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Clinical Reviews in Allergy & Immunology

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07.02.2024 | Review

Advancing Understanding of Childhood Asthma: Lessons Learned from Birth Cohort Studies

verfasst von: Yuhan Xing, Xinmeng Yang, Zhaoyinqian Li, Qiyuan Zou, Ping Yang, Qinzheng Wang, Wei Ni, Dongze Wu, Guoju Li

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 1/2024

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Abstract

Asthma and allergies are some of the most common chronic disorders affecting children, the prevalence of which has been increasing in countries and regions undergoing rapid development like China. To curb the rising tide of allergies and safeguard the health of future generations, it is of critical importance to understand how asthma inception is influenced by factors acting at different life stages. Birth cohorts represent a powerful tool to investigate the temporal sequence of exposures along the natural course of asthma. We examined recent evidence on birth cohort studies of asthma and allergic diseases and evaluated their strengths and weaknesses. Essential elements for a successful birth cohort are proposed to further elucidate asthma etiology and pathogenies. Initiating new cohorts in understudied populations with the application of advanced analytical approaches will be needed. Moreover, fostering collaborative networks using standardized methodologies should be prioritized to enable integration of findings across diverse cohorts. There remains an urgent and unmet need to further translate the seminal findings from asthma birth cohort studies into targeted primary prevention strategies to eradicate the disease.

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Titel: Advancing Understanding of Childhood Asthma: Lessons Learned from Birth Cohort Studies
verfasst von: Yuhan Xing
Xinmeng Yang
Zhaoyinqian Li
Qiyuan Zou
Ping Yang
Qinzheng Wang
Wei Ni
Dongze Wu
Guoju Li
Publikationsdatum: 07.02.2024
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 1/2024
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-024-08979-3

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