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27.04.2024 | Advanced Neuroimaging

Altered functional connectivity of cerebellar subregions in male patients with obstructive sleep apnea: A resting-state fMRI study

verfasst von: Lifeng Li, Yuting Liu, Yongqiang Shu, Xiang Liu, Yucheng Song, Ting Long, Kunyao Li, Wei Xie, Yaping Zeng, Li Zeng, Ling Huang, Yumeng Liu, Yingke Deng, Haijun Li, Dechang Peng

Erschienen in: Neuroradiology | Ausgabe 6/2024

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Abstract

Purpose

Previous studies have demonstrated impaired cerebellar function in patients with obstructive sleep apnea (OSA), which is associated with impaired cognition. However, the effects of OSA on resting-state functional connectivity (FC) in the cerebellum has not been determined. The purpose of this study was to investigate resting-state FC of the cerebellar subregions and its relevance to clinical symptoms in patients with OSA.

Methods

Sixty-eight patients with OSA and seventy-two healthy controls (HCs) were included in the study. Eight subregions of the cerebellum were selected as regions of interest, and the FC values were calculated for each subregion with other voxels. A correlation analysis was performed to examine the relationship between clinical and cognitive data.

Results

Patients with OSA showed higher FC in specific regions, including the right lobule VI with the right posterior middle temporal gyrus and right angular gyrus, the right Crus I with the bilateral precuneus/left superior parietal lobule, and the right Crus II with the precuneus/right posterior cingulate cortex. Furthermore, the oxygen depletion index was negatively correlated with aberrant FC between the right Crus II and the bilateral precuneus / right posterior cingulate cortex in OSA patients (p = 0.004).

Conclusion

The cerebellum is functionally lateralized and closely linked to the posterior default mode network. Higher FC is related to cognition, emotion, language, and sleep in OSA. Abnormal FC may offer new neuroimaging evidence and insights for a deeper comprehension of OSA-related alterations.

Graphical Abstract

This study reveals altered resting-state functional connectivity in the cerebellum (8 cerebellar subregions) of obstructive sleep apnea (OSA) patients. These changes correlate with cognitive, emotional, linguistic, and sleep deficits, suggesting functional impairments and compensation in the cerebellum of OSA patients.

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Titel: Altered functional connectivity of cerebellar subregions in male patients with obstructive sleep apnea: A resting-state fMRI study
verfasst von: Lifeng Li
Yuting Liu
Yongqiang Shu
Xiang Liu
Yucheng Song
Ting Long
Kunyao Li
Wei Xie
Yaping Zeng
Li Zeng
Ling Huang
Yumeng Liu
Yingke Deng
Haijun Li
Dechang Peng
Publikationsdatum: 27.04.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Neuroradiology / Ausgabe 6/2024
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-024-03356-5

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