Background
Methods
Study population
Standard echocardiographic examination
Speckle tracking imaging
Reproducibility
Statistical analysis
Results
Participant characteristics
Groupa
| |||
---|---|---|---|
Characteristic | Coronary artery disease | Control |
P
|
Age, mean (SD), y | 70 (8) | 35 (13) | <0.001 |
BMI, mean (SD) | 27 (5) | 26 (7) | 0.23 |
SBP, mean (SD) | 137 (19) | 110 (15) | <0.001 |
DBP, mean (SD) | 74 (10) | 65 (10) | =0.004 |
HR, mean (SD) | 76 (12) | 75 (11) | 0.94 |
PR interval, mean (SD) | 165 (21) | 143 (17) | <0.001 |
QRS duration, mean (SD) | 84 (10) | 88 (12) | 0.17 |
Hypertension | 71 | 3 | <0.001 |
Hyperlipidemia | 69 | 3 | <0.001 |
Dyspnea | 100 | 0 | <0.001 |
Fatigue | 23 | 0 | <0.001 |
Diabetes mellitus | 9 | 0 | <0.001 |
Smoker, ever | 26 | 3 | <0.001 |
Standard echocardiographic data
Global longitudinal, circumferential and radial S and SRs
Groupa
| |||
---|---|---|---|
Variables | Coronary artery disease, Mean (SD) | Control, Mean (SD) |
P Value |
Global longitudinal LV strain, % | −14.3 (4) | −17.2 (3) | <.001 |
Global longitudinal systolic strain rate, s−1
| −0.92 (0.2) | −0.99 (0.1) | 0.07 |
Global longitudinal LV strain TTP, ms | 399 (65) | 381 (46) | <.001 |
1SD Global longitudinal strain TTP, ms | 99 (43) | 33 (17) | <.001 |
Global circumferential strain, % | −19.4 (6) | −22.4 (4) | 0.02 |
Global circumferential systolic strain rate, s−1
| −1.3 (0.4) | −1.4 (0.3) | 0.16 |
Global radial strain, % | 49 (37) | 34 (16) | 0.03 |
Global radial systolic strain rate, s−1
| 2.4 (1.5) | 1.9 (0.7) | 0.05 |
Measurement | Cutoff value | Sensitivity, % | Specificity, % | AUC |
---|---|---|---|---|
Global longitudinal strain, % | −15.87 | 71 | 74 | 0.74 |
1 SD LV longitudinal TTP, ms | 45 | 97 | 89 | 0.96 |
2 SD longitudinal strain TTP, ms | 90 | 97 | 89 | 0.96 |
Global circumferential strain, % | −21.31 | 60 | 60 | 0.64 |
Combined plot (global longitudinal strain, circumferential strain, SD longitudinal TTP LV) | NA | 97 | 86 | 0.96 |