | |
Whether patients lived alone | Yes | 38, 4.98% | 112, 4.10% | 0.289 |
No | 725, 95.02% | 2620, 95.90% | ||
Residential location | City | 521, 68.28% | 1341, 49.08% | 0.000 |
Rural and other areas | 242, 31.72% | 1391, 50.92% | ||
Medical insurance | Yes | 638, 83.62% | 2315, 84.74% | 0.450 |
No | 125, 16.38% | 417, 15.26% | ||
Educational level | Illiterate | 32, 4.19% | 219, 8.02% | 0.000 |
Primary or junior high school | 397, 52.03% | 1462, 53.51% | ||
High school or junior college | 293, 38.40% | 835, 30.56% | ||
University or above | 41.5, 38% | 216, 7.91% | ||
Whether patient or his family knew the stroke emergency map | ||||
Yes | 37, 4.85% | 115, 4.21% | 0.444 | |
No | 726, 95.15% | 2617, 95.79% | ||
Whether patient or his family visited the WeChat official account of the stroke emergency map | ||||
Yes | 14, 1.83% | 35, 1.28% | 0.250 | |
No | 749, 98.17% | 2697, 98.72% | ||
Wake-up stroke | Yes | 118, 15.47% | 488, 17.86% | 0.122 |
No | 645, 84.53% | 2244, 82.14% | ||
Distance between onset location and first-visit hospital | >20 km | 135, 17.69% | 1161, 42.50% | 0.000 |
≤ 20 km | 628, 82.31% | 1571, 57.50% | ||
Transfer method for patients | Emergency Medical Services | 143, 18.74% | 136, 4.98% | 0.000 |
Reaching hospital by oneself | 620, 81.26% | 2596, 95.02% | ||
Whether inter-hospital transfer was carried out | Yes | 10,1.31% | 259,9.48% | 0.000 |
No | 753, 98.69% | 2473, 90.52% | ||
Medical history | ||||
Smoking | Present | 222, 29.10% | 741, 27.12% | 0.281 |
Absent | 541, 70.90% | 1991, 72.88% | ||
Drinking | Present | 149, 21.85% | 447, 17.48% | 0.009 |
Absent | 533, 78.15% | 2110, 82.52% | ||
Diabetes | Present | 148, 19.40% | 712, 26.06% | 0.000 |
Absent | 615, 80.60% | 2020, 73.94% | ||
Diabetes duration, y | 7.58 ± 6.92 | 7.90 ± 6.26 | 0.586 | |
Hypertension | Present | 478, 62.65% | 1774, 64.93% | 0.243 |
Absent | 285,3 7.35% | 958, 35.07% | ||
Hypertension duration, y | 9.29 ± 8.82 | 8.13 ± 7.07 | 0.003 | |
Hyperlipidemia | Present | 69, 15.20% | 428, 23.14% | 0.000 |
Absent | 385, 84.80% | 1422, 76.86% | ||
TIA or ischemic stroke | Present | 329, 43.12% | 1172, 42.90% | 0.913 |
Absent | 434, 56.88% | 1560, 57.10% | ||
Atrial fibrillation | Present | 89, 11.66% | 126, 4.61% | 0.000 |
Absent | 674, 88.34% | 2606, 95.39% | ||
Pre-onset mRS score | 0.43 ± 1.01 | 0.38 ± 0.92 | 0.237 | |
First symptom of AIS | Vomit | 34, 4.46% | 109, 3.99% | 0.565 |
Unconscious | 77, 10.09% | 107, 3.92% | 0.000 | |
Paralysis | 580, 76.02% | 1998, 73.13% | 0.110 | |
Diplopia | 6, 0.79% | 40, 1.46% | 0.146 | |
Aphasia | 93, 12.19% | 152, 5.56% | 0.000 | |
Dysarthria | 276, 36.17% | 844, 30.89% | 0.006 | |
Drooping of angle of mouth | 39, 5.11% | 139, 5.09% | 0.979 | |
Headache | 8, 1.05% | 78, 2.86% | 0.004 | |
Paresthesia | 100, 13.11% | 306, 11.2% | 0.473 | |
Vertigo | 107, 14.02% | 471, 17.24% | 0.034 | |
Other symptoms | 115, 15.07% | 522, 19.11% | 0.011 | |
TOAST classification of stroke | LAA stroke | 396, 51.90% | 1204, 44.07% | 0.000 |
Cardiogenic stroke | 126, 16.51% | 220, 8.05% | ||
SAO stroke | 195, 25.56% | 1139, 41.69% | ||
SOE | 17, 2.23% | 51, 1.87% | ||
Unexplained stroke | 29, 3.80% | 118, 4.32% | ||
Stroke severity | Mild stroke | 380, 49.80% | 1798, 65.81% | 0.000 |
Moderate stroke | 283, 37.09% | 787, 28.81% | ||
Severe stroke | 100, 13.11% | 147, 5.38% |
Baseline characteristics and single-factor analysis of ODT in patients with acute ischemic stroke (Table 1)
Analysis of delayed ODT (> 3 h) with binary logistic regression analysis
Adjusted Odds Ratio | 95% confidence interval | P-value | |
---|---|---|---|
Living in rural- areas | 1.478 | 1.024–2.146 | 0.038 |
Distance between onset location and the first-visit hospital ≤ 20 km | 0.355 | 0.236–0.530 | 0.000 |
Transportation- using EMS | 0.346 | 0.216–0.555 | 0.000 |
Existing inter-hospital transfer | 7.479 | 2.548–32.337 | 0.001 |
History of Atrial fibrillation | 0.375 | 0.207–0.679 | 0.001 |
Moderate stroke | 0.644 | 0.462–0.901 | 0.010 |
Severe stroke | 0.506 | 0.285–0.908 | 0.021 |