Introduction
Origin and polarization of TAMs
Origins and functions of TAMs
Polarization of TAMs
Biological significance of TAM polarization in CRC progression and metastasis
Multi-dimensional landscape of TAM-mediated cellular carcinogenesis in CRC metastasis
Activating the invasion of CRC cells
Inducing the angiogenesis of CRC cells
Promoting the intravasation and extravasation of CRC cells
Enhancing the survival of CRC cells in the circulatory system
Contributing to the formation of pre-metastatic niches (PMN) in CRC cells
TAMs as therapeutic targets in metastatic CRC therapy
Drug | Type | Target | Function | PMID |
---|---|---|---|---|
Reprogramming TAMs | ||||
Anti-MARCO IgG | Monoclonal antibody | MARCO | Increasing population of M1 macrophages and decreasing population of M2 macrophages | 27210762 |
Tasquinimod | S100A9 inhibitor | S100A9 | Leading to the transformation of M2 macrophages into M1 macrophages | 26673090 |
Actibind (T2 RNases) | Ribonuclease | N/A | Rebalancing the ratio of M1/M2 macrophages and recruiting CD8 + T cells | 32197460 |
EZH2 inhibitor | Small-molecule inhibitors | STAT3 | Leading to the transformation of M2 macrophages into M1 macrophages | 35432300 |
Inhibiting TAMs survival | ||||
Pexidartinib (PLX3397) | CSF1R inhibitor | CSF1R | Depleting M2 macrophages and increasing CD8+ T cell infiltration | 36600555 |
Trifluridine/Tripiracil (FTD/TPI) | Combination drug of trifluridine and tipiracil | N/A | Depleting TAMs | 31611243 |
Oxaliplatin | Platinum based chemotherapy drugs | N/A | Depleting TAMs | 31611243 |
M2pep | M2 macrophage-targeting peptide | Macrophages | Reducing M2 macrophages | 24046373 |
RG7155 | Monoclonal antibody | CSF-1R | Depleting TAMs and increasing CD8+/CD4+ T cell ratio | 24898549 |
Lenvatinib | Tyrosine kinase inhibitor | VEGF and FGF receptors | Reducing TAMs numbers | 30811474 |
Inhibiting TAMs recruitment | ||||
NT157 | IGF-1R inhibitor | IGF-1R and STAT3 | Inhibiting expression of CCL2 to inhibit recruitment of TAMs | 26364612 34580284 |
AMG 820 | CSF1R antibody | CSF1 | blocking the CSF1-CSF1R signaling to inhibit recruitment of TAMs | 28655795 35718267 |
PF-04136309 | CCR2 inhibitor | CCR2 | Inhibiting CCL2 binding to CCR2 to inhibit recruitment of TAMs | 34729117 34580284 |