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The development of clinical allergy as a discipline of scientific medicine has, until recently, lagged behind that of other subspecialties in internal medicine and pediatrics. The discovery of immunoglobulin E, the development of standardized protocols for allergy skin testing and challenge procedures, and concurrent advances in cell biology have all led to a major thrust by new data in changing the approach to the clinical management of allergic disease. The object of this journal is to publish scholarly review papers, with each issue devoted to a single theme, in an attempt to provide comprehensive treatment of a subject of critical importance to allergists. The journal publishes both experimental papers and comprehensive treatises placing new data in perspective. The ultimate objective is to help improve the care and management of patients with allergic disease.