Skip to main content
7082 Suchergebnisse für:

PLC 

sortieren nach |
"Aktualität" sortiert die Ergebnisse nach Publikationsdatum. "Relevanz" berücksichtigt auch noch andere Faktoren wie zum Beispiel die Häufigkeit der Suchbegriffe im Text.
  1. Open Access 01.12.2024 | OriginalPaper

    PLCD3 inhibits apoptosis and promotes proliferation, invasion and migration in gastric cancer

    Gastric cancer (GC) is a heterogeneous disease whose development is accompanied by alterations in a variety of pathogenic genes. The phospholipase C Delta 3 enzyme is a member of the phospholipase C family, which controls substance transport …

  2. Open Access 01.12.2024 | OriginalPaper

    Higher insoluble fiber intake is associated with a lower risk of prostate cancer: results from the PLCO cohort

    Studies regarding the relationship between fiber intake and prostate cancer (PCa) have conflicting results. Therefore, this study examined the relationship between fiber intake and the risk of PCa by using data from Prostate, Lung, Colorectal, and …

  3. 19.01.2024 | Online First

    APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant

    Autoinflammatory diseases (AIDs) are a group of hereditary diseases characterized by systemic or organ-specific inflammation that is driven by gene variants [ 1 ]. These conditions can be inherited as monogenic or polygenic diseases and are often …

  4. 05.09.2023 | OriginalPaper

    Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families

    Nephrotic syndrome (NS) in childhood is defined by proteinuria of > 40 mg/m 2 per hour, hypoalbuminemia, edema, and hyperlipidemia. It can cause severe complications, which include hypertension, infections, and thrombotic events. Children and young …

  5. Open Access 01.12.2023 | OriginalPaper

    PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling

    There are two major subtypes of esophageal cancer, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). More than 90% of all esophageal cancers in China are ESCC [ 1 ]. Because of the lack of clear symptoms and sensitive …

  6. Open Access 01.12.2023 | OriginalPaper

    MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway

    Oral squamous cell carcinoma (OSCC), the sixth mostcommon malignant tumor in humans, accounts for approximately 2% of all malignancies. 90% of oral carcinoma are squamous cells. There are approximately 350,000 new cases of oral carcinoma and up to …

  7. Open Access 01.12.2023 | OriginalPaper

    Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system

    The average human lifespan has greatly expanded in the past decennia. In most individuals, increase in age coincides with a decline in cognitive and physical health. Many age-related impairments, such as lowered resistance to infection, dementia …

  8. 19.12.2022 | OriginalPaper

    Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure

    Fertilization is an essential process in sexual reproduction in which capacitated sperm fuses with matured oocyte to form a two-pronucleus (2PN) zygote [ 1 ]. All eggs/zygotes other than 2PN are considered abnormal, such as fertilization failure …

  9. 01.08.2021 | Letter

    GABA Signaling Pathway-associated Gene PLCL1 Rare Variants May be Associated with Autism Spectrum Disorders

    Autism spectrum disorders (ASDs) are neurodevelopmental disorders with phenotypic and genetic heterogeneity, and are among the most heritable of neurodevelopmental disorders [ 1 ]. Rare single nucleotide variants (SNVs) of genes and/or rare copy …

  10. 01.08.2020 | Letter

    Ghrelin Reduces A-Type Potassium Currents in Dopaminergic Nigral Neurons via the PLC/PKCδ Pathway

  11. Open Access 01.12.2020 | OriginalPaper

    Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

    Missense variants ABI3_rs616338-T and PLCG2_rs72824905-G were previously associated with elevated or reduced risk of Alzheimer’s disease (AD), respectively. Despite reports of associations with other neurodegenerative diseases, there are few …

  12. Open Access 01.12.2022 | OriginalPaper

    Prediction of future risk of any and higher-grade prostate cancer based on the PLCO and SELECT trials

    Prostate cancer (PCa) is the most prevalent non-skin cancer in men in the United States [ 1 ]. Rates of PCa diagnosis may be decreasing but are most affected by screening practices, modulated by recommendations from groups such as the US …

  13. 16.01.2022 | OriginalPaper

    A broad clinical spectrum of PLCε1-related kidney disease and intrafamilial variability

    Disease-causing variants of PLCε1 have been associated with early-onset nephrotic syndrome (NS) [ 1 ]. Certain pathogenetic mechanisms in PLCε1 -related kidney disease have not yet been clearly elucidated. However, it is known that PLCε1 catalyzes …

  14. Open Access 01.12.2016 | OriginalPaper

    The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture

    The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to large-amplitude, low-frequency EEG …

  15. Open Access 01.12.2021 | OriginalPaper

    Effect of PLC- β1/CaM signaling pathway mediated by AT1R on the occurrence and development of hepatocellular carcinoma

    Primary hepatocellular carcinoma (HCC) is one of the common malignant tumors in the digestive system. Currently, the incidence rate of HCC presents an upward trend around the world. In China, the prevalence rate of HCC exceeds 20/1,00,000, while …

  16. Open Access 01.12.2021 | OriginalPaper

    The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

    Deleted in liver cancer 1 ( DLC1 ) is a tumor suppressor gene that was first discovered because it was deleted in hepatocarcinomas, and was later found to be downregulated, via genetic, epigenetic, and post-translational mechanisms, in many other …

  17. 01.05.2004 | OriginalPaper

    Effect of PLCβ4 in the thalamus on the EEG in REM sleep

  18. Open Access 18.04.2024 | Rheumatoide Arthritis | Online First

    Welche ACR-Antwort soll in Zulassungsstudien bei der Rheumatoiden Arthritis zum Einsatz kommen?

    Die American College of Rheumatology (ACR)-Antworten werden seit ihrer Entwicklung im Jahr 1995 in nahezu allen bedeutenden Medikamentenstudien in der Rheumatoiden Arthritis (RA) als primäre und sekundäre Endpunkte verwendet [1]. Welche …

  19. 10.04.2024 | Abstract

    Abstracts zum 130. Kongress der Deutschen Gesellschaft für Innere Medizin e.V.

  20. Open Access 01.12.2021 | OriginalPaper

    Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer’s amyloidosis

    Alzheimer’s disease (AD) is a neurodegenerative disorder mainly characterized by a progressive memory impairment and cognitive decline [ 1 – 3 ]. It has been proposed that abnormal accumulation of soluble amyloid beta oligomers (AβO), a proteolytic …

Suchergebnisse filtern:

Suchoperatoren:

„ ... ... “ Findet Dokumente mit genau dieser Wortgruppe in exakt dieser Schreibweise und Reihenfolge (z.B., "rheumatische Beschwerden").
AND / UND Findet Dokumente, in denen beide Begriffe zusammen vorkommen (z.B., alkohol UND demenz).
OR / ODER Findet Dokumente, in denen einer der beiden oder beide Begriffe vorkommen (z.B., hiv ODER aids).
Leerzeichen Findet Dokumente, in denen alle Begriffe vorkommen. Der Leerschritt wird als UND interpretiert (z.B., isolierte systolische hypertonie).
NOT / NICHT Findet Dokumente, in denen der Begriff nach NOT nicht vorkommt (z.B., sars NOT sars-cov-2).
COUNT(...)>n Findet Dokumente, in denen der gesuchte Begriff mehr als n mal vorkommt. n steht für eine beliebige Anzahl (z.B., COUNT(mammakarzinom)>8).
NEAR(..., ..., ) Findet Dokumente, in denen beide Begriffe in beliebiger Reihenfolge innerhalb von maximal n Worten zueinander stehen. Empfehlung: wählen Sie zwischen 15 und 30 als maximale Wortanzahl (z.B., NEAR(covid, diabetes,20)).
* Findet Dokumente, in denen der Begriff in Wortvarianten vorkommt, wobei diese VOR, HINTER oder VOR und HINTER dem Suchbegriff anschließen können (z.B., thrombose*, *thrombose, *thrombose*).
? Findet Dokumente mit dem Suchbegriff in verschiedenen Schreibweisen, hier mit s oder z, also organisation und organization. Das ? steht für eine einzige Stelle (z.B., organi?ation).
& + - Sonderzeichen werden als UND interpretiert (z.B., Diagnose + Therapie).

Sie können Operatoren mit Ihrer Suchanfrage kombinieren, um diese noch präziser einzugrenzen.

Fahren Sie mit der Maus über den Suchoperator, um eine Erklärung seiner Funktionsweise anzuzeigen.