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07.03.2024 | Research

Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes

verfasst von: Hongmei Liu, Jin Li, Niting Wu, Yuanting She, Yadan Luo, Yan Huang, Hongyu Quan, Wenying Fu, Xiaohui Li, Dongfeng Zeng, Yi Jia

Erschienen in: Inflammation | Ausgabe 2/2024

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Abstract

Siglec-9/E is a cell surface receptor expressed on immune cells and can be activated by sialoglycan ligands to play an immunosuppressive role. Our previous study showed that increasing the expression of Siglec-9 (the human paralog of mouse Siglec-E) ligands maintains functionally quiescent immune cells in the bloodstream, but the biological effects of Siglec-9 ligand alteration on atherogenesis were not further explored. In the present study, we demonstrated that the atherosclerosis risk factor ox-LDL or a high-fat diet could decrease the expression of Siglec-9/E ligands on erythrocytes. Increased expression of Siglec-E ligands on erythrocytes caused by dietary supplementation with glucose (20% glucose) had anti-inflammatory effects, and the mechanism was associated with glucose intake. In high-fat diet-fed apoE^−/− mice, glucose supplementation decreased the area of atherosclerotic lesions and peripheral inflammation. These data suggested that increased systemic inflammation is attenuated by increasing the expression of Siglec-9/E ligands on erythrocytes. Therefore, Siglec-9/E ligands might be valuable targets for atherosclerosis therapy.

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Titel: Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes
verfasst von: Hongmei Liu
Jin Li
Niting Wu
Yuanting She
Yadan Luo
Yan Huang
Hongyu Quan
Wenying Fu
Xiaohui Li
Dongfeng Zeng
Yi Jia
Publikationsdatum: 07.03.2024
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 2/2024
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-023-01932-0

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Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes

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